Frontiers in Pharmacology

Original Research

Published on 05 Dec 2025

Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status

in Drug Metabolism and Transport

Lan Gao
Neil Smith
Ronald Kong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701617

618 views

Original Research

Published on 05 Dec 2025

Comparative study of the registration procedure of locally manufactured herbal products in selected African countries

in Ethnopharmacology

Aisha Gambo
Nceba Gqaleni
Limakatso Lebina
Lehlohonolo J. Mathibe

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695809

543 views

Original Research

Published on 05 Dec 2025

Machine learning-based prediction model for teicoplanin plasma concentrations in adults with liver disease using real-world data

in Drug Metabolism and Transport

Fengbi Jian
Xiaodong Chen
Ming Wang
Zhihao Guo
Xuechun Li
Haobin Jian
Ronghong Ji
Liying Liang
Ze Yu
Yanfang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703976

678 views

Brief Research Report

Published on 05 Dec 2025

CCR2 improves tumor directed CAR-T cell trafficking in ovarian cancer

in Pharmacology of Anti-Cancer Drugs

Raj Kumar
Irva E. Veillard
Mengyao Xu
Linah Al-Alem
Bo R. Rueda
Oladapo O. Yeku

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651526

909 views

Original Research

Accepted on 04 Dec 2025

Erythrosine-Induced Hepatic Biomarkers and Histopathological Changes in Male Rats: Protective Effects of Lycopene and Anthocyanin

in Gastrointestinal and Hepatic Pharmacology

Dr.SAFAA H QAHAL
Fatimah A Alqahtani
Haleema Al-Nahari
Fawzyah A Alghamdi
Fatimah H Khouja
Amna H Khouja

Frontiers in Pharmacology

143 views

Original Research

Accepted on 04 Dec 2025

Economic Value and Clinical Impact Association of a Supervised Lifestyle-improving Program for MASLD

in Gastrointestinal and Hepatic Pharmacology

Maurizio Gaetano Polignano
Antonella Bianco
Davide Guido
Pietro Trisolini
Isabella Franco
Caterina Bonfiglio
Gianluigi Giannelli

Frontiers in Pharmacology

143 views

Original Research

Accepted on 04 Dec 2025

β-sitosterol ameliorates myocardial infarction injury via modulating the NF-κB and necroptosis signaling pathways

in Cardiovascular and Smooth Muscle Pharmacology

Jia-jia Xu
Min-wei Chen
Long-zhen Lai
Di Xiao
Shu-yan Jiang
Jun-xin Lin
Zheng-hao Zhang
Zhonggui Shan

Frontiers in Pharmacology

182 views

Original Research

Accepted on 04 Dec 2025

Steaming Duration-Dependent Effects on the In Vivo Distribution, Anti-Fatigue Activity, and Gut Microbiota Modulation of Polygonatum cyrtonema Hua Polysaccharides

in Ethnopharmacology

Shengrong Lin
Yanling Wang
Weijing Wu
Xinqi Cai
Jiaqi Huang

Frontiers in Pharmacology

159 views

Review

Accepted on 04 Dec 2025

Bioactive Metabolites of Botanical Drugs in the Treatment of Intervertebral Disc Degeneration-A Review of Promising Therapeutic Candidate

in Ethnopharmacology

Le Qi
Xinming Fan
Jiabing Sun

Frontiers in Pharmacology

139 views

Original Research

Accepted on 04 Dec 2025

Schisandra chinensis Alleviates Hypertriglyceridemia in Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Hepatic Lipid Metabolism: Identification of Its Active Fractions

in Ethnopharmacology

琪李
mei feng
qi luo
chen yalin ye
yi ke luo
ling yu xu

Frontiers in Pharmacology

132 views

Original Research

Accepted on 04 Dec 2025

Genome-wide CRISPR screen identified NEK6 as a determinant of sensitivity to CDK4/6 inhibitor in endometrial cancer

in Pharmacology of Anti-Cancer Drugs

Fangfang Jian
Chongying Zhu
Yiwei Wang
Tianyu Zhou
Chenmin Yang
Weiwei Feng

Frontiers in Pharmacology

127 views

Original Research

Accepted on 04 Dec 2025

Historical studies on the use of Rhubarb in Japan

in Ethnopharmacology

Misato Ota
Toshiaki Makino

Frontiers in Pharmacology

197 views

Original Research

Published on 04 Dec 2025

Rhein ameliorates inflammation, gut dysbiosis, and renal injury in obesity-related glomerulopathy mice

in Ethnopharmacology

Minmin Xu
Yue Yu
Lijie Li
Kang Zhao
Jingjing Lai
Lifang Wei
Li Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654062

640 views

Systematic Review

Published on 04 Dec 2025

Effectiveness and safety of tocilizumab in refractory noninfectious uveitis: a systematic review and meta-analysis

in Inflammation Pharmacology

Huanmin Kang
Xue Wu
Hanyue Xu
Yufan Huang
Ming Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694311

774 views

Review

Published on 04 Dec 2025

Botany, traditional uses, phytochemistry, pharmacology, toxicology and processing of Rhizoma alismatis: a review

in Ethnopharmacology

Tianhan Pan
Ruonan Tang
Jiawen Wang
Jia Gao
Fusheng Jiang
Buyang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722483

922 views

Mini Review

Published on 04 Dec 2025

Effect of plant-derived exosome-like nanoparticles in ultraviolet-induced skin photoaging

in Experimental Pharmacology and Drug Discovery

Hai Dong
Yi Deng
Jiayan Li
Wen Lin
Yangyan Luo
Yuan Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721879

624 views

Original Research

Published on 04 Dec 2025

Physiologically-based pharmacokinetic modeling and simulation for initial dose optimization of levetiracetam in pediatrics

in Obstetric and Pediatric Pharmacology

Julia Macente
Rodolfo Hernandes Bonan
Edilainy Rizzieri Caleffi-Marchesini
Leonardo Régis Leira Pereira
Priscila De Freitas Lima
Pieter Annaert
Karel Allegaert
Andrea Diniz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678960

812 views

Case Report

Published on 04 Dec 2025

Case Report: Exercise-associated changes of leukocyte gene expression in statin-associated myopathy

in Cardiovascular and Smooth Muscle Pharmacology

Galyna Bondar
Abhinandan Das Mahapatra
Irina Silacheva
Tra-Mi Bao
Thomas Vu
Stephanie Su
Adrian Hairapetian
Ananya Katappagari
Liana Galan
Joshua Chandran

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695543

2,703 views

Review

Published on 04 Dec 2025

Endothelium glutamate receptors in brain pathology

in Pharmacology of Ion Channels and Channelopathies

Sergey V. Pirozhkov
Marina N. Vukolova
Varvara V. Bulgakova
Yulia A. Lutokhina
Sergey B. Bolevich
Alexander I. Sobolevsky
Maria V. Yelshanskaya

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709274

1,010 views

Original Research

Published on 04 Dec 2025

A food-medicine homology formulation ameliorates atherosclerosis by attenuating dyslipidemia and inflammation via the PI3K/Akt/NF-κB pathway

in Experimental Pharmacology and Drug Discovery

Yadong Zheng
Kaili Chen
Shuo Zhang
Junsong Jing
Zhihao Zhou
Junfeng Lu
Christian Holscher
Wenlong Chen
Liguo Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710585

1,540 views

Systematic Review

Published on 04 Dec 2025

Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials

in Drugs Outcomes Research and Policies

Renshu Zhang
Rui Wang
Yun Li
Wenqi Tian
Dandan Niu
Wencong Cheng
Xiaofang Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708316

767 views

Original Research

Published on 04 Dec 2025

Xiaoyao Pill alleviates ulcerative colitis by inhibiting ferroptosis of enterocytes via activating Nrf2/Gpx4 signaling pathway

in Ethnopharmacology

Zehua Zhou
Xueting Xing
Ruomei Zhang
Xiaoqing Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702452

885 views

Review

Published on 04 Dec 2025

Application of neural stem cells in the treatment of intracerebral hemorrhage: a systematic review

in Neuropharmacology

Ping Song
Zohaib Shafiq
Hongxiang Jiang
Qiang Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660614

869 views

Editorial

Published on 04 Dec 2025

Editorial: The multiple applications of marine-derived bioactives

in Ethnopharmacology

Patricia Rijo
Deniz Tasdemir
Ana Rotter

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1733987

497 views