Frontiers in Pharmacology

Original Research

Published on 15 Apr 2025

Acute and subacute toxicity evaluation of ZhenzhuXiaoji decoction in preclinical models: implications for safe clinical use

in Predictive Toxicology

Songzhe Li
Shuchang Bao
Lingyun Cai
Baolong Li
Yue Sun
Yang Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554732

323 views

Review

Published on 15 Apr 2025

Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection

in Gastrointestinal and Hepatic Pharmacology

Qin Ye
Zi-Hang Yu
Liang Nie
Fei-Xiang Wang
Guo Mu
Bin Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533628

185 views

Review

Published on 15 Apr 2025

Parthenolide: pioneering new frontiers in hematological malignancies

in Pharmacology of Anti-Cancer Drugs

Elmira Zarei
Ayda Zarei
Azadeh Omidkhoda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534686

247 views

Perspective

Published on 15 Apr 2025

Metabolic anomalies in vitiligo: a new frontier for drug repurposing strategies

in Experimental Pharmacology and Drug Discovery

Alessia Paganelli
Federica Papaccio
Mauro Picardo
Barbara Bellei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546836

450 views

Review

Published on 15 Apr 2025

Artificial intelligence in traditional Chinese medicine: advances in multi-metabolite multi-target interaction modeling

in Ethnopharmacology

Yu Li
Xiangjun Liu
Jingwen Zhou
Fengjiao Li
Yuting Wang
Qingzhong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541509

427 views

Original Research

Published on 15 Apr 2025

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

in Experimental Pharmacology and Drug Discovery

Yongxue Gu
Mengmeng Yang
Wenbin Wang
Lihua Li
Ying Ma
Wenshan Liu
Qiang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571135

288 views

Original Research

Published on 15 Apr 2025

Multiscale screening and identifying specific targets for artesunate in suppressing bladder cancer

in Pharmacology of Anti-Cancer Drugs

Yi Yuan
Guangdi Chu
Qingyue Ma
Zhijuan Liang
Ye Liang
Haitao Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584502

284 views

Systematic Review

Published on 15 Apr 2025

Safety and efficacy of intravesical instillation of botulinum toxin-A in the treatment of interstitial cystitis/bladder pain syndrome and overactive bladder: a systematic review and meta-analysis

in Renal Pharmacology

Yongheng Zhou
Zitian He
Tianyu Xiang
Xiaoyan Cao
Huiling Cong
Qinggang Liu
Haoyu Sun
Limin Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586845

378 views

Original Research

Published on 15 Apr 2025

Construction and application of a precise evaluation method for the quality of traditional Chinese medicine based on “target-combined quality evaluation” using safflower as an example

in Ethnopharmacology

Yongfeng Zhou
Qinghua Wu
Chaoxiang Ren
Huajuan Jiang
Xulong Huang
Jiang Chen
Ping Zhang
Dingkun Zhang
Jin Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554895

274 views

Mini Review

Published on 15 Apr 2025

The functional significance of vascular DNA hypermethylation in atherosclerosis: a historical perspective

in Cardiovascular and Smooth Muscle Pharmacology

Silvio Zaina

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562674

233 views

Original Research

Published on 15 Apr 2025

Statins and long-term risk of revision surgery after total hip arthroplasty in osteoarthritis: a multi-source data linkage study

in Drugs Outcomes Research and Policies

Andrea D'Amuri
Barbara Bordini
Mauro Pagani
Jacopo Ciaffi
Claudio D'Agostino
Alberto Di Martino
Cesare Faldini
Francesco Ursini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1492200

240 views

Original Research

Published on 15 Apr 2025

Integrative analysis of m6A-SNPs and single-cell RNA sequencing reveals key drivers of endocrine combined with CDK4/6 inhibitor therapy resistance in ER+ breast cancer

in Pharmacology of Anti-Cancer Drugs

Ruijie Ming
Han Zhang
Huan Wu
Fangbiao Zhan
Xiaoping Huang
Huawen Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590363

265 views

Case Report

Published on 15 Apr 2025

Case Report: Neoadjuvant therapy with ripretinib for gastrointestinal stromal tumor: a case report

in Pharmacology of Anti-Cancer Drugs

Guanmo Liu
Zicheng Zheng
Jie Li
Yixuan He
Chenggang Zhang
Yihua Wang
Weiming Kang
Xin Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573610

216 views

Editorial

Published on 15 Apr 2025

Editorial: Emerging trends in real-world pharmacoepidemiology: 2023

in Pharmacoepidemiology

Mohammed S. Salahudeen
Tatiane Da Silva Dal Pizzol
Li-Ting Kao
Gregory M. Peterson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601477

329 views

Review

Accepted on 14 Apr 2025

Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

in Gastrointestinal and Hepatic Pharmacology

Francesco Rettura
Christian Lambiase
Riccardo Tedeschi
Antonio Grosso
Lorenzo Cancelli
Angelo Ricchiuti
Andrea Bottari
Luca Giacomelli
Nicola De Bortoli
Massimo Bellini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538791

102 views

Original Research

Accepted on 14 Apr 2025

Thrombotic adverse events associated with TNF-alpha blockers: a realworld pharmacovigilance analysis of the FAERS database

in Cardiovascular and Smooth Muscle Pharmacology

Lijuan Song
Nan Yang
Xinglong Xing
Yicong Zhao
Jingkai Di

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512806

135 views