Frontiers in Pharmacology

Original Research

Published on 28 Nov 2025

Diacetyl-induced bronchiolitis obliterans involves ubiquitin C upregulation and fibrosis-related gene activation in rats

in Respiratory Pharmacology

Hailian Wang
Wen Jiang
Junchao Xiao
Yan Geng
Qing Ye
Wei Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671557

1,089 views

Original Research

Published on 28 Nov 2025

Different degrees of expression of pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses in male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis)

in Experimental Pharmacology and Drug Discovery

Elena A. Tukhovskaya
Yulia A. Palikova
Maria S. Severyukhina
Alina M. Ismailova
Victor Palikov
Gulsara A. Slashcheva
Natalya A. Borozdina
Evgeniy S. Mikhaylov
Irina N. Kravchenko
Vitaly Kazakov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702991

849 views

Original Research

Published on 28 Nov 2025

A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation

in Experimental Pharmacology and Drug Discovery

Zebanuer Yuemaierjiang
Jingjing Sun
Jiamin Song
Jiaping Huang
Huiyu Zhang
Lili Xi
Jingjing Guo
Xinyi Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687517

916 views

Original Research

Published on 28 Nov 2025

Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation

in Ethnopharmacology

Chaoxi Tian
Aolong Ma
Tianying Song
Fangyu Zhao
Jing Huang
Jianhong Gao
Honglin Yan
Xianbing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671678

1,114 views

Review

Published on 28 Nov 2025

Targeting L-arginine/NO/cGMP/KATP pathway by phytochemicals: therapeutic applications and clinical perspectives

in Cardiovascular and Smooth Muscle Pharmacology

Seyede Zahra Hosseini
Fatemeh Abbaszadeh
Seyede Darya Alavi
Mohammad Mehdi Gravandi
Roshanak Amirian
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708659

1,388 views

Review

Published on 28 Nov 2025

Part II – imidazolines and rhinitis medicamentosa: how can we tackle the rebound dilemma?

in Translational Pharmacology

Rebecca J. Stinson
Laura R. Sadofsky

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655254

2,391 views

Systematic Review

Published on 28 Nov 2025

Systematic review and network meta-analysis of the effects of plant active substance on quality of life in breast cancer patients

in Experimental Pharmacology and Drug Discovery

Lu Wang
Xiaofan Xu
Mengmeng Guo
Yanxu Dong
Helin Ding
Shuai Hao
Liqun Huo
Yuqing Song
Jun Gu
Zhenghong Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622479

1,278 views

Original Research

Published on 27 Nov 2025

Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stromal cells

in Ethnopharmacology

Huijie Lai
Jinjin Jia
Zijun Kuang
Jie Lu
Yuyan Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665911

1,259 views

Original Research

Published on 27 Nov 2025

The complications of cyclosporine a in pediatric use and its effectiveness in treating pediatric congenital heart diseases-a meta analysis in combined with a retrospective clinical study

in Cardiovascular and Smooth Muscle Pharmacology

Yiting Xue
Siqi She
Sijuan Sun
Junxian Chen
Lincai Ye
Yanhui Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1727970

1,403 views

Original Research

Published on 27 Nov 2025

Ofatumumab-mediated CD20+ B-cell depletion promotes neuromuscular junction functional recovery and sustains long-term efficacy in refractory generalized myasthenia gravis

in Integrative and Regenerative Pharmacology

Zhuangzhuang Ren
Yuping Chen
Yudan Liu
Yan Wang
Shengjie Xu
Yanhua Yang
Feng Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1728721

1,539 views

Original Research

Published on 27 Nov 2025

Functional interaction between orexin/dynorphin transmission in the posterior paraventricular nucleus of the thalamus following alcohol dependence: mediation of alcohol-seeking behavior

in Neuropharmacology

Francisco J. Flores-Ramirez
Glenn Pascasio
Rémi Martin-Fardon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718540

1,672 views
1 citation

Systematic Review

Published on 27 Nov 2025

Mesenchymal stem cell–derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yan Pan
Youting Xu
Ting Shui
Jiao Hong
Xuan Lu
Huilin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707784

1,143 views

Opinion

Published on 27 Nov 2025

Breaking barriers: how generic drugs democratize mental health

in Drugs Outcomes Research and Policies

Gilberto Uriel Rosas-Sánchez
Marisol Mercado-Serna
Rafael Fernández-Demeneghi
María Isabel Pérez-Vega
Cesar Soria-Fregozo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1733732

1,265 views

Original Research

Published on 27 Nov 2025

DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway

in Translational Pharmacology

Zhijun Yu
Aihua Jiang
Kai Yang
Lin Zhan
Zifei Xiang
Li Chen
Zheng Kuai
Qiong Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721188

1,126 views

Original Research

Published on 27 Nov 2025

Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes

in Drug Metabolism and Transport

Gajanan R. Jadhav
Pius S. Fasinu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656437

1,054 views

Case Report

Published on 27 Nov 2025

Case Report: A pharmacist-led precision therapy framework for managing invasive fungal infection in CSF1R-Related leukoencephalopathy post Allo-HSCT

in Translational Pharmacology

Jin Lu
Mengqi Jia
Xinghua Luan
Zhongqiu Zhang
Jingying Wu
Xiaojun Huang
Li Yang
Xincai Zhao
Miaomiao Zhou
Yao Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656503

1,260 views

Review

Published on 27 Nov 2025

Silymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications

in Ethnopharmacology

Mahewish Sayyad
Ashish Dilip Sutar
Kamini Shivhare
Rahul Shukla
Swaran J. S. Flora

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1711653

2,525 views

Review

Published on 27 Nov 2025

Evaluation of natural products bioactivity in cardiovascular diseases utilizing zebrafish models: a comprehensive review

in Ethnopharmacology

Yiming Wang
Xiang Meng
Xuting Song
Lulu Wang
Xianghe Meng
Xiaoya Du
Ziyoviddin Yusupov
Komiljon Tojibaev
Yunpeng Wang
Min He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713417

1,151 views

Original Research

Published on 27 Nov 2025

Polyphenol-rich Morus nigra L. extract mitigates neuroinflammation and cognitive impairment through gut–brain axis modulation in an Alzheimer’s disease rat model

in Ethnopharmacology

Yue Li
Yangyi Zhang
Mengwen Liu
Tuerxunayi Dawuti
Xuanshi Chen
Hui Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695768

1,408 views

Systematic Review

Published on 27 Nov 2025

The efficacy and safety of combining different Chinese patent medicines with conventional Western drugs in the treatment of pediatric allergic rhinitis: network meta-analysis

in Obstetric and Pediatric Pharmacology

Yue Ma
Wenrui Huang
Hang Wu
Chunbo Zhang
Zhiyue Xiao
Yuying Gao
Junying Xie
Jingyao Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693357

1,599 views

Original Research

Published on 27 Nov 2025

Gentamicin-loaded exosomes from IMMUNEPOTENT CRP enhance healing of infected diabetic wound in mice

in Integrative and Regenerative Pharmacology

Paola Leonor García Coronado
Brandon Alberto Garza Martínez
Kenia Arisbe Moreno Amador
David Reding Hernández
Diana G. Zárate Triviño
Diana Elia Caballero Hernández
Pablo Zapata Benavides
Gabriel Luna Barcenas
Cristina Rodríguez‐Padilla
Moisés Armides Franco Molina

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682468

1,286 views

Review

Published on 27 Nov 2025

Echocardiographic assessment and new advances of right ventricle function in rats with pulmonary hypertension

in Cardiovascular and Smooth Muscle Pharmacology

Weijie Wang
Ming Ren
Dianxiang Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682105

1,135 views

Mini Review

Published on 27 Nov 2025

The risk of developing more potent fentanyl analogs: a mini review

in Experimental Pharmacology and Drug Discovery

Benjamín Bustamante-Elgueta
Maikol D. Andrade
Cristóbal A. Quintul
Daniel A. Medina
Javier Campanini-Salinas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723733

1,972 views

Original Research

Published on 27 Nov 2025

Effectiveness of treatments to prevent femoral periprosthetic bone loss following total hip arthroplasty: a network meta-analysis

in Pharmacogenetics and Pharmacogenomics

Zhi-Hu Zhao
Tao Ling
Songqing Ye
Wei Luo
Jian-Xiong Ma
Xinlong Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566890

1,432 views
1 citation

29,498 articles

articles

Diacetyl-induced bronchiolitis obliterans involves ubiquitin C upregulation and fibrosis-related gene activation in rats

Different degrees of expression of pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses in male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis)

A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation

Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation

Targeting L-arginine/NO/cGMP/KATP pathway by phytochemicals: therapeutic applications and clinical perspectives

Part II – imidazolines and rhinitis medicamentosa: how can we tackle the rebound dilemma?

Systematic review and network meta-analysis of the effects of plant active substance on quality of life in breast cancer patients

Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stromal cells

The complications of cyclosporine a in pediatric use and its effectiveness in treating pediatric congenital heart diseases-a meta analysis in combined with a retrospective clinical study

Ofatumumab-mediated CD20+ B-cell depletion promotes neuromuscular junction functional recovery and sustains long-term efficacy in refractory generalized myasthenia gravis

Functional interaction between orexin/dynorphin transmission in the posterior paraventricular nucleus of the thalamus following alcohol dependence: mediation of alcohol-seeking behavior

Mesenchymal stem cell–derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis

Breaking barriers: how generic drugs democratize mental health

DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway

Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes

Case Report: A pharmacist-led precision therapy framework for managing invasive fungal infection in CSF1R-Related leukoencephalopathy post Allo-HSCT

Silymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications

Evaluation of natural products bioactivity in cardiovascular diseases utilizing zebrafish models: a comprehensive review

Polyphenol-rich Morus nigra L. extract mitigates neuroinflammation and cognitive impairment through gut–brain axis modulation in an Alzheimer’s disease rat model

The efficacy and safety of combining different Chinese patent medicines with conventional Western drugs in the treatment of pediatric allergic rhinitis: network meta-analysis

Gentamicin-loaded exosomes from IMMUNEPOTENT CRP enhance healing of infected diabetic wound in mice

Echocardiographic assessment and new advances of right ventricle function in rats with pulmonary hypertension

The risk of developing more potent fentanyl analogs: a mini review

Effectiveness of treatments to prevent femoral periprosthetic bone loss following total hip arthroplasty: a network meta-analysis