Frontiers in Pharmacology

Original Research

Published on 10 Nov 2025

Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway

in Pharmacology of Anti-Cancer Drugs

Qin Ren
Xiaobing Li
Xiangmei Ye
Leiguang Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676034

1,318 views

Clinical Trial

Published on 10 Nov 2025

Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [14C]JP-1366

in Drug Metabolism and Transport

Xuemei Liu
Decheng Deng
Jian Meng
Haitang Hu
Quankun Zhuang
Xue Zhou
Long Fu
Binke Fan
Xueting Xu
Qin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701581

1,403 views

Original Research

Published on 10 Nov 2025

The correlation between the use of ondansetron and mortality in sepsis associated encephalopathy patients: a retrospective ICU cohort study

in Pharmacoepidemiology

Shuo Yang
Yi-Qu Wei
Ya-Zhou Liu
Xiao-Lin Wang
Jin-Xia Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712328

1,595 views

Review

Published on 10 Nov 2025

Natural medicines for treating liver fibrosis by modulating post-translational modifications

in Ethnopharmacology

Qun Niu
Yu Mou
Kaixin Wang
Haijian Dong
Zijian Zeng
Hui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660908

1,730 views

Original Research

Published on 10 Nov 2025

Mechanism of hepatotoxicity induced by ethanol extract of Emilia sonchifolia (L.) DC revealed by proteomics and metabolomics

in Predictive Toxicology

Gongzhen Chen
Qiantonghan Luo
Zicong Song
Ping Zheng
Xin Liu
Ting Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669607

1,478 views

Original Research

Published on 10 Nov 2025

A novel drug that reduces pneumococcal toxicity by targeting pneumolysin (PLY): efficacy of the traditional Chinese medicine Radix Paeoniae Alba

in Pharmacology of Infectious Diseases

Yan Xu
Jing Han
Yonglin Zhou
Liping Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609457

1,077 views

Original Research

Published on 10 Nov 2025

Effects of Bairui granules (Thesium chinense Turcz.) on patients with the common cold (wind-heat syndrome): a multicenter, randomized, double-blind, double-dummy, controlled trial

in Ethnopharmacology

Mingzhe Wang
Shuyang Ji
Youqiang Wu
Guantong Shen
Weicheng Nie
Chengjun Ban
Miao Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610896

2,153 views

Review

Published on 10 Nov 2025

The antitumor potential of Polygonatum spp.: a narrative review of traditional uses, bioactive metabolites, and multi-targeted mechanisms

in Ethnopharmacology

Mengqin Zhu
Guang Chen
Jinyu Li
Chang Yi
Yanfeng Yuan
Wenlong Liu
Xili Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662839

1,693 views
1 citation

Original Research

Published on 10 Nov 2025

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes

in Pharmacology of Ion Channels and Channelopathies

Lars Johannesen
Najah Abi-Gerges
Katrina Sweat
Ana Roup
Guy Page
Claudia Alvarez Baron
Huimei Yu
Wendy W. Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674861

2,216 views
1 citation

Original Research

Published on 10 Nov 2025

A single-center, randomized, open-label, two-period, crossover, fasted bioequivalence study: comparing recombinant human follicle-stimulating hormone for injection (JZB30) with Gonal-f® in healthy Chinese female participants

in Experimental Pharmacology and Drug Discovery

Zhuo Chen
Qin Yu
Shiyin Feng
Li Mo
Linrui Cai
Chunfeng Du
Dan Du
Qin Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678830

1,001 views

Review

Published on 10 Nov 2025

The unmet promise: a critical review of antioxidant strategies in myocardial ischemia-reperfusion injury and the path towards precision medicine

in Cardiovascular and Smooth Muscle Pharmacology

Hao Chen
Yutao Tang
Pan Ren
Wenbin Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693441

1,784 views
2 citations

Original Research

Published on 10 Nov 2025

A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure

in Cardiovascular and Smooth Muscle Pharmacology

Ambrish Kumar
Sarah Deloach
Lernix Williams
Donald J. DiPette
Jay D. Potts

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692472

1,660 views

Review

Published on 10 Nov 2025

Natural metabolites used in traditional Chinese medicine for cardiovascular diseases: pharmacological mechanisms, evidence, and future directions

in Ethnopharmacology

Xinyu Liu
Wenfeng Zhang
Xiao Miao
Yinghua Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656751

2,353 views

Original Research

Published on 10 Nov 2025

Tibetan medicine Pa Zhu Wan ameliorates carbon tetrachloride-induced liver fibrosis in rats by regulating the TGF-β-Smad2/3 and IL-6/JAK2/STAT3 signaling pathways

in Ethnopharmacology

Linlin Zhao
Yan Jiang
Jing Ma
Yongjing Yang
Guo Liu
Zhengxing Wang
Tin Wui Wong
Dejun Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667685

1,292 views

Original Research

Published on 10 Nov 2025

Disproportionality evaluation of adverse effects and suicide/self-injury risk factors associated with vortioxetine: a large-scale pharmacovigilance study

in Pharmacoepidemiology

Xiangyu Li
Fang Yang
Lingjing Yuan
Li Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689634

1,637 views

Review

Published on 10 Nov 2025

Recent advances in understanding oxidative stress in sepsis: pathogenic roles and antioxidant therapeutic prospects - a narrative review

in Inflammation Pharmacology

Yijuan Lin
Ahmad Alhaskawi
Lin Chen
Safwat Adel Abdo Moqbel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695992

2,015 views
1 citation

Original Research

Published on 10 Nov 2025

Modulation of TNFα-driven neuroinflammation by Gardenin A: insights from in vitro, in vivo, and in silico studies

in Inflammation Pharmacology

Prashsti Chadha
Hiral Aghara
Harshrajsinh Solanki
Manali Patel
Dhrubjyoti Sharma
Vijay Thiruvenkatam
Palash Mandal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681403

2,092 views

Correction

Published on 10 Nov 2025

Correction: Biotechnological production of terpenoids using cell factories

in Experimental Pharmacology and Drug Discovery

Yalan Si
Shasha Li
Chen Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729872

646 views

Original Research

Published on 07 Nov 2025

Development and validation of a predictive nomogram for severe adverse drug reactions: a dual-center pharmacovigilance study

in Predictive Toxicology

Wei Bu
Xinjing Wu
Chengyu Wang
Yan Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669995

1,518 views

Original Research

Published on 07 Nov 2025

Ginkgolide C alleviates atherosclerosis by activating LAMP-2A to enhance chaperone-mediated autophagy and promote NLRP3 inflammasome degradation

in Ethnopharmacology

Rui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658725

1,746 views

Original Research

Published on 07 Nov 2025

A retrospective analysis of small molecule targeting inhibitor usage for lung cancer among outpatients in six major regions of China (2016–2022)

in Pharmacology of Anti-Cancer Drugs

Bo Chen
Chen Wang
Li-Ying Chen
Yan Hu
Yu-Zhen Wang
Liu-Cheng Li
Kai-Li Mao
Qiu Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700389

1,347 views

Review

Published on 07 Nov 2025

The canonical Wnt pathway in osteoporosis: a scoping review of key compounds and proteins modulating Wnt-induced osteogenesis

in Predictive Toxicology

Nyruz Elahmer
Norazlina Mohamed
Sok Kuan Wong
Nur Khadijah Muhamad Jamil
Isa Naina Mohamed
Sabarul Afian Mokhtar
Norliza Muhammad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669222

2,606 views
2 citations

Original Research

Published on 07 Nov 2025

Cistanche deserticola-derived exosome-like nanovesicles target the Microbiota-GABA signaling axis to ameliorate loperamide-induced constipation

in Gastrointestinal and Hepatic Pharmacology

Xiaoyu Zhang
Keqiu Yan
Xinkun Bao
Dequn Yang
Xiaoyin Chen
Wenjie Xiao
Jinbo Zhou
Yifan Cai
Hao Wang
Guangjun Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693366

1,830 views

Original Research

Published on 07 Nov 2025

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

in Neuropharmacology

Sadaf Abdian
Sajad Fakhri
Amir Kiani
Mohammad Mehdi Gravandi
Fatemeh Abbaszadeh
Mohammad Hosein Farzaei
Ehsan Mohammadi-Noori
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691130

12,625 views

29,532 articles

articles

Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway

Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [14C]JP-1366

The correlation between the use of ondansetron and mortality in sepsis associated encephalopathy patients: a retrospective ICU cohort study

Natural medicines for treating liver fibrosis by modulating post-translational modifications

Mechanism of hepatotoxicity induced by ethanol extract of Emilia sonchifolia (L.) DC revealed by proteomics and metabolomics

A novel drug that reduces pneumococcal toxicity by targeting pneumolysin (PLY): efficacy of the traditional Chinese medicine Radix Paeoniae Alba

Effects of Bairui granules (Thesium chinense Turcz.) on patients with the common cold (wind-heat syndrome): a multicenter, randomized, double-blind, double-dummy, controlled trial

The antitumor potential of Polygonatum spp.: a narrative review of traditional uses, bioactive metabolites, and multi-targeted mechanisms

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes

A single-center, randomized, open-label, two-period, crossover, fasted bioequivalence study: comparing recombinant human follicle-stimulating hormone for injection (JZB30) with Gonal-f® in healthy Chinese female participants

The unmet promise: a critical review of antioxidant strategies in myocardial ischemia-reperfusion injury and the path towards precision medicine

A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure

Natural metabolites used in traditional Chinese medicine for cardiovascular diseases: pharmacological mechanisms, evidence, and future directions

Tibetan medicine Pa Zhu Wan ameliorates carbon tetrachloride-induced liver fibrosis in rats by regulating the TGF-β-Smad2/3 and IL-6/JAK2/STAT3 signaling pathways

Disproportionality evaluation of adverse effects and suicide/self-injury risk factors associated with vortioxetine: a large-scale pharmacovigilance study

Recent advances in understanding oxidative stress in sepsis: pathogenic roles and antioxidant therapeutic prospects - a narrative review

Modulation of TNFα-driven neuroinflammation by Gardenin A: insights from in vitro, in vivo, and in silico studies

Correction: Biotechnological production of terpenoids using cell factories

Development and validation of a predictive nomogram for severe adverse drug reactions: a dual-center pharmacovigilance study

Ginkgolide C alleviates atherosclerosis by activating LAMP-2A to enhance chaperone-mediated autophagy and promote NLRP3 inflammasome degradation

A retrospective analysis of small molecule targeting inhibitor usage for lung cancer among outpatients in six major regions of China (2016–2022)

The canonical Wnt pathway in osteoporosis: a scoping review of key compounds and proteins modulating Wnt-induced osteogenesis

Cistanche deserticola-derived exosome-like nanovesicles target the Microbiota-GABA signaling axis to ameliorate loperamide-induced constipation

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties