Frontiers in Pharmacology

Original Research

Published on 24 Nov 2025

Large language models management of complex medication regimens: a case-based evaluation

in Drugs Outcomes Research and Policies

Aaron Chase
Amoreena Most
Shaochen Xu
Erin Barreto
Brian Murray
Kelli Henry
Susan Smith
Tanner Hedrick
Xianyan Chen
Sheng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1514445

1,274 views
1 citation

Original Research

Published on 24 Nov 2025

Combining mechanistic quantitative systems pharmacology modeling and patient-derived organoid testing in MET-aberrant non-small cell lung cancer for high-throughput combination efficacy analysis and personalized treatment design

in Experimental Pharmacology and Drug Discovery

Jingjing Hu
Yanyong Zhao
Qi Rao
Geli Li
Zichen Jiao
Haoxiang Wang
Yuchen Qu
Shihui Xu
Zhongze Gu
Tao Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685468

1,396 views

Original Research

Published on 24 Nov 2025

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

in Neuropharmacology

Lihua Chen
Stefanie L. Cassoday
Joao I. Mamede
Lena Al-Harthi
Xiu-Ti Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691165

987 views

Clinical Trial

Published on 24 Nov 2025

Bioequivalence of a single dose of two palbociclib formulations in healthy Chinese subjects under fasting conditions: a two-period crossover study with rabeprazole pre-treatment

in Drug Metabolism and Transport

Wanjun Bai
Shuo Shi
Deliang Yin
Caihui Guo
Haojing Song
Yiting Hu
Jin Gao
Bo Qiu
Xueyuan Zhang
Lusha Bi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722151

1,108 views

Review

Published on 24 Nov 2025

The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies

in Ethnopharmacology

Xiao Li
Yiting Wang
Maocheng Xiong
Chunfang Xie
Dianxing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714245

1,899 views
1 citation

Hypothesis and Theory

Published on 24 Nov 2025

Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes

in Experimental Pharmacology and Drug Discovery

Kalpana Panati
Parasuraman Aiya Subramani
Venkata Ramireddy Narala

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712511

941 views

Original Research

Published on 24 Nov 2025

Disproportionality analysis of biliary adverse events associated with fibrates using the JADER and FAERS databases

in Pharmacoepidemiology

Satoko Watanabe
Kyosuke Nagura
Naoto Okada
Taro Watanabe
Hidenori Sagara

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700589

1,878 views

Systematic Review

Published on 24 Nov 2025

The impact of climate change on medicinal plants and natural products: A scoping review

in Ethnopharmacology

Marce Inggritha Takubessi
Banaz Jalil
Michael Heinrich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697581

3,426 views
1 citation

Correction

Published on 24 Nov 2025

Correction: Wild Cordyceps sinensis exhibits far lower arsenic accumulation and hepatorenal toxicity in mice compared to equivalent dose of inorganic arsenic

in Ethnopharmacology

Liang Gao
Hongxia Yang
Jinmei Ma
Hongtao Bi
Yuancan Xiao
Cen Li
Lixin Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730109

576 views

Original Research

Published on 24 Nov 2025

Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and experimental evaluation

in Ethnopharmacology

Yin Huang
Jingxing Bai
Biao Ran
Jinze Li
Bo Chen
Zeyu Chen
Jie Chen
Yan Wang
Jin Li
Qiang Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654757

1,486 views

Original Research

Published on 24 Nov 2025

Temporal metabolic reprogramming in DSS-induced colitis identifies purine metabolism and trigonelline as novel therapeutic targets

in Gastrointestinal and Hepatic Pharmacology

Qi Zhang
Jianguo Wang
Long Zhang
Kangjie Song
Xiaoming Sun
Yaming Zhang
Fubao Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691978

1,113 views

Original Research

Published on 24 Nov 2025

Effects of remimazolam on hemodynamics in children with congenital heart disease undergoing cardiac catheterization

in Obstetric and Pediatric Pharmacology

Hongyun Li
Zhaomeng Song
Xunwei Jiang
Wei Liu
Yan Jiang
Rong Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714645

941 views

Mini Review

Published on 24 Nov 2025

Overcoming the blood-brain barrier: targeted delivery strategies for gliomas

in Drug Metabolism and Transport

Xue Du
Chunbao Chen
Yijun Zeng
Zhinei Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705234

1,938 views

Review

Published on 24 Nov 2025

Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review

in Ethnopharmacology

Yi Wang
Huan Chen
Pucheng Feng
Deyun Wang
Xiaoquan Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713957

2,139 views

Review

Published on 24 Nov 2025

The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances

in Ethnopharmacology

Yan Chen
He Li
Qiuju Dai
Zhen Tan
Huihui Wu
Zhiyi Xu
Guangwei Wang
Yang Fang
Jie Luo
Chenghao Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669424

1,667 views

Original Research

Published on 24 Nov 2025

Safety profile of lutein-based blue dyes and surgical lights

in Experimental Pharmacology and Drug Discovery

Mario R. Romano
Federica Conti
Francesca Lazzara
Barbara Parolini
Mariantonia Ferrara
Claudio Bucolo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704098

847 views

Original Research

Published on 24 Nov 2025

Cannabis-based extract for managing pain in dogs with osteoarthritis: efficacy and safety assessment

in Ethnopharmacology

Neide Maria Griebeler
Ricardo Penayo Cremonese
Yasmin Rafaela Fakih Correa
Priscila Romero Mazzini Pereira
Amanda Furjan Rial
Emanuela Leite
Maria Victoria Luz Gonçalves
Luiz Renato Marques das Almas
Nedice Borges Cardoso
Fernando Cezar-dos-Santos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539704

1,846 views

Clinical Trial

Published on 24 Nov 2025

Remimazolam combined with propofol for intraoperative wake-up testing in scoliosis correction surgery: a prospective, blind, randomized controlled trial

in Neuropharmacology

Jing Luo
Da-Lin Chen
Zong-Long Lv
Hui Zhong
Yong-Hui Zhao
Yu-Jin Li
Xin-Nan Li
Jing-Ce Chen
Wen-Bao Shi
Yun Bo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685683

1,266 views

Original Research

Accepted on 21 Nov 2025

Machine learning-assisted analysis of serum metabolomics for Identifying Biomarkers in Intrinsic and Idiosyncratic Drug-Induced Liver Injury

in Gastrointestinal and Hepatic Pharmacology

Xianni Wei
Jinbao Wei
Yuhong Huang
Siheng Lian

Frontiers in Pharmacology

278 views

Original Research

Published on 21 Nov 2025

Knowledge, attitudes, and practices of inpatients with chronic cardiovascular comorbidities regarding polypharmacy: a cross-sectional study

in Drugs Outcomes Research and Policies

Lijun Xu
Chenggui Zhuo
Hongyan Xu
Zhelin Xia
Meicui Wu
Haipeng Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702721

1,041 views

Correction

Published on 21 Nov 2025

Correction: Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway

in Ethnopharmacology

Yuche Wu
Bing Wang
Xuwen Mao
Wei Chen
Haji Akber Aisa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701287

528 views

Correction

Published on 21 Nov 2025

Correction: Methodological study protocol for the European Atlas of clinical trials in cancer and haematology

in Drugs Outcomes Research and Policies

Mercè Cases
Rachel Giles
Tamás Ágh
Maria Piggin
Jan Geissler
Monica Racovita
Judit Hagymásy
Lora Ruth Wogu
Ákos Józwiak
Albina Hyseni-Bocolli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743351

539 views

Original Research

Published on 21 Nov 2025

Integrated effects of Kampo treatment on gastrointestinal symptoms and stress in patients with functional dyspepsia: a preliminary prospective observational study

in Ethnopharmacology

Lian Liang
Hongyang Li
Hirokazu Doi
Yaxuan Jiang
Satoshi Tashiro
Jiying Sun
Akihiro Kawahara
Shiro Oka
Masanori Ito
Keiko Ogawa-Ochiai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685656

1,255 views

Original Research

Published on 21 Nov 2025

Assessing the views and opinions of psychiatric patients receiving genome-guided treatment within the scope of the PREPARE preemptive pharmacogenomics clinical study

in Pharmacogenetics and Pharmacogenomics

Margarita-Ioanna Koufaki
Maria-Theodora Pandi
Maria Skokou
Kariofyllis Karamperis
Konstantinos Vasileiou
Christina Mitropoulou
Marc S. Williams
George P. Patrinos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722339

1,090 views

29,512 articles

articles

Large language models management of complex medication regimens: a case-based evaluation

Combining mechanistic quantitative systems pharmacology modeling and patient-derived organoid testing in MET-aberrant non-small cell lung cancer for high-throughput combination efficacy analysis and personalized treatment design

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

Bioequivalence of a single dose of two palbociclib formulations in healthy Chinese subjects under fasting conditions: a two-period crossover study with rabeprazole pre-treatment

The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies

Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes

Disproportionality analysis of biliary adverse events associated with fibrates using the JADER and FAERS databases

The impact of climate change on medicinal plants and natural products: A scoping review

Correction: Wild Cordyceps sinensis exhibits far lower arsenic accumulation and hepatorenal toxicity in mice compared to equivalent dose of inorganic arsenic

Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and experimental evaluation

Temporal metabolic reprogramming in DSS-induced colitis identifies purine metabolism and trigonelline as novel therapeutic targets

Effects of remimazolam on hemodynamics in children with congenital heart disease undergoing cardiac catheterization

Overcoming the blood-brain barrier: targeted delivery strategies for gliomas

Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review

The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances

Safety profile of lutein-based blue dyes and surgical lights

Cannabis-based extract for managing pain in dogs with osteoarthritis: efficacy and safety assessment

Remimazolam combined with propofol for intraoperative wake-up testing in scoliosis correction surgery: a prospective, blind, randomized controlled trial

Machine learning-assisted analysis of serum metabolomics for Identifying Biomarkers in Intrinsic and Idiosyncratic Drug-Induced Liver Injury

Knowledge, attitudes, and practices of inpatients with chronic cardiovascular comorbidities regarding polypharmacy: a cross-sectional study

Correction: Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway

Correction: Methodological study protocol for the European Atlas of clinical trials in cancer and haematology

Integrated effects of Kampo treatment on gastrointestinal symptoms and stress in patients with functional dyspepsia: a preliminary prospective observational study

Assessing the views and opinions of psychiatric patients receiving genome-guided treatment within the scope of the PREPARE preemptive pharmacogenomics clinical study