Frontiers in Pharmacology

Review

Published on 18 Dec 2025

Systemic metabolic reprogramming and microbial dysbiosis in Fabry disease: Multi-omics mechanisms and implications for drug development

in Experimental Pharmacology and Drug Discovery

Nuria Gómez-Cebrián
María Chovi Trull
Elena Gras-Colomer
María Dolores Edo Solsona
José Luis Poveda Andrés
Leonor Puchades-Carrasco

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702682

1,299 views
1 citation

Original Research

Published on 18 Dec 2025

Exploring medication adherence in racial/ethnic minorities

in Drugs Outcomes Research and Policies

Joronia Chery
Lisa Gualtieri
Ian Lee
Grace Sheng
Meera Singhal
Sebastian Z. Ramos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670633

952 views

Original Research

Published on 18 Dec 2025

Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology

in Pharmacology of Infectious Diseases

Hanem F. El-Gendy
Shimaa R. Masoud
Nagwa I. Sheraiba
Shimaa S. Elnahriry
Doaa A. Madkour
Reda M. S. Korany
Hazim O. Khalifa
Hanaa Y. Elnagar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679854

1,330 views

Editorial

Published on 18 Dec 2025

Editorial: Non-coding RNAs as potential therapeutics and biomarkers for human diseases

in Experimental Pharmacology and Drug Discovery

Margarida Gama-Carvalho
Alice Conigliaro
Chiara De Santi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1753536

846 views

Original Research

Published on 18 Dec 2025

The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids

in Predictive Toxicology

Rocío Rivera Rodríguez
Siri Sæterstad
Ann-Therese Chattergoon Ali
Linn-Karina M. Selvik
Ingunn Bakke
Torunn Bruland
Jeremy J. Johnson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1696576

1,623 views

Original Research

Published on 18 Dec 2025

Nanozyme-armored natural enzymes for acute kidney injury management via inflammation regulation and oxidative damage mitigation

in Renal Pharmacology

Juntao Wang
Ruifeng Li
Xiaofei Fu
Shuai Huo
Lijiao Wang
Fengmin Shao
Yue Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686323

814 views

Original Research

Published on 18 Dec 2025

A warming-yang herbal decoction protects against high-altitude hypoxia–induced osteoblast injury through modulation of HIF-1 signaling

in Ethnopharmacology

Xuehai Liu
Yaqian Qi
Rui Zhao
Binkui Jia
Xilin Lei
Hongfan Li
Di Wang
Haoling Zhang
Wei Wang
Zhijing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673146

1,154 views

Systematic Review

Published on 18 Dec 2025

Synergistic antitumor effects of astragalus polysaccharide: a preclinical systematic review and meta-analysis

in Ethnopharmacology

Ruo Zhang
Qian Yang
Zhi Chen
Jianming Huang
Guonan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672450

1,536 views

Original Research

Published on 18 Dec 2025

Effect of itraconazole on pharmacokinetics of ZX-7101A tablets in healthy Chinese subjects

in Drug Metabolism and Transport

Junzhen Wu
Yin Wang
Wei Liu
Jinjie He
Jufang Wu
Jicheng Yu
Xiaojie Wu
Jianguang Su
Mei Liu
Yilin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722747

660 views

Policy and Practice Reviews

Published on 18 Dec 2025

Regulatory considerations for developing phage therapy medicinal products for the treatment of antimicrobial resistant bacterial infections

in Pharmacology of Infectious Diseases

Ai Fukaya-Shiba
Akiko Ogata
Ryosuke Kuribayashi
Akira Sakurai
Kanako Suzuki
Shunsuke Takadama
Jihei Nishimura
Jumpei Uchiyama
Hiroki Ohge
Takamasa Takeuchi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713471

2,965 views
1 citation

Original Research

Published on 18 Dec 2025

Nonclinical evaluation of HS630, a proposed biosimilar of trastuzumab emtansine: affinity, pharmacokinetics, and immunogenicity

in Drug Metabolism and Transport

Hui Jiang
Jinjing Che

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698727

1,214 views

Mini Review

Published on 18 Dec 2025

Intranasal delivery of iron chelators and management of central nervous system disease

in Experimental Pharmacology and Drug Discovery

Ruiying Cheng
Jonghan Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709259

1,197 views

Original Research

Published on 18 Dec 2025

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

in Renal Pharmacology

Stefano Turolo
Alberto Edefonti
Marie-Louise Syren
Anita S. Bellotti
William Morello
Federica Collino
Carlo Agostoni
Giovanni Montini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672304

1,029 views

Original Research

Published on 18 Dec 2025

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue

in Inflammation Pharmacology

Amal Kouadri
Camille Lyko
Carine El Hajjar
Johanna Cormenier
Kevin Kevin Gemy
Nadia Alfaidy
Mohamed Benharouga

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657688

821 views

Original Research

Published on 18 Dec 2025

Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation

in Pharmacology of Anti-Cancer Drugs

Yanjie Zhong
Ruiqi Zou
Ximei Luo
Siqi Yang
Zhiqiang He
Haijie Hu
Fuyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658462

1,249 views

Original Research

Published on 18 Dec 2025

Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration in vitro and in vivo of clear cell renal cell carcinoma

in Pharmacology of Anti-Cancer Drugs

Zhongjun Jiang
Lanlan Wang
Zhongrun He
Lian Guo
Wen Luo
Ying Fu
Qiyu Xiao
Guanglan Chen
Yinzi Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736086

836 views

Opinion

Published on 18 Dec 2025

Voriconazole injection use in patients receiving continuous renal replacement therapy

in Drug Metabolism and Transport

Ling Zhou
Zhenwei Yu
Xia Wang
Huaiyu Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736767

903 views

Clinical Trial

Published on 18 Dec 2025

Pharmacokinetics and safety of the antitumor drug everolimus in healthy Chinese subjects: a single-dose, open-label, randomized, two-sequence, two-period crossover, phase I bioequivalence study

in Pharmacology of Anti-Cancer Drugs

Xiaodan Chen
Xiaoyi Yi
Yuting Liu
Xiaosong Wang
Yahui Peng
Qiong Wang
Ying Shuai
Hong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718032

842 views

Original Research

Published on 18 Dec 2025

Differential effects of PCSK9 inhibitors and statins on plasma ceramides in coronary artery disease

in Cardiovascular and Smooth Muscle Pharmacology

Liang Zhang
Yaodong Ding
Yong Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726925

1,043 views

Original Research

Published on 18 Dec 2025

Anti-inflammatory effect of a pimarane diterpenoid isolated from Nepeta adenophyta Hedge based on a network analysis approach and experimental assessment

in Ethnopharmacology

Wei Zhao
Meng Li
Chuanqing Jia
Iftikhar Ali
Long Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652902

1,111 views

Review

Published on 18 Dec 2025

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

in Renal Pharmacology

Jiahuan Gong
Xingxing Fang
Xinlei Yao
Fei Xue
Guangdong Qi
Bingqian Chen
Hualin Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729941

1,877 views

Original Research

Published on 18 Dec 2025

Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment

in Ethnopharmacology

Hayder A. Hammoodi
Rofida Albash
Mohammed I. A. Hamed
Khaled M. Darwish
Amira B. Kassem
Asmaa Saleh
Jawaher Abdullah Alamoudi
Noha M. Badawi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685423

725 views

Original Research

Accepted on 17 Dec 2025

Benefit-risk Assessment of the use of toxic botanical drugs in superiority field: A case study on Aconitum carmichaeli Debx

in Ethnopharmacology

Xiaomeng Zhang
Bing Zhang
Jintao Lyv
Zhijian Lin
Xinlong Liu

Frontiers in Pharmacology

158 views

Systematic Review

Accepted on 17 Dec 2025

Efficacy and safety of efruxifermin for patients with NASH/MASH:an updated systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yajun Xiao
Xue-Ping Liu
Yan-Ling Zhang
Xiao-Li Tian
Yan-Qun Liu
Yan Cheng
Cunliang Deng
Hao Sun

Frontiers in Pharmacology

254 views

29,475 articles

articles

Systemic metabolic reprogramming and microbial dysbiosis in Fabry disease: Multi-omics mechanisms and implications for drug development

Exploring medication adherence in racial/ethnic minorities

Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology

Editorial: Non-coding RNAs as potential therapeutics and biomarkers for human diseases

The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids

Nanozyme-armored natural enzymes for acute kidney injury management via inflammation regulation and oxidative damage mitigation

A warming-yang herbal decoction protects against high-altitude hypoxia–induced osteoblast injury through modulation of HIF-1 signaling

Synergistic antitumor effects of astragalus polysaccharide: a preclinical systematic review and meta-analysis

Effect of itraconazole on pharmacokinetics of ZX-7101A tablets in healthy Chinese subjects

Regulatory considerations for developing phage therapy medicinal products for the treatment of antimicrobial resistant bacterial infections

Nonclinical evaluation of HS630, a proposed biosimilar of trastuzumab emtansine: affinity, pharmacokinetics, and immunogenicity

Intranasal delivery of iron chelators and management of central nervous system disease

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue

Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation

Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration in vitro and in vivo of clear cell renal cell carcinoma

Voriconazole injection use in patients receiving continuous renal replacement therapy

Pharmacokinetics and safety of the antitumor drug everolimus in healthy Chinese subjects: a single-dose, open-label, randomized, two-sequence, two-period crossover, phase I bioequivalence study

Differential effects of PCSK9 inhibitors and statins on plasma ceramides in coronary artery disease

Anti-inflammatory effect of a pimarane diterpenoid isolated from Nepeta adenophyta Hedge based on a network analysis approach and experimental assessment

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment

Benefit-risk Assessment of the use of toxic botanical drugs in superiority field: A case study on Aconitum carmichaeli Debx

Efficacy and safety of efruxifermin for patients with NASH/MASH:an updated systematic review and meta-analysis