Frontiers in Pharmacology

Original Research

Published on 21 Nov 2025

Anti-inflammatory and analgesic effects of Kaihoujian throat spray, and therapeutic mechanism in acute pharyngitis: involvement of the NF-κB/COX-2 pathway and formula deconstruction strategy

in Ethnopharmacology

Hui Shi
Jinhe Zhang
Liyan Zhang
Xiu Dong
Chang Liu
Xiongwei Liu
Ying Zhou
Tingting Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687046

1,351 views

Original Research

Published on 21 Nov 2025

Integrated effects of Kampo treatment on gastrointestinal symptoms and stress in patients with functional dyspepsia: a preliminary prospective observational study

in Ethnopharmacology

Lian Liang
Hongyang Li
Hirokazu Doi
Yaxuan Jiang
Satoshi Tashiro
Jiying Sun
Akihiro Kawahara
Shiro Oka
Masanori Ito
Keiko Ogawa-Ochiai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685656

1,266 views

Review

Published on 21 Nov 2025

Curcumin mediates oxidative stress to play an anti-fibrotic role, focusing on liver, renal, myocardial and pulmonary fibrosis

in Ethnopharmacology

Shishuang Yu
Jufang Pu
Ke Liu
Cuifang He
Feifei Yang
Ke Chen
Xiuli Yang
Yi Zhu
Jun Jiang
Maocai Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636538

2,149 views

Original Research

Published on 21 Nov 2025

Anti-ulcer activity of green synthesized selenium nanoparticles using Nigella sativa L. seed extract in rats

in Ethnopharmacology

Awatef Elwej
Fawziah Al-Otaibi
Khadija Boukholda
Fahad Alminderej
Faez Alotaibi
Amani Kaabi
Nada M. Ali
Hamadi Fetoui
Kaiss Aouadi
Adel Kadri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1638593

1,699 views
1 citation

Review

Published on 21 Nov 2025

A critical review of natural products driven correction of bile acid dysregulation: a therapeutic strategy for nonalcoholic fatty liver disease

in Ethnopharmacology

Qing Peng
Liyuan Hao
Shenghao Li
Fei Yu
Na Li
Xiaoyu Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640873

2,758 views
1 citation

Original Research

Published on 21 Nov 2025

Carnosine as a protective metabolic mediator in inflammatory lung injury by inhibiting macrophage infiltration and M1-like polarization

in Inflammation Pharmacology

Lianjie Ruan
Dekai Lin
Binqin Lin
Qingqing Zhan
Lili Zheng
Dandan Lin
Yaoning Zhuang
Yiming Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689575

1,175 views

Original Research

Published on 21 Nov 2025

Structure-based identification of Jervine as a potent dual-targeting inhibitor of cell cycle kinases

in Pharmacology of Anti-Cancer Drugs

Md Nayab Sulaimani
Khadija Imtiyaz
Md. Imtaiyaz Hassan
Fohad Mabood Husain
Aanchal Rathi
Mir Ovais Farooq
Anam Ashraf
Ravins Dohare
Sukhwinder Singh Sohal
Saba Noor

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662556

1,282 views

Systematic Review

Published on 21 Nov 2025

Efficacy comparison of four different Chinese herbal mediciness in intervening acute respiratory distress syndrome: a bayesian network meta-analysis

in Ethnopharmacology

Xinhui Wu
Sisi Feng
Xuemei Dai
Zhihao Liu
Yi Luo
Fei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671930

1,279 views

Systematic Review

Published on 21 Nov 2025

Impact of CYP2C19 point-of-care testing on the clinical outcome in patients receiving personalized clopidogrel therapy: systemic review and meta-analysis

in Pharmacogenetics and Pharmacogenomics

Shaban Mohammed
Zainab Ali
Nermin Mohammed
Ayman El-Menyar
Jassim Al Suwaidi
Moza Al-Hail
Wadha Al-Muftah
Rania Abdel-Latif
Maw Shin Sim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621327

1,723 views

Review

Published on 21 Nov 2025

Licorice in nephropathy treatment: phytochemical compositions and pharmacological mechanisms

in Renal Pharmacology

Ya-Long Feng
Le Shui
Yin-Xuan Jiang
Yan-Ni Wang
Lin Chen
Hua Chen
Wen-Bo Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672643

1,949 views

Original Research

Published on 21 Nov 2025

Medical cannabis utilization in children – a study based on a nationwide cohort

in Obstetric and Pediatric Pharmacology

Nir Treves
Noa Yakirevich-Amir
Karel Allegaert
John N. van den Anker
Elkana Kohn
Maya Berlin
Ariela Hazan
Elyad Davidson
Matitiahu Berkovitch
Omer Bonne

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646560

1,237 views

Clinical Trial

Published on 21 Nov 2025

Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study

in Translational Pharmacology

Hongzhong Liu
Tao Liu
Ming Liu
Xin Zheng
Wen Zhong
Qian Zhao
Ji Jiang
Pei Hu
Yishi Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713702

1,205 views

Original Research

Published on 21 Nov 2025

Development and validation of a two-dimensional liquid chromatography method for therapeutic drug monitoring of pyrotinib in human plasma

in Pharmacology of Anti-Cancer Drugs

Chunxia Gao
Yuzhi Cao
Mengna An
Zhihui Li
Chao Meng
Jingjing Lan
Haisheng You
Siying Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704594

859 views
1 citation

Original Research

Published on 21 Nov 2025

THBS1 as a candidate biomarker and fibrotic mediator in radiation-induced liver injury: insights from TMT-labeled quantitative proteomics

in Experimental Pharmacology and Drug Discovery

Zixi Wang
Tong Wu
Haixu Wang
Yawen Deng
Jing Liu
Tingting Wang
Xue Ren
Ying Sun
Haibo Zhang
Defu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659870

1,391 views

Review

Published on 21 Nov 2025

Gepants: targeting the CGRP pathway for migraine relief

in Neuropharmacology

Bernadetta Jakubowska
Magdalena Sowa-Kućma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708226

4,376 views
1 citation

Original Research

Published on 21 Nov 2025

Preclinical pharmacokinetic characterization of (R)-ketamine injection, a novel antidepressant glutamatergic agent

in Drug Metabolism and Transport

Rui Wang
Yongchao Jin
Bingjie Zou
Li Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699304

1,497 views

General Commentary

Published on 21 Nov 2025

Commentary: Hyperoside alleviates myocardial ischemia-reperfusion injury in heart transplantation by promoting mitochondrial fusion via activating the Stat3-Tom70-Opa1 pathway

in Cardiovascular and Smooth Muscle Pharmacology

Qin Yang
Yingjie Liu
Xinzheng Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1724858

721 views

Original Research

Published on 21 Nov 2025

Comparative safety profile of levofloxacin versus moxifloxacin in first-line tuberculosis therapy: a pharmacovigilance study of the FAERS database

in Pharmacoepidemiology

Yanlang He
Lifen Liang
Sheng Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713170

1,849 views

Original Research

Published on 21 Nov 2025

EAR-20 peptide, a novel NMDA receptor positive allosteric modulator

in Pharmacology of Ion Channels and Channelopathies

Roberto García-Díaz
Aida Castellanos
Federico Miguez-Cabello
Javier Picañol
Anna Priscil·la Pérez-González
Esther Gratacòs-Batlle
Nohora Vega-Castro
Xavier Altafaj
Edwin A. Reyes-Guzmán
Edgar A. Reyes-Montaño

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639698

1,590 views

Original Research

Published on 21 Nov 2025

Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway

in Ethnopharmacology

Lu Liu
Xiaoyan Zhan
Xianling Wang
Jincai Wen
Caiping He
Xiaoyan Chen
Yuanyuan Guo
Xueting Wang
Liu Li
Haibo Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681650

1,575 views

Systematic Review

Published on 21 Nov 2025

Preclinical evidence and mechanistic insights of ligustilide in ischemic stroke: a systematic review and meta-analysis

in Ethnopharmacology

Hengtong An
Shuhan Guo
Wei Wang
Tiangang Zheng
Xiaofei Jin
Xiaohong Zhou
Weijuan Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666207

1,093 views
1 citation

Original Research

Published on 21 Nov 2025

Ivarmacitinib reduces the need for adding/escalating medications in moderate-to-severe rheumatoid arthritis patients: a post hoc analysis from a phase III trial

in Inflammation Pharmacology

Huaxiang Liu
Jie Li
Lijun Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683508

1,145 views

Systematic Review

Published on 21 Nov 2025

Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement

in Neuropharmacology

Abdulrahman M. Khojah
Hussain Al Dera

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687119

1,558 views

Review

Published on 21 Nov 2025

Antiretroviral therapy and associated drug interactions with cardiovascular drugs: a critical review

in Pharmacology of Infectious Diseases

Marios Spanakis
Konstantinos Alexakis
Petros Ioannou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685710

1,663 views