Frontiers in Pharmacology

Original Research

Published on 11 Dec 2025

Ensemble learning approach with explainable AI for improved heart disease prediction

in Cardiovascular and Smooth Muscle Pharmacology

Ayomide Adekoya
Faisal Saeed
Wad Ghaban
Sultan Noman Qasem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654681

568 views

Original Research

Published on 11 Dec 2025

Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223–associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure

in Ethnopharmacology

Zelin Ye
Mingrui Liu
Xiaohan Zhang
Huaqin Wu
Zhiling Qiu
Ruoning Chai
Yuanhui Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697422

771 views

Correction

Published on 11 Dec 2025

Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

in Pharmacology of Anti-Cancer Drugs

Zhixin Zhan
Ziqiang Liu
Chaochao Zhang
Haijun Gao
Jiacheng Lai
Yong Chen
Haiyan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1754450

373 views

Original Research

Published on 11 Dec 2025

Disproportionality analysis of safety signals for milnacipran and levomilnacipran: a pharmacovigilance study using the FDA adverse event reporting system

in Pharmacoepidemiology

Tao Huang
Po Zhang
Yan Zhou
Lei Wang
Qing Zhang
Mingxing Li
Junli Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719881

725 views

Original Research

Published on 11 Dec 2025

Real-world safety of tirofiban: a disproportionality analysis using data from FAERS and WHO-VigiAccess

in Pharmacoepidemiology

Jia Li
Fang Wang
Lingquan Zhong
Lei Zhang
Kaiyun Ji
Yifan Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713141

853 views

Correction

Published on 11 Dec 2025

Correction: Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock

in Experimental Pharmacology and Drug Discovery

Xiang-Yu Liu
Yu-Shou Wu
Yi-Rui Qu
Hui Zhou
Tian Liu
Xiao-Wei Su
Fang-Chao Hu
Jin-Guang Zheng
Shao-Fang Han
Jia-Ke Chai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1750337

311 views

Original Research

Published on 11 Dec 2025

Efficacy and safety of Jinhuang ointment in treating acute gouty arthritis: a retrospective cohort study

in Experimental Pharmacology and Drug Discovery

Honglin Wang
Huiling Mei
Yuyu Duan
Wei Hua
Aoshuang Xu
Lin Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1728414

614 views

Correction

Published on 11 Dec 2025

Correction: Cimifugin suppresses NF-κB signaling to prevent osteoclastogenesis and periprosthetic osteolysis

in Translational Pharmacology

Juan Duan
Xuantao Hu
Tao Li
Gen Wu
Pengcheng Dou
Zhengxiao Ouyang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678203

313 views

Original Research

Published on 11 Dec 2025

Fraxin modulates lipid metabolism as well as gut flora to avert NAFLD

in Gastrointestinal and Hepatic Pharmacology

Yang Jing
Dong Huicong
Guo Xuanchi
Li Cao
Zhang Huanhuan
Guo Yongze

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657966

631 views

Original Research

Published on 11 Dec 2025

Safety evaluation and toxicokinetics of repeated inhalation exposure to pegylated interferon α-2b

in Drug Metabolism and Transport

Cuifang Ji
Xunlian Ji
Huan Li
Qinfang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689087

411 views

Review

Published on 11 Dec 2025

Pharmacological mechanisms of traditional Chinese medicine metabolites in regulating Treg cells: an integrative pathway review

in Ethnopharmacology

Chao Wang
Ming-Jie Liao
Yao Wu
Heng Lin
Zhen-Zhong Ye
Wen-Zhe Ma
Qing Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527421

753 views

Original Research

Accepted on 10 Dec 2025

Troxerutin, an efficient herbal metabolite with anti-diabetic and anti-hypercholesterolemic potential, regulates metabolic genes in male diabetic rats

in Ethnopharmacology

Saira Gul
Mahrukh Naseem
Irfan Shahzad Sheikh
Hafiz Muhammad Ali
Imtiaz Rabbani
Tariq Jamil
Sehar Gul
Zaid Chachar
Sana Ullah
Saima Asif

Frontiers in Pharmacology

260 views

Systematic Review

Accepted on 10 Dec 2025

Efficacy and safety of oral proprietary Chinese medicines in the treatment of stable chronic obstructive pulmonary disease: a network meta-analysis

in Ethnopharmacology

Hao Yan
Jingwen Zhang
Hutao Yan
Dandan Yang

Frontiers in Pharmacology

204 views

Review

Accepted on 10 Dec 2025

A Comprehensive Review on Indigenous Therapeutic Approaches in Kidney Care using Ayush Medicine

in Ethnopharmacology

Niharika Singh
Rabea Parveen
Bushra Parveen
Shahid Umar
Sayeed Ahmad

Frontiers in Pharmacology

122 views

Original Research

Accepted on 10 Dec 2025

Multi-Omics study of the anti-colorectal cancer mechanisms of formononetin in Hedysari Radix

in Ethnopharmacology

Jun Rao
Xing Wang
Tanxiu Chen
Mingzi Mo
Conglong Xu
So-Yi Chang
Ssu-Wei Hsu
Xiaoqun Han
Ching-Hsien Chen
Zhi Zheng

Frontiers in Pharmacology

194 views

Case Report

Accepted on 10 Dec 2025

Recurrent Hyperammonemic Encephalopathy in a Breast Cancer Patient Receiving Capecitabine Therapy: A Case Report

in Predictive Toxicology

Yuling Mu
Qing Li
Jilin Kong
Yuyao Zhao

Frontiers in Pharmacology

152 views

Review

Accepted on 10 Dec 2025

Comparative Efficacy of Pharmacological Agents on Abdominal Aortic Aneurysm Growth Rate: A Systematic Review and Network Meta-Analysis

in Cardiovascular and Smooth Muscle Pharmacology

Cheng Wen
Lilong Li
Bo Wang
Linyang Xie
Huaping Wu

Frontiers in Pharmacology

132 views

Original Research

Accepted on 10 Dec 2025

In vitro exploration of drug-induced thrombotic microangiopathies: clues of diverse endothelial activation pathways respective to interferon-β1a, ciclosporin A, and gemcitabine exposure

in Cardiovascular and Smooth Muscle Pharmacology

Edouard Cubilier
Maxime Taghavi
Eric De Prez
Lucas Jacobs
Sébastien Sinaeve
Joelle Nortier
Marie-Hélène Antoine

Frontiers in Pharmacology

148 views

Original Research

Accepted on 10 Dec 2025

Patients' Experiences and Practices of Medication Literacy in Inflammatory Bowel Disease: A Qualitative Study

in Drugs Outcomes Research and Policies

Wanya Pan
Wenhao Tian
Shuyan Li
Yuan Zhao
Yan He
Yanjie Liu
Xiuqin Feng

Frontiers in Pharmacology

131 views

Original Research

Accepted on 10 Dec 2025

Randomized Trial and Multi-Omics, Machine Learning–Based Mechanistic Exploration of Daixie Decoction Granules in Type 2 Diabetes

in Integrative and Regenerative Pharmacology

Zhong Zheng
Kepei Zhang
Xiaogang Ma
Yuezhou Qian
Miao Wang

Frontiers in Pharmacology

135 views

Original Research

Published on 10 Dec 2025

Isoliensinine confers neuroprotection and alleviates LPS-induced neuroinflammation in microglia by regulating the MAPK/NF-κB signaling

in Inflammation Pharmacology

Mengqin Yuan
Jinda Hu
Lichen Gao
Wei Long
Sirui Wang
Xinyue Tan
Jinyue Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675865

619 views

Systematic Review

Published on 10 Dec 2025

From mechanisms to anti-fibrotic drugs in hepatic stellate cell research: a global bibliometric analysis with patent and clinical perspectives (2000–2025)

in Gastrointestinal and Hepatic Pharmacology

Xiaowen Mao
Peng Chen
Palidan Wubur
Yi Liu
Yuan Zhao
Siwei Zhang
Na Guan
Bin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734449

1,188 views

Original Research

Published on 10 Dec 2025

Real-world patient outcomes with Blinatumomab and Inotuzumab in adult relapsed/refractory B-cell acute lymphoblastic leukemia: a retrospective analysis from two Romanian oncology centers

in Translational Pharmacology

Ion Antohe
Amalia Titieanu
Vlad Andrei Cianga
Cosmin Minciună
Cătălin Dănăilă
Alina Daniela Tănase
Iuliu Ivanov
Loredana Dragoş
Mihaela Zlei
Mihaela Mențel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684382

657 views

Original Research

Published on 10 Dec 2025

Real-world data analysis of the risk of Fournier’s gangrene in patients using sodium-glucose cotransporter 2 inhibitors (SGLT2i)

in Translational Pharmacology

Moritz Hertel
Hanno Jaoulak
Max Heiland
Susanne Nahles
Robert Preissner
Saskia Preissner

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643866

611 views

29,106 articles

articles

Ensemble learning approach with explainable AI for improved heart disease prediction

Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223–associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure

Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

Disproportionality analysis of safety signals for milnacipran and levomilnacipran: a pharmacovigilance study using the FDA adverse event reporting system

Real-world safety of tirofiban: a disproportionality analysis using data from FAERS and WHO-VigiAccess

Correction: Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock

Efficacy and safety of Jinhuang ointment in treating acute gouty arthritis: a retrospective cohort study

Correction: Cimifugin suppresses NF-κB signaling to prevent osteoclastogenesis and periprosthetic osteolysis

Fraxin modulates lipid metabolism as well as gut flora to avert NAFLD

Safety evaluation and toxicokinetics of repeated inhalation exposure to pegylated interferon α-2b

Pharmacological mechanisms of traditional Chinese medicine metabolites in regulating Treg cells: an integrative pathway review

Troxerutin, an efficient herbal metabolite with anti-diabetic and anti-hypercholesterolemic potential, regulates metabolic genes in male diabetic rats

Efficacy and safety of oral proprietary Chinese medicines in the treatment of stable chronic obstructive pulmonary disease: a network meta-analysis

A Comprehensive Review on Indigenous Therapeutic Approaches in Kidney Care using Ayush Medicine

Multi-Omics study of the anti-colorectal cancer mechanisms of formononetin in Hedysari Radix

Recurrent Hyperammonemic Encephalopathy in a Breast Cancer Patient Receiving Capecitabine Therapy: A Case Report

Comparative Efficacy of Pharmacological Agents on Abdominal Aortic Aneurysm Growth Rate: A Systematic Review and Network Meta-Analysis

In vitro exploration of drug-induced thrombotic microangiopathies: clues of diverse endothelial activation pathways respective to interferon-β1a, ciclosporin A, and gemcitabine exposure

Patients' Experiences and Practices of Medication Literacy in Inflammatory Bowel Disease: A Qualitative Study

Randomized Trial and Multi-Omics, Machine Learning–Based Mechanistic Exploration of Daixie Decoction Granules in Type 2 Diabetes

Isoliensinine confers neuroprotection and alleviates LPS-induced neuroinflammation in microglia by regulating the MAPK/NF-κB signaling

From mechanisms to anti-fibrotic drugs in hepatic stellate cell research: a global bibliometric analysis with patent and clinical perspectives (2000–2025)

Real-world patient outcomes with Blinatumomab and Inotuzumab in adult relapsed/refractory B-cell acute lymphoblastic leukemia: a retrospective analysis from two Romanian oncology centers

Real-world data analysis of the risk of Fournier’s gangrene in patients using sodium-glucose cotransporter 2 inhibitors (SGLT2i)