Frontiers in Pharmacology

Brief Research Report

Published on 05 Dec 2025

CCR2 improves tumor directed CAR-T cell trafficking in ovarian cancer

in Pharmacology of Anti-Cancer Drugs

Raj Kumar
Irva E. Veillard
Mengyao Xu
Linah Al-Alem
Bo R. Rueda
Oladapo O. Yeku

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651526

1,411 views
1 citation

Systematic Review

Published on 04 Dec 2025

Effectiveness and safety of tocilizumab in refractory noninfectious uveitis: a systematic review and meta-analysis

in Inflammation Pharmacology

Huanmin Kang
Xue Wu
Hanyue Xu
Yufan Huang
Ming Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694311

1,484 views

Original Research

Published on 04 Dec 2025

Rhein ameliorates inflammation, gut dysbiosis, and renal injury in obesity-related glomerulopathy mice

in Ethnopharmacology

Minmin Xu
Yue Yu
Lijie Li
Kang Zhao
Jingjing Lai
Lifang Wei
Li Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654062

927 views

Mini Review

Published on 04 Dec 2025

Effect of plant-derived exosome-like nanoparticles in ultraviolet-induced skin photoaging

in Experimental Pharmacology and Drug Discovery

Hai Dong
Yi Deng
Jiayan Li
Wen Lin
Yangyan Luo
Yuan Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721879

1,341 views

Review

Published on 04 Dec 2025

Endothelium glutamate receptors in brain pathology

in Pharmacology of Ion Channels and Channelopathies

Sergey V. Pirozhkov
Marina N. Vukolova
Varvara V. Bulgakova
Yulia A. Lutokhina
Sergey B. Bolevich
Alexander I. Sobolevsky
Maria V. Yelshanskaya

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709274

2,222 views

Review

Published on 04 Dec 2025

Botany, traditional uses, phytochemistry, pharmacology, toxicology and processing of Rhizoma alismatis: a review

in Ethnopharmacology

Tianhan Pan
Ruonan Tang
Jiawen Wang
Jia Gao
Fusheng Jiang
Buyang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722483

1,489 views

Case Report

Published on 04 Dec 2025

Case Report: Exercise-associated changes of leukocyte gene expression in statin-associated myopathy

in Cardiovascular and Smooth Muscle Pharmacology

Galyna Bondar
Abhinandan Das Mahapatra
Irina Silacheva
Tra-Mi Bao
Thomas Vu
Stephanie Su
Adrian Hairapetian
Ananya Katappagari
Liana Galan
Joshua Chandran

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695543

3,193 views

Original Research

Published on 04 Dec 2025

Physiologically-based pharmacokinetic modeling and simulation for initial dose optimization of levetiracetam in pediatrics

in Obstetric and Pediatric Pharmacology

Julia Macente
Rodolfo Hernandes Bonan
Edilainy Rizzieri Caleffi-Marchesini
Leonardo Régis Leira Pereira
Priscila De Freitas Lima
Pieter Annaert
Karel Allegaert
Andrea Diniz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678960

1,297 views

Review

Published on 04 Dec 2025

Application of neural stem cells in the treatment of intracerebral hemorrhage: a systematic review

in Neuropharmacology

Ping Song
Zohaib Shafiq
Hongxiang Jiang
Qiang Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660614

1,417 views

Original Research

Published on 04 Dec 2025

A food-medicine homology formulation ameliorates atherosclerosis by attenuating dyslipidemia and inflammation via the PI3K/Akt/NF-κB pathway

in Experimental Pharmacology and Drug Discovery

Yadong Zheng
Kaili Chen
Shuo Zhang
Junsong Jing
Zhihao Zhou
Junfeng Lu
Christian Holscher
Wenlong Chen
Liguo Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710585

2,162 views

Systematic Review

Published on 04 Dec 2025

Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials

in Drugs Outcomes Research and Policies

Renshu Zhang
Rui Wang
Yun Li
Wenqi Tian
Dandan Niu
Wencong Cheng
Xiaofang Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708316

1,207 views

Original Research

Published on 04 Dec 2025

Xiaoyao Pill alleviates ulcerative colitis by inhibiting ferroptosis of enterocytes via activating Nrf2/Gpx4 signaling pathway

in Ethnopharmacology

Zehua Zhou
Xueting Xing
Ruomei Zhang
Xiaoqing Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702452

1,547 views

Mini Review

Published on 04 Dec 2025

CX3CR1: a potential microglia-specific PET imaging target in Alzheimer’s and Parkinson’s diseases

in Inflammation Pharmacology

Hongzhi Yang
Yanli Wang
Yulong Xu
Changning Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678159

1,645 views

Review

Published on 04 Dec 2025

The PI3K/AKT/mTOR pathway in scar remodeling and keloid formation: mechanisms and therapeutic perspectives

in Integrative and Regenerative Pharmacology

Jing Liu
Junfei Yan
Shengbin Qi
Jie Zhang
Xin Zhang
Yaping Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678953

2,172 views

Editorial

Published on 04 Dec 2025

Editorial: The multiple applications of marine-derived bioactives

in Ethnopharmacology

Patricia Rijo
Deniz Tasdemir
Ana Rotter

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1733987

807 views

Hypothesis and Theory

Published on 04 Dec 2025

Ibogaine’s potential role in supporting reward system recovery across diagnostic boundaries

in Neuropharmacology

Mark Nicolas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1744383

2,640 views

Mini Review

Published on 04 Dec 2025

Recent advances in gut microbiota-based nanotherapies for cancer treatment

in Pharmacology of Anti-Cancer Drugs

Yuan Xu
Menglu Zhu
Yongchang Zhao
Enjia Chai
Miaolian Wu
Mengmeng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617942

934 views

Original Research

Published on 03 Dec 2025

T817MA attenuates oxidative stress and ER stress via the HSP70–HSP90 pathway after brain ischemia in vitro and in vivo

in Neuropharmacology

Tao Wang
Ya-Juan Pan
Mei-Mei Zhang
Xuan Wang
Wei Li
Jian-Meng Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701967

1,027 views

Correction

Published on 03 Dec 2025

Correction: The role of panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

in Neuropharmacology

Bin Wang
Xu Gao
Yali Zhang
Yuhua Xiao
Tong Chen
Zhouying Shi
Yue Yuan
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1750932

741 views

Original Research

Published on 03 Dec 2025

Eriodictyol alleviates ovarian dysfunction in a mouse model of premature ovarian failure via the PI3K/Akt/NF-κB pathway and suppression of macrophage inflammation

in Ethnopharmacology

Miao Qu
Lusheng Liu
Jianwei Wang
Fangyu Sui
Miao Zhang
Xinyu Wu
Shixin Luo
Min Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710805

1,112 views

Clinical Trial

Published on 03 Dec 2025

Ningmitai capsule in patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, prospective, randomized, parallel, positive-controlled study

in Ethnopharmacology

Jingjing Gao
Yao Zhang
Junhua Du
Qiang Liu
Yi Cheng
Wentao Yang
Daoyuan Wang
Wei Wang
Liang Zheng
Dong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667819

1,659 views

Original Research

Published on 03 Dec 2025

An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target

in Experimental Pharmacology and Drug Discovery

Kate Gunther
Dongli Liu
Gill Stannard
Melissa Holmes
Christine Loo
Belinda Guo
Nikola Bowden
Jason Abbott
Caroline E. Ford

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1716062

1,800 views

Correction

Published on 03 Dec 2025

Correction: The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research

in Respiratory Pharmacology

Mingjun Wu
Qian Yang
Youcheng Xie
Yan Hou
Qingliang Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1751855

522 views

Original Research

Published on 03 Dec 2025

Essential amino acids preserve intestinal barrier integrity via mitochondrial protection in obesity and gut inflammation

in Translational Pharmacology

Letizia Spataro
Maurizio Ragni
Agnese Segala
Alice Vetturi
Giulia Sofia Marcotto
Luca Canciani
Michele O. Carruba
Roberto Aquilani
Ginetta Collo
Alessandra Valerio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694723

2,252 views