Frontiers in Pharmacology

Review

Published on 26 Jan 2026

Guarding the heart in the era of immunotherapies: insights for cardio-oncology practice

in Cardiovascular and Smooth Muscle Pharmacology

Umamah Iram
Djamel Lebeche

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1762239

1,133 views

Opinion

Published on 26 Jan 2026

Challenges in performing clinical research on herbal products – experiences from Switzerland and the UK

in Ethnopharmacology

Angélique Bourqui
Chantal Csajka
Michael Heinrich
Clara Podmore
Catherine Simpson
Jeanne Trill
Merlin Willcox
Pierre-Yves Rodondi

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1766381

964 views

Review

Published on 26 Jan 2026

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

in Neuropharmacology

Hui Wang
Yining Chen
Allen Zhao
Zhongxia Shen
Yu Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709060

1,132 views

Review

Published on 26 Jan 2026

Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus

in Neuropharmacology

Gabriel Holguin
Rémi Martin-Fardon

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1729040

780 views

Original Research

Published on 26 Jan 2026

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID

in Neuropharmacology

Laura Seixas Bianco
Tiago Nicoliche
Nelson Francisco Corrêa-Neto
Rafael Lanaro
Ariadiny L. Caetano
Carla Maximo Prado
Rodrigo Portes Ureshino
Iolanda de Fátima Lopes Calvo Tibério
Renato Fraga Righetti
Roberta Sessa Stilhano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703727

900 views

Review

Published on 26 Jan 2026

The dual effects of anesthetics on glial cells: a review of neuroprotection and neurotoxicity

in Neuropharmacology

Xiaodong Wang
Minghe Zhao
Zhihui Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1724695

620 views

Original Research

Published on 26 Jan 2026

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk

in Renal Pharmacology

Yue Tu
Wenjie Liu
Tianqing Sang
Liuyunxin Pan
Wei Wu
Qijun Fang
Yinglu Liu
Buhui Liu
Yigang Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1693000

684 views

Case Report

Published on 26 Jan 2026

Occult cerebral hemorrhage induced by high-dose oral methanol poisoning: a case report

in Predictive Toxicology

Yuncheng Tang
Pengfei Liang
Qiming Fang
Juan Zhao
Li Zhang
Xiaolin Zhang
Haowen Tang
Yu Jiang
Zhiwen Zhao
Bo Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1757281

582 views

Policy Brief

Published on 26 Jan 2026

Designing integrated early-phase protocols to reduce substantial modifications, including considerations for patient cohorts – a multi-stakeholder consensus view for a practical approach in Germany

in Drugs Outcomes Research and Policies

R. Schultz-Heienbrok
S. Baumann
R. Böhm
A. Bonertz
K. Breithaupt-Groegler
U. Buckpesch-Heberer
M. Coenen
K. Erb-Zohar
N. Faisst
G. Grass

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699906

850 views

Review

Published on 26 Jan 2026

Epidemiology and diagnostic of MASLD in Latin America: a yet to be met challenge

in Gastrointestinal and Hepatic Pharmacology

Carolina Elizabeth Olaez-Ramos
Karla Lizette Mojica-Zamudio
Ana Sandoval-Rodríguez
Juan Armendáriz-Borunda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700072

687 views

Systematic Review

Published on 26 Jan 2026

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer: a focus on the ferroptosis regulation

in Gastrointestinal and Hepatic Pharmacology

Shanshan Gao
Huijuan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700849

827 views

Review

Published on 26 Jan 2026

Therapeutic strategies for KRAS G12C-mutant non-small cell lung cancer: from bench to bedside and beyond

in Pharmacology of Anti-Cancer Drugs

Renjie Huang
Xian Gong
Jianting Du
Guobing Xu
Jiekun Qian
Guoliang Liao
Yuxing Lin
Maojie Pan
Bin Zheng
Wenjie Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704347

847 views

Review

Published on 26 Jan 2026

Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects

in Ethnopharmacology

Yan-Xin Li
Han-Zhi Zhong
Shao-Bin Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1755093

835 views

Review

Published on 26 Jan 2026

Pulmonary hypertension: etiology and anti-inflammatory treatment pathways of natural products

in Ethnopharmacology

Liyang Li
Xing Huang
Maojun Cheng
Chengxun He
Changmao Dai
Fang Ding
Jia Xu
Feier Chen
Kaichen Zhang
Xueping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743782

614 views

Systematic Review

Published on 26 Jan 2026

Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis

in Pharmacoepidemiology

Yifan Gao
Yanmin Bai
Xu Mu
Xingxue Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1736821

677 views

Original Research

Published on 26 Jan 2026

A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells

in Pharmacology of Anti-Cancer Drugs

Houmin Lin
Jianhua Wei
Wenmin Yao
Qinqin Zhang
Junfei Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1739226

766 views

Original Research

Accepted on 23 Jan 2026

Integrative Analysis of Trichosanthes kirilowii Maxim Formula Granules' Anti-Triple-Negative Breast Cancer Mechanism via Network Pharmacology, Metabolomics, and Molecular Pharmacology

in Experimental Pharmacology and Drug Discovery

Yuzhen Gao
Yan Lu
Yaping Liu
Fen Liu
Jiaqi Zhang
Fei Xu
Zongwen Ji
Tian Fu
Shulong Shi
Shulong Jiang

Frontiers in Pharmacology

788 views

Review

Accepted on 23 Jan 2026

Uncaria rhynchophylla: An Ethnopharmacological Review Integrating Traditional Chinese Medicine Uses with Phytochemical and Pharmacological Evidence

in Ethnopharmacology

Tongzheng Liu
Wanqing Ren
Chuanguo Liu
Xiwen Geng

Frontiers in Pharmacology

322 views

Original Research

Accepted on 23 Jan 2026

lncRNAs Transcriptomics Elucidates the Potential Mechanism of Naoshuantong Capsule in Alleviating Synaptic Dysfunction in a murine model of Cerebral Ischemia/Reperfusion Injury

in Ethnopharmacology

Ke Song
Hongrui Zhang
Haoqi Liu
Yuanyuan Li
Yikun Sun
Xinglu Dong
Chenxi Tao
Yannan He
Zhenhong Liu
Yonghong Gao

Frontiers in Pharmacology

194 views

Review

Published on 23 Jan 2026

Silent inflammation: a hidden cause of liver fibrosis

in Gastrointestinal and Hepatic Pharmacology

Hans-Theo Schon
Ralf Weiskirchen

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1676534

701 views
1 citation

Original Research

Published on 23 Jan 2026

Integrative multi-omics and experimental analyses implicate PTK2 as a lorazepam-associated biomarker and potential therapeutic target in ovarian cancer

in Experimental Pharmacology and Drug Discovery

Xia Hong
Xingjun He
Suli He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1744802

718 views

Case Report

Published on 23 Jan 2026

Case Report: A patient harboring rare EGFR S768I/V769L compound mutation benefited from afatinib and osimertinib

in Pharmacology of Anti-Cancer Drugs

Qingli Cui
Jiuzhou Zhao
Yichen Ma
Yanhui Hu
Dongyang Ma
Huaimin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1714221

811 views

Original Research

Published on 23 Jan 2026

EMMPRIN deficiency alleviated metabolic-associated steatohepatitis progression via regulation of the UBA52–MCT1 axis

in Gastrointestinal and Hepatic Pharmacology

Linying Lai
Baoyuan Huang
Ziping Song
Xinyan Zhu
Wenzhuo Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1706859

627 views

Review

Published on 23 Jan 2026

Improving kidney transplantation through the addition of pharmacological agents to hypothermic preservation solutions: a scoping review

in Renal Pharmacology

Vincent Mayoral
Tom Darius
Sarah Bruneau
Christophe Masset
Jérôme Rigaud
Gilles Blancho
Thomas Prudhomme
Julien Branchereau
Benoît Mesnard

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692398

711 views

29,570 articles

articles

Guarding the heart in the era of immunotherapies: insights for cardio-oncology practice

Challenges in performing clinical research on herbal products – experiences from Switzerland and the UK

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus

Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID

The dual effects of anesthetics on glial cells: a review of neuroprotection and neurotoxicity

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk

Occult cerebral hemorrhage induced by high-dose oral methanol poisoning: a case report

Designing integrated early-phase protocols to reduce substantial modifications, including considerations for patient cohorts – a multi-stakeholder consensus view for a practical approach in Germany

Epidemiology and diagnostic of MASLD in Latin America: a yet to be met challenge

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer: a focus on the ferroptosis regulation

Therapeutic strategies for KRAS G12C-mutant non-small cell lung cancer: from bench to bedside and beyond

Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects

Pulmonary hypertension: etiology and anti-inflammatory treatment pathways of natural products

Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis

A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells

Integrative Analysis of Trichosanthes kirilowii Maxim Formula Granules' Anti-Triple-Negative Breast Cancer Mechanism via Network Pharmacology, Metabolomics, and Molecular Pharmacology

Uncaria rhynchophylla: An Ethnopharmacological Review Integrating Traditional Chinese Medicine Uses with Phytochemical and Pharmacological Evidence

lncRNAs Transcriptomics Elucidates the Potential Mechanism of Naoshuantong Capsule in Alleviating Synaptic Dysfunction in a murine model of Cerebral Ischemia/Reperfusion Injury

Silent inflammation: a hidden cause of liver fibrosis

Integrative multi-omics and experimental analyses implicate PTK2 as a lorazepam-associated biomarker and potential therapeutic target in ovarian cancer

Case Report: A patient harboring rare EGFR S768I/V769L compound mutation benefited from afatinib and osimertinib

EMMPRIN deficiency alleviated metabolic-associated steatohepatitis progression via regulation of the UBA52–MCT1 axis

Improving kidney transplantation through the addition of pharmacological agents to hypothermic preservation solutions: a scoping review