Frontiers in Pharmacology

Original Research

Published on 06 Jan 2026

Identification of novel germline and somatic mutations associated with hepatocellular carcinoma by next-generation sequencing

in Pharmacology of Anti-Cancer Drugs

Ahmed Baligh Laaribi
Wafa Babay
Abdelmalek Lekired
Bochra Bouchabou
Asma Mehri
Dhouha Bacha
Riadh Sassi
Sana Ben Slama
Rached Bayar
Sahir Omrani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699280

923 views

Original Research

Published on 06 Jan 2026

Efficacy and safety of vunakizumab in moderate-to-severe plaque psoriasis patients with different body mass index: a post hoc analysis based on a phase III trial

in Experimental Pharmacology and Drug Discovery

Xin Wang
Linfeng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685072

856 views

Original Research

Accepted on 05 Jan 2026

Enhancement of gemcitabine toxicity and specificity through PI3K/Akt/Nrf2 pathway inhibition in pancreatic cancer

in Predictive Toxicology

Yu-Shan Chen
Steve O'Hagan
Philip Day

Frontiers in Pharmacology

236 views

Original Research

Accepted on 05 Jan 2026

Paclitaxel-Induced Germline DNA-Damage Signatures Independent of Mismatch Repair in C. elegans

in Pharmacology of Anti-Cancer Drugs

Yebin Hong
Zifei Liu
Hyun-Min Kim

Frontiers in Pharmacology

176 views

Policy and Practice Reviews

Accepted on 05 Jan 2026

International Standards and Good Practice Guidelines in Traditional, Complementary and Integrative Medicine: A Scoping Review

in Ethnopharmacology

Xuanbin Wang
Hongliang Li
Shun Jiang
Nian Yang
Dongpeng Wang
Hongxi Xu
Nicola Robinson
Lie-Fen Shyur
Michael Heinrich
Mei Wang

Frontiers in Pharmacology

367 views

Review

Accepted on 05 Jan 2026

Rethinking Network Analysis in Ethnopharmacology: A Multi-omics and AI Roadmap to Overcome Homogeneity

in Ethnopharmacology

Xuewen Diao
Zhang Hao
Shiqi Wang
Zulong Wang
Qi Zhang

Frontiers in Pharmacology

297 views

Review

Accepted on 05 Jan 2026

Polydatin in Respiratory Diseases: Multi-Target Mechanisms and Therapeutic Potential

in Respiratory Pharmacology

Chanjun Wan
Xinyang Liu
zhengtao chen
Yueqi Xu
Li Kang
Xuelong Yu
Min Wang
Min Zhao
HanXin Li
Jianguang Wu

Frontiers in Pharmacology

186 views

Original Research

Accepted on 05 Jan 2026

Quercetin Attenuates Acute Alcohol-Induced Liver Injury in Mice by Modulating Lipid Metabolism, Oxidative Stress, and Inflammation

in Gastrointestinal and Hepatic Pharmacology

Yuanyuan Qian

Frontiers in Pharmacology

341 views

Original Research

Published on 05 Jan 2026

Genome-wide CRISPR screen identified NEK6 as a determinant of sensitivity to CDK4/6 inhibitor in endometrial cancer

in Pharmacology of Anti-Cancer Drugs

Fangfang Jian
Chongying Zhu
Yiwei Wang
Tianyu Zhou
Chenmin Yang
Weiwei Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725886

730 views

Review

Published on 05 Jan 2026

Epilepsy, neuroinflammation and cannabidiol What do we know thus far?

in Drugs Outcomes Research and Policies

Gabriela Pesántez Ríos
Emilio Perucca
Pasquale Striano
Roberto Caraballo
Ximena Pesántez Ríos
S. I. Pascual-Pascual
Galo Pesántez Cuesta

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1749260

1,520 views

Brief Research Report

Published on 05 Jan 2026

Local and systemic safety of deproteinized calf blood extract injection: hypersensitivity, hemolysis, local tolerance, and acute intravenous toxicity in rodents and rabbits

in Experimental Pharmacology and Drug Discovery

Guodong Qin
Pengfei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709084

671 views

Original Research

Published on 05 Jan 2026

Enhanced CYP2C19-mediated drug-drug interaction risk with escitalopram in geriatric populations

in Drug Metabolism and Transport

Seonyoung Byoun
Dong-Gyu Heo
Minsoo Lee
Ryunghwa Lee
Yuanyuan Li
Ju-Yeun Lee
Eunjin Hong
Wooin Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1711196

1,171 views

Original Research

Published on 05 Jan 2026

Acceptability of minitablets in soft food. A randomised cross-over study in children

in Obstetric and Pediatric Pharmacology

Jennifer C. Duncan
Rebecca Page
Janet Clark
Gabrielle Seddon
Joy Slater
Andrea Gill
Silothabo Dliso
Udeme Ohia
Nikolaos Skoutelis
Leonie Wagner-Hattler

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702183

736 views

Original Research

Published on 05 Jan 2026

Preclinical pharmacological profiles of cofrogliptin, a novel and bi-weekly DPP-4 inhibitor

in Experimental Pharmacology and Drug Discovery

Xiaoli Gou
Caixia Dou
Pingming Tang
Xiaoxiao Zheng
Chen Zhang
Jianmin Wang
Qingyuan Meng
Ju Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702101

782 views

Original Research

Published on 05 Jan 2026

Schisandra chinensis alleviates Hypertriglyceridemia in nonalcoholic fatty liver disease by modulating the gut microbiota and hepatic lipid metabolism: identification of its active fractions

in Ethnopharmacology

Qi Li
Mei Feng
Qi luo
Chen Yalin Ye
Yi Ke Luo
Ling Yu Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715364

1,088 views

Original Research

Published on 05 Jan 2026

Voriconazole-associated liver injury: clinical risk factor identification and predictive nomogram construction

in Pharmacoepidemiology

Dongge Feng
Yiyi Ma
Xiaoyi Liu
Si Tang
Shijian Xiang
Jinghao Wang
Shasha Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688711

778 views

Opinion

Published on 05 Jan 2026

What role will physiological resilience play in brown-white fat dynamic in obesity management?

in Translational Pharmacology

Oksana Zayachkivska
Iryna Kovalchuk
Iryna Muzyka
Maryana Savytska

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691149

798 views

Original Research

Published on 05 Jan 2026

Antibiotic use for respiratory tract infections in nursing homes: a multicentre cross-sectional study

in Pharmacology of Infectious Diseases

Carl Llor
Rosa Morros
Jesús Mateos-Nozal
Carlota Manuela Zárate Sáez
María N. Vaquero Pinto
Consuelo Rodríguez Jiménez
Carmen Sáez Bejar
Rosa Magallón-Botaya
Priscila Matovelle
Alicia Navarro Sanmartín

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721689

782 views

Review

Published on 05 Jan 2026

Osteoarthritis: multitissue pathology, molecular mechanisms, clinical management, and emerging precision and regenerative therapies

in Integrative and Regenerative Pharmacology

Lina Qiu
Ahmad Alhaskawi
Safwat Adel Abdo Moqbel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697192

1,243 views

Original Research

Published on 05 Jan 2026

Lauric acid modulates the cyclooxygenases and nitric oxide pathways and reduces oxidative stress in preventing tracheal hyperresponsiveness in asthmatic Wistar rats

in Respiratory Pharmacology

Indyra Alencar Duarte Figueiredo
Alissa Maria de Oliveira Martins
Alexya Mikelle Teixeira Cavalcanti
Jayne Muniz Fernandes
Ludmila Emilly da Silva Gomes
Gabriel Nunes Machado de Oliveira
Lucas Nóbrega de Oliveira
Isabela Motta Felício
Adriana Maria Fernandes de Oliveira Golzio
Adriano Francisco Alves

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657799

3,340 views

Original Research

Published on 05 Jan 2026

Maternal influenza vaccination during pregnancy and the risk of adverse pregnancy and birth outcomes

in Pharmacoepidemiology

Vanina Tchuente
Odile Sheehy
Gina Muckle
Mark Walker
William D. Fraser
Anick Bérard

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691111

810 views

Systematic Review

Published on 05 Jan 2026

Different traditional Chinese medicine injections combined with conventional therapy for sepsis-induced myocardial dysfunction: a systematic review and network meta-analysis

in Ethnopharmacology

Wenjie Deng
Xiaolei Fang
Po Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688113

731 views

Original Research

Published on 05 Jan 2026

Cost-effectiveness analysis of inavolisib combined with palbociclib plus fulvestrant in PIK3CA-mutated HR+/Her2− advanced breast cancer in China

in Pharmacology of Anti-Cancer Drugs

Weiwei Huang
Cijuan Li
Yuanqing Huang
Chang Wang
Yingxin Zhang
Yingtao Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1742507

963 views

Original Research

Published on 05 Jan 2026

Astaxanthin activates the Nrf2/HO-1 pathway to attenuate indoxyl sulfate-induced oxidative stress and DNA damage in renal tubular epithelial cells

in Experimental Pharmacology and Drug Discovery

Xiaoli Qian
Zhixia Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715462

1,010 views

29,455 articles

articles

Identification of novel germline and somatic mutations associated with hepatocellular carcinoma by next-generation sequencing

Efficacy and safety of vunakizumab in moderate-to-severe plaque psoriasis patients with different body mass index: a post hoc analysis based on a phase III trial

Enhancement of gemcitabine toxicity and specificity through PI3K/Akt/Nrf2 pathway inhibition in pancreatic cancer

Paclitaxel-Induced Germline DNA-Damage Signatures Independent of Mismatch Repair in C. elegans

International Standards and Good Practice Guidelines in Traditional, Complementary and Integrative Medicine: A Scoping Review

Rethinking Network Analysis in Ethnopharmacology: A Multi-omics and AI Roadmap to Overcome Homogeneity

Polydatin in Respiratory Diseases: Multi-Target Mechanisms and Therapeutic Potential

Quercetin Attenuates Acute Alcohol-Induced Liver Injury in Mice by Modulating Lipid Metabolism, Oxidative Stress, and Inflammation

Genome-wide CRISPR screen identified NEK6 as a determinant of sensitivity to CDK4/6 inhibitor in endometrial cancer

Epilepsy, neuroinflammation and cannabidiol What do we know thus far?

Local and systemic safety of deproteinized calf blood extract injection: hypersensitivity, hemolysis, local tolerance, and acute intravenous toxicity in rodents and rabbits

Enhanced CYP2C19-mediated drug-drug interaction risk with escitalopram in geriatric populations

Acceptability of minitablets in soft food. A randomised cross-over study in children

Preclinical pharmacological profiles of cofrogliptin, a novel and bi-weekly DPP-4 inhibitor

Schisandra chinensis alleviates Hypertriglyceridemia in nonalcoholic fatty liver disease by modulating the gut microbiota and hepatic lipid metabolism: identification of its active fractions

Voriconazole-associated liver injury: clinical risk factor identification and predictive nomogram construction

What role will physiological resilience play in brown-white fat dynamic in obesity management?

Antibiotic use for respiratory tract infections in nursing homes: a multicentre cross-sectional study

Osteoarthritis: multitissue pathology, molecular mechanisms, clinical management, and emerging precision and regenerative therapies

Lauric acid modulates the cyclooxygenases and nitric oxide pathways and reduces oxidative stress in preventing tracheal hyperresponsiveness in asthmatic Wistar rats

Maternal influenza vaccination during pregnancy and the risk of adverse pregnancy and birth outcomes

Different traditional Chinese medicine injections combined with conventional therapy for sepsis-induced myocardial dysfunction: a systematic review and network meta-analysis

Cost-effectiveness analysis of inavolisib combined with palbociclib plus fulvestrant in PIK3CA-mutated HR+/Her2− advanced breast cancer in China

Astaxanthin activates the Nrf2/HO-1 pathway to attenuate indoxyl sulfate-induced oxidative stress and DNA damage in renal tubular epithelial cells