Frontiers in Pharmacology

Original Research

Published on 09 Dec 2025

Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study

in Cardiovascular and Smooth Muscle Pharmacology

Juan Yu
Zufeng Zhang
Qingru Yuan
Haobing Hu
Huimin Li
Meifang Huang
Youlin Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714318

1,505 views

Systematic Review

Published on 09 Dec 2025

Is tranexamic acid effective for all traumatic brain injury patients? a severity based systematic review and meta-analysis

in Neuropharmacology

Wentao Bian
Mengxia Qi
Lu Ding
Yixuan Lu
Kangling Yan
Ziqi Wang
Jiancheng Zhang
Ping Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677936

1,326 views

Original Research

Published on 09 Dec 2025

Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans

in Predictive Toxicology

Mengyuan Zhang
Xin Zhao
Hua Bai
Qi Wang
Wei Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657527

1,262 views

Conceptual Analysis

Published on 09 Dec 2025

The night is dark and full of hesitation. The latest step in the legal trajectory of assisted suicide in Italy: through tentative judicial openings, bioethical contradictions and the Parliament’s deafness

in Drugs Outcomes Research and Policies

Paola Frati
Marco Albore
Eleonora Micaela Ertola
Sossio Del Prete
Letizia Sorace
Raffaele La Russa
Giorgio Bolino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520136

778 views

Original Research

Published on 09 Dec 2025

Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide

in Gastrointestinal and Hepatic Pharmacology

Rasha A. Tawfiq
Yasmeen M. Attia
Hameis M. Sleem
Mai El-Sayed Ghoneim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610718

1,528 views

Editorial

Published on 09 Dec 2025

Editorial: Efficacy and mechanism of herbal medicines and their functional compounds in preventing and treating cardiovascular diseases and cardiovascular disease risk factors-Volume II

in Ethnopharmacology

Tiantian Meng
Yuqing Zhang
Jie Wang
Chen Huei Leo
Zhongfeng Li
Jian Zhang
Kuo Gao
Qingyong He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1742260

848 views

Original Research

Published on 09 Dec 2025

Ethnobotany, chemical analysis, and antiglycation activity of Elsholtzia species from Northern Thailand

in Ethnopharmacology

Angkhana Inta
Pitchaya Mungkornasawakul
Lalida Shank
Wittaya Pongamornkul
Yinxian Shi
Yao Fu
Ruyu Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673250

1,169 views

Original Research

Published on 09 Dec 2025

Cryptotanshinone targets tumor-immune-microbiome axis to suppress colorectal cancer

in Ethnopharmacology

Zhenya Yang
Mengting Zhou
Fenglin Luo
Shiqi Feng
Yu Tan
Qiqian Wang
Zeneng Cheng
Ruirong Tan
Rui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667500

1,441 views

Review

Published on 08 Dec 2025

Cost-effectiveness analysis of commercial Chinese polyherbal preparations for primary insomnia: based on network meta-analysis

in Ethnopharmacology

Sihong Yang
Fanya Yu
Xinghua Xiang
Chuchuan Wan
Yumeng Tan
Ning Ma
Yajing Li
Long Ge
Xing Liao
Hui Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682173

1,094 views

Original Research

Published on 08 Dec 2025

Selective cytotoxicity of Gomortega keule essential oil through a ROS-mediated pro-apoptotic mechanism

in Ethnopharmacology

Alejandro Madrid
Valentina Silva
Alessandra Russo
Alejandra Catalina Moller
Elizabeth Sánchez
Joan Villena
Carlos Jara-Gutiérrez
Iván Montenegro

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722619

795 views
1 citation

Correction

Published on 08 Dec 2025

Correction: DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway

in Translational Pharmacology

Zhijun Yu
Aihua Jiang
Kai Yang
Lin Zhan
Zifei Xiang
Li Chen
Zheng Kuai
Qiong Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1756716

1,012 views

Original Research

Published on 08 Dec 2025

Pterostilbene mitigates the senescence of human dermal fibroblast cells by enhancing mitochondrial quality

in Translational Pharmacology

Xinyu Zhou
Ning Wang
Jihua Wei
Guizhi Li
Zhengwei Lue
Chang Liu
Qi Bao
Zhe Feng
Minjie Zhang
Hu Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732154

2,020 views

Systematic Review

Published on 08 Dec 2025

Therapeutic efficacy and safety of Xuebijing in traumatic brain injury: systematic review and meta-analysis

in Ethnopharmacology

Yihan Sun
Jiaqi Li
Xinyue Cui
Meiyu Yu
Boying Xiao
Junyuan Lv
Ziqi Li
Zhijing Wei
Niaoyao He
Zhuoyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669352

934 views

Original Research

Published on 08 Dec 2025

Validation of diagnostic screening test for pharmacogenomic targets for thiopurine drugs in indian pediatric acute lymphoblastic leukemia patients

in Obstetric and Pediatric Pharmacology

Gratial Theres Joseph
Sandeep Kumar Swain
Tejas Somwanshi
Aarishi Singh
Manpreet Kaur
Raj Kamal
Himanshu Dhanda
Prashant Kumar
Upasana Kaushik
Baseer Noor

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714797

1,433 views

Original Research

Published on 08 Dec 2025

Effects of methylphenidate on children with attention deficit hyperactivity disorder: a study using clinical and multimodal approaches including go/no-go task and functional near-infrared spectroscopy

in Obstetric and Pediatric Pharmacology

Fang Shen
Hui Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726716

1,599 views

Correction

Published on 08 Dec 2025

Correction: Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement

in Neuropharmacology

Abdulrahman M. Khojah
Hussain Al Dera

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1751557

643 views

Original Research

Published on 08 Dec 2025

Moxibustion combined with chemotherapy inhibits gastric cancer growth by modulating the immunosuppressive microenvironment involving the Treg/IL-10/TGF-β1 axis

in Pharmacology of Anti-Cancer Drugs

Yong Wu
Li Ma
Mengying Mao
Yuling Leng
Xianyang Zhou
Heng Xu
Yanqi Ding
Wanrong Hao
Wanhui Dong
Yonglei Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688182

1,353 views

Original Research

Published on 08 Dec 2025

Nobiletin mitigates benign prostatic hyperplasia by suppressing prostate cell proliferation through regulation of cell cycle progression, signaling pathways, transcription factor activity, and the androgen-signaling axis

in Pharmacology of Anti-Cancer Drugs

Jun-Hui Song
Daeun Lee
Byungdoo Hwang
Seon-Kyung Hwang
Sumin Choo
Hyeon Ji Jeong
Hoon Kim
Byungyoon Cha
Seok-Joong Yun
Yung Hyun Choi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661201

1,726 views

Correction

Published on 05 Dec 2025

Correction: Transdermal administration of herbal essential oil alleviates high-fat diet-induced obesity by regulating metabolism and gut microbiota

in Experimental Pharmacology and Drug Discovery

Zu-Wen Ye
Qi-Yue Yang
Dong-Hua Yang
Qiao-Hong Lin
Xiao-Xia Liu
Feng-Qin Li
Fang-Fang Yan
Ping Luo
Si Qin
Fang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743063

599 views

Review

Published on 05 Dec 2025

Navigating hepatotoxicity of antibody-drug conjugates: from mechanistic insights to clinical and postmarketing evidence

in Pharmacology of Anti-Cancer Drugs

Yinuo Dong
Yang Zhi
Xiaoyun Li
Mingyang Ma
Minyan Ye
Sha Huang
Jieting Tang
Wei Zhong
Xiaohong Lei
Yimin Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694436

2,130 views

Original Research

Published on 05 Dec 2025

Impact of lymphocyte transformation test on the diagnostic accuracy of the culprit drug in drug-induced cytopenias: a case-control study

in Drugs Outcomes Research and Policies

Susana Martín-López
Olga Rogozina
Daniela Aguilar-Concepción
Miguel Álvarez-Montero
Ramón Pardo-Puras
Ibtissam Akatbach-Bousaid
María Jiménez-González
Ana Martínez Feito
Miguel González-Muñoz
Elena Ramírez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601450

2,046 views

Original Research

Published on 05 Dec 2025

Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status

in Drug Metabolism and Transport

Lan Gao
Neil Smith
Ronald Kong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701617

1,206 views

Original Research

Published on 05 Dec 2025

Comparative study of the registration procedure of locally manufactured herbal products in selected African countries

in Ethnopharmacology

Aisha Gambo
Nceba Gqaleni
Limakatso Lebina
Lehlohonolo J. Mathibe

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695809

1,104 views
1 citation

Original Research

Published on 05 Dec 2025

Machine learning-based prediction model for teicoplanin plasma concentrations in adults with liver disease using real-world data

in Drug Metabolism and Transport

Fengbi Jian
Xiaodong Chen
Ming Wang
Zhihao Guo
Xuechun Li
Haobin Jian
Ronghong Ji
Liying Liang
Ze Yu
Yanfang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703976

997 views

29,485 articles

articles

Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study

Is tranexamic acid effective for all traumatic brain injury patients? a severity based systematic review and meta-analysis

Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans

The night is dark and full of hesitation. The latest step in the legal trajectory of assisted suicide in Italy: through tentative judicial openings, bioethical contradictions and the Parliament’s deafness

Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide

Editorial: Efficacy and mechanism of herbal medicines and their functional compounds in preventing and treating cardiovascular diseases and cardiovascular disease risk factors-Volume II

Ethnobotany, chemical analysis, and antiglycation activity of Elsholtzia species from Northern Thailand

Cryptotanshinone targets tumor-immune-microbiome axis to suppress colorectal cancer

Cost-effectiveness analysis of commercial Chinese polyherbal preparations for primary insomnia: based on network meta-analysis

Selective cytotoxicity of Gomortega keule essential oil through a ROS-mediated pro-apoptotic mechanism

Correction: DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway

Pterostilbene mitigates the senescence of human dermal fibroblast cells by enhancing mitochondrial quality

Therapeutic efficacy and safety of Xuebijing in traumatic brain injury: systematic review and meta-analysis

Validation of diagnostic screening test for pharmacogenomic targets for thiopurine drugs in indian pediatric acute lymphoblastic leukemia patients

Effects of methylphenidate on children with attention deficit hyperactivity disorder: a study using clinical and multimodal approaches including go/no-go task and functional near-infrared spectroscopy

Correction: Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement

Moxibustion combined with chemotherapy inhibits gastric cancer growth by modulating the immunosuppressive microenvironment involving the Treg/IL-10/TGF-β1 axis

Nobiletin mitigates benign prostatic hyperplasia by suppressing prostate cell proliferation through regulation of cell cycle progression, signaling pathways, transcription factor activity, and the androgen-signaling axis

Correction: Transdermal administration of herbal essential oil alleviates high-fat diet-induced obesity by regulating metabolism and gut microbiota

Navigating hepatotoxicity of antibody-drug conjugates: from mechanistic insights to clinical and postmarketing evidence

Impact of lymphocyte transformation test on the diagnostic accuracy of the culprit drug in drug-induced cytopenias: a case-control study

Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status

Comparative study of the registration procedure of locally manufactured herbal products in selected African countries

Machine learning-based prediction model for teicoplanin plasma concentrations in adults with liver disease using real-world data