Frontiers in Pharmacology

Original Research

Accepted on 26 Jan 2026

Lycium barbarum Polysaccharides as Prebiotics Prevent Colorectal Cancer Liver Metastasis in Non-Alcoholic Fatty Liver Disease by Modulating Gut Microbiota–FGF21-PI3K-AKT Axis

in Ethnopharmacology

Shuai Zhao
Zhenyao Tan
Jiaxin Suo
Yang Bu

Frontiers in Pharmacology

183 views

Review

Accepted on 26 Jan 2026

Natural Products as Kinase Inhibitors in Lung Cancer: Molecular Mechanisms, Therapeutic Potential, and Clinical Trials

in Pharmacology of Anti-Cancer Drugs

Adil Farooq Wali
Sirajunisa Talath
Rasha Babiker
Mohamed El-Tanani
Imran Rangraze
Walaa Ibraheem
Yusra Saif Al Dhaheri
Shakta Mani Satyam
Yahia El-Tanani

Frontiers in Pharmacology

188 views

Review

Accepted on 26 Jan 2026

Early Biomarkers for Predicting Sepsis-Induced Shock: Insights from Inflammatory Pathways and Immune Response

in Inflammation Pharmacology

Xiaoling Feng
Jia Li
Qiufang Zhao
Haiyun Gao
Hongjun Wang
Cong Guo

Frontiers in Pharmacology

158 views

Review

Accepted on 26 Jan 2026

The "Habitat-Phytochemistry-Pharmacological Effect(HPPE)" Nexus: A Multidimensional Review of Ethnomedicinal Salvia in China

in Ethnopharmacology

琳琳赵
Xing Yang
Sijing Su
Jihang Xie
Qian Zhang
Houyu Sen
Jiaxin Li
Xianzhe Li
Mingkun Meng
Ting Wang

Frontiers in Pharmacology

116 views

Perspective

Accepted on 26 Jan 2026

A Transdisciplinary Framework for Managing Metabolic Dysfunction Associated Steatotic Liver Disease

in Ethnopharmacology

Sania Kouser
Sanket V Sharma
Arun Bhanu
Subrahmanya K Kumar
Vishnuprasad N Chethala

Frontiers in Pharmacology

184 views

Systematic Review

Accepted on 26 Jan 2026

Efficacy and Safety of Immune Checkpoint Inhibitors Combined with Chemoradiotherapy in Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

in Pharmacology of Anti-Cancer Drugs

Chao Xiao
Siyuan Zeng
Luying Li
Ruiqi Wang
XUE XIAO

Frontiers in Pharmacology

175 views

Systematic Review

Accepted on 26 Jan 2026

Ethnopharmacology and ecosystem applications of woody plant species in the Southern European Alps: A systematic review

in Ethnopharmacology

Matteo Orlando
Parham Joolaei
Giovanna FERRENTINO
Maria Concetta Tenuta
Stefan Zerbe

Frontiers in Pharmacology

138 views

Original Research

Accepted on 26 Jan 2026

In silico and in vitro investigation of the mechanisms of the drug-drug interaction between Fludarabine and Busulfan

in Drug Metabolism and Transport

Khalil Ben Hassine
Shannon Robin
Frederic Baleydier
Mourad Mseddi
Vid Mlakar
Jayaraman Muthukumaran
Marc Ansari
Chakradhara Rao Satyanarayana Uppugunduri

Frontiers in Pharmacology

204 views

Original Research

Accepted on 26 Jan 2026

3D-QSAR study for the development of chalcone-based inhibitors targeting ovarian cancer cells with experimental validation

in Pharmacology of Anti-Cancer Drugs

Manuel Valenzuela-Valderrama
Aranxa Varas
Mariaignacia Rubilar
Marcos Lorca
Jaime Mella
Christian Espinosa-Bustos
Javier Echeverría
Marco Mellado

Frontiers in Pharmacology

131 views

Review

Accepted on 26 Jan 2026

Exploring Colombian Medicinal Flora Used in Indigenous Health Systems for Neuropsychiatric Disorders and Neuropharmacological Potential: An Ethnopharmacological Review

in Ethnopharmacology

Katrin Brache
Mauricio Diazgranados

Frontiers in Pharmacology

142 views

Original Research

Accepted on 26 Jan 2026

A highly specific fluorescent probe with facile pretreatment for rapid and accurate detection of sulfur dioxide residues in Wolfberry (Lycium barbarum L.)

in Ethnopharmacology

Xie-an Yu
Yuanyuan Ge
Wei Chen
Lingling Jiang
Kunhui Sun
Guojing Liu
Yanfeng Liu
Yibao JIN
Ping Wang
Lan Ma

Frontiers in Pharmacology

143 views

Systematic Review

Accepted on 26 Jan 2026

Natural Compounds as Multitarget Agents in Alzheimer's Diseases: Evidence from In Vivo and In Vitro Models

in Neuropharmacology

Vicko Suswidiantoro
Kim San Tang
Khalid Rahman
Donna Maretta Ariestanti
Richard Johari James
Choo Chee Yan
Mitsuyasu Kato
Fadlina Chany Saputri

Frontiers in Pharmacology

135 views

Review

Accepted on 26 Jan 2026

Opening Pharmacological Avenues in Mitochondrial Dysfunction: From Mood Disorders to Perioperative Anesthetic Complications

in Experimental Pharmacology and Drug Discovery

Florencia Verbal
Nicole Rubilar
Ana Marileo
Humberto Fierro
Oscar Guillermo Ramírez-Molina
Araceli Pinto
Gonzalo E Yevenes
Jorge Fuentealba
Jessica Panes-Fernández

Frontiers in Pharmacology

101 views

Review

Accepted on 26 Jan 2026

AI-Driven Pilot Platforms and Computational Pharmaceutics: Accelerating Innovation in Small Molecule Drug Development under Industry 4.0 and 5.0 Paradigms

in Experimental Pharmacology and Drug Discovery

Kaixin Luo
Yuhan Yang
Chenggong Zhong
Meiqi Chen
Jun Xiong
Lianyi He
Dingying Liu
Ihab Mohamed Elshoura
Zaid Chachar
Yuanzhe Cai

Frontiers in Pharmacology

134 views

Review

Published on 26 Jan 2026

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

in Neuropharmacology

Hui Wang
Yining Chen
Allen Zhao
Zhongxia Shen
Yu Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709060

1,100 views

Original Research

Published on 26 Jan 2026

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID

in Neuropharmacology

Laura Seixas Bianco
Tiago Nicoliche
Nelson Francisco Corrêa-Neto
Rafael Lanaro
Ariadiny L. Caetano
Carla Maximo Prado
Rodrigo Portes Ureshino
Iolanda de Fátima Lopes Calvo Tibério
Renato Fraga Righetti
Roberta Sessa Stilhano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703727

881 views

Review

Published on 26 Jan 2026

Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus

in Neuropharmacology

Gabriel Holguin
Rémi Martin-Fardon

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1729040

770 views

Opinion

Published on 26 Jan 2026

Challenges in performing clinical research on herbal products – experiences from Switzerland and the UK

in Ethnopharmacology

Angélique Bourqui
Chantal Csajka
Michael Heinrich
Clara Podmore
Catherine Simpson
Jeanne Trill
Merlin Willcox
Pierre-Yves Rodondi

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1766381

944 views

Review

Published on 26 Jan 2026

Guarding the heart in the era of immunotherapies: insights for cardio-oncology practice

in Cardiovascular and Smooth Muscle Pharmacology

Umamah Iram
Djamel Lebeche

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1762239

1,125 views

Original Research

Published on 26 Jan 2026

Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury

in Inflammation Pharmacology

Hong Hu
Zike Chen
Jinlu Han
Mengyan Chen
Yun Song
De Zhao
Chen Wang
Min Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1754172

524 views

Review

Published on 26 Jan 2026

The dual effects of anesthetics on glial cells: a review of neuroprotection and neurotoxicity

in Neuropharmacology

Xiaodong Wang
Minghe Zhao
Zhihui Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1724695

614 views

Original Research

Published on 26 Jan 2026

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk

in Renal Pharmacology

Yue Tu
Wenjie Liu
Tianqing Sang
Liuyunxin Pan
Wei Wu
Qijun Fang
Yinglu Liu
Buhui Liu
Yigang Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1693000

680 views

Case Report

Published on 26 Jan 2026

Occult cerebral hemorrhage induced by high-dose oral methanol poisoning: a case report

in Predictive Toxicology

Yuncheng Tang
Pengfei Liang
Qiming Fang
Juan Zhao
Li Zhang
Xiaolin Zhang
Haowen Tang
Yu Jiang
Zhiwen Zhao
Bo Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1757281

577 views

Policy Brief

Published on 26 Jan 2026

Designing integrated early-phase protocols to reduce substantial modifications, including considerations for patient cohorts – a multi-stakeholder consensus view for a practical approach in Germany

in Drugs Outcomes Research and Policies

R. Schultz-Heienbrok
S. Baumann
R. Böhm
A. Bonertz
K. Breithaupt-Groegler
U. Buckpesch-Heberer
M. Coenen
K. Erb-Zohar
N. Faisst
G. Grass

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699906

843 views

29,545 articles

articles

Lycium barbarum Polysaccharides as Prebiotics Prevent Colorectal Cancer Liver Metastasis in Non-Alcoholic Fatty Liver Disease by Modulating Gut Microbiota–FGF21-PI3K-AKT Axis

Natural Products as Kinase Inhibitors in Lung Cancer: Molecular Mechanisms, Therapeutic Potential, and Clinical Trials

Early Biomarkers for Predicting Sepsis-Induced Shock: Insights from Inflammatory Pathways and Immune Response

The "Habitat-Phytochemistry-Pharmacological Effect(HPPE)" Nexus: A Multidimensional Review of Ethnomedicinal Salvia in China

A Transdisciplinary Framework for Managing Metabolic Dysfunction Associated Steatotic Liver Disease

Efficacy and Safety of Immune Checkpoint Inhibitors Combined with Chemoradiotherapy in Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

Ethnopharmacology and ecosystem applications of woody plant species in the Southern European Alps: A systematic review

In silico and in vitro investigation of the mechanisms of the drug-drug interaction between Fludarabine and Busulfan

3D-QSAR study for the development of chalcone-based inhibitors targeting ovarian cancer cells with experimental validation

Exploring Colombian Medicinal Flora Used in Indigenous Health Systems for Neuropsychiatric Disorders and Neuropharmacological Potential: An Ethnopharmacological Review

A highly specific fluorescent probe with facile pretreatment for rapid and accurate detection of sulfur dioxide residues in Wolfberry (Lycium barbarum L.)

Natural Compounds as Multitarget Agents in Alzheimer's Diseases: Evidence from In Vivo and In Vitro Models

Opening Pharmacological Avenues in Mitochondrial Dysfunction: From Mood Disorders to Perioperative Anesthetic Complications

AI-Driven Pilot Platforms and Computational Pharmaceutics: Accelerating Innovation in Small Molecule Drug Development under Industry 4.0 and 5.0 Paradigms

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID

Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus

Challenges in performing clinical research on herbal products – experiences from Switzerland and the UK

Guarding the heart in the era of immunotherapies: insights for cardio-oncology practice

Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury

The dual effects of anesthetics on glial cells: a review of neuroprotection and neurotoxicity

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk

Occult cerebral hemorrhage induced by high-dose oral methanol poisoning: a case report

Designing integrated early-phase protocols to reduce substantial modifications, including considerations for patient cohorts – a multi-stakeholder consensus view for a practical approach in Germany