Frontiers in Pharmacology

Original Research

Published on 17 Dec 2025

Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511

in Pharmacology of Anti-Cancer Drugs

Xiaoli Deng
Chunjie Hu
Lin Li
Guixian Yang
Chikun Li
Wanxun Zhang
Guangyu Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586657

949 views

Original Research

Published on 17 Dec 2025

The mechanistic role of gitogenin as a treatment for laryngeal cancer: a network pharmacology and experimental analysis

in Pharmacology of Anti-Cancer Drugs

Zhuo Fu
Yue Guan
Zhangwei Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1663323

981 views

Original Research

Published on 17 Dec 2025

Rapid health technology assessment of six non-ergot dopamine-receptor agonists for the treatment of early Parkinson’s disease

in Drugs Outcomes Research and Policies

Jieqiong Lv
Hongbo Fu
Yanqiong Zhou
Wenwei Li
Jiaxin Zhang
Zhihua Zhou
Sha Lai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648833

1,208 views

Review

Published on 17 Dec 2025

Research progress on the regulatory effects and mechanisms of natural active products on intestinal barrier function

in Gastrointestinal and Hepatic Pharmacology

Fuyixuan Zheng
Yuemei Sun
Minghui Zhao
Rong Wang
Wenbin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673568

1,035 views

Review

Published on 17 Dec 2025

Novel protein acylations in ferroptosis: decoding the regulatory roles of lactylation, crotonylation, succinylation, and β-hydroxybutyrylation

in Pharmacology of Anti-Cancer Drugs

Meiquan Wei
Shiming Wei
Xuhua Xie
Taotao Liu
Jun Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688548

1,982 views

Review

Accepted on 16 Dec 2025

Harnessing Curcumin in Oral Medicine: Mechanisms, Therapeutic Potential, and Future Innovations

in Ethnopharmacology

Chengchen Hu
Shengguo Wang
Zhi Gao
Maofeng Qing
Lian Tan
Lu Yang
Fang Li

Frontiers in Pharmacology

416 views

Original Research

Published on 16 Dec 2025

Fedratinib reveals chemotherapeutic potential in esophageal squamous cell cancer

in Pharmacology of Anti-Cancer Drugs

Man Luo
Jiang Zhu
Yong Yang
Chongbo Liao
Xiao Liu
Maoju Tang
Lei Xu
Xiaowu Zhong
Qiang Ma
Xiaolan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689663

1,281 views

Original Research

Published on 16 Dec 2025

O-GlcNAcylation of eNOS in high-salt-induced thoracic aorta endothelial dysfunction in mice

in Cardiovascular and Smooth Muscle Pharmacology

Chang Li
Liuming Gao
Yi Ling
Zhan Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730447

1,050 views

Review

Published on 16 Dec 2025

Recent advances in mineralocorticoid receptor antagonists for heart failure with preserved ejection fraction: focus on finerenone in the era of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists

in Cardiovascular and Smooth Muscle Pharmacology

Tian-Yu Wang
Lei Zhang
Huan-Yi Wang
Fen-Fen Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725782

2,449 views

Original Research

Published on 16 Dec 2025

Integrated gut microbiota and metabolomics analysis reveals the antitumor effects of ergosta-4,6,8(14),22-tetraen-3-one purified from the medicinal fungus pholiota adiposa in tumor-bearing mice

in Ethnopharmacology

Boyuan Liu
Junsen Qin
Shan Zheng
Jiaxin Zhang
Xuemei Hu
Xiaoyan Wang
Yan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653035

1,246 views

Original Research

Published on 16 Dec 2025

Developing a value assessment index system of anti-tumour commercial Chinese polyherbal preparation in China: a modified Delphi study

in Ethnopharmacology

Tongchao Xia
Min Hu
Chunmei Luo
Mengmeng Yang
Mingming Chu
Xing Xiang
Zhe Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681174

1,183 views

Original Research

Published on 16 Dec 2025

Total alkaloids of Corydalis saxicola Bunting ameliorate ulcerative colitis through regulation of metabolite networks and gut microbiota

in Ethnopharmacology

Shuyi Jin
Xinyi Cheng
Feng Han
Qien Li
Jing Shang
Guoyong Xie
Minjian Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721116

1,097 views

Original Research

Accepted on 15 Dec 2025

Miquelianin and spiraeoside from Filipendula ulmaria mitigate α-synuclein accumulation in C.elegans and reduce the expression of neuroinflammatory cytokines in human microglia

in Ethnopharmacology

Martina Redl
Sabrina Weisenburger
Andreas Wasilewicz
Ulrike Grienke
Martin D. Lehner
Dirk Bredenbröker
Judith Maria Rollinger

Frontiers in Pharmacology

198 views

Correction

Published on 15 Dec 2025

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity

in Renal Pharmacology

Hui-Fang Deng
Lan-Xin Yue
Ning-Ning Wang
Yong-Qiang Zhou
Wei Zhou
Xian Liu
Yu-Hao Ni
Cong-Shu Huang
Li-Zhen Qiu
Hong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734058

633 views

Editorial

Published on 15 Dec 2025

Editorial: Traditional, complementary and integrative medicine – opportunities for managing and treating neurodegenerative diseases and ischaemic stroke

in Ethnopharmacology

Huazheng Liang
Chunguang Li
Bin Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1749624

827 views

Original Research

Published on 15 Dec 2025

Selective anti-cancer effects of cannabidiol and Δ9-tetrahydrocannabinol via PI3K/AKT/mTOR inhibition and PTEN restoration in ovarian cancer cells

in Pharmacology of Anti-Cancer Drugs

Siyao Tong
Watcharin Loilome
Nisana Namwat
Poramate Klanrit
Arporn Wangwiwatsin
Zar Zar Win
Preeya Koyabuth
Bandit Chumworathayi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693129

6,246 views

Original Research

Accepted on 12 Dec 2025

Stratification System for Pharmaceutical Care in Cancer Patients: Chinese Expert Consensus

in Drugs Outcomes Research and Policies

Ya Chen
Xue Ma
Mao Lin
Zhiqiang Hu
Junxiang Zhou
Yue Qiu
Zhixi Liu
Suya Du
Lihong Shi
Li Han

Frontiers in Pharmacology

362 views

Original Research

Accepted on 12 Dec 2025

Historical texts as a potential resource for plant-based antiviral agents against SARS-CoV-2 – the example of the Receptarium of Burkhard III von Hallwyl from 16th century Switzerland

in Ethnopharmacology

Nina Vahekeni
Jonas Stehlin
Corinna Urmann
Evelyn Wolfram
Yannick Geissmann
Yelena Ruedin
Samuel Peter
Olivier Engler
Andreas Lardos

Frontiers in Pharmacology

291 views

Original Research

Published on 12 Dec 2025

Targeting lipogenesis promotes the synergistic effect of the selective HDAC6 inhibitor ITF3756 with bortezomib in colon cancer cells

in Pharmacology of Anti-Cancer Drugs

Marzia Franzò
Chiara Zichittella
Diana Di Liberto
Giovanni Pratelli
Federica Affranchi
Antonietta Notaro
Michela Giuliano
Sonia Emanuele

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706770

1,394 views

Review

Published on 12 Dec 2025

Clinical relevance of PLK1 in epithelial ovarian cancer

in Pharmacology of Anti-Cancer Drugs

Xiaochang Shen
Jiandong Wang
Shuning Chen
Haomeng Zhang
Chunxiao Zhou
Victoria L. Bae-Jump

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702273

1,066 views

Methods

Published on 12 Dec 2025

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism

in Drug Metabolism and Transport

Yifei Shen
Bingyi Yao
Yuanqing Guo
Yujia Yang
Chenmeizi Liang
Junze Huang
Yuanjin Zhang
Xin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714686

1,081 views

Review

Published on 12 Dec 2025

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review

in Translational Pharmacology

César Alas-Pineda
Dennis J. Pavón-Varela
Kristhel Gaitán-Zambrano
Gustavo Ferrer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1737690

2,103 views

Editorial

Published on 12 Dec 2025

Editorial: Cell death in kidney diseases: novel biomarkers, mechanisms, and therapeutic strategies

in Renal Pharmacology

Min Chen
Yu Ning Liu
Wei Jing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715728

735 views

Original Research

Published on 12 Dec 2025

Medication adherence in the elderly population with chronic diseases: a factor analysis

in Pharmacoepidemiology

Doris Cardona
Valeria Santacruz-Restrepo
Alejandra Rendón-Montoya
Juliana Madrigal-Cadavid
Alejandra Segura-Cardona
Jorge Iván Estrada-Acevedo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699999

1,381 views

29,475 articles

articles

Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511

The mechanistic role of gitogenin as a treatment for laryngeal cancer: a network pharmacology and experimental analysis

Rapid health technology assessment of six non-ergot dopamine-receptor agonists for the treatment of early Parkinson’s disease

Research progress on the regulatory effects and mechanisms of natural active products on intestinal barrier function

Novel protein acylations in ferroptosis: decoding the regulatory roles of lactylation, crotonylation, succinylation, and β-hydroxybutyrylation

Harnessing Curcumin in Oral Medicine: Mechanisms, Therapeutic Potential, and Future Innovations

Fedratinib reveals chemotherapeutic potential in esophageal squamous cell cancer

O-GlcNAcylation of eNOS in high-salt-induced thoracic aorta endothelial dysfunction in mice

Recent advances in mineralocorticoid receptor antagonists for heart failure with preserved ejection fraction: focus on finerenone in the era of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists

Integrated gut microbiota and metabolomics analysis reveals the antitumor effects of ergosta-4,6,8(14),22-tetraen-3-one purified from the medicinal fungus pholiota adiposa in tumor-bearing mice

Developing a value assessment index system of anti-tumour commercial Chinese polyherbal preparation in China: a modified Delphi study

Total alkaloids of Corydalis saxicola Bunting ameliorate ulcerative colitis through regulation of metabolite networks and gut microbiota

Miquelianin and spiraeoside from Filipendula ulmaria mitigate α-synuclein accumulation in C.elegans and reduce the expression of neuroinflammatory cytokines in human microglia

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity

Editorial: Traditional, complementary and integrative medicine – opportunities for managing and treating neurodegenerative diseases and ischaemic stroke

Selective anti-cancer effects of cannabidiol and Δ9-tetrahydrocannabinol via PI3K/AKT/mTOR inhibition and PTEN restoration in ovarian cancer cells

Stratification System for Pharmaceutical Care in Cancer Patients: Chinese Expert Consensus

Historical texts as a potential resource for plant-based antiviral agents against SARS-CoV-2 – the example of the Receptarium of Burkhard III von Hallwyl from 16th century Switzerland

Targeting lipogenesis promotes the synergistic effect of the selective HDAC6 inhibitor ITF3756 with bortezomib in colon cancer cells

Clinical relevance of PLK1 in epithelial ovarian cancer

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review

Editorial: Cell death in kidney diseases: novel biomarkers, mechanisms, and therapeutic strategies

Medication adherence in the elderly population with chronic diseases: a factor analysis