Frontiers in Pharmacology

Original Research

Published on 26 Nov 2025

Cost-effectiveness analysis of first-line versus second-line use of CDK4/6 inhibitors combined with endocrine therapy in advanced HR+/HER2- breast cancer in China: based on the SONIA trial

in Drugs Outcomes Research and Policies

Xiaohu Jin
Zhifeng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700291

1,074 views

Review

Published on 26 Nov 2025

Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems

in Neuropharmacology

Shengnan Zhang
Peixiang Wang
Bingyuan Ji
Yuming Shao
Sen Hou
Jing Chen
Chunmei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697406

1,871 views
2 citations

Original Research

Published on 26 Nov 2025

Identification of a novel dual-targeting peptide inhibitor of SARS-CoV-2 RBD and NRP1 through structure-based virtual screening

in Experimental Pharmacology and Drug Discovery

Nan Yao
Lixia Guan
Li Feng
Gang Wang
Yuting Wang
Miao-Miao Niu
Mei Yu
Shengnan Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691679

1,041 views

Review

Published on 26 Nov 2025

CXCR4-targeted therapy in lung cancer: plerixafor as a promising antimetastatic agent

in Pharmacology of Anti-Cancer Drugs

Prasanna Srinivasan Ramalingam
Muhammad Afzal
M. Arockia Babu
Manjunath Mirle Rekha
Samir Sahoo
Surya Nath Pandey
Kavita Goyal
Md Sadique Hussain
Gaurav Gupta
Purushothaman Balakrishnan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683585

2,282 views

Clinical Trial

Published on 26 Nov 2025

Efficacy and safety of Centella asiatica (L.) Urb. [Apiaceae] as a dietary supplement for glycemic control and lipid regulation in patients with type 2 diabetes: a randomized controlled trial in Thailand

in Ethnopharmacology

Weeratian Tawanwongsri
Auemphon Mordmuang
Tharin Phenwan
Doungkamol Siri-archawawat

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1680647

1,054 views

Original Research

Published on 26 Nov 2025

Intranasal Galanin (1–15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

in Neuropharmacology

Noelia Cantero-García
Antonio Flores-Burgess
Marta Flores-Gómez
Juan Pedro Pineda-Gómez
Maria C. Ramos
Caridad Diaz
Carmelo Millón
Zaida Díaz-Cabiale

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719440

1,127 views

Original Research

Published on 26 Nov 2025

Behavioral and neurochemical alterations induced by long-term exposure to tobacco heating system emissions in rats

in Predictive Toxicology

Rajeev Sood
Devesh Tewari
Musarrat Husain Warsi
Anoop Kumar
Shweta Kasna
J. P. Jaiswal
Pranay R. Sakya
Sonam Yoezer
Gaurav K. Jain

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705059

1,506 views

Original Research

Published on 26 Nov 2025

Drug combination discovery assisted by AI and untargeted metabolomics: pamiparib and anlotinib synergistic potentiation for ovarian cancer treatment

in Pharmacology of Anti-Cancer Drugs

Dong Wang
Baiwang Chu
Tingjie Wen
Xueyu Wang
Ying Li
Hanning Chen
Zhao Zhang
Hua Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702014

1,115 views

Review

Published on 26 Nov 2025

Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential

in Neuropharmacology

Ziyan Hu
Shujing Xie
Cheng Chen
Zhihui Luo
Xiao Deng
Renjie Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713748

1,126 views

Original Research

Published on 26 Nov 2025

Severe cutaneous adverse reactions to anti-osteoporosis drugs: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database and a review of published cases

in Pharmacoepidemiology

Jun-Wei Li
Xin-Dong Lei
Bing Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707885

1,523 views

Original Research

Published on 26 Nov 2025

Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis

in Experimental Pharmacology and Drug Discovery

Fan-E. Cheng
Yaxi Zhang
Shihao Zheng
Wenying Qi
Xiaomei Zhang
Size Li
Qiuyue Wang
Xiangyun Zou
Xiaoke Li
Yongan Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686535

1,293 views

Original Research

Published on 26 Nov 2025

Intraoperative dexmedetomidine use associated with prolonged postanesthesia care unit recovery time after lung resection: a retrospective cohort study

in Translational Pharmacology

Zhenglian Gao
Yan Jiang
Yixin Liu
Chang Yang
Bangjian Zhang
Ming Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649139

817 views

Review

Published on 26 Nov 2025

Eryptosis in renal anemia: mechanisms, clinical implications, and therapeutic targeting

in Integrative and Regenerative Pharmacology

Xiang Deng
Xiangyu Gong
Yi Huang
Jie Zhou
Sichong Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718803

1,548 views
2 citations

Mini Review

Published on 26 Nov 2025

Botanical drug preparations for alleviating hair loss in menopausal women: a global ethnopharmacological mini-review

in Ethnopharmacology

Zhuo Huang
Wen-Jie Zhao
Yong-Jie Gao
Zhi-Rong Huang
Qing-Rui Huang
Sui-Zhen Cai
Ming-Hui Bi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725691

2,179 views

Review

Published on 26 Nov 2025

Endoplasmic reticulum stress and exosomes secretion in the pathogenesis of inflammatory bowel disease: a concise summary of research findings

in Integrative and Regenerative Pharmacology

Ashiq Shibili P
Antara Banerjee
Soham Chakraborty
Suresh Babu Kondaveeti
Andrea Porzionato
Silvia Barbon
Surajit Pathak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702825

1,751 views

Review

Published on 26 Nov 2025

Natural products intervene in non-alcoholic fatty liver disease by regulating the AMPK signaling pathway: preclinical evidence and mechanism

in Ethnopharmacology

Chuyue Zhang
Jianing Shi
Lijun Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1696506

2,061 views
1 citation

Original Research

Published on 25 Nov 2025

Perception and readiness of community pharmacists in delivering palliative care services in Saudi Arabia: a new role in the game

in Drugs Outcomes Research and Policies

Sultan M. Alshahrani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646531

815 views

Clinical Trial

Published on 25 Nov 2025

Clinical efficacy and metabolomics profiling of dachaihu decoction for patients with septic liver injury: a randomized controlled trial

in Ethnopharmacology

Zhen Yang
Xingyu Kao
Tianwei Zhu
Junna Lei
Na Huang
Jingli Chen
Mingfeng He
Qi Tang
Zhangrong Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671732

1,470 views

Original Research

Published on 25 Nov 2025

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

in Neuropharmacology

Yue Zhao
Shu Li
Linhong Jiang
Ying Zhao
Weihong Kuang
Qingfan Wei
Yuanyi Zhou
Shuang Han
Liang Wang
Hongchun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677343

1,117 views

Review

Published on 25 Nov 2025

Therapeutic efficacy and mechanisms of gentiopicroside in various diseases

in Ethnopharmacology

Ling Kui
Guoyun Wang
Jinqun Huang
Xiaonan Yang
Jinshi Yu
Xi Li
Huaming Peng
Bingfeng Leng
Yinming Jiao
Zhanjiang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1634722

2,513 views

Original Research

Published on 25 Nov 2025

Knowledge, attitudes, and practices toward linezolid–serotonergic drug interactions: a cross-sectional study

in Drugs Outcomes Research and Policies

Atheer Aldairem
Sumaya N. Almohareb
Shuroug A. Alowais
Mohammad S. Shawaqfeh
Abdullah A. Alzahrani
Abdullah Y. Alzahrani
Khalid H. Alqahtani
Khalid Bin Saleh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1720903

1,048 views

Original Research

Published on 25 Nov 2025

Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study

in Drugs Outcomes Research and Policies

Jessica Hamuy Blanco
Dina C. Janse van Rensburg
Audrey Jansen van Rensburg
Corrie Uys
Natalie Schellack

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701588

1,297 views

Original Research

Published on 25 Nov 2025

Allocryptopine, tetrahydropalmatine, and tetrahydroberberine N-oxide alkaloids alleviate cellular stress by modulating calcium homeostasis and the MAPK and akt/GSK-3β/tau signaling pathways

in Ethnopharmacology

Serap Nigdelioglu Dolanbay
Belma Aslim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589390

1,100 views

Original Research

Published on 25 Nov 2025

Identification of active metabolites from Gentiana scabra Bunge ethanol-water extract for chicken metatarsal fracture repair

in Ethnopharmacology

Yi Jiang Liu
Yue Min Wang
Bin Jiang
Hou Qiang Luo
Su Zhen Liu
Shuai Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706754

820 views
1 citation

29,505 articles

articles

Cost-effectiveness analysis of first-line versus second-line use of CDK4/6 inhibitors combined with endocrine therapy in advanced HR+/HER2- breast cancer in China: based on the SONIA trial

Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems

Identification of a novel dual-targeting peptide inhibitor of SARS-CoV-2 RBD and NRP1 through structure-based virtual screening

CXCR4-targeted therapy in lung cancer: plerixafor as a promising antimetastatic agent

Efficacy and safety of Centella asiatica (L.) Urb. [Apiaceae] as a dietary supplement for glycemic control and lipid regulation in patients with type 2 diabetes: a randomized controlled trial in Thailand

Intranasal Galanin (1–15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

Behavioral and neurochemical alterations induced by long-term exposure to tobacco heating system emissions in rats

Drug combination discovery assisted by AI and untargeted metabolomics: pamiparib and anlotinib synergistic potentiation for ovarian cancer treatment

Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential

Severe cutaneous adverse reactions to anti-osteoporosis drugs: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database and a review of published cases

Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis

Intraoperative dexmedetomidine use associated with prolonged postanesthesia care unit recovery time after lung resection: a retrospective cohort study

Eryptosis in renal anemia: mechanisms, clinical implications, and therapeutic targeting

Botanical drug preparations for alleviating hair loss in menopausal women: a global ethnopharmacological mini-review

Endoplasmic reticulum stress and exosomes secretion in the pathogenesis of inflammatory bowel disease: a concise summary of research findings

Natural products intervene in non-alcoholic fatty liver disease by regulating the AMPK signaling pathway: preclinical evidence and mechanism

Perception and readiness of community pharmacists in delivering palliative care services in Saudi Arabia: a new role in the game

Clinical efficacy and metabolomics profiling of dachaihu decoction for patients with septic liver injury: a randomized controlled trial

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

Therapeutic efficacy and mechanisms of gentiopicroside in various diseases

Knowledge, attitudes, and practices toward linezolid–serotonergic drug interactions: a cross-sectional study

Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study

Allocryptopine, tetrahydropalmatine, and tetrahydroberberine N-oxide alkaloids alleviate cellular stress by modulating calcium homeostasis and the MAPK and akt/GSK-3β/tau signaling pathways

Identification of active metabolites from Gentiana scabra Bunge ethanol-water extract for chicken metatarsal fracture repair