Frontiers in Pharmacology

Original Research

Published on 05 Nov 2025

Effect of recombinant human erythropoietin on postoperative anemia in children and adolescents undergoing osteosarcoma and potential influencing factors: a single-center retrospective study

in Translational Pharmacology

Lulu Liu
Meili Lin
Wenjun Yang
Difei Yao
Huan Luo
Lingyan Yu
Haibin Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637441

1,125 views

Perspective

Published on 05 Nov 2025

Not quite a cure yet: unlocking the unfulfilled promise of live biotherapeutics for disease treatment

in Gastrointestinal and Hepatic Pharmacology

Andrea Verdugo-Meza
Han M. Chiang
Emeran A. Mayer
Deanna L. Gibson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695976

1,894 views
1 citation

Case Report

Published on 05 Nov 2025

Case Report: HGF and NF1 mutations as putative bypass mechanisms of MET inhibitor resistance in hepatocellular carcinoma: a case study

in Pharmacology of Anti-Cancer Drugs

Zhitao Chen
Shan Luo
Yangjun Gu
Qiyong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659463

1,297 views

Original Research

Published on 05 Nov 2025

SUMOylation involved in malignant progression of multiple tumors and SENP5 may improve the chemotherapy sensitivity of hypoxic tumors

in Pharmacology of Anti-Cancer Drugs

Chunyan Zhang
Bing Han
Yanxia Li
Yuxiang Wang
Min Liu
Zhongmin Jiang
Wenhan Wu
Xiaozhi Liu
Yafei Liu
Mingyong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648271

1,243 views

Review

Published on 05 Nov 2025

Mylabris: a review of its biological characteristics, chemical composition, pharmacological, toxicology, pharmacokinetics, and marketed drugs

in Ethnopharmacology

Qingqing Cai
Jing Yan
Xinghong Li
Lihua He
Shan Xie
Yaxin Yang
Hongwei Wu
Fangbo Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652857

1,728 views

Review

Published on 05 Nov 2025

Recent advances in Bletilla striata polysaccharide research: extraction methodologies, structural elucidation, pharmacological mechanisms, structure–activity relationships, and therapeutic delivery applications

in Ethnopharmacology

Bo Wang
Chaomeng Wu
Yingjuan Ma
Xiaofen Liu
Lijun Tao
Xuebing Zhou
Limin Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688676

2,271 views

Original Research

Published on 04 Nov 2025

Oral administration of the probiotic strain Lactobacillus helveticus BGRA43 reduces high-fat diet–induced hepatic steatosis in mice and restores gut microbiota composition

in Gastrointestinal and Hepatic Pharmacology

Ana Teofilović
Miloš Vratarić
Biljana Bursać
Ljupka Gligorovska
Danijela Vojnović Milutinović
Nemanja Stanisavljević
Ivana Strahinić
Danijela Mišić
Filip Nikolić
Bojan Pavlović

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688777

1,630 views

Systematic Review

Published on 04 Nov 2025

Comparative efficacy of commercial Chinese polyherbal preparation for coronary microvascular dysfunction: a systematic review and network meta-analysis of randomized controlled trials

in Ethnopharmacology

Wujiao Wang
Jun Zhang
Xinyue Wang
Yuxuan Li
Yudou Li
Fenglan Pu
Zhifei Yang
Jie Wan
Haiyan Zhu
Tianli Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642864

2,064 views

Case Report

Published on 04 Nov 2025

Case Report: Carbonic anhydrase inhibitor brinzolamide dramatically improved the morphology and also function of a patient with RS1 mutation

in Neuropharmacology

Yue Ren
Shu Liu
Jia Rong
Di Wang
Miao Diao
Yaqi Zhang
Shimiao Tian
Mingxin Shang
Chuqiao Song
Yan Guan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706488

4,264 views

Original Research

Published on 03 Nov 2025

Multi-omics analysis elucidates the therapeutic mechanisms of the Quzhi formula in metabolic dysfunction-associated steatohepatitis targeting gut microbiota, lipid metabolism, and the role of its metabolite fraxin

in Ethnopharmacology

Jiao-Xiang Wu
Yue-Lan Wu
Mei-Fang Li
Nian Liu
Ying Liu
Yan-Ping Huang
Yuan Gan
Xiao-Yu Wang
Hai-Sheng Chai
Jin Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694242

1,467 views

Original Research

Published on 03 Nov 2025

Characterization of Androctonus mauritanicus venom and in vitro screening of SARS-CoV-2 entry inhibitors candidates

in Experimental Pharmacology and Drug Discovery

Reda Chahir
Jacob Galan
Hicham Hboub
Ahmed Salim Lahlou
Salma Chakir
Hinde Aassila
Reda Ben Mrid
Najat Bouchmaa
Reto Stöcklin
Rachid El Fatimy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678606

2,528 views

Original Research

Published on 03 Nov 2025

Propranolol (1 mg/kg/day) with intralesional bleomycin versus propranolol monotherapy for infantile hemangioma: a randomized controlled trial

in Obstetric and Pediatric Pharmacology

Yanyan Guo
Xinxian Liu
Sicheng He
Bin Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710517

1,031 views

Original Research

Published on 03 Nov 2025

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

in Predictive Toxicology

Kristina Jochum
Veronika Städele
Philip Marx-Stoelting

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690384

1,258 views

Original Research

Published on 03 Nov 2025

Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis

in Neuropharmacology

Maha Abdulrahman Aldubayan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706224

4,931 views
2 citations

Original Research

Published on 03 Nov 2025

Crosstalk between MSC-extracellular vesicles and Olea europaea leaf extract in encapsulated liposomal hydrogel: attenuation of neuroinflammation and brain neurotransmitter and memory impairment associated with obesity-induced high-fat diet

in Ethnopharmacology

Doaa Ibrahim
Ioan Pet
Hoda S. Sherkawy
Haitham Eldoumani
Ola M. Fathy
Aya Elgamal
Heba S. A. Gharib
Asmaa A. Muhammed
Aya Sh. Metwally
Mirela Ahmadi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621092

1,713 views

Original Research

Published on 03 Nov 2025

Medical dispensation in La Rioja, Spain: epidemiology and its relationship with social determinants: a descriptive study

in Pharmacoepidemiology

Gonzalo Aparicio-Rodríguez
Raúl Juárez-Vela
Amaya Burgos-Esteban
Consuelo Sancho-Sánchez
José Ángel Santos-Sanchez
Noelia Navas-Echazarreta
Ana Cobos-Rincón
Antonio Cardoso-Muñoz
Regina Ruiz de Viñaspre-Hernández
Ignacio M. Larrayoz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667148

1,617 views

Review

Published on 03 Nov 2025

Integrated toxicology of Aconitum carmichaelii Debx.: bridging traditional toxicity-efficacy understanding and modern toxicology

in Ethnopharmacology

Xin-Yu Li
Li Zhou
Zhen-Hong Jiang
Yong Liang
Ya-Guo Fan
Zhao-Hui Ding
Hao Chen
Wen-Jun Liu
Xiang Zhou
Huan-Hua Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667059

2,386 views
1 citation

Original Research

Published on 03 Nov 2025

The potential value of the use of berberine in depression: a systematic review and meta-analysis of preclinical studies

in Ethnopharmacology

Bifang Yao
Zhengxiang Long
Xiaojiao Lin
Guangqiang Chen
Xiaoyu Li
Ziqi Ye
Jiahong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664784

1,931 views
1 citation

Original Research

Published on 03 Nov 2025

Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy

in Translational Pharmacology

Andrew Gregory
Ahmed M. Awad
Shaimaa Eltanani
Thangal Yumnamcha
Jenna Hart
Rao Me
Xihui Lin
Mohamed Shawky
Ahmed S. Ibrahim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660067

2,569 views

Review

Accepted on 31 Oct 2025

Olanzapine and Peripheral Metabolic Dysregulation: Organ-Resolved Mechanisms, Risk, and MASLD-Aligned Care Pathways

in Gastrointestinal and Hepatic Pharmacology

Shuwei Weng
Jinxiu Lin
Dajun Chai

Frontiers in Pharmacology

285 views

Original Research

Published on 31 Oct 2025

Total alkaloids from Coptis chinensis Franch ameliorate hyperlipidemia and hepatic steatosis via dual pathway modulation of AMPK/SREBP-1c and PPARα/LXRα in mice

in Ethnopharmacology

Xiangyang Li
Xiaomin Zhang
Nina Wei
Haibo Peng
Xianli Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662325

1,468 views

Original Research

Published on 31 Oct 2025

Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

in Renal Pharmacology

Weili Liao
Rui Fan
Yuman Du
Hairong Wang
Yong Yang
Yuan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648623

2,473 views

Original Research

Published on 31 Oct 2025

Perceptions and attitudes toward clinical trial participation: a study on Moringa oleifera Lam. supplementation in adult HIV patients in Kano State, Nigeria

in Ethnopharmacology

Aisha Gambo
Musa Babashani
Nceba Gqaleni
Limakatso Lebina

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676393

1,044 views

Systematic Review

Published on 31 Oct 2025

Efficacy and safety of traditional Chinese medicine (TCM) combined with immune checkpoint inhibitors (ICIs) for the treatment of cancer: a systematic review and meta-analysis

in Ethnopharmacology

Yani Ke
Yuyan Pan
Xueru Huang
Xing Bai
Xiaojuan Liu
Mingsi Zhang
Yunhai Wei
Tao Jiang
Guangji Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661503

2,553 views
2 citations

29,532 articles

articles

Effect of recombinant human erythropoietin on postoperative anemia in children and adolescents undergoing osteosarcoma and potential influencing factors: a single-center retrospective study

Not quite a cure yet: unlocking the unfulfilled promise of live biotherapeutics for disease treatment

Case Report: HGF and NF1 mutations as putative bypass mechanisms of MET inhibitor resistance in hepatocellular carcinoma: a case study

SUMOylation involved in malignant progression of multiple tumors and SENP5 may improve the chemotherapy sensitivity of hypoxic tumors

Mylabris: a review of its biological characteristics, chemical composition, pharmacological, toxicology, pharmacokinetics, and marketed drugs

Recent advances in Bletilla striata polysaccharide research: extraction methodologies, structural elucidation, pharmacological mechanisms, structure–activity relationships, and therapeutic delivery applications

Oral administration of the probiotic strain Lactobacillus helveticus BGRA43 reduces high-fat diet–induced hepatic steatosis in mice and restores gut microbiota composition

Comparative efficacy of commercial Chinese polyherbal preparation for coronary microvascular dysfunction: a systematic review and network meta-analysis of randomized controlled trials

Case Report: Carbonic anhydrase inhibitor brinzolamide dramatically improved the morphology and also function of a patient with RS1 mutation

Multi-omics analysis elucidates the therapeutic mechanisms of the Quzhi formula in metabolic dysfunction-associated steatohepatitis targeting gut microbiota, lipid metabolism, and the role of its metabolite fraxin

Characterization of Androctonus mauritanicus venom and in vitro screening of SARS-CoV-2 entry inhibitors candidates

Propranolol (1 mg/kg/day) with intralesional bleomycin versus propranolol monotherapy for infantile hemangioma: a randomized controlled trial

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis

Crosstalk between MSC-extracellular vesicles and Olea europaea leaf extract in encapsulated liposomal hydrogel: attenuation of neuroinflammation and brain neurotransmitter and memory impairment associated with obesity-induced high-fat diet

Medical dispensation in La Rioja, Spain: epidemiology and its relationship with social determinants: a descriptive study

Integrated toxicology of Aconitum carmichaelii Debx.: bridging traditional toxicity-efficacy understanding and modern toxicology

The potential value of the use of berberine in depression: a systematic review and meta-analysis of preclinical studies

Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy

Olanzapine and Peripheral Metabolic Dysregulation: Organ-Resolved Mechanisms, Risk, and MASLD-Aligned Care Pathways

Total alkaloids from Coptis chinensis Franch ameliorate hyperlipidemia and hepatic steatosis via dual pathway modulation of AMPK/SREBP-1c and PPARα/LXRα in mice

Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

Perceptions and attitudes toward clinical trial participation: a study on Moringa oleifera Lam. supplementation in adult HIV patients in Kano State, Nigeria

Efficacy and safety of traditional Chinese medicine (TCM) combined with immune checkpoint inhibitors (ICIs) for the treatment of cancer: a systematic review and meta-analysis