Frontiers in Pharmacology

Original Research

Published on 02 Feb 2026

Hydroxysafflor yellow A attenuates sepsis-induced intestinal barrier dysfunction by modulating Bcl-2/SOD2-mediated mitochondrial apoptosis

in Inflammation Pharmacology

Jinzhong Fei
Chencheng Xu
Chaochao Chen
Qing Chen
Zhengbin Wu
Yaoli Wang
Daiqin Bao
Shifeng Shao

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1728183

490 views

Editorial

Published on 02 Feb 2026

Editorial: Prevention and treatment of metabolic diseases using bioactive metabolites of herbal medicines also used as foods

in Ethnopharmacology

Rong-Rui Wei
Wen-Min Liu
Chun-Su Yuan
Chun-Lei Zhang
Zhi-Pei Sang
Qin-Ge Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1779704

559 views

Original Research

Published on 02 Feb 2026

In vitro exploration of drug-induced thrombotic microangiopathies: clues of diverse endothelial activation pathways respective to interferon-β1a, ciclosporin A, and gemcitabine exposure

in Cardiovascular and Smooth Muscle Pharmacology

Edouard Cubilier
Maxime Taghavi
Eric De Prez
Lucas Jacobs
Sébastien Sinaeve
Joëlle Nortier
Marie-Hélène Antoine

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719192

627 views

Mini Review

Published on 02 Feb 2026

Repurposing metformin for cardioprotection: mechanisms and therapeutic potential across cardiovascular pathologies

in Cardiovascular and Smooth Muscle Pharmacology

Julia Khinchin
Ani Rakoubian
Valentina Romano
Thomas Ryan
Johnathan Yarbro
Satoru Kobayashi
Qiangrong Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1681783

899 views

Original Research

Published on 02 Feb 2026

Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer

in Pharmacology of Anti-Cancer Drugs

Dongsheng Tan
Gengdong Li
Xiaoda Li
Weiwei Zhai
Lijia Jing

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1734653

764 views

Original Research

Published on 02 Feb 2026

Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion

in Experimental Pharmacology and Drug Discovery

Yaoyuan Zhang
Wanyi Chen
Xinyuan Yu
Jianhua Feng
Abdul Sammad
Zhenbo Wang
Kai Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1747267

407 views

Review

Published on 02 Feb 2026

Advances in pharmacokinetic-pharmacodynamic modeling for anesthesia, 1987–2024: a review

in Neuropharmacology

Yara Tulbah
Ibrahim Aljamaan

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1741851

702 views

Original Research

Published on 02 Feb 2026

From pharmacokinetics to precision dosing: optimizing continuous infusion regimens of ciprofol for elderly patients

in Drug Metabolism and Transport

Jiaxi Zhu
Jing He
Bowen Zhong
Ying Cao
Xingan Zhang
Bo Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1764590

647 views

Review

Accepted on 31 Jan 2026

sAlpha-7 Nicotinic Acetylcholine Receptor: Targeting the interplay between inflammation, Renin-Angiotensin Aldosterone System, and nervous system for the novel treatment of heart failure

in Cardiovascular and Smooth Muscle Pharmacology

Jordan Swiderski
Laura Kate Gadanec
Stephen James Hearth
Benjamin Rowlands
Andrew James Murphy
Vasso Apostolopoulos
Anthony Zulli

Frontiers in Pharmacology

183 views

Original Research

Accepted on 31 Jan 2026

Pharmacological Mechanism of Active Components in Polygonatum odoratum for Idiopathic Pulmonary Fibrosis: A Study Integrating Bioinformatics and Experimental Validation

in Experimental Pharmacology and Drug Discovery

Qun Liang
Xuedan Cao
Shixuan Kuang
Keyi Jiang
Yaqing He
Fengfu Luo
Yuying Li
Miao Zhang
Dong He

Frontiers in Pharmacology

186 views

Original Research

Accepted on 30 Jan 2026

Rescue of cognitive and negative-like symptoms by chronic aripiprazole treatment in a 3-hit mouse model of neurodevelopmental disorder

in Neuropharmacology

Imane Mouffok
Noa Roudaut
Cécile Chofflet
Thomas Freret
Michel Boulouard
Valentine Bouet

Frontiers in Pharmacology

411 views

Original Research

Accepted on 30 Jan 2026

Role of albumin in regulating platelet function

in Cardiovascular and Smooth Muscle Pharmacology

Qiwen Tai
Mengnan Yang
Shuang Chen
Yue Xia
Chenglin Sun
Lili Zhao
Kangxi Zhou
Pixia Gong
Jie Shen
Qiuxia Huang

Frontiers in Pharmacology

456 views

Original Research

Accepted on 30 Jan 2026

Reduced-order modeling of solute transport within physiologically realistic solid tumor microenvironment

in Pharmacology of Anti-Cancer Drugs

Mohammad Mehedi Hasan Akash
Mohammad Yeasin
Shima Mahmoudirad
Redowan A Niloy
Jiyan Mohammad
Katie Reindl
Anupam Pandey
Saikat Basu

Frontiers in Pharmacology

208 views

Original Research

Accepted on 30 Jan 2026

Preliminary Evaluation of a Monovalent Antivenom Targeting Cerastes cerastes Envenomation in North Africa: Feasibility and Specificity Assessment

in Experimental Pharmacology and Drug Discovery

Nihal Mesmoudi
Salma Chakir
Khawla Ammouch
Reda Chahir
Hinde Aassila
Abdellah Moustaghfir
Mehdi KARKOURI
Naoual Oukkache

Frontiers in Pharmacology

142 views

Mini Review

Accepted on 30 Jan 2026

Modulation of Disease-Associated Gut Microbiota by Schisandra chinensis: A Literature Review

in Ethnopharmacology

Tianxia Sun
Zhimei Liu
Caiwen Wang
Hui Fan
Yifei Yue
Liping Sun

Frontiers in Pharmacology

198 views

Review

Accepted on 30 Jan 2026

Application of the miRNAs as biomarkers and therapeutic strategies in periodontal inflammation

in Cardiovascular and Smooth Muscle Pharmacology

Sarmistha Saha
Nadezhda Sachivkina
Olga Pilshchikova
Alexandr Muraev
Sergey Ivanov
Sergey G. Ivashkevih
Regina Gurina

Frontiers in Pharmacology

112 views

Original Research

Accepted on 30 Jan 2026

MSAT: A FAERS-Informed Heterogeneous Graph Neural Network for Pharmacovigilance Prediction of Chinese Materia Medica–Associated Adverse Drug Reactions

in Pharmacoepidemiology

Bowen Shi
Xiaojie Li
Jinghao Fang
Jisheng Chen
Jin Yang

Frontiers in Pharmacology

136 views

Original Research

Accepted on 30 Jan 2026

Prospective evaluation of medication-related problems and pharmacist interventions in liver transplant recipients

in Pharmacoepidemiology

Sena GÜZEL KARAHAN
Mefküre DURMUŞ
Ahmet ÇAKIR
Zeynep Ülkü GÜN
Sezai YILMAZ

Frontiers in Pharmacology

232 views

Original Research

Accepted on 30 Jan 2026

Applicability of Academic Real-World Data Research in the Case Studies of the HTx Project to Practical Health Technology Assessment Work

in Drugs Outcomes Research and Policies

Carl Björvang
Johan Pontén
Anders Viberg
Andrea Manca
Georgia Salanti
Pekka Siirtola
Gema García Sáez
Saskia Knies
Diana Delnoij
Dalia M Dawoud

Frontiers in Pharmacology

124 views

Original Research

Accepted on 30 Jan 2026

Knowledge and attitudes towards antibiotics and antimicrobial resistance among patients in rural South Africa and the implications for future policies

in Drugs Outcomes Research and Policies

Tiyani Milta Maluleke
Morgan Tiyiselani Maluleke
Nishana Ramdas
Ana Golić Jelić
Amanj Kurdi
Inaam Ur Rehman
Stephen Campbell
Vanda Marković-Peković
Natalie Schellack
Audrey Chigome

Frontiers in Pharmacology

158 views

Review

Accepted on 30 Jan 2026

Clinical Characteristics of Myelosuppression Induced by Conventional Synthetic DMARDs in 24 Rheumatoid Arthritis Patients: A Case Series

in Pharmacoepidemiology

Jingqiao TIAN
Xiaoli PAN
Juan CHEN
Yulei AO
Mei Tian
Anmao Li

Frontiers in Pharmacology

Review

Accepted on 30 Jan 2026

Upadacitinib in Rheumatoid Arthritis: Progress and Challenges

in Inflammation Pharmacology

Qiaofen Wang
Long Zhong
Yujing Fu
Yang Zhou

Frontiers in Pharmacology

223 views

Original Research

Accepted on 30 Jan 2026

A network pharmacology–guided multi-omics and spatial single-cell framework nominates WT1 as a spironolactone-linked immune biomarker in prostate cancer

in Pharmacology of Anti-Cancer Drugs

Zhen Zhu
Xingjun He

Frontiers in Pharmacology

132 views

Original Research

Accepted on 30 Jan 2026

CRIP1 promotes docetaxel resistance and immune-associated cell death modulation in prostate cancer

in Experimental Pharmacology and Drug Discovery

Dehua zhang
Meilin Han
Ni Yan
Yu Zhang
Chao Wang
Wenzhong Shi
Wenxue Jia
Jun Gao

Frontiers in Pharmacology

123 views

29,512 articles

articles

Hydroxysafflor yellow A attenuates sepsis-induced intestinal barrier dysfunction by modulating Bcl-2/SOD2-mediated mitochondrial apoptosis

Editorial: Prevention and treatment of metabolic diseases using bioactive metabolites of herbal medicines also used as foods

In vitro exploration of drug-induced thrombotic microangiopathies: clues of diverse endothelial activation pathways respective to interferon-β1a, ciclosporin A, and gemcitabine exposure

Repurposing metformin for cardioprotection: mechanisms and therapeutic potential across cardiovascular pathologies

Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer

Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion

Advances in pharmacokinetic-pharmacodynamic modeling for anesthesia, 1987–2024: a review

From pharmacokinetics to precision dosing: optimizing continuous infusion regimens of ciprofol for elderly patients

sAlpha-7 Nicotinic Acetylcholine Receptor: Targeting the interplay between inflammation, Renin-Angiotensin Aldosterone System, and nervous system for the novel treatment of heart failure

Pharmacological Mechanism of Active Components in Polygonatum odoratum for Idiopathic Pulmonary Fibrosis: A Study Integrating Bioinformatics and Experimental Validation

Rescue of cognitive and negative-like symptoms by chronic aripiprazole treatment in a 3-hit mouse model of neurodevelopmental disorder

Role of albumin in regulating platelet function

Reduced-order modeling of solute transport within physiologically realistic solid tumor microenvironment

Preliminary Evaluation of a Monovalent Antivenom Targeting Cerastes cerastes Envenomation in North Africa: Feasibility and Specificity Assessment

Modulation of Disease-Associated Gut Microbiota by Schisandra chinensis: A Literature Review

Application of the miRNAs as biomarkers and therapeutic strategies in periodontal inflammation

MSAT: A FAERS-Informed Heterogeneous Graph Neural Network for Pharmacovigilance Prediction of Chinese Materia Medica–Associated Adverse Drug Reactions

Prospective evaluation of medication-related problems and pharmacist interventions in liver transplant recipients

Applicability of Academic Real-World Data Research in the Case Studies of the HTx Project to Practical Health Technology Assessment Work

Knowledge and attitudes towards antibiotics and antimicrobial resistance among patients in rural South Africa and the implications for future policies

Clinical Characteristics of Myelosuppression Induced by Conventional Synthetic DMARDs in 24 Rheumatoid Arthritis Patients: A Case Series

Upadacitinib in Rheumatoid Arthritis: Progress and Challenges

A network pharmacology–guided multi-omics and spatial single-cell framework nominates WT1 as a spironolactone-linked immune biomarker in prostate cancer

CRIP1 promotes docetaxel resistance and immune-associated cell death modulation in prostate cancer