Frontiers in Pharmacology

Mini Review

Published on 04 Dec 2025

CX3CR1: a potential microglia-specific PET imaging target in Alzheimer’s and Parkinson’s diseases

in Inflammation Pharmacology

Hongzhi Yang
Yanli Wang
Yulong Xu
Changning Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678159

856 views

Mini Review

Published on 04 Dec 2025

Recent advances in gut microbiota-based nanotherapies for cancer treatment

in Pharmacology of Anti-Cancer Drugs

Yuan Xu
Menglu Zhu
Yongchang Zhao
Enjia Chai
Miaolian Wu
Mengmeng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617942

575 views

Hypothesis and Theory

Published on 04 Dec 2025

Ibogaine’s potential role in supporting reward system recovery across diagnostic boundaries

in Neuropharmacology

Mark Nicolas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1744383

1,355 views

Editorial

Published on 04 Dec 2025

Editorial: The multiple applications of marine-derived bioactives

in Ethnopharmacology

Patricia Rijo
Deniz Tasdemir
Ana Rotter

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1733987

503 views

Original Research

Accepted on 03 Dec 2025

Mechanistic Insights into Shenqi Dihuang Decoction in the Treatment of Immunoglobulin A Nephropathy

in Experimental Pharmacology and Drug Discovery

Yachan Gao
Xinxin Pang
Dongdong Li
Xiaoyong Chen
Dongyang Li
Zhenyi Chen

Frontiers in Pharmacology

198 views

Original Research

Accepted on 03 Dec 2025

Therapeutic effects of Lactobacillus rhamnosus and/or thymol against neurotoxicity in propionic acid (PA)-induced autistic rats: Insights for the role of Nrf2/HO-1, Wnt3/β-Catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1 and PERK/CHOP/Bcl-2 pathways

in Neuropharmacology

Hoda A. Salem
Nermin Rizk
Moustafa H Abdelsalam
Rehab Ahmed
Hebatallah Atteia
Ahmed M.E. Hamdan
Areej A. Alghamdi
Manar A. Alghusn
Renad A. Alatawi
Rawan A. Atallah

Frontiers in Pharmacology

253 views

Review

Accepted on 03 Dec 2025

The improvement effect and mechanism of traditional Chinese medicine on chemotherapy-induced diarrhea: a systematic review

in Ethnopharmacology

Xiaoyan Cao
Yuzheng WU
Lequan Yu
Jingchun Yao
Chenghong Sun
Jingya Ruan
Dan Wang
Yi Zhang
Tao Wang

Frontiers in Pharmacology

181 views

Original Research

Accepted on 03 Dec 2025

Antiviral Activity of Hellenia speciosa (J. Koenig) S.R. Dutta Rhizome Metabolites Against Human Adenovirus: Insights from Molecular Docking and In Vitro Studies

in Ethnopharmacology

SARA ALNHHAS
Thamer Bouback
Abdulaziz Albeshri
Tasneem Alsahafi
Faisal Al-Sarraj
Faten A. Al-sulaimany
Mohamed Ahmed Ali
Yassmin Moatasim
Omnia Kutkat
Mohamed Gaballah

Frontiers in Pharmacology

147 views

Review

Accepted on 03 Dec 2025

Traditional Chinese medicine for HIV-related chronic comorbidities: evidence and potential therapeutic mechanisms

in Ethnopharmacology

Jiahe Li
Liran Xu
Xue Ding
Xiuxia Ma
Pengyu Qian
Nao Qiu
Jingyu Yue

Frontiers in Pharmacology

337 views

Systematic Review

Accepted on 03 Dec 2025

The Potential Role of GLP-1 Receptor Agonists in Substance Use Disorders: A Systematic Review

in Neuropharmacology

Kim Martina Völker
Bastian Lucas Holger Prechtl
Nicholas Bormann
Doo-Sup Choi

Frontiers in Pharmacology

238 views

Systematic Review

Accepted on 03 Dec 2025

Optimizing Phenytoin Therapy: A Systematic Review of Clinically Relevant Food and Herb Interactions

in Neuropharmacology

ADRIANA MONSERRATH ORELLANA PAUCAR
Erick Thomas Mosquera-Lopez
Nancy Michelle Bustamante-Alvarez
María Gabriela Machado-Orellana
Daniela Alejandra Vintimilla-Rojas
John Diego Atiencia-Palacios
Ana Cristina Espinoza Fajardo

Frontiers in Pharmacology

177 views

Review

Accepted on 03 Dec 2025

Evidence-Based Production Framework for Herbal Medicine Regulation in Indonesia

in Ethnopharmacology

Mohamad Kashuri
Taruna Ikrar
Sutriyo Sutriyo
Abdul Munim
Arry Yanuar

Frontiers in Pharmacology

152 views

Original Research

Accepted on 03 Dec 2025

DX243 counteracts both acoustic trauma-induced reduction in cortical brain oscillations and cochlear synaptopathy

in Neuropharmacology

Stefan Fink
Csaba Harasztosi
Li Xie
Stephane Silvente
Pierre Attali
Nicolas Caron
Wibke Singer
Lukas Rüttiger
Marlies Knipper

Frontiers in Pharmacology

231 views

Original Research

Accepted on 03 Dec 2025

Identify the Therapeutic Role and Potential Mechanism of α-Cyperone in diminished ovarian reserve Based on Network Pharmacology, Molecular docking, Lip-MS and Experimental Validation

in Experimental Pharmacology and Drug Discovery

Jingwen Guo
Xitang Yang
Xue Chen
Rong Hu
Hua Guo

Frontiers in Pharmacology

185 views

Correction

Published on 03 Dec 2025

Correction: The role of panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

in Neuropharmacology

Bin Wang
Xu Gao
Yali Zhang
Yuhua Xiao
Tong Chen
Zhouying Shi
Yue Yuan
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1750932

381 views

Original Research

Published on 03 Dec 2025

Eriodictyol alleviates ovarian dysfunction in a mouse model of premature ovarian failure via the PI3K/Akt/NF-κB pathway and suppression of macrophage inflammation

in Ethnopharmacology

Miao Qu
Lusheng Liu
Jianwei Wang
Fangyu Sui
Miao Zhang
Xinyu Wu
Shixin Luo
Min Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710805

605 views

Original Research

Published on 03 Dec 2025

T817MA attenuates oxidative stress and ER stress via the HSP70–HSP90 pathway after brain ischemia in vitro and in vivo

in Neuropharmacology

Tao Wang
Ya-Juan Pan
Mei-Mei Zhang
Xuan Wang
Wei Li
Jian-Meng Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701967

705 views

Correction

Published on 03 Dec 2025

Correction: The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research

in Respiratory Pharmacology

Mingjun Wu
Qian Yang
Youcheng Xie
Yan Hou
Qingliang Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1751855

351 views

Review

Published on 03 Dec 2025

Preparation and biomedical application of light-responsive hydrogels based on natural products

in Experimental Pharmacology and Drug Discovery

Xinyi Fan
Haihua Shang
Leyuan Ji
Shitang Ma
Maoliang Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714907

554 views

Original Research

Published on 03 Dec 2025

An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target

in Experimental Pharmacology and Drug Discovery

Kate Gunther
Dongli Liu
Gill Stannard
Melissa Holmes
Christine Loo
Belinda Guo
Nikola Bowden
Jason Abbott
Caroline E. Ford

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1716062

1,040 views

Original Research

Published on 03 Dec 2025

Essential amino acids preserve intestinal barrier integrity via mitochondrial protection in obesity and gut inflammation

in Translational Pharmacology

Letizia Spataro
Maurizio Ragni
Agnese Segala
Alice Vetturi
Giulia Sofia Marcotto
Luca Canciani
Michele O. Carruba
Roberto Aquilani
Ginetta Collo
Alessandra Valerio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694723

1,011 views

Clinical Trial

Published on 03 Dec 2025

Ningmitai capsule in patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, prospective, randomized, parallel, positive-controlled study

in Ethnopharmacology

Jingjing Gao
Yao Zhang
Junhua Du
Qiang Liu
Yi Cheng
Wentao Yang
Daoyuan Wang
Wei Wang
Liang Zheng
Dong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667819

925 views

Original Research

Published on 03 Dec 2025

Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway

in Cardiovascular and Smooth Muscle Pharmacology

Chenchao Zou
Huaihan Xu
Fajia Hu
Yuxian Yu
Lanxiang Liu
Xiuqi Wang
Zheyu Zhang
Huaxi Zou
Jichun Liu
Huang Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661144

905 views

Original Research

Published on 03 Dec 2025

Novel drug candidates targeting Toxoplasma gondii in maternal–fetal interface models

in Experimental Pharmacology and Drug Discovery

Rafael Martins de Oliveira
Natália Carine Lima dos Santos
Marcos Paulo Oliveira Almeida
Joed Pires De Lima Júnior
Guilherme De Souza
Matheus Carvalho Barbosa
Guilherme Vieira Faria
Marina Paschoalino
Rosiane Nascimento Alves
Angelica Oliveira Gomes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673462

946 views

29,106 articles

articles

CX3CR1: a potential microglia-specific PET imaging target in Alzheimer’s and Parkinson’s diseases

Recent advances in gut microbiota-based nanotherapies for cancer treatment

Ibogaine’s potential role in supporting reward system recovery across diagnostic boundaries

Editorial: The multiple applications of marine-derived bioactives

Mechanistic Insights into Shenqi Dihuang Decoction in the Treatment of Immunoglobulin A Nephropathy

Therapeutic effects of Lactobacillus rhamnosus and/or thymol against neurotoxicity in propionic acid (PA)-induced autistic rats: Insights for the role of Nrf2/HO-1, Wnt3/β-Catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1 and PERK/CHOP/Bcl-2 pathways

The improvement effect and mechanism of traditional Chinese medicine on chemotherapy-induced diarrhea: a systematic review

Antiviral Activity of Hellenia speciosa (J. Koenig) S.R. Dutta Rhizome Metabolites Against Human Adenovirus: Insights from Molecular Docking and In Vitro Studies

Traditional Chinese medicine for HIV-related chronic comorbidities: evidence and potential therapeutic mechanisms

The Potential Role of GLP-1 Receptor Agonists in Substance Use Disorders: A Systematic Review

Optimizing Phenytoin Therapy: A Systematic Review of Clinically Relevant Food and Herb Interactions

Evidence-Based Production Framework for Herbal Medicine Regulation in Indonesia

DX243 counteracts both acoustic trauma-induced reduction in cortical brain oscillations and cochlear synaptopathy

Identify the Therapeutic Role and Potential Mechanism of α-Cyperone in diminished ovarian reserve Based on Network Pharmacology, Molecular docking, Lip-MS and Experimental Validation

Correction: The role of panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

Eriodictyol alleviates ovarian dysfunction in a mouse model of premature ovarian failure via the PI3K/Akt/NF-κB pathway and suppression of macrophage inflammation

T817MA attenuates oxidative stress and ER stress via the HSP70–HSP90 pathway after brain ischemia in vitro and in vivo

Correction: The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research

Preparation and biomedical application of light-responsive hydrogels based on natural products

An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target

Essential amino acids preserve intestinal barrier integrity via mitochondrial protection in obesity and gut inflammation

Ningmitai capsule in patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, prospective, randomized, parallel, positive-controlled study

Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway

Novel drug candidates targeting Toxoplasma gondii in maternal–fetal interface models