Frontiers in Pediatrics | Pediatric Hematology and Hematological Malignancies

Case Report

Published on 19 Dec 2025

Congenital factor XIII deficiency caused by F13A1 gene mutations presenting with intracranial hemorrhage: a case report

in Pediatric Hematology and Hematological Malignancies

Hao Wang
Ruotong Yang
Jiangchang Li

Frontiers in Pediatrics

doi 10.3389/fped.2025.1732065

472 views

Original Research

Published on 18 Dec 2025

Pediatric acute lymphoblastic leukemia relapse and prognosis: key predictors and therapeutic implications

in Pediatric Hematology and Hematological Malignancies

XiaoYan Chen
LingLing Wu
CaiYun Kuang
JiaYi Wang
WenGe Hao
Hua Jiang
WeiNa Zhang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1710578

635 views

Review

Accepted on 17 Dec 2025

Current Research Status of Third-Generation Sequencing Technology in Thalassemia Detection

in Pediatric Hematology and Hematological Malignancies

Feng Lin Zhu
Yunli Lai
Sheng He

Frontiers in Pediatrics

102 views

Original Research

Published on 17 Dec 2025

Optimizing nursing care in phototherapy to improve treatment outcomes in neonatal jaundice management

in Pediatric Hematology and Hematological Malignancies

Qian Dong
Fan Huang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1652188

638 views

Original Research

Accepted on 16 Dec 2025

Influence of White Blood Cell Count Trajectories on the Risk of Differentiation Syndrome during Induction Therapy with All-trans-retinoic Acid and Arsenic Trioxide in Pediatric Acute Promyelocytic Leukemia

in Pediatric Hematology and Hematological Malignancies

Houxin Fu
Yuchen Liu
Shaoyan Hu

Frontiers in Pediatrics

Original Research

Published on 16 Dec 2025

Molecular classification and outcomes in pediatric aplastic anemia with myeloid neoplasm-associated gene variants

in Pediatric Hematology and Hematological Malignancies

Danni Li
Meiling Liao
Yuye Liu
Luying Zhang
Yingxue Hong
Yuxia Guo
Xianmin Guan
Ying Dou
Xianhao Wen

Frontiers in Pediatrics

doi 10.3389/fped.2025.1700402

410 views

Review

Published on 16 Dec 2025

Mixed phenotype acute leukemia, the dissection of an enigmatic disease in the era of novel therapies

in Pediatric Hematology and Hematological Malignancies

Magdalena Karasek
Izabela Kubiszewska
Marta Sobas

Frontiers in Pediatrics

doi 10.3389/fped.2025.1715087

504 views

Original Research

Published on 12 Dec 2025

P2RX1 promotes mitochondrial apoptosis via calcium/CaM KII-mediated suppression of PI3K/Akt signaling in Philadelphia chromosome-positive acute lymphoblastic leukemia

in Pediatric Hematology and Hematological Malignancies

Xiao bing Li
Qin Ren
Xiang mei Ye
Jing lie Li
Lei guang Feng

Frontiers in Pediatrics

doi 10.3389/fped.2025.1730429

582 views

Brief Research Report

Accepted on 11 Dec 2025

RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN SLOVENIAN CHILDREN AND ADOLESCENTS: A SINGLE CENTER EXPERIENCE

in Pediatric Hematology and Hematological Malignancies

Mineja Leban
Marko Kavcic
Jakob Peterlin
Janez Jazbec
Barbara Faganel Kotnik

Frontiers in Pediatrics

113 views

Case Report

Accepted on 09 Dec 2025

Early Diagnostic Precision Matters: Navigating Therapeutic Uncertainty in Pediatric BPDCN Illustrated by Misdiagnosis Sequelae and Fleeting CAR-T Response

in Pediatric Hematology and Hematological Malignancies

Xiao-Yan Chen
JiaYi Wang
Wenge Hao
Qu Yuhua
Xiaojing Wang
Hua Jiang
Weina Zhang

Frontiers in Pediatrics

101 views

Brief Research Report

Accepted on 04 Dec 2025

Outcomes of T-cell Lymphoblastic Lymphoma in Children and Adolescents Treated with Dana-Farber Cancer Institute Childhood ALL Consortium Protocols

in Pediatric Hematology and Hematological Malignancies

Giacomo Gotti
Yael Flamand
Victoria Koch
Sabrina Testa
Kristen Stevenson
Thai H. Tran
Bruno Michon
Uma Athale
Lewis B. Silverman
Yana Pikman

Frontiers in Pediatrics

158 views

Editorial

Published on 04 Dec 2025

Editorial: Diagnosis and therapy pediatric hematological malignancies—recent progress—volume II

in Pediatric Hematology and Hematological Malignancies

Joanna Zawitkowska
Monika Lejman
Katarzyna Derwich

Frontiers in Pediatrics

doi 10.3389/fped.2025.1749385

597 views

Case Report

Published on 26 Nov 2025

Case Report: A case report and literature review of shwachman-diamond syndrome concurrent with klinefelter syndrome

in Pediatric Hematology and Hematological Malignancies

Chenyang Chang
Hao Chen
Hao Zhang
Jingshan Chen
Qinxin Wan
Huifang Zhu
Kaiyuan Luo
Xingyu Rao

Frontiers in Pediatrics

doi 10.3389/fped.2025.1671169

714 views

Case Report

Published on 11 Nov 2025

Hemophagocytic lymphohistiocytosis as the initial manifestation of Epstein–Barr virus-related T/NK-cell lymphoproliferative disorders in a pediatric patient: a case report and literature review

in Pediatric Hematology and Hematological Malignancies

Lianwei Ma
Xue Xing
Yonge Liu
Wei Jiang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1662074

1,408 views

Original Research

Published on 06 Nov 2025

Clinical analysis of secondary hemophagocytic syndrome in children in Gansu province

in Pediatric Hematology and Hematological Malignancies

Yongkang Zhou
Junqiang Yang
Zhongbin Tao

Frontiers in Pediatrics

doi 10.3389/fped.2025.1660880

1,193 views

Case Report

Published on 27 Oct 2025

Case Report: Autoimmune hemolytic anemia associated with ovarian teratoma in a 13-year-old: a rare paraneoplastic presentation

in Pediatric Hematology and Hematological Malignancies

Salman Althobaiti
Ahmad Assinnari
Mayes Alharbi
Razan Kurdi

Frontiers in Pediatrics

doi 10.3389/fped.2025.1700443

1,101 views

Original Research

Published on 21 Oct 2025

Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia

in Pediatric Hematology and Hematological Malignancies

Zhenzhen Zhu
Junchen Yan

Frontiers in Pediatrics

doi 10.3389/fped.2025.1665431

1,290 views

Case Report

Published on 10 Oct 2025

Case Report: Refractory systemic nmastocytosis with AML1::ETO+ acute myeloid leukemia driven by rare KIT mutation: remarkable therapeutic efficacy of avapritinib

in Pediatric Hematology and Hematological Malignancies

Song Xue
Man Chen
Hui-peng Sun
Xing-yu Cao

Frontiers in Pediatrics

doi 10.3389/fped.2025.1646001

1,875 views

Original Research

Published on 03 Oct 2025

Study on the influencing factors of the first-line treatment response to primary immune thrombocytopenia in children

in Pediatric Hematology and Hematological Malignancies

Bihan Zhang
Qian Hu
Qiaodao Wu
Jianying Ning

Frontiers in Pediatrics

doi 10.3389/fped.2025.1679463

2,026 views

Mini Review

Published on 12 Sep 2025

Revisiting cytomegalovirus in pediatric allogeneic hematopoietic stem cell transplant recipients: current strategies for prevention and management in the letermovir era

in Pediatric Hematology and Hematological Malignancies

Lisa Hiskey
Diego R. Hijano
Ramia Zakhour

Frontiers in Pediatrics

doi 10.3389/fped.2025.1663600

2,984 views

Case Report

Published on 04 Sep 2025

Case report: Successful treatment of a patient presenting with a very rare association of acute lymphoblastic leukemia and mucopolysaccharidosis type IVA

in Pediatric Hematology and Hematological Malignancies

Sofia Maria Carlotta Arnaboldi
Martha Caterina Faraguna
Antonella Colombini
Alessandra Sala
Veronica Leoni
Marco Spinelli
Giacomo Gotti
Laura Rachele Bettini
Viola Crescitelli
Anna Commone

Frontiers in Pediatrics

doi 10.3389/fped.2025.1644720

2,117 views

Case Report

Published on 02 Sep 2025

Vitamin B12 deficiency in a young male with Imerslund-Gräsbeck syndrome: case report

in Pediatric Hematology and Hematological Malignancies

Lina Xing
Yujie Guo
Yang Li
Xuquan Zhou
Fengru Lin
Yan Wang

Frontiers in Pediatrics

doi 10.3389/fped.2025.1645600

1,854 views

Editorial

Published on 22 Aug 2025

Editorial: Anemia in children: from nutritional deficits to genetic disorders

in Pediatric Hematology and Hematological Malignancies

Sachith Mettananda
Duantida Songdej
Nirmani Yasara

Frontiers in Pediatrics

doi 10.3389/fped.2025.1678056

1,934 views

Original Research

Published on 20 Aug 2025

Genotype clinical phenotype analysis of 35 cases of hereditary spherocytosis in children

in Pediatric Hematology and Hematological Malignancies

Huang Duowen
Guo Xia
Gao Ju

Frontiers in Pediatrics

doi 10.3389/fped.2025.1650295

1,333 views

291 articles

articles

Congenital factor XIII deficiency caused by F13A1 gene mutations presenting with intracranial hemorrhage: a case report

Pediatric acute lymphoblastic leukemia relapse and prognosis: key predictors and therapeutic implications

Current Research Status of Third-Generation Sequencing Technology in Thalassemia Detection

Optimizing nursing care in phototherapy to improve treatment outcomes in neonatal jaundice management

Influence of White Blood Cell Count Trajectories on the Risk of Differentiation Syndrome during Induction Therapy with All-trans-retinoic Acid and Arsenic Trioxide in Pediatric Acute Promyelocytic Leukemia

Molecular classification and outcomes in pediatric aplastic anemia with myeloid neoplasm-associated gene variants

Mixed phenotype acute leukemia, the dissection of an enigmatic disease in the era of novel therapies

P2RX1 promotes mitochondrial apoptosis via calcium/CaM KII-mediated suppression of PI3K/Akt signaling in Philadelphia chromosome-positive acute lymphoblastic leukemia

RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN SLOVENIAN CHILDREN AND ADOLESCENTS: A SINGLE CENTER EXPERIENCE

Early Diagnostic Precision Matters: Navigating Therapeutic Uncertainty in Pediatric BPDCN Illustrated by Misdiagnosis Sequelae and Fleeting CAR-T Response

Outcomes of T-cell Lymphoblastic Lymphoma in Children and Adolescents Treated with Dana-Farber Cancer Institute Childhood ALL Consortium Protocols

Editorial: Diagnosis and therapy pediatric hematological malignancies—recent progress—volume II

Case Report: A case report and literature review of shwachman-diamond syndrome concurrent with klinefelter syndrome

Hemophagocytic lymphohistiocytosis as the initial manifestation of Epstein–Barr virus-related T/NK-cell lymphoproliferative disorders in a pediatric patient: a case report and literature review

Clinical analysis of secondary hemophagocytic syndrome in children in Gansu province

Case Report: Autoimmune hemolytic anemia associated with ovarian teratoma in a 13-year-old: a rare paraneoplastic presentation

Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia

Case Report: Refractory systemic nmastocytosis with AML1::ETO+ acute myeloid leukemia driven by rare KIT mutation: remarkable therapeutic efficacy of avapritinib

Study on the influencing factors of the first-line treatment response to primary immune thrombocytopenia in children

Revisiting cytomegalovirus in pediatric allogeneic hematopoietic stem cell transplant recipients: current strategies for prevention and management in the letermovir era

Case report: Successful treatment of a patient presenting with a very rare association of acute lymphoblastic leukemia and mucopolysaccharidosis type IVA

Vitamin B12 deficiency in a young male with Imerslund-Gräsbeck syndrome: case report

Editorial: Anemia in children: from nutritional deficits to genetic disorders

Genotype clinical phenotype analysis of 35 cases of hereditary spherocytosis in children