Frontiers in Pharmacology

Review

Published on 19 Dec 2025

Recent advances in natural polysaccharides for type 2 diabetes management: sources, structural characteristics, and mechanistic insights

in Ethnopharmacology

Zexiang Liu
Hanlong Wang
Xiujuan Gong
Xiao Jiang
Kangyi Yang
Linfang Jiang
Zhihui Wang
Qiaozhen Tong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705122

1,429 views

Study Protocol

Published on 19 Dec 2025

Rifapentine- and moxifloxacin-containing short-course regimens for mild spinal tuberculosis: study protocol for a multicenter, randomized, non-inferiority phase II clinical trial

in Pharmacology of Infectious Diseases

Yue-E Wu
Jing Cao
Li Wang
Ying-Ji Wei
Hui-Xin Liu
Lei Qi
Wen Zhang
Feng Liu
Zhong-Jiao Zhu
Xu-Tao Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684771

1,162 views

Original Research

Published on 19 Dec 2025

Hydroxyurea utilization among individuals with sickle cell disease in Tennessee: a pooled analysis of claims data

in Pharmacoepidemiology

Ayesha Mukhopadhyay
Matthew P. Smeltzer
Judy Dudley
Sherif M. Badawy
Joacy G. Mathias
Allison P. Plaxco
Meredith A. Ray
Andrew D. Wiese
Walter I. Stevens
James G. Gurney

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693126

1,174 views

Mini Review

Published on 19 Dec 2025

Research progress in the prevention and treatment of radiation-induced heart disease

in Cardiovascular and Smooth Muscle Pharmacology

Ye Sun
Chenyi Zheng
Lin Li
Shenglin Zhang
Jiajuan Guo
Jincheng Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1745302

1,602 views

Review

Published on 19 Dec 2025

Engineering immunity with CAR-NK cells: advancing the frontiers of cancer immunotherapy

in Translational Pharmacology

Vlad Andrei Cianga
Ion Antohe
Cosmin Minciună
Angela Dăscălescu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1738558

1,845 views

Correction

Published on 19 Dec 2025

Correction: Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status

in Drug Metabolism and Transport

Lan Gao
Neil Smith
Ronald Kong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1764401

743 views

Original Research

Published on 19 Dec 2025

Environmental enrichment enhances anesthetic actions in rat amygdala hippocampal circuits in vitro

in Neuropharmacology

Kenta Onishi
Rika Sasaki
Koki Hirota
Tomonori Takazawa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732630

1,116 views

Clinical Trial

Published on 19 Dec 2025

Effects and safety of a CBD-rich Cannabis sativa oil in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial – CANOA – cannabis for osteoarthritis

in Ethnopharmacology

Andrés Mojoli
Osvaldo Haider
Yasmin Fakih
Maria Victoria Luz Gonçalves
Bruno Zepeda Rojas
Giovanna Xaia
Emanuelly Krefta
Maíra Assunção Bicca
Thiago Lopes de Mari
Charles Francisco Ferreira

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657065

2,012 views

Original Research

Published on 19 Dec 2025

Oleanolic acid cubic liquid crystal nanoparticle-based thermosensitive gel attenuates knee osteoarthritis symptoms in rats

in Inflammation Pharmacology

Zhiqi Shi
Fan Jia
Xiaoyu Tang
Qing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730566

1,402 views

Systematic Review

Published on 19 Dec 2025

Effectiveness and safety of Ayurvedic intervention in essential hypertension: a systematic review with meta-analysis

in Ethnopharmacology

Saylee Deshmukh
Kuldeep Choudhary
Azeem Ahmad
Govind Reddy
B. C. S. Rao
Narayanam Srikanth
Rabinarayan Acharya

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695614

2,706 views

Original Research

Published on 19 Dec 2025

Multilocus inherited neoplasia allele syndrome (MINAS) in a Turkish cohort: molecular insights and clinical relevance for precision oncology

in Pharmacology of Anti-Cancer Drugs

Taha Bahsi
Serhat Seyhan
Kaan Helvaci
Umut Demirci
Irem Bilgetekin
Selami Bayram
Mehmet Akif Ozturk
Fatih Aydogan
Serkan Keskin
Kezban Pilanci

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672774

1,545 views

Original Research

Published on 19 Dec 2025

Systemic angiogenic protein changes following propranolol therapy in infantile hemangioma: a multi-target perspective

in Experimental Pharmacology and Drug Discovery

Lijun Liang
Yan Zhang
Yan Ma
Jing Liu
Wangnan Du
Qiang Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706048

1,294 views

Original Research

Published on 19 Dec 2025

Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia

in Integrative and Regenerative Pharmacology

Patrícia Terra Alves
Sayone Andrade de Moura
Helen Taylor
Antonella Fidanza
Cristiane Damas Gil
Leonardo Martin
Aléx Martins Nasare
André van Helvoort Lengert
Bianca Bonetto Moreno Garcia
Gabriel Cicolin Guarache

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698623

1,475 views

Original Research

Published on 19 Dec 2025

Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system

in Ethnopharmacology

Zhihui Li
Yanqiu Gu
Jianbo Yang
Shaozhan Wang
Shengnan Li
Panpan Chen
Ru Yao
Fangbin Liu
Ying Wang
Rong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706401

1,501 views

Case Report

Published on 19 Dec 2025

Case Report: Tislelizumab–induced panuveitis: a report of two cases

in Pharmacology of Anti-Cancer Drugs

Huan Ding
Shuyuan Zhang
Lin Lin
Kaiyan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678663

1,275 views

Mini Review

Published on 19 Dec 2025

Abhraka Bhasma (mica based nanomedicine): an ayurvedic herbomineral perspective in breast cancer management

in Ethnopharmacology

Dhanya Soman Pillai
Amarnath Karavettekudy Ranjit

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656846

1,518 views

Systematic Review

Published on 19 Dec 2025

Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

in Drugs Outcomes Research and Policies

Marta Mazur
Artnora Ndokaj
Claudia Salerno
Jessica Vallone
Roman Ardan
Sabina Bietolini
Florence Carrouel
Aleksandra Wilk
Rachel Sarig
Livia Ottolenghi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602976

6,584 views

Mini Review

Published on 19 Dec 2025

Transcriptional rewiring in cancer driven by POLR2A/RPB1: mechanistic insights, non-coding RNA crosstalk, and therapeutic opportunities

in Pharmacogenetics and Pharmacogenomics

Adrian Szczepaniak
Kinga Jaskuła
Marta Zielińska
Jakub Godlewski

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1745087

1,424 views

Systematic Review

Published on 19 Dec 2025

Efficacy and safety of later-line targeted therapies in advanced non-small cell lung cancer with EGFR exon 20 insertion mutations: a systematic review

in Pharmacology of Anti-Cancer Drugs

Qiang Wen
Yue Zhuang
Silv Fu
Chunguo Pan
Zhihua Liu
Lei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707050

2,364 views

Original Research

Accepted on 18 Dec 2025

Pharmacological Activation of SIRT1-AMPK by Ginsenoside Rb1: A Novel Therapeutic Strategy for Pressure Injury via Dual Suppression of Ferroptosis and Inflammation

in Integrative and Regenerative Pharmacology

Hongbo Zhu
Hang Li
Yinong Shi
Hua Zhi
Xuelu Zhao
Zhiwen Wang
Jinhui Liu

Frontiers in Pharmacology

320 views

Review

Accepted on 18 Dec 2025

Plant Polysaccharides in Neuroprotection: Mechanistic Insights Across Central Nervous System Disorders.

in Ethnopharmacology

Qiyue Yu
Hui Chen
Zhuofeng Qu
Jialin Qu
Yan Wang
Lina Liang
Shouyu Hu

Frontiers in Pharmacology

161 views

Original Research

Published on 18 Dec 2025

Impact of postoperative flurbiprofen axetil on renal function in spontaneously hypertensive rats

in Renal Pharmacology

Liang Sun
Xiaoran Ma
Yuhui Jiang
Wanda Zhang
Yi Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686334

1,136 views

Original Research

Published on 18 Dec 2025

Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations

in Pharmacology of Anti-Cancer Drugs

Jia Xu
Liang Qin
Xiao Liang
Lulu Chen
Juexin Wang
Hua Guo
Fengmei Wang
Ran Wu
Xiaojing An
Wenjuan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627864

1,127 views

Review

Published on 18 Dec 2025

Systemic metabolic reprogramming and microbial dysbiosis in Fabry disease: Multi-omics mechanisms and implications for drug development

in Experimental Pharmacology and Drug Discovery

Nuria Gómez-Cebrián
María Chovi Trull
Elena Gras-Colomer
María Dolores Edo Solsona
José Luis Poveda Andrés
Leonor Puchades-Carrasco

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702682

1,299 views
1 citation

29,475 articles

articles

Recent advances in natural polysaccharides for type 2 diabetes management: sources, structural characteristics, and mechanistic insights

Rifapentine- and moxifloxacin-containing short-course regimens for mild spinal tuberculosis: study protocol for a multicenter, randomized, non-inferiority phase II clinical trial

Hydroxyurea utilization among individuals with sickle cell disease in Tennessee: a pooled analysis of claims data

Research progress in the prevention and treatment of radiation-induced heart disease

Engineering immunity with CAR-NK cells: advancing the frontiers of cancer immunotherapy

Correction: Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status

Environmental enrichment enhances anesthetic actions in rat amygdala hippocampal circuits in vitro

Effects and safety of a CBD-rich Cannabis sativa oil in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial – CANOA – cannabis for osteoarthritis

Oleanolic acid cubic liquid crystal nanoparticle-based thermosensitive gel attenuates knee osteoarthritis symptoms in rats

Effectiveness and safety of Ayurvedic intervention in essential hypertension: a systematic review with meta-analysis

Multilocus inherited neoplasia allele syndrome (MINAS) in a Turkish cohort: molecular insights and clinical relevance for precision oncology

Systemic angiogenic protein changes following propranolol therapy in infantile hemangioma: a multi-target perspective

Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia

Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system

Case Report: Tislelizumab–induced panuveitis: a report of two cases

Abhraka Bhasma (mica based nanomedicine): an ayurvedic herbomineral perspective in breast cancer management

Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

Transcriptional rewiring in cancer driven by POLR2A/RPB1: mechanistic insights, non-coding RNA crosstalk, and therapeutic opportunities

Efficacy and safety of later-line targeted therapies in advanced non-small cell lung cancer with EGFR exon 20 insertion mutations: a systematic review

Pharmacological Activation of SIRT1-AMPK by Ginsenoside Rb1: A Novel Therapeutic Strategy for Pressure Injury via Dual Suppression of Ferroptosis and Inflammation

Plant Polysaccharides in Neuroprotection: Mechanistic Insights Across Central Nervous System Disorders.

Impact of postoperative flurbiprofen axetil on renal function in spontaneously hypertensive rats

Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations

Systemic metabolic reprogramming and microbial dysbiosis in Fabry disease: Multi-omics mechanisms and implications for drug development