Frontiers in Pharmacology

Original Research

Published on 03 Dec 2025

Eriodictyol alleviates ovarian dysfunction in a mouse model of premature ovarian failure via the PI3K/Akt/NF-κB pathway and suppression of macrophage inflammation

in Ethnopharmacology

Miao Qu
Lusheng Liu
Jianwei Wang
Fangyu Sui
Miao Zhang
Xinyu Wu
Shixin Luo
Min Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710805

605 views

Original Research

Published on 03 Dec 2025

T817MA attenuates oxidative stress and ER stress via the HSP70–HSP90 pathway after brain ischemia in vitro and in vivo

in Neuropharmacology

Tao Wang
Ya-Juan Pan
Mei-Mei Zhang
Xuan Wang
Wei Li
Jian-Meng Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701967

705 views

Correction

Published on 03 Dec 2025

Correction: The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research

in Respiratory Pharmacology

Mingjun Wu
Qian Yang
Youcheng Xie
Yan Hou
Qingliang Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1751855

351 views

Review

Published on 03 Dec 2025

Preparation and biomedical application of light-responsive hydrogels based on natural products

in Experimental Pharmacology and Drug Discovery

Xinyi Fan
Haihua Shang
Leyuan Ji
Shitang Ma
Maoliang Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714907

554 views

Original Research

Published on 03 Dec 2025

An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target

in Experimental Pharmacology and Drug Discovery

Kate Gunther
Dongli Liu
Gill Stannard
Melissa Holmes
Christine Loo
Belinda Guo
Nikola Bowden
Jason Abbott
Caroline E. Ford

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1716062

1,040 views

Original Research

Published on 03 Dec 2025

Essential amino acids preserve intestinal barrier integrity via mitochondrial protection in obesity and gut inflammation

in Translational Pharmacology

Letizia Spataro
Maurizio Ragni
Agnese Segala
Alice Vetturi
Giulia Sofia Marcotto
Luca Canciani
Michele O. Carruba
Roberto Aquilani
Ginetta Collo
Alessandra Valerio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694723

1,011 views

Clinical Trial

Published on 03 Dec 2025

Ningmitai capsule in patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, prospective, randomized, parallel, positive-controlled study

in Ethnopharmacology

Jingjing Gao
Yao Zhang
Junhua Du
Qiang Liu
Yi Cheng
Wentao Yang
Daoyuan Wang
Wei Wang
Liang Zheng
Dong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667819

925 views

Original Research

Published on 03 Dec 2025

Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway

in Cardiovascular and Smooth Muscle Pharmacology

Chenchao Zou
Huaihan Xu
Fajia Hu
Yuxian Yu
Lanxiang Liu
Xiuqi Wang
Zheyu Zhang
Huaxi Zou
Jichun Liu
Huang Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661144

905 views

Original Research

Published on 03 Dec 2025

Novel drug candidates targeting Toxoplasma gondii in maternal–fetal interface models

in Experimental Pharmacology and Drug Discovery

Rafael Martins de Oliveira
Natália Carine Lima dos Santos
Marcos Paulo Oliveira Almeida
Joed Pires De Lima Júnior
Guilherme De Souza
Matheus Carvalho Barbosa
Guilherme Vieira Faria
Marina Paschoalino
Rosiane Nascimento Alves
Angelica Oliveira Gomes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673462

946 views

Review

Published on 03 Dec 2025

Dapansutrile in multidisciplinary therapeutic applications: mechanisms and clinical perspectives

in Inflammation Pharmacology

Fuwei Bai
Dongyang Wang
Yingying Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1731165

884 views

Original Research

Published on 03 Dec 2025

The clinical value of PLR, NLR, and MLR in predicting mortality risk in hospitalized patients

in Inflammation Pharmacology

Guoxiang Fang
Yunfei Mo
Yangwen Bao
Chunbiao Gao
Qiuya Pan
Tongbo Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736947

748 views

Editorial

Published on 03 Dec 2025

Editorial: Exploring the role of exosomes in cancer metastasis

in Pharmacology of Anti-Cancer Drugs

Anil Kumar Kalvala
Venkatesh Pooladanda
Nagavendra Kommineni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721903

748 views

Review

Published on 03 Dec 2025

Advances in ginsenoside treatment for common kidney diseases: pharmacological evaluation and potential mechanisms

in Renal Pharmacology

Tonghui Jin
Yu Du
Chaoyue Liu
Jingming Zhao
Tiejun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702234

1,112 views

Original Research

Published on 03 Dec 2025

Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis

in Translational Pharmacology

Shengfa Li
Peili Liang
Jian Chen
Youming Zhang
Haixiong Miao
Ting Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616070

711 views

Original Research

Published on 03 Dec 2025

Darolutamide-based triple therapy combined with PSMA imaging guided focal treatment in patients with prostate cancer: a multicenter retrospective study

in Pharmacology of Anti-Cancer Drugs

Dewen Zhong
Ruochen Zhang
Jinling Wu
Zhixun Guo
Yu Zhang
Qinfei Zhou
Zijun Zou
Deng Lin
Zhonglei Lu
Jiawen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692407

602 views

Original Research

Published on 03 Dec 2025

The therapeutic efficacy of radical resection for hepatocellular carcinoma varies markedly by tumor location: a retrospective real-world study

in Gastrointestinal and Hepatic Pharmacology

Xu Feng
Yi-Qiu Wei
Jia-Rui Liu
Zheng-Rong Shi
Kai Chen
Yong-Shuang Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674998

672 views

Review

Published on 03 Dec 2025

Cryptocarya alba (Peumo): an endemic Chilean tree with phytochemicals with bioactive potential

in Ethnopharmacology

Gonzalo Fuentes-Barros
Sebastián Castro-Saavedra
Nicolás Montalva
Marco Mellado
Antonia Diaz-Valdés
Claudia Guerrero-Rodríguez
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665897

1,049 views

Review

Published on 03 Dec 2025

Preclinical research of dihydromyricetin for fibrotic diseases

in Ethnopharmacology

Xiao-Chun Wang
Ping Mai
Zuo-Hui Yuan
Zhi-Sheng Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691796

507 views

Review

Published on 03 Dec 2025

Multitarget antitumor effects of panacis japonici rhizoma

in Ethnopharmacology

Xixing Fang
Xiao Yang
Changyuan Zhou
Di Zeng
Zehua Hu
Xing Tu
Bao Yang
Yuanxin Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591638

606 views

Case Report

Published on 03 Dec 2025

Case Report: Photodynamic therapy meets Chinese herbal medicine: a promising approach for advanced hypopharyngeal carcinoma

in Pharmacology of Anti-Cancer Drugs

Mingsheng Lyu
Huayang Wu
Weixia Yu
Hang Zou
Chengjun Ban
Lu Wang
Hongwu Wang
Linyang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602910

474 views

Original Research

Published on 03 Dec 2025

Farrerol inhibits proliferation and migration of colorectal cancer via the VEGF signaling pathway: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments

in Pharmacology of Anti-Cancer Drugs

Longhui Zhang
Qijing Xu
Guanduo Sun
Xiaokang Zhang
Jialong Xue
Chun Yao
Dechun Liu
Jingming Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1717293

907 views

Review

Published on 03 Dec 2025

Treatment strategies for motor fluctuations in Parkinson’s disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America

in Experimental Pharmacology and Drug Discovery

Oscar Arias-Carrión
Emmanuel Ortega-Robles

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725248

1,293 views

Original Research

Accepted on 02 Dec 2025

Natural Product Extracts for Ischemic Stroke: A methodological evaluation and meta-epidemiological analysis

in Ethnopharmacology

Sijin Wang
Minghui Zhang
Yao Lu
Peipei Du
Ziwen Xu
Xu Pang
Li Li
Chi Zhang

Frontiers in Pharmacology

268 views

Original Research

Accepted on 02 Dec 2025

HARNESSING RED GRAPE POMACE EXTRACT FOR SUSTAINABLE BROAD-SPECTRUM PHOTOPROTECTION IN A RECONSTRUCTED HUMAN EPIDERMIS MODEL

in Ethnopharmacology

Antonella Smeriglio
Marta Mangano
Mariarosaria Ingegneri
Annarita La Neve
Chiara Brenna
Luca Mastracci
Francesco Merlino
Giancarlo Tonon
Diego Bosco
Domenico Trombetta

Frontiers in Pharmacology

107 views

29,106 articles

articles

Eriodictyol alleviates ovarian dysfunction in a mouse model of premature ovarian failure via the PI3K/Akt/NF-κB pathway and suppression of macrophage inflammation

T817MA attenuates oxidative stress and ER stress via the HSP70–HSP90 pathway after brain ischemia in vitro and in vivo

Correction: The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research

Preparation and biomedical application of light-responsive hydrogels based on natural products

An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target

Essential amino acids preserve intestinal barrier integrity via mitochondrial protection in obesity and gut inflammation

Ningmitai capsule in patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, prospective, randomized, parallel, positive-controlled study

Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway

Novel drug candidates targeting Toxoplasma gondii in maternal–fetal interface models

Dapansutrile in multidisciplinary therapeutic applications: mechanisms and clinical perspectives

The clinical value of PLR, NLR, and MLR in predicting mortality risk in hospitalized patients

Editorial: Exploring the role of exosomes in cancer metastasis

Advances in ginsenoside treatment for common kidney diseases: pharmacological evaluation and potential mechanisms

Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis

Darolutamide-based triple therapy combined with PSMA imaging guided focal treatment in patients with prostate cancer: a multicenter retrospective study

The therapeutic efficacy of radical resection for hepatocellular carcinoma varies markedly by tumor location: a retrospective real-world study

Cryptocarya alba (Peumo): an endemic Chilean tree with phytochemicals with bioactive potential

Preclinical research of dihydromyricetin for fibrotic diseases

Multitarget antitumor effects of panacis japonici rhizoma

Case Report: Photodynamic therapy meets Chinese herbal medicine: a promising approach for advanced hypopharyngeal carcinoma

Farrerol inhibits proliferation and migration of colorectal cancer via the VEGF signaling pathway: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments

Treatment strategies for motor fluctuations in Parkinson’s disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America

Natural Product Extracts for Ischemic Stroke: A methodological evaluation and meta-epidemiological analysis

HARNESSING RED GRAPE POMACE EXTRACT FOR SUSTAINABLE BROAD-SPECTRUM PHOTOPROTECTION IN A RECONSTRUCTED HUMAN EPIDERMIS MODEL