Frontiers in Pharmacology

Review

Published on 03 Dec 2025

Preparation and biomedical application of light-responsive hydrogels based on natural products

in Experimental Pharmacology and Drug Discovery

Xinyi Fan
Haihua Shang
Leyuan Ji
Shitang Ma
Maoliang Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714907

1,043 views

Original Research

Published on 03 Dec 2025

Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway

in Cardiovascular and Smooth Muscle Pharmacology

Chenchao Zou
Huaihan Xu
Fajia Hu
Yuxian Yu
Lanxiang Liu
Xiuqi Wang
Zheyu Zhang
Huaxi Zou
Jichun Liu
Huang Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661144

1,538 views

Original Research

Published on 03 Dec 2025

Novel drug candidates targeting Toxoplasma gondii in maternal–fetal interface models

in Experimental Pharmacology and Drug Discovery

Rafael Martins de Oliveira
Natália Carine Lima dos Santos
Marcos Paulo Oliveira Almeida
Joed Pires De Lima Júnior
Guilherme De Souza
Matheus Carvalho Barbosa
Guilherme Vieira Faria
Marina Paschoalino
Rosiane Nascimento Alves
Angelica Oliveira Gomes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673462

1,551 views

Original Research

Published on 03 Dec 2025

Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis

in Translational Pharmacology

Shengfa Li
Peili Liang
Jian Chen
Youming Zhang
Haixiong Miao
Ting Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616070

1,140 views

Original Research

Published on 03 Dec 2025

The clinical value of PLR, NLR, and MLR in predicting mortality risk in hospitalized patients

in Inflammation Pharmacology

Guoxiang Fang
Yunfei Mo
Yangwen Bao
Chunbiao Gao
Qiuya Pan
Tongbo Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736947

1,135 views

Review

Published on 03 Dec 2025

Dapansutrile in multidisciplinary therapeutic applications: mechanisms and clinical perspectives

in Inflammation Pharmacology

Fuwei Bai
Dongyang Wang
Yingying Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1731165

1,840 views

Editorial

Published on 03 Dec 2025

Editorial: Exploring the role of exosomes in cancer metastasis

in Pharmacology of Anti-Cancer Drugs

Anil Kumar Kalvala
Venkatesh Pooladanda
Nagavendra Kommineni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721903

1,071 views

Original Research

Published on 03 Dec 2025

Darolutamide-based triple therapy combined with PSMA imaging guided focal treatment in patients with prostate cancer: a multicenter retrospective study

in Pharmacology of Anti-Cancer Drugs

Dewen Zhong
Ruochen Zhang
Jinling Wu
Zhixun Guo
Yu Zhang
Qinfei Zhou
Zijun Zou
Deng Lin
Zhonglei Lu
Jiawen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692407

1,094 views

Review

Published on 03 Dec 2025

Advances in ginsenoside treatment for common kidney diseases: pharmacological evaluation and potential mechanisms

in Renal Pharmacology

Tonghui Jin
Yu Du
Chaoyue Liu
Jingming Zhao
Tiejun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702234

2,025 views
1 citation

Original Research

Published on 03 Dec 2025

The therapeutic efficacy of radical resection for hepatocellular carcinoma varies markedly by tumor location: a retrospective real-world study

in Gastrointestinal and Hepatic Pharmacology

Xu Feng
Yi-Qiu Wei
Jia-Rui Liu
Zheng-Rong Shi
Kai Chen
Yong-Shuang Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674998

949 views

Original Research

Published on 03 Dec 2025

Farrerol inhibits proliferation and migration of colorectal cancer via the VEGF signaling pathway: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments

in Pharmacology of Anti-Cancer Drugs

Longhui Zhang
Qijing Xu
Guanduo Sun
Xiaokang Zhang
Jialong Xue
Chun Yao
Dechun Liu
Jingming Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1717293

1,391 views

Review

Published on 03 Dec 2025

Treatment strategies for motor fluctuations in Parkinson’s disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America

in Experimental Pharmacology and Drug Discovery

Oscar Arias-Carrión
Emmanuel Ortega-Robles

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725248

2,377 views
1 citation

Review

Published on 03 Dec 2025

Preclinical research of dihydromyricetin for fibrotic diseases

in Ethnopharmacology

Xiao-Chun Wang
Ping Mai
Zuo-Hui Yuan
Zhi-Sheng Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691796

890 views

Review

Published on 03 Dec 2025

Multitarget antitumor effects of panacis japonici rhizoma

in Ethnopharmacology

Xixing Fang
Xiao Yang
Changyuan Zhou
Di Zeng
Zehua Hu
Xing Tu
Bao Yang
Yuanxin Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591638

1,016 views

Case Report

Published on 03 Dec 2025

Case Report: Photodynamic therapy meets Chinese herbal medicine: a promising approach for advanced hypopharyngeal carcinoma

in Pharmacology of Anti-Cancer Drugs

Mingsheng Lyu
Huayang Wu
Weixia Yu
Hang Zou
Chengjun Ban
Lu Wang
Hongwu Wang
Linyang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602910

739 views

Review

Published on 03 Dec 2025

Cryptocarya alba (Peumo): an endemic Chilean tree with phytochemicals with bioactive potential

in Ethnopharmacology

Gonzalo Fuentes-Barros
Sebastián Castro-Saavedra
Nicolás Montalva
Marco Mellado
Antonia Diaz-Valdés
Claudia Guerrero-Rodríguez
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665897

1,658 views

Opinion

Published on 02 Dec 2025

CCR5-targeted γδ CAR-T cells: a rational step toward HIV-resistant allogeneic immunotherapy

in Inflammation Pharmacology

Lina Hu
Haiyan Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734423

1,066 views

Original Research

Published on 02 Dec 2025

Navigating barriers to real-world evidence utilization for drug regulatory affairs and market access in Saudi Arabia

in Drugs Outcomes Research and Policies

Hatouf H. Sukkarieh
Nourah Al Fayez
Hussain Abdulrahman Al-Omar
Nura O. Azmi
Bushra Syed
Raed A. Albar
Nawaf Al Bali

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712147

1,416 views

Original Research

Published on 02 Dec 2025

Branched tetrameric lactoferricin peptides modified with diaminopropionic acid exhibit potent antimicrobial and wound-healing activities

in Pharmacology of Infectious Diseases

Nikitha Vavilthota
Gizem Babuççu
Robert A. Cordfunke
Leonie de Boer
Payal Balraadjsing
Bouke K. H. L. Boekema
Jan W. Drijfhout
Martijn Riool
Sebastian A. J. Zaat

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719557

1,452 views

Review

Published on 02 Dec 2025

The role of natural products and traditional Chinese medicine formulas in postpartum depression: mechanism and prospects

in Ethnopharmacology

Ruirui Shang
Yitong Lu
Haonan Gao
Xia Zhong
Xiaowen Yu
Guoqiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686499

1,196 views

Methods

Published on 02 Dec 2025

StarTRAC-CYP2D6: a method for CYP2D6 allele-specific copy number determination using digital PCR

in Pharmacogenetics and Pharmacogenomics

Wendy Y. Wang
Erin C. Boone
Lancy Lin
David Joun
Andrea Gaedigk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715830

1,556 views

Original Research

Published on 02 Dec 2025

TCMRGAT: Relational graph attention networks for predicting stroke treatment efficacy of traditional Chinese medicine prescriptions

in Ethnopharmacology

Ning Cheng
Changsong Ding
Xuekun Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570094

1,031 views

Review

Published on 02 Dec 2025

Modulation of STAT6 signaling for hepatoprotection

in Gastrointestinal and Hepatic Pharmacology

Emmanuel Somm
Mahdi Rahman
Ildiko Szanto
Karim Gariani
François R. Jornayvaz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659227

1,729 views
1 citation

Original Research

Published on 02 Dec 2025

Airway microbial and metabolic features associated with ICS therapy in COPD

in Drug Metabolism and Transport

Lijun Chen
Mei Yang
Qixin Wang
Yan Tang
Hongxia Yu
Xianhui Luo
Xiaochao Du
Haizong Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714879

960 views
1 citation

29,485 articles

articles

Preparation and biomedical application of light-responsive hydrogels based on natural products

Gallic acid attenuates diabetic cardiomyopathy by inhibiting ferroptosis and protecting mitochondria via the TSPO/FTMT pathway

Novel drug candidates targeting Toxoplasma gondii in maternal–fetal interface models

Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosis

The clinical value of PLR, NLR, and MLR in predicting mortality risk in hospitalized patients

Dapansutrile in multidisciplinary therapeutic applications: mechanisms and clinical perspectives

Editorial: Exploring the role of exosomes in cancer metastasis

Darolutamide-based triple therapy combined with PSMA imaging guided focal treatment in patients with prostate cancer: a multicenter retrospective study

Advances in ginsenoside treatment for common kidney diseases: pharmacological evaluation and potential mechanisms

The therapeutic efficacy of radical resection for hepatocellular carcinoma varies markedly by tumor location: a retrospective real-world study

Farrerol inhibits proliferation and migration of colorectal cancer via the VEGF signaling pathway: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments

Treatment strategies for motor fluctuations in Parkinson’s disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America

Preclinical research of dihydromyricetin for fibrotic diseases

Multitarget antitumor effects of panacis japonici rhizoma

Case Report: Photodynamic therapy meets Chinese herbal medicine: a promising approach for advanced hypopharyngeal carcinoma

Cryptocarya alba (Peumo): an endemic Chilean tree with phytochemicals with bioactive potential

CCR5-targeted γδ CAR-T cells: a rational step toward HIV-resistant allogeneic immunotherapy

Navigating barriers to real-world evidence utilization for drug regulatory affairs and market access in Saudi Arabia

Branched tetrameric lactoferricin peptides modified with diaminopropionic acid exhibit potent antimicrobial and wound-healing activities

The role of natural products and traditional Chinese medicine formulas in postpartum depression: mechanism and prospects

StarTRAC-CYP2D6: a method for CYP2D6 allele-specific copy number determination using digital PCR

TCMRGAT: Relational graph attention networks for predicting stroke treatment efficacy of traditional Chinese medicine prescriptions

Modulation of STAT6 signaling for hepatoprotection

Airway microbial and metabolic features associated with ICS therapy in COPD