Frontiers in Pharmacology

Original Research

Published on 31 Oct 2025

Clinical efficacy and safety of tripterygium wilfordii glycosides in the treatment of idiopathic membranous nephropathy: a systematic review and meta-analysis

in Renal Pharmacology

Ying Liu
Keda Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652789

1,346 views

Original Research

Published on 31 Oct 2025

Screening and experimental validation of modified Gandou Decoction-targeted inhibitors for alleviating AD components via network pharmacology, machine learning, and molecular dynamics simulation

in Experimental Pharmacology and Drug Discovery

Shixin Ye
Shun Zhang
Liangdong Zhang
Guorong Peng
Ming Xie
Xiongfeng Huang
Yousheng Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685866

2,519 views

Original Research

Published on 31 Oct 2025

Agonizing GABABR suppresses GLP-1RA’s chronotropic effect and reduces post-myocardial infarction arrhythmogenesis

in Cardiovascular and Smooth Muscle Pharmacology

Run Qi
Zhang Jingjing
Gu Hongchang
Li Chenyu
Hu He
Li Juan
Zhao Yuqin
Wu Xiaolin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616181

3,271 views
1 citation

Original Research

Published on 31 Oct 2025

Chemosensitizing effect of apigenin on T-ALL cell therapy

in Pharmacology of Anti-Cancer Drugs

Nigar Huseynova
Züleyha Baran
Rovshan Khalilov
Afat Mammadova
Yusuf Baran

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631505

2,108 views

Original Research

Published on 31 Oct 2025

Achyranthes bidentata polysaccharides attenuate hypoxic renal injury by reducing neutrophil extracellular traps and suppressing the NLRP3/ASC/caspase-1 pathway: a preliminary study

in Ethnopharmacology

Kai Li
JingWei Fang
GuangMin Xie
FangNing Wei
JunYing Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606851

1,899 views

Review

Published on 31 Oct 2025

Potential biomarkers in early detection of gastric cancer

in Experimental Pharmacology and Drug Discovery

Supreet Kaur
Ankush Kumar
Rohit Bhatia
Diksha Choudhary
Rajwinder Kaur
Balakumar Chandrasekaran
Wael Abu Dayyih
Majd Nawras Maaita
Wafa Hourani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642927

2,864 views

Original Research

Published on 31 Oct 2025

The RET inhibitor pralsetinib suppresses TMZ-resistant glioma growth by regulating spermine production

in Pharmacology of Anti-Cancer Drugs

Lingyun Ma
Hang Gong
Wei Sun
Jialing Deng
Qinghua Zhang
Jianzhao Niu
Huimin Sun
Xue Han
Tingting Du
Nina Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671798

1,421 views

Case Report

Published on 31 Oct 2025

Case Report: Near-fatal adverse effects of dopamine agonist for the treatment of restless legs syndrome

in Neuropharmacology

Jeremiah B. Joyce
Liliana Patarroyo Rodriquez
Christopher L. Sola

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697935

7,827 views
1 citation

Original Research

Published on 31 Oct 2025

Net health benefit of mavacamten for the treatment of Chinese patients with obstructive hypertrophic cardiomyopathy: a model-based economic evaluation

in Translational Pharmacology

Han Bao
Yu Jia
Xingzhi Wang
Michael Hurst
Zoe Cheah
Melissa Ho
Jianwei Xuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636732

1,629 views

Original Research

Published on 31 Oct 2025

Huashi Runzao decoction for primary Sjögren disease: a double-blind, randomized controlled trial combined with m6A and m5C RNA modification analysis

in Ethnopharmacology

Ziwei Huang
Tiantian Deng
Xiya Zhang
Chunxin Lei
Yan Zhang
Jianying Yang
Qian He
Jiahe Liao
Jiaqi Chen
Liwen Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1618649

1,814 views

Original Research

Published on 30 Oct 2025

Anti-inflammatory effects of Frondanol, a nutraceutical extract from Cucumaria frondosa, via modulation of NF-κB and MAPK pathways in LPS-induced RAW 264.7 cells

in Ethnopharmacology

Hardik Ghelani
Kerat Hanspal
Lana Talo
Sami Talo
Hala Altaher
Hadil Sarsour
Marah Tabbal
Sally Badawi
Peter Collin
Thomas E. Adrian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683630

1,741 views
1 citation

Original Research

Published on 30 Oct 2025

Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarction

in Cardiovascular and Smooth Muscle Pharmacology

Haiping Du
Hui Xu
Jinwei Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693420

1,608 views

Original Research

Published on 30 Oct 2025

Therapeutic efficacy of deslanoside in oleic acid-induced acute lung injury in rabbits: Implications for clinical drug use and pharmacological strategies

in Respiratory Pharmacology

Rong Hu
Yi Zheng
Ning Li
Yong Pan
Xiaozhen Zhou
Lu Liu
Dizheng Liao
Yafei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683838

1,040 views

Original Research

Published on 30 Oct 2025

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

in Pharmacogenetics and Pharmacogenomics

Daniel Hain
Andria L. Del Tredici
Ryan B. Griggs
Rebecca Law
Brent Mabey
Holly L. Johnson
Katherine Johansen Taber
Kevin G. Lynch
Alexander Gutin
David W. Oslin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658616

2,881 views
1 citation

Original Research

Published on 30 Oct 2025

The herbal pharmacopoeia of Ecuador: a national model for integrating traditional knowledge and biodiscovery

in Ethnopharmacology

Susana Llivisaca-Contreras
Jaime Naranjo-Morán
Martín Bastidas-Gálvez
Jairo Jaime-Carvajal
María Muenala-Tituaña
Patricia Manzano-Santana
Adrián Abad-Mihalache
Andrea Abril-Novillo
Juan M. Cevallos-Cevallos
Andrea Orellana-Manzano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662980

2,655 views

Original Research

Published on 30 Oct 2025

Effect of adjuvant treatment with Xiyanping injection on the prognosis of viral encephalitis in children: a multicenter retrospective study

in Ethnopharmacology

Wen Tian
Yang Chen
Huazhang Liu
Danning Wen
Zhe Wang
Ying Li
Li Liu
Xiangna Yang
Xueyan Ma
Yuanyuan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632728

1,414 views

Original Research

Published on 30 Oct 2025

1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing

in Inflammation Pharmacology

Jian Wu
Yifang Sun
Shuyue Wang
Qian Zhang
Ying Lin
Caipeng Liu
Maomao Ai
Feng Yu
Lei Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719897

1,243 views

Systematic Review

Published on 30 Oct 2025

Assessment of the efficacy of Chinese herbal medicine combined with western medicine for treating severe acute pancreatitis-related acute lung injury/acute respiratory distress syndrome: a systematic review and meta-analysis based on randomized controlled trials

in Ethnopharmacology

Xin Han
Ming Zhang
Congcong Dou
Lianfeng Shan
Qingqiang Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551652

1,942 views

Brief Research Report

Published on 30 Oct 2025

Impact on health outcomes and productive work of adding anti-PD-1 agents to treat early-stage cancers in the United Kingdom: a modelling study

in Drugs Outcomes Research and Policies

Hannah Burton
Yan Zhi Tan
Sam Greenall
Catarina Neves
Neil Macdonald
Raquel Aguiar-Ibáñez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613120

1,551 views
1 citation

Editorial

Published on 30 Oct 2025

Editorial: Emerging trends in the quality check of herbal medicines, supplements, and “botanicals”

in Ethnopharmacology

Niccolò Pilla
Daniel Dias Rufino Arcanjo
Massimo Lucarini
Alessandra Durazzo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715714

1,200 views

Original Research

Published on 30 Oct 2025

Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulation

in Ethnopharmacology

Bo-Ram Lee
No Soo Kim
Ui-Jin Bae
Yujin Choi
Changsop Yang
Mi Young Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565592

1,990 views

Review

Published on 30 Oct 2025

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

in Pharmacogenetics and Pharmacogenomics

Haikuan Yu
Taojin Feng
Chengcheng Zhang
Zhouguang Jiao
Wenkai Fan
Rongxian Jiang
Dewen Kong
Fubing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699296

4,220 views

Systematic Review

Published on 30 Oct 2025

Pharmacological insights into Arthrospira platensis (Oscillatoriaceae): Ethnopharmacology, mechanisms, and therapeutic potential in smooth muscle disorders

in Ethnopharmacology

Anderson Fellyp Avelino Diniz
Bárbara Cavalcanti Barros
João Marcos Araújo da Silva
Ray Ravilly Alves Arruda
Brena Freire de Oliveira Claudino
Michel Benício de Melo
José Edvaldo Cavalcanti de Sousa Filho
Francisco Fernandes Lacerda Júnior
Maxsyara Felismino da Silva Soares
Thais Rosa de Sousa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653808

1,362 views

Systematic Review

Published on 29 Oct 2025

Comparative safety and tolerability of ketamine and esketamine for major depressive disorder: a systematic review and meta-analysis

in Neuropharmacology

Haoning Guo
Liling Tang
Miaoquan He
Wencheng Tang
Jing Liu
Silin Wu
Shuying Yuan
Jisheng Wang
Xueli Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681060

8,934 views

29,532 articles

articles

Clinical efficacy and safety of tripterygium wilfordii glycosides in the treatment of idiopathic membranous nephropathy: a systematic review and meta-analysis

Screening and experimental validation of modified Gandou Decoction-targeted inhibitors for alleviating AD components via network pharmacology, machine learning, and molecular dynamics simulation

Agonizing GABABR suppresses GLP-1RA’s chronotropic effect and reduces post-myocardial infarction arrhythmogenesis

Chemosensitizing effect of apigenin on T-ALL cell therapy

Achyranthes bidentata polysaccharides attenuate hypoxic renal injury by reducing neutrophil extracellular traps and suppressing the NLRP3/ASC/caspase-1 pathway: a preliminary study

Potential biomarkers in early detection of gastric cancer

The RET inhibitor pralsetinib suppresses TMZ-resistant glioma growth by regulating spermine production

Case Report: Near-fatal adverse effects of dopamine agonist for the treatment of restless legs syndrome

Net health benefit of mavacamten for the treatment of Chinese patients with obstructive hypertrophic cardiomyopathy: a model-based economic evaluation

Huashi Runzao decoction for primary Sjögren disease: a double-blind, randomized controlled trial combined with m6A and m5C RNA modification analysis

Anti-inflammatory effects of Frondanol, a nutraceutical extract from Cucumaria frondosa, via modulation of NF-κB and MAPK pathways in LPS-induced RAW 264.7 cells

Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarction

Therapeutic efficacy of deslanoside in oleic acid-induced acute lung injury in rabbits: Implications for clinical drug use and pharmacological strategies

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

The herbal pharmacopoeia of Ecuador: a national model for integrating traditional knowledge and biodiscovery

Effect of adjuvant treatment with Xiyanping injection on the prognosis of viral encephalitis in children: a multicenter retrospective study

1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing

Assessment of the efficacy of Chinese herbal medicine combined with western medicine for treating severe acute pancreatitis-related acute lung injury/acute respiratory distress syndrome: a systematic review and meta-analysis based on randomized controlled trials

Impact on health outcomes and productive work of adding anti-PD-1 agents to treat early-stage cancers in the United Kingdom: a modelling study

Editorial: Emerging trends in the quality check of herbal medicines, supplements, and “botanicals”

Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulation

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Pharmacological insights into Arthrospira platensis (Oscillatoriaceae): Ethnopharmacology, mechanisms, and therapeutic potential in smooth muscle disorders

Comparative safety and tolerability of ketamine and esketamine for major depressive disorder: a systematic review and meta-analysis