Frontiers in Pharmacology

Review

Published on 02 Jul 2025

Regulation of anti-tumour effects of Paris polyphylla saponins via ROS: molecular mechanisms and therapeutic potentials

in Pharmacology of Anti-Cancer Drugs

Jia Liu
Yongping Mu
Ke Qi
Jiayi Li
Yang Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611911

256 views

Original Research

Published on 02 Jul 2025

Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation

in Experimental Pharmacology and Drug Discovery

Asmaa M. Gaber
Adel Abdel-Moneim
Eman S. Abdel-Reheim
Gamal Allam
Manal Abdul-Hamid
Ahmed Hosni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553992

293 views

Original Research

Published on 02 Jul 2025

Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

in Inflammation Pharmacology

Shuzhen Mao
Jiahui Huang
Junyan Li
Fang Sun
Qilian Zhang
Qing Cheng
Wei Zeng
Dongya Lei
Shiyan Wang
Jing Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551843

286 views

Original Research

Published on 02 Jul 2025

Nimotuzumab plus chemotherapy and immunotherapy as first-line/neoadjuvant therapy for advanced esophageal squamous cell carcinoma

in Gastrointestinal and Hepatic Pharmacology

Qi Wang
Zhi Cui
Muhong Deng
Guoqing Zhang
Fangfang Jing
Yue Ma
Fang Pang
Quanli Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585048

480 views

Original Research

Published on 02 Jul 2025

Advanced therapeutic strategy for managing surgical site infections with natural nanoemulsion-antimicrobial combination

in Pharmacology of Infectious Diseases

Fatma Alshehri
Nada K. Alharbi
AbdelNaser Zaid
Amira H. Eltrawy
Shereen Fawzy
Attia M. Gabr
Sawsan A. Zaitone
Majid Alhomrani
Abdulhakeem S. Alamri
Rasha A. Mosbah

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617184

194 views

Systematic Review

Published on 02 Jul 2025

Long-term effects of SGLT2 inhibitors on arrhythmias: a systematic review and meta-analysis

in Pharmacoepidemiology

Peipei Li
Weiwei Chen
Rui Chen
Hanmo Zhang
Zhixi Yu
Hongyu Yan
Beibei Du
Ping Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558367

320 views

Original Research

Published on 02 Jul 2025

Integrating network pharmacology, IPA, and molecular docking to reveal the anti-osteoporosis effects of EA and EB via the FAK pathway

in Experimental Pharmacology and Drug Discovery

Ziheng Wei
Fei You
Henghui Li
Si Wu
Fen Tang
Xiangyang Wan
Huizhong Dong
Wenxuan Huang
Songyan Gao
Bo Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532665

532 views

Original Research

Published on 02 Jul 2025

Interaction of blood-entry components, network pharmacology and transcriptomics to elucidate the mechanism of Wentong plaster in treating primary dysmenorrhea

in Experimental Pharmacology and Drug Discovery

Zongtong Yang
Ziqi Jiao
Cheng Wang
Xiaojing Li
Mengyu Yuan
Zaiyun Sui
Wenhui Wang
Wenjing Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591558

225 views

Original Research

Published on 02 Jul 2025

Acute pharmacological effects of α-PVP in humans: a naturalistic observational study

in Neuropharmacology

Georgina De la Rosa
Esther Papaseit
Olga Hladun
Lourdes Poyatos
Dolly Andrea Caicedo
Martha Catalina Argote
Soraya Martín
Mireia Ventura
Nunzia La Maida
Annagiulia Di Trana

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626692

303 views

Review

Published on 02 Jul 2025

Research progress on peptides that inhibit melanin synthesis

in Experimental Pharmacology and Drug Discovery

Binrui Yu
Nailong Wang
Shanshan Cai
Hao Yan
Shaojia Sun
Siru Wang
Ye Li
Zhengting Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610623

414 views

Original Research

Published on 02 Jul 2025

Comprehensive profiling of Rhodiola rosea roots and corresponding products: phytochemical insights and modulation of neuroinflammation in BV2 microglial cell model

in Ethnopharmacology

Małgorzata Kołtun-Jasion
Karolina Czerwiec
Andrzej Parzonko
Aleksandra Bakiera
Marcin Ożarowski
Anna Karolina Kiss

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1608767

395 views

Original Research

Published on 02 Jul 2025

Antidepressant use in the Canary Islands (Spain): a retrospective study of provincial, island and municipal trends and associated factors

in Pharmacoepidemiology

Alexis Oliva
Vanessa Moreno
Mariana Sapino
Sandra Dévora
Susana Abdala-Kuri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1511936

217 views

Review

Accepted on 01 Jul 2025

Genetic Implication of GABAB Receptors in the Etiology of Neurological and Psychiatric Disorders

in Neuropharmacology

Martin Gassmann
Michal Stawarski
Stylianos E. Antonarakis
Bernhard Bettler

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1634128

158 views

Original Research

Accepted on 01 Jul 2025

Exposure-response analyses of venetoclax combined with hypomethylating agents in myelodysplastic syndromes: a retrospective study

in Pharmacology of Anti-Cancer Drugs

Jixin Tian
Ping Zhang
Xiao-Xu Wang
Jin-Wen Li
Dong-Xue Liu
Yi-Ying Liu
Zhijian Xiao
Wen-Juan Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586910

179 views

Original Research

Accepted on 01 Jul 2025

The functional roles of deoxyelephantopin potential target circTNPO3 in regulating pancreatic cancer malignant phenotype and gemcitabine chemoresistance via miR-188-5p/CDCA3/TRAF2-mediated remodeling of NF-κB signaling pathway

in Pharmacology of Anti-Cancer Drugs

Daolin Ji
Jia Liu
Yanhui Zhang
Li Hou
Haonan Feng
Xue Xing
Deming Guan
Tiangang Cui
Yi Xu
Gang Tan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613560

111 views

Original Research

Accepted on 01 Jul 2025

Comparative Effects of Raw and Processed Cistanche Glycosides on the HPT Axis and Gut Microbiota in a Rat Model of Kidney-Yang Deficiency

in Ethnopharmacology

Xiaoqing Shen
Jing Lian
Chao Zhang
Yixiang Miu
Yuan Zhang
Ji Shi
Nan Xu
Tianzhu Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1597564