Frontiers in Pharmacology

Clinical Trial

Published on 14 Apr 2025

Bioequivalence and safety assessment of sorafenib tosylate tablets in healthy Chinese subjects under fasting conditions

in Drug Metabolism and Transport

Zhaoyu Wang
Hong Peng
Yun Zhang
Xijing Chen
Jiye A

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1470095

264 views

Original Research

Published on 14 Apr 2025

5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway

in Renal Pharmacology

Shaona Li
Hongjuan Yang
Bing Zhang
Lingyu Li
Xiangkun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1506482

213 views

Original Research

Accepted on 11 Apr 2025

Anti-inflammatory effect and mechanism of stytontriterpene D on RAW264.7 cells and zebrafish

in Inflammation Pharmacology

Chuqin Yu
Gao Qiu
Quanwei Xie
Xiangying Liu
Zonghao Lin
Feng Wang
Lei Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559022

338 views

Original Research

Accepted on 11 Apr 2025

Antibacterial activity of tamoxifen derivatives against methicillinresistant Staphylococcus aureus

in Pharmacology of Infectious Diseases

Irene Molina Panadero
Javier Falcón Torres
Abdelkrim Hmadcha
Salvatore Princioto
Luigi Cutarella
Mattia Mori
Sabrina Dallavalle
Michail Christodoulou
Younes Smani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549288

196 views

Original Research

Accepted on 11 Apr 2025

Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells

in Experimental Pharmacology and Drug Discovery

Ye Yang
Jieyun Zhou
Qiaoying Lv
Qicheng Ni
Baichun Hu
Yulong Wang
Shuning Qu
Guoting Li
Wenjie Yang
Ruihua Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573032

144 views

Original Research

Accepted on 11 Apr 2025

Synergistic Effects of Retinol and Retinyl Palmitate in Alleviating UVB-Induced DNA Damage and Promoting the Homologous Recombination Repair in Keratinocytes

in Experimental Pharmacology and Drug Discovery

Jiangming Zhong
Ling Liang
Nan Zhao
Jing Wang
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562244

182 views

Original Research

Accepted on 11 Apr 2025

Triptolide alleviates psoriasis through inhibiting the Wnt5a/β-Catenin signaling pathway

in Ethnopharmacology

Chengguang Zhao
Eryang Chen
Lei Wang
Qu Wang
Yaning Dou
Hongyan Qu
Junyi Zhu
Haiyang Zhao
Suqing Zheng
Bin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534118

126 views

Original Research

Accepted on 11 Apr 2025

Multi-Target Neuroprotection by dl-PHPB in APP/PS1 Mice: a proteomic analysis

in Neuropharmacology

Yingni Sun
Guoliang Bai
Kangmin Yang
Yong Feng
Hongmei Sun
Li Xian
Hongwei Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554168

Original Research

Accepted on 11 Apr 2025

Prognostic Significance and Multivariate Modeling of COL4A Family Genes and HMGA2 in Glioma

in Experimental Pharmacology and Drug Discovery

Aijun Lu
Jiankun Zang
Na Tan
Liping Wei
Ying Liang
Zefeng Tan
Anding Xu
Dan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591932

Original Research

Accepted on 11 Apr 2025

Bioactive Compounds Combination from Rhodiola tangutica Alleviates Pulmonary Vascular Remodeling in High-Altitude Pulmonary Hypertension Rat through PI3K-AKT Pathway

in Ethnopharmacology

Na Yang
Meiduo Huayu
Shanshan Su
Bin Hou
Zhanting Yang
Xingmei Nan
Zhanqiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582677

157 views

Original Research

Accepted on 11 Apr 2025

Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-Candida albicans agent targeting cellular iron homeostasis

in Experimental Pharmacology and Drug Discovery

Xiaowei Chai
Yuanying Jiang
Hui Lu
Xin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574990

188 views

Original Research

Accepted on 11 Apr 2025

Exploring the therapeutic potential and in vitro validation of Baicalin for the treatment of triple-negative breast cancer

in Ethnopharmacology

Yuan Ma
Ying Pan
乾程赵
Chongheng Zhang
Haitao He
Lihua Pan
Jianling Jia
Aiping Shi
Yiming Yang
Wenfeng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530056

105 views

Editorial

Accepted on 11 Apr 2025

Advanced Therapeutic Strategies and Safety Profiles in Heart Failure with Reduced Ejection Fraction: Contextualizing Recent Findings

in Cardiovascular and Smooth Muscle Pharmacology

Maria del Carmen Asensio Lopez
Paolo Severino
Antonio Lax

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607362

212 views

Original Research

Accepted on 11 Apr 2025

Prediction of pharmacokinetic/pharmacodynamic properties of aldosterone synthase inhibitors at drug discovery stage using an artificial intelligence-physiologically based pharmacokinetic model

in Drug Metabolism and Transport

Mengjun Zhang
Keheng Wu
Sihui Long
Xiong Jin
Bo Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578117

Original Research

Accepted on 11 Apr 2025

Loss of expression and function of Gβγ by GNB1 Encephalopathy-associated L95P mutation of Gβ 1 subunit

in Neuropharmacology

Haritha Polagari Reddy
Tal Keren-Raifman
Galit Tabak
Nathan Dascal
Daniel Yakubovich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592012

111 views

Perspective

Accepted on 11 Apr 2025

How to protect Chinese medicine prescriptions more effectively？

in Ethnopharmacology

Xiaochang Liu
Gaoyuan Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545986