Frontiers in Pharmacology

Original Research

Published on 06 Nov 2025

Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus

in Respiratory Pharmacology

Marion Brollo
Stanislas Grassin-Delyle
Camille Roquencourt
Elisabeth Longchampt
Isabelle Miguet-Besson
Matthieu Glorion
Hélène Salvator
Philippe Devillier

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677183

985 views

Original Research

Published on 06 Nov 2025

The development and verification of clinical medication pathway for tic disorder in west China

in Neuropharmacology

Dan Li
Chunsong Yang
Jianhua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682518

6,615 views

Review

Published on 06 Nov 2025

siRNA-mediated therapeutic approaches improve acute kidney injury and limit its worsening

in Renal Pharmacology

Xijian Wang
Xinzhong Huang
Bin Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697460

2,217 views

Clinical Trial

Published on 06 Nov 2025

Prophylactic effect of the traditional Chinese medicine formula danxiong granules (TDX105) on hand–foot skin reaction associated with the antitumor targeted drug regorafenib: a randomized, double-blind, placebo-controlled trial

in Ethnopharmacology

Shuang Yu
Xinrui Hu
Yaqin Tan
Caixia Wang
Zhenyu Shao
Ying Xiao
Hailong Liu
Jing Lv
Sheng Li
Xuan Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641477

1,609 views

Original Research

Published on 06 Nov 2025

In-depth analysis for TKI-driven real-world management of 201 CML patients using TFR

in Translational Pharmacology

Mihnea Lucian Micu
Simion Florin Cira
Mihnea Zdrenghea
Anca Bojan
Andrada Parvu
Tunde Torok-Vistai
Anca Vasilache
Laura Urian
Bancos Anamaria
Laura Ioana Jimbu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673056

2,398 views

Systematic Review

Published on 06 Nov 2025

Association between point mutations of macrolide-resistant Mycoplasma pneumoniae and clinical antibiotic treatment efficacy: a meta-analysis

in Pharmacology of Infectious Diseases

Rutong Wang
Junfeng He
Yingqi Feng
Mengyao Wang
Chi Zhong
Siqin He
Siqi Tu
Na Wen
Chuan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682167

1,469 views

Editorial

Published on 06 Nov 2025

Editorial: Bioactive metabolites in traditional medicine: dual pathways to metabolic health

in Ethnopharmacology

Wenlong Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729667

669 views

General Commentary

Published on 06 Nov 2025

Commentary: Iridoids derived from Valeriana jatamansi jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway

in Ethnopharmacology

Kai Zhang
Lei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699044

756 views

Original Research

Published on 06 Nov 2025

Development of a venous thromboembolism risk prediction model for patients with primary membranous nephropathy based on machine learning

in Renal Pharmacology

Lian Li
Liuyun Wu
Yin Wang
Hulin Wang
Xingyue Zheng
Lizhu Han
Qinan Yin
Xingwei Wu
Yuan Bian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683708

1,502 views

Review

Published on 06 Nov 2025

Potential of herbal formulas and bioactive metabolites in treating atherosclerosis: targeted modulation of macrophage polarization

in Ethnopharmacology

Shixin Liu
Jinpeng Jing
Yunsha Zhang
Junchao Sun
Chaojun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631274

2,258 views

Original Research

Published on 06 Nov 2025

Ocular toxicity events of cyclin-dependent kinase 4/6 inhibitors in breast cancer: a pharmacovigilance study based on the faers database

in Pharmacology of Anti-Cancer Drugs

Mengdi Zhang
Dongqing Pu
Minmin Yu
Guangxi Shi
Jingwei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1668446

1,997 views

Original Research

Published on 06 Nov 2025

Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models

in Translational Pharmacology

Francesca Bompan
Giada Lodi
Rebecca Foschi
Anna Dipinto
Lucia Carmela Cosenza
Fabio Casciano
Paolo Severi
Anna Sanvido
Lorenzo Caruso
Luisa Giari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692250

1,091 views

Original Research

Published on 06 Nov 2025

Efficacy analysis of remifentanil mild sedation anesthesia for painless gastroscopy

in Neuropharmacology

Dongfeng Xi
Huiling Zhang
Mengyuan Gu
Yao Wang
Jiangbo Qu
Huibin Mao
Lina Mi
Bin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692910

7,865 views

Original Research

Published on 06 Nov 2025

Low-dose methotrexate adverse reaction risk in renal impairment: pharmacovigilance and physiological pharmacokinetic model assessment

in Drug Metabolism and Transport

Lichang Zhang
Jianling Li
Xin Wang
Yaolei Zhang
Sen Gao
Deshi Dong
Yanna Zhu
Shilei Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703557

2,298 views

Original Research

Published on 06 Nov 2025

Trehalose alleviates nephropathy in focal segmental glomerulosclerosis via the upregulation of the WT-1/EZH2 pathway

in Experimental Pharmacology and Drug Discovery

Maha Al-Asmakh
Marwa AL Riyami
Miytha Al Marbuii
Shadia Al Sinawi
Suaad Al-Badi
Faisal AL Ismaili
Amira AlKharusi
Razan Zadjali
Zaina Alharthi
Sara Al Mashrafi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706617

1,327 views
1 citation

Opinion

Published on 06 Nov 2025

Glucose may be biotransformed and then react with alcohol, fats, endocannabinoids, or various amino acids to form dopamine or norepinephrine in vivo

in Neuropharmacology

Paul J. Fitzgerald

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715092

7,806 views

Systematic Review

Published on 06 Nov 2025

Clinical benefits and complication profile of IL-23 inhibitors in patients with psoriatic arthritis: a systematic review and meta-analysis

in Inflammation Pharmacology

Jingxin Zeng
Ling Lin
Wei Li
Xinjing Gao
Qian Li
Xin Zhou
Weiyu Liu
Xuelian Zhong
Yunqing Yang
Xibao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669786

1,984 views

Review

Published on 06 Nov 2025

The therapeutic potential of phytochemicals in morphine tolerance: targeting microglia-mediated neuroinflammation

in Ethnopharmacology

Ruizhen Shi
Tingting Jin
Weilong Xu
Yongxin Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669257

1,222 views

Mini Review

Published on 06 Nov 2025

Post-traumatic epilepsy: bridging pathogenesis, diagnosis, and pharmacotherapeutic strategies

in Neuropharmacology

Xiaoyu Yang
Siyang Chen
Haozhou Wang
Tong Sun
Ke Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697391

7,506 views

Original Research

Published on 06 Nov 2025

Prediction and quality evaluation of quality markers of Gentiana scabra Bunge. in treatment of liver injury

in Ethnopharmacology

Jiayi Liu
Xuelin Yu
Jiayi Luo
Dan Wang
Haibo Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679981

933 views

Review

Accepted on 05 Nov 2025

Medication Adherence in Burn Care: A Systematic Analysis of Barriers and Interventions Using the WHO Framework

in Drugs Outcomes Research and Policies

Jiaqi Lou
Ziyi Xiang
Xiaoyu Zhu
Jiliang Li
Guoying Jin
Shengyong Cui
Neng Huang
Xin Le
Youfen Fan
Qionghui Sun

Frontiers in Pharmacology

206 views

Original Research

Published on 05 Nov 2025

HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway

in Experimental Pharmacology and Drug Discovery

Chelimuge Gong
Dalintai Wang
Qingshan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683575

1,533 views

Original Research

Published on 05 Nov 2025

Effects of plant extracts on patients with heart failure: a network meta-analysis of randomized controlled trials

in Ethnopharmacology

Jieyin Deng
Ye Huang
Dehui Fu
Yi Deng
Ke Yu
Cong Lan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648811

1,975 views

Clinical Trial

Published on 05 Nov 2025

Combination of remazolam and alfentanil on hemodynamics, postoperative cognitive function, and adverse cardiovascular events in elderly patients undergoing laparoscopic cholecystectomy: a randomized controlled trial

in Translational Pharmacology

Chaolei Liu
Jin Li
Junna He
Jingjing Zhang
Lijun Bo
Jiaojiao Yang
Yuan Ma
Jianzhang Qin
Yanjie Yang
Zhangnan Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653593

1,288 views

29,532 articles

articles

Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus

The development and verification of clinical medication pathway for tic disorder in west China

siRNA-mediated therapeutic approaches improve acute kidney injury and limit its worsening

Prophylactic effect of the traditional Chinese medicine formula danxiong granules (TDX105) on hand–foot skin reaction associated with the antitumor targeted drug regorafenib: a randomized, double-blind, placebo-controlled trial

In-depth analysis for TKI-driven real-world management of 201 CML patients using TFR

Association between point mutations of macrolide-resistant Mycoplasma pneumoniae and clinical antibiotic treatment efficacy: a meta-analysis

Editorial: Bioactive metabolites in traditional medicine: dual pathways to metabolic health

Commentary: Iridoids derived from Valeriana jatamansi jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway

Development of a venous thromboembolism risk prediction model for patients with primary membranous nephropathy based on machine learning

Potential of herbal formulas and bioactive metabolites in treating atherosclerosis: targeted modulation of macrophage polarization

Ocular toxicity events of cyclin-dependent kinase 4/6 inhibitors in breast cancer: a pharmacovigilance study based on the faers database

Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models

Efficacy analysis of remifentanil mild sedation anesthesia for painless gastroscopy

Low-dose methotrexate adverse reaction risk in renal impairment: pharmacovigilance and physiological pharmacokinetic model assessment

Trehalose alleviates nephropathy in focal segmental glomerulosclerosis via the upregulation of the WT-1/EZH2 pathway

Glucose may be biotransformed and then react with alcohol, fats, endocannabinoids, or various amino acids to form dopamine or norepinephrine in vivo

Clinical benefits and complication profile of IL-23 inhibitors in patients with psoriatic arthritis: a systematic review and meta-analysis

The therapeutic potential of phytochemicals in morphine tolerance: targeting microglia-mediated neuroinflammation

Post-traumatic epilepsy: bridging pathogenesis, diagnosis, and pharmacotherapeutic strategies

Prediction and quality evaluation of quality markers of Gentiana scabra Bunge. in treatment of liver injury

Medication Adherence in Burn Care: A Systematic Analysis of Barriers and Interventions Using the WHO Framework

HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway

Effects of plant extracts on patients with heart failure: a network meta-analysis of randomized controlled trials

Combination of remazolam and alfentanil on hemodynamics, postoperative cognitive function, and adverse cardiovascular events in elderly patients undergoing laparoscopic cholecystectomy: a randomized controlled trial