Frontiers in Pharmacology

Mini Review

Published on 25 Nov 2025

Harnessing marine algal polysaccharides for combination cancer therapy: pharmacological mechanisms and clinical perspectives

in Ethnopharmacology

Jing Zhong
Sookja Kim Chung
Xiaoling Han
Riming Huang
Baojun Xu
Io Nam Wong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682025

1,033 views

Original Research

Published on 25 Nov 2025

Opioid-free anesthesia with esketamine combined with interpectoral plane block and pectoralis-serratus plane blocks in radical mastectomy: a randomized controlled trial

in Experimental Pharmacology and Drug Discovery

Wenping Ding
Youming Deng
Nuo Sun
Rongguo Wang
Qian Liu
Yan Zhang
Meiyan Zhou
Yan Liu
Liwei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679423

1,110 views

Review

Published on 25 Nov 2025

Integrating clinical evidence with natural product therapies for elderly-onset type 2 diabetes

in Ethnopharmacology

Chae-Eun Kim
Kyong Kim
Eun-Young Park
Yoon Sin Oh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658881

1,275 views

Systematic Review

Published on 25 Nov 2025

Adjunctive esketamine in propofol-based sedation for gastrointestinal endoscopy: a systematic review and meta-analysis of randomized trials

in Experimental Pharmacology and Drug Discovery

Jiazheng Qi
Mengqiang Luo
Wenru Zong
Lingjing Zhang
Baoxuan Chen
Xiaoyu Yang
Bo Xu
Xu Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662057

1,275 views

Original Research

Published on 25 Nov 2025

Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway

in Gastrointestinal and Hepatic Pharmacology

Junming Xu
Xiaopu Sang
Yongfei He
Jie Ke
Jiasen Xu
Tanbin Liu
Jicai Wang
Hang Zhai
Xiaoni Chen
Xianjie Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730255

1,389 views

Original Research

Published on 25 Nov 2025

Galunisertib attenuates pulmonary fibrosis with silicosis in mouse via TGF-β/TRAF6/Beclin1 signaling pathway

in Translational Pharmacology

Rou Li
Huimin Kang
Aoxiang Hu
Guo Chen
Tinghua Yan
Ting Liu
Shi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702511

1,480 views

Original Research

Published on 25 Nov 2025

Evaluation of the clinical application of histamine H2 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting based on the attribute hierarchy model method

in Drugs Outcomes Research and Policies

Jiawei Song
Li Liu
Bingbing Meng
Huanhuan Zhao
Pengcheng Zhang
Huijuan Chen
Yuanyuan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700075

882 views

Original Research

Published on 25 Nov 2025

Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

in Pharmacogenetics and Pharmacogenomics

Santenna Chenchula
Atal Shubham
Rozatkar Abhijit
Tamonud Modak
Kohat Komal
Ratinder Jhaj
Singh Jitendra
Satyaprakash V.
Sadasivam Balakrishnan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697866

1,632 views

Original Research

Published on 25 Nov 2025

Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models

in Neuropharmacology

Nikita Shah
Ameya Sanjay Kasture
Vasylyna Kovalchuk
Lara Bjeletic
Thomas Hummel
Harald H. Sitte
Sonja Sucic

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674737

1,338 views

Original Research

Published on 25 Nov 2025

Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation

in Ethnopharmacology

Wenli Li
Wei Huang
Peng Zhou
Yongchuan Yao
Biao Cai
Shu Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690192

1,224 views

Original Research

Published on 25 Nov 2025

SLC11A1 protein as a key regulator of iron metabolism, ferroptosis mediator, and putative therapeutic target in nonalcoholic fatty liver disease: an integrated bioinformatics analysis

in Gastrointestinal and Hepatic Pharmacology

Yang Wang
Bugao Zhou
Shanshan Li
Linxin Zheng
Xiongfeng Huang
Huiyu Wang
Sili Li
Yuhan Lin
Yanhe Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715699

1,951 views

Original Research

Published on 25 Nov 2025

Selaginella extracts extend lifespan and mitigate oxidative stress in Caenorhabditis elegans

in Ethnopharmacology

Xueqing Chen
Bingjian Yan
Yingmei Wu
Wenjing Quan
Yu Liu
Yaning Huang
Yinjie Shao
Yuan Wang
Qi Zhou
Yifei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658991

1,247 views

Review

Published on 25 Nov 2025

Icariin against osteoporosis: a review of advances in molecular mechanisms to biomedical applications

in Experimental Pharmacology and Drug Discovery

Boyi Fu
Shasha Yu
Shengxiong Chen
Bo Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688847

1,684 views

Original Research

Published on 25 Nov 2025

Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial

in Obstetric and Pediatric Pharmacology

Guolin Xu
Zhuhong Tian
Yong Ding
Jingjing Ma
Rui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661683

901 views

Original Research

Published on 25 Nov 2025

Efficacy and safety of tranexamic acid combined with low molecular weight heparin versus fondaparinux sodium following total knee arthroplasty: a retrospective cohort study

in Drugs Outcomes Research and Policies

Abuduwupuer Haibier
Miying Pan
Dilxat Anwar
Pengcheng Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667528

1,276 views

Original Research

Published on 25 Nov 2025

Trend analysis and future projections of global burden of opioid use disorder (OUD) from 1990 to 2030

in Pharmacoepidemiology

Wenshuo Jiang
Zhigang Zhao
Bin Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669269

1,612 views

Clinical Trial

Published on 25 Nov 2025

Population pharmacokinetics/pharmacodynamics and safety of YPEG-rhGH in elderly subjects

in Drug Metabolism and Transport

Yajie He
Jingwen Hu
Xin Zeng
Qianfeng Yang
Qiuyun You
Jiangeng Huang
Yu Zhang
Luqin Si
Xuejia Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651323

1,267 views

Original Research

Published on 24 Nov 2025

Combining mechanistic quantitative systems pharmacology modeling and patient-derived organoid testing in MET-aberrant non-small cell lung cancer for high-throughput combination efficacy analysis and personalized treatment design

in Experimental Pharmacology and Drug Discovery

Jingjing Hu
Yanyong Zhao
Qi Rao
Geli Li
Zichen Jiao
Haoxiang Wang
Yuchen Qu
Shihui Xu
Zhongze Gu
Tao Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685468

1,356 views

Original Research

Published on 24 Nov 2025

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

in Neuropharmacology

Lihua Chen
Stefanie L. Cassoday
Joao I. Mamede
Lena Al-Harthi
Xiu-Ti Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691165

979 views

Original Research

Published on 24 Nov 2025

Large language models management of complex medication regimens: a case-based evaluation

in Drugs Outcomes Research and Policies

Aaron Chase
Amoreena Most
Shaochen Xu
Erin Barreto
Brian Murray
Kelli Henry
Susan Smith
Tanner Hedrick
Xianyan Chen
Sheng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1514445

1,253 views
1 citation

Clinical Trial

Published on 24 Nov 2025

Bioequivalence of a single dose of two palbociclib formulations in healthy Chinese subjects under fasting conditions: a two-period crossover study with rabeprazole pre-treatment

in Drug Metabolism and Transport

Wanjun Bai
Shuo Shi
Deliang Yin
Caihui Guo
Haojing Song
Yiting Hu
Jin Gao
Bo Qiu
Xueyuan Zhang
Lusha Bi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722151

1,091 views

Review

Published on 24 Nov 2025

The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies

in Ethnopharmacology

Xiao Li
Yiting Wang
Maocheng Xiong
Chunfang Xie
Dianxing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714245

1,888 views
1 citation

Original Research

Published on 24 Nov 2025

Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and experimental evaluation

in Ethnopharmacology

Yin Huang
Jingxing Bai
Biao Ran
Jinze Li
Bo Chen
Zeyu Chen
Jie Chen
Yan Wang
Jin Li
Qiang Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654757

1,474 views

Hypothesis and Theory

Published on 24 Nov 2025

Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes

in Experimental Pharmacology and Drug Discovery

Kalpana Panati
Parasuraman Aiya Subramani
Venkata Ramireddy Narala

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712511

934 views

29,505 articles

articles

Harnessing marine algal polysaccharides for combination cancer therapy: pharmacological mechanisms and clinical perspectives

Opioid-free anesthesia with esketamine combined with interpectoral plane block and pectoralis-serratus plane blocks in radical mastectomy: a randomized controlled trial

Integrating clinical evidence with natural product therapies for elderly-onset type 2 diabetes

Adjunctive esketamine in propofol-based sedation for gastrointestinal endoscopy: a systematic review and meta-analysis of randomized trials

Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway

Galunisertib attenuates pulmonary fibrosis with silicosis in mouse via TGF-β/TRAF6/Beclin1 signaling pathway

Evaluation of the clinical application of histamine H2 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting based on the attribute hierarchy model method

Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models

Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation

SLC11A1 protein as a key regulator of iron metabolism, ferroptosis mediator, and putative therapeutic target in nonalcoholic fatty liver disease: an integrated bioinformatics analysis

Selaginella extracts extend lifespan and mitigate oxidative stress in Caenorhabditis elegans

Icariin against osteoporosis: a review of advances in molecular mechanisms to biomedical applications

Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial

Efficacy and safety of tranexamic acid combined with low molecular weight heparin versus fondaparinux sodium following total knee arthroplasty: a retrospective cohort study

Trend analysis and future projections of global burden of opioid use disorder (OUD) from 1990 to 2030

Population pharmacokinetics/pharmacodynamics and safety of YPEG-rhGH in elderly subjects

Combining mechanistic quantitative systems pharmacology modeling and patient-derived organoid testing in MET-aberrant non-small cell lung cancer for high-throughput combination efficacy analysis and personalized treatment design

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

Large language models management of complex medication regimens: a case-based evaluation

Bioequivalence of a single dose of two palbociclib formulations in healthy Chinese subjects under fasting conditions: a two-period crossover study with rabeprazole pre-treatment

The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies

Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and experimental evaluation

Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes