Frontiers in Pharmacology

Review

Published on 01 Dec 2025

Repurposing dimethyl fumarate for cancer therapy: current evidence and future directions

in Experimental Pharmacology and Drug Discovery

Mingjuan Zhang
Yaping Jing
Qingbin Cui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721876

608 views

Clinical Trial

Published on 01 Dec 2025

The median effective dose of esketamine with different doses of oliceridine during hysteroscopic surgery

in Drugs Outcomes Research and Policies

Min Shi
Tong Wang
Weiwei Wang
Jiafeng Wang
Lulu Li
Lulong Bo
Xiaolin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1728802

784 views

Original Research

Published on 01 Dec 2025

Decoding the therapeutic potential mechanism of Cornus officinalis in Parkinson’s disease: a network pharmacology insight

in Experimental Pharmacology and Drug Discovery

Zheng Wu
Jiwei Zhao
Wen Wang
Yuan Dong
Taotao Zhou
Yide Feng
Yalan Deng
Yingmei Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714796

875 views

Original Research

Published on 01 Dec 2025

Population pharmacokinetics of efpeglenatide in individuals with obesity and with type 2 diabetes

in Drug Metabolism and Transport

Seungchan Choi
Jiyoung Seo
Suemin Park
Na Young Kim
Hyeeun Kim
Hyeong-Seok Lim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715585

669 views

Technology and Code

Published on 01 Dec 2025

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data

in Predictive Toxicology

Austin Ross
Vijay Gombar
Alexander Sedykh
Adrian J. Green
Alexandre Borrel
Brian Kidd
Jason Phillips
Mihir Shah
Dhiral Phadke
Deepak Mav

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710864

895 views

Original Research

Published on 01 Dec 2025

A hierarchical and configurational analysis of Health Technology Assessment outcomes for cell and gene therapies

in Drugs Outcomes Research and Policies

Ziyad S. Almalki
Renad M. Alshammari
Nadia A. Dahduli
Mouaddh Abdulmalik Nagi
Syeda Juweria
Moayad M. Alhamdani
Yazan M. Alzahrani
Saja H. Almazrou
Nehad Jaser Ahmed
Abdullah K. Alahmari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695961

874 views

Original Research

Published on 01 Dec 2025

Improved exposure of curcumin-loaded nanocapsules: drug quantification in LPS-induced Drosophila melanogaster and pharmacokinetics in Wistar rats

in Experimental Pharmacology and Drug Discovery

Ana Pozzato Funghetto-Ribeiro
Camila de Oliveira Pacheco
Flávia Elizabete Guerra Teixeira
Joane Ferreira
Eliana Fernandes
Gustavo Guerra
Francine Johansson Azeredo
Sandra Elisa Haas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688992

647 views

Original Research

Published on 01 Dec 2025

Acetyl-11-keto-beta-boswellic acid ameliorates monosodium iodoacetate-induced osteoarthritis in rats: implications of HMGB1/TLR4/NF-κB and Nrf2/HO-1

in Inflammation Pharmacology

Hagar B. Abo-Zalam
Abdallah M. Gendy
Bassam Mohamed Ali
Ghada M. Ragab
Heba Mohammed Refat M. Selim
Najat O. Hamed
Fatemah A. Alherz
Asmaa Saleh
Einas M. Yousef
Amira A. El-Gazar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694803

997 views

Original Research

Published on 01 Dec 2025

An intelligent framework for dynamic modeling of therapeutic response using clinical compliance data

in Drugs Outcomes Research and Policies

Xinyi Wang
Haoran Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631599

884 views

Original Research

Published on 01 Dec 2025

Clinical application of combined anticoagulation therapy in anti-MDA5 antibody-positive associated interstitial lung disease-a retrospective study

in Respiratory Pharmacology

Ting Zhang
Yuanyuan Song
Hua Ma
Lina Cao
Li Lu
Hai Tang
Dongmei Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662306

745 views

Original Research

Published on 01 Dec 2025

Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors

in Neuropharmacology

Katerina Janisova
Monika Uhlirova
Sandor Forczek
Jaromir Myslivecek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691118

611 views

Editorial

Published on 01 Dec 2025

Editorial: Extracellular vesicles in cancer research: a new era for therapeutic interventions

in Pharmacology of Anti-Cancer Drugs

Tejveer Singh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687011

386 views

Systematic Review

Published on 01 Dec 2025

The efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis of randomized controlled trials

in Pharmacology of Anti-Cancer Drugs

Yingyu Lai
Qianni Pan
Shiyu Wang
Qingmao Luo
Zhencong Huang
Mingzhong Wei
Zhouqian Jiang
Wenyan Yi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683857

839 views

Correction

Published on 01 Dec 2025

Correction: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo

in Ethnopharmacology

Hongshan Li
Yingfei Xi
Xin Xin
Qin Feng
Yiyang Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657343

745 views

Original Research

Published on 01 Dec 2025

Machine learning–based prognostic modeling for locally advanced non-small cell lung cancer treated with immuno-radiotherapy

in Pharmacology of Anti-Cancer Drugs

Simin Lu
Xin Zheng
Yi Wang
Yafei Li
Xuan Yu
Yan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723874

572 views

Original Research

Published on 01 Dec 2025

Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of Fructus Xanthii in treating asthma

in Experimental Pharmacology and Drug Discovery

Yiqun Dong
Zhaosen Fan
Xiaoxiao Li
Yucheng Ming
Dong Wang
Yuanda Song
Youpeng Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722150

967 views

Systematic Review

Published on 01 Dec 2025

Microplastics in focus: a silent disruptor of liver health- a systematic review

in Gastrointestinal and Hepatic Pharmacology

Zahra Beyzaei
Bita Geramizadeh
Zahra Bagheri
Sara Karimzadeh
Ralf Weiskirchen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721644

1,021 views

Original Research

Published on 01 Dec 2025

Investigating the pathways of medication adherence in renal transplant recipients based on the COM-B model: the parallel mediating effects of beliefs and emotion regulation efficacy

in Drugs Outcomes Research and Policies

Lili Zhou
Ke Cheng
Linbin Chen
San Han
Jingjing Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702618

572 views

Systematic Review

Published on 01 Dec 2025

Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials

in Neuropharmacology

Tingyu Jiang
Rui Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708221

779 views

Systematic Review

Accepted on 30 Nov 2025

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer:A focus on the ferroptosis regulation

in Gastrointestinal and Hepatic Pharmacology

Shanshan Gao
Huijuan Wang

Frontiers in Pharmacology

303 views

Original Research

Accepted on 30 Nov 2025

Comparative Safety Profiles of Spironolactone, Eplerenone, and Finerenone: A Pharmacovigilance Study Based on FAERS Data from 2004 to 2024

in Pharmacoepidemiology

Kaiyun Ji
Xingjun Huang
Fang Wang
Lei Zhang
Yifan Zheng
Ligang Ji
Ying Ju
Jia Li

Frontiers in Pharmacology

288 views

Review

Accepted on 30 Nov 2025

Probucol: Revisiting as a Multi-faceted Therapeutic Agent in Atherosclerosis

in Cardiovascular and Smooth Muscle Pharmacology

Sha Li
Hui-Hui Liu
Ruixia Xu
Jian-Jun Li

Frontiers in Pharmacology

383 views

Review

Accepted on 30 Nov 2025

Pharmacological potential of Chinese botanical drugs in managing chronic kidney disease by targeting mitochondrial quality control

in Ethnopharmacology

Hongyu Liu
Shumin Huang
Shichun Chen
Shuzhen Liang
Minying Huang
Shiyu Li
Yongxiang Xu
Baocheng Xie

Frontiers in Pharmacology

145 views

Review

Accepted on 30 Nov 2025

Osteoarthritis: Multitissue Pathology, Molecular Mechanisms, Clinical Management, and Emerging Precision and Regenerative TherapiesJoint complexity in osteoarthritis: Multitissue interactions, molecular drivers, and therapeutic innovation

in Integrative and Regenerative Pharmacology

Lina Qiu
AHMAD ALHASKAWI
Safwat Adel Abdo Moqbel

Frontiers in Pharmacology

172 views

29,106 articles

articles

Repurposing dimethyl fumarate for cancer therapy: current evidence and future directions

The median effective dose of esketamine with different doses of oliceridine during hysteroscopic surgery

Decoding the therapeutic potential mechanism of Cornus officinalis in Parkinson’s disease: a network pharmacology insight

Population pharmacokinetics of efpeglenatide in individuals with obesity and with type 2 diabetes

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data

A hierarchical and configurational analysis of Health Technology Assessment outcomes for cell and gene therapies

Improved exposure of curcumin-loaded nanocapsules: drug quantification in LPS-induced Drosophila melanogaster and pharmacokinetics in Wistar rats

Acetyl-11-keto-beta-boswellic acid ameliorates monosodium iodoacetate-induced osteoarthritis in rats: implications of HMGB1/TLR4/NF-κB and Nrf2/HO-1

An intelligent framework for dynamic modeling of therapeutic response using clinical compliance data

Clinical application of combined anticoagulation therapy in anti-MDA5 antibody-positive associated interstitial lung disease-a retrospective study

Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors

Editorial: Extracellular vesicles in cancer research: a new era for therapeutic interventions

The efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis of randomized controlled trials

Correction: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo

Machine learning–based prognostic modeling for locally advanced non-small cell lung cancer treated with immuno-radiotherapy

Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of Fructus Xanthii in treating asthma

Microplastics in focus: a silent disruptor of liver health- a systematic review

Investigating the pathways of medication adherence in renal transplant recipients based on the COM-B model: the parallel mediating effects of beliefs and emotion regulation efficacy

Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer:A focus on the ferroptosis regulation

Comparative Safety Profiles of Spironolactone, Eplerenone, and Finerenone: A Pharmacovigilance Study Based on FAERS Data from 2004 to 2024

Probucol: Revisiting as a Multi-faceted Therapeutic Agent in Atherosclerosis

Pharmacological potential of Chinese botanical drugs in managing chronic kidney disease by targeting mitochondrial quality control

Osteoarthritis: Multitissue Pathology, Molecular Mechanisms, Clinical Management, and Emerging Precision and Regenerative TherapiesJoint complexity in osteoarthritis: Multitissue interactions, molecular drivers, and therapeutic innovation