Frontiers in Pharmacology

Technology and Code

Published on 01 Dec 2025

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data

in Predictive Toxicology

Austin Ross
Vijay Gombar
Alexander Sedykh
Adrian J. Green
Alexandre Borrel
Brian Kidd
Jason Phillips
Mihir Shah
Dhiral Phadke
Deepak Mav

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710864

1,268 views

Original Research

Published on 01 Dec 2025

Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors

in Neuropharmacology

Katerina Janisova
Monika Uhlirova
Sandor Forczek
Jaromir Myslivecek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691118

853 views
1 citation

Systematic Review

Published on 01 Dec 2025

The efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis of randomized controlled trials

in Pharmacology of Anti-Cancer Drugs

Yingyu Lai
Qianni Pan
Shiyu Wang
Qingmao Luo
Zhencong Huang
Mingzhong Wei
Zhouqian Jiang
Wenyan Yi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683857

1,625 views

Original Research

Published on 01 Dec 2025

Clinical application of combined anticoagulation therapy in anti-MDA5 antibody-positive associated interstitial lung disease-a retrospective study

in Respiratory Pharmacology

Ting Zhang
Yuanyuan Song
Hua Ma
Lina Cao
Li Lu
Hai Tang
Dongmei Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662306

1,090 views

Correction

Published on 01 Dec 2025

Correction: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo

in Ethnopharmacology

Hongshan Li
Yingfei Xi
Xin Xin
Qin Feng
Yiyang Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657343

1,144 views

Original Research

Published on 01 Dec 2025

An intelligent framework for dynamic modeling of therapeutic response using clinical compliance data

in Drugs Outcomes Research and Policies

Xinyi Wang
Haoran Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631599

1,443 views

Editorial

Published on 01 Dec 2025

Editorial: Extracellular vesicles in cancer research: a new era for therapeutic interventions

in Pharmacology of Anti-Cancer Drugs

Tejveer Singh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687011

640 views

Systematic Review

Published on 01 Dec 2025

Microplastics in focus: a silent disruptor of liver health- a systematic review

in Gastrointestinal and Hepatic Pharmacology

Zahra Beyzaei
Bita Geramizadeh
Zahra Bagheri
Sara Karimzadeh
Ralf Weiskirchen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721644

2,256 views

Original Research

Published on 01 Dec 2025

Machine learning–based prognostic modeling for locally advanced non-small cell lung cancer treated with immuno-radiotherapy

in Pharmacology of Anti-Cancer Drugs

Simin Lu
Xin Zheng
Yi Wang
Yafei Li
Xuan Yu
Yan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723874

897 views

Original Research

Published on 01 Dec 2025

Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of Fructus Xanthii in treating asthma

in Experimental Pharmacology and Drug Discovery

Yiqun Dong
Zhaosen Fan
Xiaoxiao Li
Yucheng Ming
Dong Wang
Yuanda Song
Youpeng Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722150

1,588 views

Original Research

Published on 01 Dec 2025

Investigating the pathways of medication adherence in renal transplant recipients based on the COM-B model: the parallel mediating effects of beliefs and emotion regulation efficacy

in Drugs Outcomes Research and Policies

Lili Zhou
Ke Cheng
Linbin Chen
San Han
Jingjing Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702618

1,018 views

Systematic Review

Published on 01 Dec 2025

Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials

in Neuropharmacology

Tingyu Jiang
Rui Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708221

1,289 views

Review

Accepted on 30 Nov 2025

Pharmacological potential of Chinese botanical drugs in managing chronic kidney disease by targeting mitochondrial quality control

in Ethnopharmacology

Hongyu Liu
Shumin Huang
Shichun Chen
Shuzhen Liang
Minying Huang
Shiyu Li
Yongxiang Xu
Baocheng Xie

Frontiers in Pharmacology

245 views

Original Research

Published on 28 Nov 2025

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

in Neuropharmacology

Mark K. Greenwald
Catherine Demery
Tabitha E. H. Moses
Margit Burmeister

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714546

1,077 views

Original Research

Published on 28 Nov 2025

Effect of liraglutide on the dysglycemia, inflammation, and gut microbiota in prediabetic KKay mice

in Experimental Pharmacology and Drug Discovery

Ying Zhang
Xiaoxiao Yang
Ping Yang
Huihuan Sun
Lijuan Chen
Xiaojun Zhang
Shudong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714859

1,171 views
1 citation

Original Research

Published on 28 Nov 2025

Efficacy of sulfonamides targeting malic enzyme in an animal model of Chagas disease

in Experimental Pharmacology and Drug Discovery

Thaís Cristina Ferreira dos Santos
Ramon Borges da Silva
Irene Layane de Sousa
Fabrício Fredo Naciuk
Letícia Marchese
Amanda Gonçalves Eufrásio
Angel Eduardo Lobo-Rojas
Renan Marcel Giampauli
Valéria Barbosa de Souza
André Almeida Schenka

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709223

1,160 views

Systematic Review

Published on 28 Nov 2025

Efficacy and safety of the commercial Chinese polyherbal preparation Liu Shen Wan as an adjunctive treatment for herpes zoster and postherpetic neuralgia: a systematic review and meta-analysis

in Ethnopharmacology

Yajing Li
Le Zhang
Wenya Wang
Hui Zhao
Xing Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698753

1,336 views

Original Research

Published on 28 Nov 2025

Omega 3 fatty acid docosahexaenoic acid (DHA) mitigates inflammatory responses in experimental sepsis

in Inflammation Pharmacology

Bianca Portugal Tavares de Moraes
Isabelle Moraes-de-Souza
Gabrielle Lacerda de Souza Gomes-Reis
Marina Ferreira-Costa
Carolina Medina Coeli da Cunha
Matheus Augusto Patrício de Almeida
Vanessa Estato
Kauê Francisco Corrêa Souza e Souza
Francisco da Silva dos Santos
Maria Alice dos Santos Mascarenhas Brito

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708348

1,807 views

Original Research

Published on 28 Nov 2025

Cost-effectiveness analysis of eight first-line treatments for metastatic hormone-sensitive prostate cancer in China

in Drugs Outcomes Research and Policies

Zhou Han
Youli Xi
Jian Hu
Ye Wang
Huanyu Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684966

1,833 views

Original Research

Published on 28 Nov 2025

Electrostatically driven fluorescent sensor for rapid detection of AChE activity and organophosphate pesticides via dual-enzyme cascade amplification

in Ethnopharmacology

Xiaoyi Liu
Kunhui Sun
Sitong Lai
Guojing Liu
Meifang Li
Ping Wang
Shuhong Wang
Lan Ma
Xie-An Yu
Wei Lei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679948

790 views

Original Research

Published on 28 Nov 2025

Association between ranolazine therapy and cognitive decline in elderly patients with ischemic heart disease

in Cardiovascular and Smooth Muscle Pharmacology

Giandomenico Severini
Giuseppe Armentaro
Velia Cassano
Valentino Condoleo
Carlo Alberto Pastura
Alberto Panza
Carlo Fuoco
Sofia Miceli
Vanessa Teresa Fiorentino
Maria Perticone

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664988

1,092 views

Review

Published on 28 Nov 2025

Part 1 - imidazolines and the changing face of nasal decongestants

in Translational Pharmacology

Rebecca J. Stinson
Laura R. Sadofsky

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655252

1,871 views

Original Research

Published on 28 Nov 2025

Real-world pharmacovigilance insights into drug-induced risk of alopecia

in Pharmacoepidemiology

Huixiang Li
Haijian Wei
Qiaoqiao Shentu
Jianxin Cui
Jiaojiao Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703423

1,702 views

Original Research

Published on 28 Nov 2025

Preclinical evaluation of uPAR-ICG-FVIOs for dual-mode imaging and magnetic hyperthermia therapy in pancreatic cancer

in Translational Pharmacology

Tao Luo
Kelan Zhang
Chong Wu
Xiaolong Wu
Haojie Yang
Zhigang Chen
Fen Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681718

1,624 views

29,498 articles

articles

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data

Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors

The efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis of randomized controlled trials

Clinical application of combined anticoagulation therapy in anti-MDA5 antibody-positive associated interstitial lung disease-a retrospective study

Correction: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo

An intelligent framework for dynamic modeling of therapeutic response using clinical compliance data

Editorial: Extracellular vesicles in cancer research: a new era for therapeutic interventions

Microplastics in focus: a silent disruptor of liver health- a systematic review

Machine learning–based prognostic modeling for locally advanced non-small cell lung cancer treated with immuno-radiotherapy

Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of Fructus Xanthii in treating asthma

Investigating the pathways of medication adherence in renal transplant recipients based on the COM-B model: the parallel mediating effects of beliefs and emotion regulation efficacy

Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials

Pharmacological potential of Chinese botanical drugs in managing chronic kidney disease by targeting mitochondrial quality control

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

Effect of liraglutide on the dysglycemia, inflammation, and gut microbiota in prediabetic KKay mice

Efficacy of sulfonamides targeting malic enzyme in an animal model of Chagas disease

Efficacy and safety of the commercial Chinese polyherbal preparation Liu Shen Wan as an adjunctive treatment for herpes zoster and postherpetic neuralgia: a systematic review and meta-analysis

Omega 3 fatty acid docosahexaenoic acid (DHA) mitigates inflammatory responses in experimental sepsis

Cost-effectiveness analysis of eight first-line treatments for metastatic hormone-sensitive prostate cancer in China

Electrostatically driven fluorescent sensor for rapid detection of AChE activity and organophosphate pesticides via dual-enzyme cascade amplification

Association between ranolazine therapy and cognitive decline in elderly patients with ischemic heart disease

Part 1 - imidazolines and the changing face of nasal decongestants

Real-world pharmacovigilance insights into drug-induced risk of alopecia

Preclinical evaluation of uPAR-ICG-FVIOs for dual-mode imaging and magnetic hyperthermia therapy in pancreatic cancer