Frontiers in Pharmacology

Original Research

Accepted on 17 Apr 2025

Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs

in Experimental Pharmacology and Drug Discovery

Jinpeng Lv
Duo Meng
Huansha Zhang
Wenhui Xu
Xiaohong An
Chuanwei Yin
Kun Zou
Rongyin Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572878

111 views

Original Research

Accepted on 17 Apr 2025

Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice

in Gastrointestinal and Hepatic Pharmacology

Mi Zhang
Weigang Yuan
Chun Li
Chanyuan Chen
Xiang Liu
Zhilu Ma
Yifei Xiang
Guisha Chen
Chunxu Wang
Lei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574039

105 views

Original Research

Accepted on 17 Apr 2025

Therapeutic Potential of Zinc 64 Zn Aspartate for Obesity Management: Impact on Oxidative Stress, Lipid Metabolism, Pancreas and Liver in High-Calorie Diet Model

in Experimental Pharmacology and Drug Discovery

Max Temnik
Sergey Gurin
Alexandr Balakin
Roman Byshovets
Olesia Kalmukova
Tetiana Vovk
Tetiana Halenova
Nataliia Raksha
Tetyana Falalyeyeva
Olexiy Savchuk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543166

Review

Accepted on 17 Apr 2025

Modulating mitochondria with Natural Extract Compound: from bench to clinical therapeutic opportunities for COPD

in Respiratory Pharmacology

Qiao Wang
Ziling Zeng
Linlin Guo
Kent E. Williams
Yun - Zhang
Hongmei Tang
Hang Hu
Gang Qin
Kaijin Wang
Xing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531302

230 views

Original Research

Accepted on 17 Apr 2025

Renal tubular epithelial cell related partial epithelial-mesenchymal transition in AAⅠ induced renal fibrosis via Wnt7b/β-catenin signaling

in Renal Pharmacology

Yi-fan Wang
Dan Zheng
Ying Zhang
Xiao-fen Li
Ming Xia
Hai- Ming Tang
Chun-Hua Huang
Mao-juan Li
Di-Dong Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571960

Editorial

Accepted on 17 Apr 2025

Diabetic Kidney Disease: Routes to drug development, pharmacology and underlying molecular mechanisms, Volume II

in Renal Pharmacology

Swayam Prakash Srivastava
Divya Bhatia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609100

Original Research

Accepted on 17 Apr 2025

Exploring Indigenous Knowledge and Practices of the Gurage Community on the Biosystematics and Utilization of Enset Landraces for Bone Fracture and Regeneration: The case of Gurage zone, Central Ethiopia Region

in Ethnopharmacology

TEMESGEN NEGASSA DEBELO
Asfaw Meressa
Negera Abdissa
Sileshi Degu Getnet
Getachew Addis
Eyob Debebe Arega
Negessa Abdisa
Samuel Woldekidan
Dereilo Bekere
Sintayehu Ashenef Adane

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563898

Original Research

Accepted on 17 Apr 2025

Nafamostat Mesylate Augments Survival in Rats Afflicted by Exertional Heat Stroke

in Experimental Pharmacology and Drug Discovery

Qingwei Lin
Zhuqing Luo
Longping He
Lincui Zhong
Qingbo Zeng
Ye Zhou
Qi Chen
Xingping Deng
Xiaomin Song
Qing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559181

Original Research

Accepted on 17 Apr 2025

Berberine in the Treatment of Radiation-Induced Skin Injury: Insights from Proteomics and Network Pharmacology

in Experimental Pharmacology and Drug Discovery

Jie Zou
Xia-Juan Xiao
Ping Zhang
Xing-Zi Huang
Jing Wang
Chun-Qin Tao
Xiao-Lan Ou
Gong Chen
Ting-Hao He
Long Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542851

Original Research

Accepted on 17 Apr 2025

Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients

in Respiratory Pharmacology

Lin Fu
Jing Xu
Ming-Feng Han
Kai-Shu Ma
Ting Zhang
Rui-Rui Wang
Jing-Jing Zhang
Hui Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1556185

Original Research

Accepted on 17 Apr 2025

A Multimodal Approach to Establish ACTL6A and ERCC1 as Chemoresistance Genes in Locally Advanced Head and Neck Cancer

in Pharmacology of Anti-Cancer Drugs

Raushan Kumar Chaudhary
PRAKASH PATIL
Vijith Shetty
UDAY VENKAT MATETI
Praveenkumar Shetty

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541987

Original Research

Published on 17 Apr 2025

α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT–FOXO1–CD36 pathway

in Cardiovascular and Smooth Muscle Pharmacology

Xue Bai
Ziqian Zhang
Miao Zhang
Jiaojiao Xu
Keting Dong
Qian Du
Lei Chen
Ping Ma
Jianhong Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566311

290 views

Review

Published on 17 Apr 2025

Advances in plant essential oils and drug delivery systems for skincare

in Ethnopharmacology

Wang Yihan
Dou Jinjin
Wang Yingqi
Mu Guanai
Zhang Xiwu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578280

369 views

Clinical Trial

Published on 17 Apr 2025

The pharmacokinetics and Concentration-QTc analysis of a new etomidate analog ET-26-HCl: a phase I trial in healthy Chinese subjects

in Drug Metabolism and Transport

Kun He
Wenyu Zhang
Xiangran Kong
Lize Li
Lei Diao
Qing Wen
Guohai Su
Xiaoran Yang
Hongyan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534717

228 views

Editorial

Published on 17 Apr 2025

Editorial: Model organisms in predictive toxicology 2023

in Predictive Toxicology

Cristina Luceri
Abdulahad Dogan
Angel León-Buitimea

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609126

215 views

Policy and Practice Reviews

Published on 17 Apr 2025

Different routes the same destination: a comparative study of antitrust regulation for pharmaceutical industry in the United States and China

in Drugs Outcomes Research and Policies

Jie Weng
Nailiang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557876

293 views