Frontiers in Pharmacology

Systematic Review

Published on 02 Jan 2026

A network meta-analysis of first-line treatment options for patients with Child-Pugh class B functional hepatocellular carcinoma: comparison of efficacy and safety

in Gastrointestinal and Hepatic Pharmacology

Yu-Xuan Zhang
Jia-Yi Wu
Jun-Yi Wu
Zhen-Xin Zeng
Rong-Jian Pan
Xiang-Ye Ou
Yi-Nan Li
Mao-Lin Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705502

1,271 views

Original Research

Published on 02 Jan 2026

Ferula ammoniacum gum aqueous extract exerts anti-inflammatory and antioxidant mechanisms to combat aluminum chloride-induced Alzheimer’s disease in rats: possible involvement of opioid pathways

in Experimental Pharmacology and Drug Discovery

Sajad Fakhri
Mohammad Mehdi Gravandi
Mohammad Bagher Majnooni
Mohammad Hosein Farzaei
Fatemeh Abbaszadeh
Khodabakhsh Rashidi
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708643

883 views

Original Research

Published on 02 Jan 2026

Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates

in Inflammation Pharmacology

Micha N. Ronner
Marieke L. De Kam
Silke Van Reeuwijk
Jacobus Burggraaf
Manon A. A. Jansen
Matthijs Moerland

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1717333

936 views

Correction

Published on 02 Jan 2026

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

in Renal Pharmacology

Weili Liao
Rui Fan
Yuman Du
Hairong Wang
Yong Yang
Yuan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1764700

544 views

Original Research

Published on 02 Jan 2026

Bone-targeted mitochondrial delivery via magnetic-temperature responsive artificial cells for repairing age-related fractures

in Experimental Pharmacology and Drug Discovery

Shihao Nie
Yue Yu
Rong Yan
Taoran Liu
Yue Du
Zhuojing Luo
Shengyou Li
Jinghui Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725973

1,260 views

Original Research

Published on 02 Jan 2026

Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair

in Ethnopharmacology

Mo-Rong Xu
Chia-Hsin Lin
Chung-Hsuan Wang
Sheng-Yang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1619537

1,017 views

Systematic Review

Published on 02 Jan 2026

Efficacy and safety of Chinese herbal medicine for metabolic conditions: a systematic review and meta-analysis of randomised controlled trials

in Ethnopharmacology

Yinglin Liang
Hongshen Yu
Jie Ren
Jiayi Ren
Guanlin Chen
Yikai Zhang
Yefeng Cai
Xiaojia Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644950

1,503 views

Systematic Review

Published on 02 Jan 2026

Effects of modified Soyo-san (Xiao-yao-san, Shoyo-san) combined with antidepressants on post-stroke depression and functional recovery: a systematic review and meta-analysis

in Ethnopharmacology

Jeongrim Bak
Hyowon Jin
Jong-Min Yun
Jungtae Leem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651831

905 views

Review

Published on 02 Jan 2026

Evidence-based production framework for herbal medicine regulation in Indonesia

in Ethnopharmacology

Mohamad Kashuri
Taruna Ikrar
Sutriyo
Abdul Mun’im
Arry Yanuar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730273

1,336 views

Mini Review

Published on 02 Jan 2026

Tumor-like characteristics of vascular smooth muscle cells in atherosclerosis

in Cardiovascular and Smooth Muscle Pharmacology

Xiangchun Li
Yuyan Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734123

860 views

Original Research

Published on 02 Jan 2026

Jaranol: a compound with therapeutic activity against pathological cardiac remodelling via multi-target inhibition of the Snai3/TLR2 and NF-κB signaling pathways

in Cardiovascular and Smooth Muscle Pharmacology

Yao Zhang
Nan Li
Shiqi Chu
Heqing Fu
Xiaowen Yang
Huimin Xia
Yunfeng Xiao
Zhibin Xiao
Jing Liu
Yu Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723889

804 views

Review

Accepted on 30 Dec 2025

Pharmacological Advances in Multi-Targeted Strategies for Type 2 Diabetes Mellitus: A Systematic Perspective Based on Traditional Chinese Medicine

in Ethnopharmacology

Yanli Zhao
Jiabao Liao
Panpan Pang
JingYuan Li
Suocai Su
Mengqiu Shao
Weibo Wen
Furong Xu

Frontiers in Pharmacology

244 views

Original Research

Accepted on 29 Dec 2025

Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

in Experimental Pharmacology and Drug Discovery

Shan Luo
Yake Lan
Ruoqi Zhang
Zhongqiu Luan

Frontiers in Pharmacology

268 views

Original Research

Accepted on 29 Dec 2025

Parabrachial Calcitonin Gene-Related Peptide Neurons Sex-Specifically Modulate Behavior in Anxiety Assays During Alcohol Withdrawal

in Neuropharmacology

Catherine Elizabeth Van Doorn
Jordan Brooke Tyree
Anel Ariana Jaramillo

Frontiers in Pharmacology

256 views

Review

Accepted on 25 Dec 2025

Research progress on mechanisms and applications of Chinese herbal pairs in Treating Hyperplasia of Mammary Gland

in Ethnopharmacology

Lu Liu
Yuxuan Zhang
Wei Shen
Wanyu Li
Xudong Lei
Xiaoyan Dai

Frontiers in Pharmacology

262 views

Review

Accepted on 24 Dec 2025

MOLECULAR AND PATHOPHYSIOLOGICAL INTERSECTIONS BETWEEN ARTERIAL HYPERTENSION, PULMONARY INFLAMMATION AND DIABETES MELLITUS

in Inflammation Pharmacology

Higo José Neri da Silva
Antônio Carlos Melo Lima Filho
Ester Miranda Pereira
Ian Jhemes Oliveira Sousa
Francisco Valmor Macedo Cunha
Massimo Lucarini
Alessandra Durazzo
Leonardo da Rocha Sousa
Daniel Dias Rufino Arcanjo

Frontiers in Pharmacology

199 views

Review

Accepted on 22 Dec 2025

Oleaceae Plants: A Source of Metabolites with Atheroprotective Potential

in Ethnopharmacology

Agnieszka Anna Filipek
Edyta Czepielewska

Frontiers in Pharmacology

194 views

Original Research

Accepted on 22 Dec 2025

hnRNP A2B1 as a Promising Therapeutic Target for Radiomodulatory Drug Development: Evidence from Computational and Experimental Studies

in Experimental Pharmacology and Drug Discovery

N Lubinets
I S Tonkyy
V. A. Sazonova
K. Dutta
A. E. Putintseva
O. O. Volkova
Ekaterina V. Skorb
P. Zun
A. Ruzov
V. Yu. Kravtsov

Frontiers in Pharmacology

208 views

Review

Accepted on 22 Dec 2025

Ethnopharmacological Considerations of Plants Traditionally Used by Local Communities to Manage Maternal Conditions in Tanzania: A Scoping Review

in Ethnopharmacology

Mwanaidi Omary
Maryyusta Nguyamu
Jackline Nkoma
Hamisi Japhari
Obadia K. Bishoge
Emanuel L. Peter

Frontiers in Pharmacology

185 views

Review

Published on 22 Dec 2025

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis

in Gastrointestinal and Hepatic Pharmacology

Christian Lambiase
Francesco Rettura
Giusi Desirè Sciumè
Riccardo Tedeschi
Antonio Grosso
Lorenzo Cancelli
Andrea Bottari
Matteo Fornai
Luca Antonioli
Nicola de Bortoli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677037

1,645 views

Review

Accepted on 19 Dec 2025

PDE1B and PDE10A as Novel Targets for Schizophrenia: From Molecular Design and Synthesis to Therapeutic Promise

in Experimental Pharmacology and Drug Discovery

Jaya Rautela
Anand Gaurav
Veeranoot Nissapatorn
Chung Keat Tan
Ana Paula Girol
Maria De Lourdes Pereira
Vannajan Sanghiran Lee

Frontiers in Pharmacology

974 views

Systematic Review

Accepted on 19 Dec 2025

Glycyrrhizic acid and glycyrrhetinic acid, natural products of Glycyrrhiza uralensis Fisch.: pharmacological and biological activities, pharmacokinetics, toxicological effects, and clinical applications to diseases

in Ethnopharmacology

HUA ZHANG
Chun-li Wu
Ruoyu Chao
Xiang-yu Zhao
Yan-wei Zhang
Qinwei Fu
Qinxiu Zhang
Jianlin WU

Frontiers in Pharmacology

331 views

Review

Published on 19 Dec 2025

Recent advances in natural polysaccharides for type 2 diabetes management: sources, structural characteristics, and mechanistic insights

in Ethnopharmacology

Zexiang Liu
Hanlong Wang
Xiujuan Gong
Xiao Jiang
Kangyi Yang
Linfang Jiang
Zhihui Wang
Qiaozhen Tong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705122

1,429 views

Study Protocol

Published on 19 Dec 2025

Rifapentine- and moxifloxacin-containing short-course regimens for mild spinal tuberculosis: study protocol for a multicenter, randomized, non-inferiority phase II clinical trial

in Pharmacology of Infectious Diseases

Yue-E Wu
Jing Cao
Li Wang
Ying-Ji Wei
Hui-Xin Liu
Lei Qi
Wen Zhang
Feng Liu
Zhong-Jiao Zhu
Xu-Tao Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684771

1,162 views

29,475 articles

articles

A network meta-analysis of first-line treatment options for patients with Child-Pugh class B functional hepatocellular carcinoma: comparison of efficacy and safety

Ferula ammoniacum gum aqueous extract exerts anti-inflammatory and antioxidant mechanisms to combat aluminum chloride-induced Alzheimer’s disease in rats: possible involvement of opioid pathways

Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

Bone-targeted mitochondrial delivery via magnetic-temperature responsive artificial cells for repairing age-related fractures

Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair

Efficacy and safety of Chinese herbal medicine for metabolic conditions: a systematic review and meta-analysis of randomised controlled trials

Effects of modified Soyo-san (Xiao-yao-san, Shoyo-san) combined with antidepressants on post-stroke depression and functional recovery: a systematic review and meta-analysis

Evidence-based production framework for herbal medicine regulation in Indonesia

Tumor-like characteristics of vascular smooth muscle cells in atherosclerosis

Jaranol: a compound with therapeutic activity against pathological cardiac remodelling via multi-target inhibition of the Snai3/TLR2 and NF-κB signaling pathways

Pharmacological Advances in Multi-Targeted Strategies for Type 2 Diabetes Mellitus: A Systematic Perspective Based on Traditional Chinese Medicine

Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

Parabrachial Calcitonin Gene-Related Peptide Neurons Sex-Specifically Modulate Behavior in Anxiety Assays During Alcohol Withdrawal

Research progress on mechanisms and applications of Chinese herbal pairs in Treating Hyperplasia of Mammary Gland

MOLECULAR AND PATHOPHYSIOLOGICAL INTERSECTIONS BETWEEN ARTERIAL HYPERTENSION, PULMONARY INFLAMMATION AND DIABETES MELLITUS

Oleaceae Plants: A Source of Metabolites with Atheroprotective Potential

hnRNP A2B1 as a Promising Therapeutic Target for Radiomodulatory Drug Development: Evidence from Computational and Experimental Studies

Ethnopharmacological Considerations of Plants Traditionally Used by Local Communities to Manage Maternal Conditions in Tanzania: A Scoping Review

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis

PDE1B and PDE10A as Novel Targets for Schizophrenia: From Molecular Design and Synthesis to Therapeutic Promise

Glycyrrhizic acid and glycyrrhetinic acid, natural products of Glycyrrhiza uralensis Fisch.: pharmacological and biological activities, pharmacokinetics, toxicological effects, and clinical applications to diseases

Recent advances in natural polysaccharides for type 2 diabetes management: sources, structural characteristics, and mechanistic insights

Rifapentine- and moxifloxacin-containing short-course regimens for mild spinal tuberculosis: study protocol for a multicenter, randomized, non-inferiority phase II clinical trial