Frontiers in Pharmacology

Original Research

Published on 22 Jan 2026

Ramulus mori (Sangzhi) alkaloids improve intestinal oxidative damage and inflammation in DHEA-induced polycystic ovary syndrome rats via gut microbiota and metabolite modulation

in Experimental Pharmacology and Drug Discovery

Yanping Wang
Xianmei Jiang
Shuyi Wu
Qiaohui Wang
Dan Zuo
Biao Huang
Li Jian
Yu Yang
Yong Cai
Xingjian Wen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701694

665 views

Opinion

Published on 22 Jan 2026

The ratio of effect-based combination indexes can indicate nonapoptotic cell-death in a combined cancer therapy

in Experimental Pharmacology and Drug Discovery

Tianran Yu
Yuxuan Dong
Xinya Li
Tinghe Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1737170

896 views

Review

Published on 22 Jan 2026

Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches

in Pharmacology of Anti-Cancer Drugs

Qianyu Han
Shasha Jiang
Jirui Chen
Lei Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1742651

1,011 views

General Commentary

Published on 22 Jan 2026

General commentary: 28-Day oral chronic toxicity study of arctigenin in rats

in Predictive Toxicology

Michelle Carnazza
Nan Yang
Jan Geliebter
Raj Tiwari
Victor Garcia
Xiu-Min Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1720821

529 views

Review

Published on 22 Jan 2026

Addressing genetic diversity and health inequities: RELIVAF’s proposal for Latin American pharmacogenomic guidelines

in Pharmacogenetics and Pharmacogenomics

Luis A. Quiñones
Matías F. Martínez
Rodrigo Vargas
Leslie C. Cerpa
Andrés López-Cortés
Farith González-Martínez
Dora Fonseca
Jorge Duconge
Nelson M. Varela
Ismael Lares-Asseff

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1721828

993 views

Review

Published on 22 Jan 2026

Natural compounds in ovarian cancer: mechanistic insights and therapeutic potential

in Pharmacology of Anti-Cancer Drugs

Barathan Muttiah
Nur Atiqah Haizum Abdullah

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687805

738 views

Original Research

Published on 22 Jan 2026

A study on the accessibility and utilisation of targeted drugs for pulmonary arterial hypertension in China

in Drugs Outcomes Research and Policies

Wei Li
Han Zhang
Lulu Xu
Wan Tang
Wei Lu
Zhengyi You
Huanhuan Wu
Yanquan Lin
Hongdou Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1671667

797 views

Correction

Published on 22 Jan 2026

Correction: Omega 3 fatty acid docosahexaenoic acid (DHA) mitigates inflammatory responses in experimental sepsis

in Inflammation Pharmacology

Bianca Portugal Tavares de Moraes
Isabelle Moraes-de-Souza
Gabrielle Lacerda de Souza Gomes-Reis
Marina Ferreira-Costa
Carolina Medina Coeli da Cunha
Matheus Augusto Patricio De Almeida
Vanessa Estato
Kauê Francisco Corrêa Souza e Souza
Francisco da Silva dos Santos
Maria Alice dos Santos Mascarenhas Brito

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1782326

455 views

Mini Review

Published on 22 Jan 2026

Neglected tropical diseases: recent trends and challenges associated with its rapid diagnosis and effective therapeutic strategies

in Pharmacology of Infectious Diseases

Subrat Kumar
Abdullah Alghamdi
Puneet Kumar Singh
Nirmalya Pal
Ritesh Pattnaik
Mohammed Alissa
Suad A. Alghamdi
Ghadah S. Abusalim
Subhra Subhadra

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1742086

736 views

Original Research

Accepted on 21 Jan 2026

Drug-Associated Insomnia and Sex-Specific Disproportionality in the FDA Adverse Event Reporting System (2019–Q1 2025)

in Pharmacoepidemiology

Hao Wen
Yuchuan Shen
Hai Li
Xiangbin Chen
Yanzhao Lin
Wei Bin

Frontiers in Pharmacology

192 views

Original Research

Accepted on 21 Jan 2026

Genetic Pharmacoepidemiology of JAK Inhibitors in Chronic Immune-Mediated Skin Diseases: Implications for Precision Therapy and Medication Safety

in Pharmacoepidemiology

Yuping Zhang
Yuan Qu
Qundi Luo
Bibo Liang
Qiaomu Jiang
Xiaotong Zhu
Jing Wu
Weijia Bao

Frontiers in Pharmacology

153 views

Systematic Review

Published on 21 Jan 2026

Tianqi Jiangtang Capsule in the treatment of patients with diabetes: a systematic review and meta-analysis

in Ethnopharmacology

Yanjiao Liu
Yifan Chen
Liuding Wang
Zhonghui Jiang
Zhuye Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719112

766 views

Original Research

Published on 21 Jan 2026

Pteryxin enhances human NK-cell cytotoxicity by upregulating NKp30, NKp46, and 2B4 via ERK/AKT signaling

in Experimental Pharmacology and Drug Discovery

Eun Sun Park
Jong-Tae Kim
Yo-Sep Hwang
Jahyeong Han
Hyo-Min Park
Hyang Ran Yoon
Hee Jun Cho
Hee Gu Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698826

682 views

Review

Published on 21 Jan 2026

Traditional medicine in a modern light: a scoping review on the osteoprotective potential of Eucommia ulmoides

in Ethnopharmacology

Yuanzhong Wang
Guiju Chen
Qin Wang
Bilin Liu
Qi He
Xia Huang
Kok-Yong Chin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673870

1,572 views

Original Research

Published on 21 Jan 2026

Transcriptional response to combination antiretroviral therapy predicts side effects and novel targets

in Pharmacogenetics and Pharmacogenomics

Alexander Lachmann
Letizia Amadori
Paola Nicoletti
Heidi M. Crane
Chiara Giannarelli
Avi Ma’ayan
Inga Peter

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743543

661 views

Systematic Review

Published on 21 Jan 2026

An evidence-based meta-analysis on the use of brivaracetam in treating seizures in real-world clinical practice

in Neuropharmacology

Yu Zhang
Huihui Liu
Xin Wang
Zhiqiang Zhao
Hong Su
Yanjun Ma
Jie Zhao
Qingshan Wang
Liyan Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1716128

821 views

Original Research

Published on 21 Jan 2026

Integrated network pharmacology and experimental verification to reveal the mechanisms of curcumin in the treatment of colorectal cancer

in Experimental Pharmacology and Drug Discovery

Zhilong Yuan
Jing Hu
Canfeng Cai
Fuheng Liu
Huimou Chen
Bing Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703562

1,038 views

Original Research

Published on 21 Jan 2026

Mechanism of Yiqi Huoxue Granule in promoting angiogenesis of skin lesion tissue by increasing CSF2 to reduce mesenchymal stem cell apoptosis

in Ethnopharmacology

Weili Shi
Shuhui Wang
Shanshan Liu
Zhen Lei
Peishuo Yan
Xinzhou Wang
Chaoqun Lu
Nan Qin
Pengfei Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1649017

911 views

Original Research

Published on 21 Jan 2026

A risk prediction model for medication safety: assessing cardiopulmonary adverse outcomes in 11,252 patients treated with ulinastatin

in Translational Pharmacology

Rutong Hua
Ying Zhang
Jianxiong Deng
Qiqi Wen
Guozheng Li
Rende Fang
Zhuoyu Chen
Yuxuan Cao
Xi-Yong Yu
Jin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1746148

517 views

Systematic Review

Published on 21 Jan 2026

Efficacy and safety of oral proprietary Chinese medicines in the treatment of stable chronic obstructive pulmonary disease: a network meta-analysis

in Ethnopharmacology

Hao Yan
Jingwen Zhang
Hutao Yan
Dandan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690739

876 views

Review

Published on 21 Jan 2026

Astragaloside IV is a potential natural neuroprotective agent for stroke: a review

in Ethnopharmacology

Qiao-Li Zhang
Wen-Xiu Qin
Xiu-Juan Li
Yun-Bo Zhang
Ming Li
Jun-Feng Xu
Zhong-Nan Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718700

776 views

Review

Published on 21 Jan 2026

The ubiquitination–autophagy axis in cancer therapy resistance: mechanistic insights and therapeutic opportunities

in Pharmacology of Anti-Cancer Drugs

Hengrui Zhang
Hanxi Yan
Yulin Liu
Anqi Zeng
Linjiang Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722559

898 views

Original Research

Published on 21 Jan 2026

Ginsenoside Rk1 alleviates lipopolysaccharide (LPS)-induced cognitive impairment by modulating synaptic plasticity

in Ethnopharmacology

Xuesong Zhang
Funan Ning
Biqun Zhang
Jiaqi Ji
Junzuo Zheng
Xiaosong Hu
Zhiang Liu
Li Ding
Ping Wang
Zhou Lan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1747574

650 views

General Commentary

Published on 21 Jan 2026

Commentary: Effect of injecting adipose stem cells combined with platelet-rich fibrin releasate at Shenshu acupoint (BL23) on acute kidney injury in rabbits

in Renal Pharmacology

Xun Zheng
Ruoru Yu
Cheng Feng
Lei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743787

490 views

29,570 articles

articles

Ramulus mori (Sangzhi) alkaloids improve intestinal oxidative damage and inflammation in DHEA-induced polycystic ovary syndrome rats via gut microbiota and metabolite modulation

The ratio of effect-based combination indexes can indicate nonapoptotic cell-death in a combined cancer therapy

Novel therapeutic strategies targeting resistance mechanisms in hematologic malignancies: from BCL2 inhibition to immunomodulatory approaches

General commentary: 28-Day oral chronic toxicity study of arctigenin in rats

Addressing genetic diversity and health inequities: RELIVAF’s proposal for Latin American pharmacogenomic guidelines

Natural compounds in ovarian cancer: mechanistic insights and therapeutic potential

A study on the accessibility and utilisation of targeted drugs for pulmonary arterial hypertension in China

Correction: Omega 3 fatty acid docosahexaenoic acid (DHA) mitigates inflammatory responses in experimental sepsis

Neglected tropical diseases: recent trends and challenges associated with its rapid diagnosis and effective therapeutic strategies

Drug-Associated Insomnia and Sex-Specific Disproportionality in the FDA Adverse Event Reporting System (2019–Q1 2025)

Genetic Pharmacoepidemiology of JAK Inhibitors in Chronic Immune-Mediated Skin Diseases: Implications for Precision Therapy and Medication Safety

Tianqi Jiangtang Capsule in the treatment of patients with diabetes: a systematic review and meta-analysis

Pteryxin enhances human NK-cell cytotoxicity by upregulating NKp30, NKp46, and 2B4 via ERK/AKT signaling

Traditional medicine in a modern light: a scoping review on the osteoprotective potential of Eucommia ulmoides

Transcriptional response to combination antiretroviral therapy predicts side effects and novel targets

An evidence-based meta-analysis on the use of brivaracetam in treating seizures in real-world clinical practice

Integrated network pharmacology and experimental verification to reveal the mechanisms of curcumin in the treatment of colorectal cancer

Mechanism of Yiqi Huoxue Granule in promoting angiogenesis of skin lesion tissue by increasing CSF2 to reduce mesenchymal stem cell apoptosis

A risk prediction model for medication safety: assessing cardiopulmonary adverse outcomes in 11,252 patients treated with ulinastatin

Efficacy and safety of oral proprietary Chinese medicines in the treatment of stable chronic obstructive pulmonary disease: a network meta-analysis

Astragaloside IV is a potential natural neuroprotective agent for stroke: a review

The ubiquitination–autophagy axis in cancer therapy resistance: mechanistic insights and therapeutic opportunities

Ginsenoside Rk1 alleviates lipopolysaccharide (LPS)-induced cognitive impairment by modulating synaptic plasticity

Commentary: Effect of injecting adipose stem cells combined with platelet-rich fibrin releasate at Shenshu acupoint (BL23) on acute kidney injury in rabbits