Frontiers in Pharmacology

Original Research

Published on 30 Oct 2025

Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarction

in Cardiovascular and Smooth Muscle Pharmacology

Haiping Du
Hui Xu
Jinwei Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693420

1,612 views

Original Research

Published on 30 Oct 2025

Therapeutic efficacy of deslanoside in oleic acid-induced acute lung injury in rabbits: Implications for clinical drug use and pharmacological strategies

in Respiratory Pharmacology

Rong Hu
Yi Zheng
Ning Li
Yong Pan
Xiaozhen Zhou
Lu Liu
Dizheng Liao
Yafei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683838

1,040 views

Original Research

Published on 30 Oct 2025

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

in Pharmacogenetics and Pharmacogenomics

Daniel Hain
Andria L. Del Tredici
Ryan B. Griggs
Rebecca Law
Brent Mabey
Holly L. Johnson
Katherine Johansen Taber
Kevin G. Lynch
Alexander Gutin
David W. Oslin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658616

2,881 views
1 citation

Original Research

Published on 30 Oct 2025

The herbal pharmacopoeia of Ecuador: a national model for integrating traditional knowledge and biodiscovery

in Ethnopharmacology

Susana Llivisaca-Contreras
Jaime Naranjo-Morán
Martín Bastidas-Gálvez
Jairo Jaime-Carvajal
María Muenala-Tituaña
Patricia Manzano-Santana
Adrián Abad-Mihalache
Andrea Abril-Novillo
Juan M. Cevallos-Cevallos
Andrea Orellana-Manzano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662980

2,655 views

Original Research

Published on 30 Oct 2025

Effect of adjuvant treatment with Xiyanping injection on the prognosis of viral encephalitis in children: a multicenter retrospective study

in Ethnopharmacology

Wen Tian
Yang Chen
Huazhang Liu
Danning Wen
Zhe Wang
Ying Li
Li Liu
Xiangna Yang
Xueyan Ma
Yuanyuan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632728

1,414 views

Systematic Review

Published on 30 Oct 2025

Assessment of the efficacy of Chinese herbal medicine combined with western medicine for treating severe acute pancreatitis-related acute lung injury/acute respiratory distress syndrome: a systematic review and meta-analysis based on randomized controlled trials

in Ethnopharmacology

Xin Han
Ming Zhang
Congcong Dou
Lianfeng Shan
Qingqiang Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551652

1,942 views

Brief Research Report

Published on 30 Oct 2025

Impact on health outcomes and productive work of adding anti-PD-1 agents to treat early-stage cancers in the United Kingdom: a modelling study

in Drugs Outcomes Research and Policies

Hannah Burton
Yan Zhi Tan
Sam Greenall
Catarina Neves
Neil Macdonald
Raquel Aguiar-Ibáñez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613120

1,551 views
1 citation

Editorial

Published on 30 Oct 2025

Editorial: Emerging trends in the quality check of herbal medicines, supplements, and “botanicals”

in Ethnopharmacology

Niccolò Pilla
Daniel Dias Rufino Arcanjo
Massimo Lucarini
Alessandra Durazzo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715714

1,200 views

Original Research

Published on 30 Oct 2025

1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing

in Inflammation Pharmacology

Jian Wu
Yifang Sun
Shuyue Wang
Qian Zhang
Ying Lin
Caipeng Liu
Maomao Ai
Feng Yu
Lei Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719897

1,245 views

Original Research

Published on 30 Oct 2025

Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulation

in Ethnopharmacology

Bo-Ram Lee
No Soo Kim
Ui-Jin Bae
Yujin Choi
Changsop Yang
Mi Young Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565592

1,990 views

Systematic Review

Published on 30 Oct 2025

Pharmacological insights into Arthrospira platensis (Oscillatoriaceae): Ethnopharmacology, mechanisms, and therapeutic potential in smooth muscle disorders

in Ethnopharmacology

Anderson Fellyp Avelino Diniz
Bárbara Cavalcanti Barros
João Marcos Araújo da Silva
Ray Ravilly Alves Arruda
Brena Freire de Oliveira Claudino
Michel Benício de Melo
José Edvaldo Cavalcanti de Sousa Filho
Francisco Fernandes Lacerda Júnior
Maxsyara Felismino da Silva Soares
Thais Rosa de Sousa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653808

1,362 views

Review

Published on 30 Oct 2025

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

in Pharmacogenetics and Pharmacogenomics

Haikuan Yu
Taojin Feng
Chengcheng Zhang
Zhouguang Jiao
Wenkai Fan
Rongxian Jiang
Dewen Kong
Fubing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699296

4,236 views

Systematic Review

Published on 29 Oct 2025

Comparative safety and tolerability of ketamine and esketamine for major depressive disorder: a systematic review and meta-analysis

in Neuropharmacology

Haoning Guo
Liling Tang
Miaoquan He
Wencheng Tang
Jing Liu
Silin Wu
Shuying Yuan
Jisheng Wang
Xueli Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681060

8,934 views

Clinical Trial

Published on 29 Oct 2025

Atorvastatin as an immunomodulatory adjunct in ulcerative colitis, beyond lipid lowering to inflammation control: a randomized controlled pilot study

in Gastrointestinal and Hepatic Pharmacology

Mohannad O. Khrieba
Furqan M. Abdulelah
Nada A. Alsaleh
Hayam Ali AlRasheed
Tarek I. Ahmed
Azza El-Sayed Mansy
Manal A. Hamouda
Eslam Habba
Nora Elshorbagi
Ahmed G. Abd Elhameed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690513

1,853 views

Original Research

Published on 29 Oct 2025

Febuxostat may decrease the incidence of COVID-19 infection among patients with gout: a retrospective cohort study

in Pharmacology of Infectious Diseases

Weijie Wang
Shiow-Ing Wang
Yang Cheng
Xinchang Wang
Yongsheng Fan
James Cheng-Chung Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654173

2,160 views

Original Research

Published on 29 Oct 2025

A galactoarabinan-containing glycoprotein isolated from the fruits of Lycium barbarum reverses the tumor-associated macrophage phenotype

in Pharmacology of Anti-Cancer Drugs

Bo Wang
Bowen Lu
Junqiang Lv
Caixia Dong
Changcai Bai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593407

1,297 views
1 citation

Original Research

Published on 29 Oct 2025

The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation

in Neuropharmacology

Federica Ricciardi
Andrea Maria Morace
Rebecca Limongelli
Monica Iannotta
Serena Boccella
Antimo Fusco
Roozbe Bonsale
Michela Perrone
Rosmara Infantino
Emanuele Di Martino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676421

8,122 views

Review

Published on 29 Oct 2025

Medicinal plants and compounds for chronic bronchitis treatment: efficacy and action mechanisms

in Respiratory Pharmacology

Wei Ding
Danni Chen
Jiawang Li
Yan Wang
Xiangyun Chen
Yihe Xu
Zhen Yang
Zhenhong Liu
Hongxia Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674079

2,670 views

Original Research

Published on 29 Oct 2025

Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR

in Respiratory Pharmacology

Iwona Pranke
Valeria Capurro
Benoit Chevalier
Emanuela Pesce
Valeria Tomati
Cristina Pastorino
Mairead Kelly-Aubert
Aurelie Hatton
Elise Dreano
Mariateresa Lena

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661417

2,580 views

Systematic Review

Published on 29 Oct 2025

Factors affecting the effectiveness and safety of colistin in treating drug-resistant gram-negative bacterial infections: a meta-analysis

in Pharmacology of Infectious Diseases

Pengfei Li
Shiran Li
Jiao Zhang
Siyu Zeng
Zhimin Li
Jinxian Xie
Yong Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625595

1,701 views

Original Research

Published on 29 Oct 2025

Exposure to β-hydroxybutyrate reduces the operating set point and increases excitability in hippocampal circuitry of healthy mice

in Neuropharmacology

Thais Tessari Zampieri
Guilherme Shigueto Vilar Higa
Fernando S. Borges
Felipe José Costa Viana
Emily Cruvinel
Lucas Eduardo Bentivoglio
Ademar Benevolo Lugao
Henning Ulrich
Luiz Roberto Britto
Kattesh V. Katti

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557612

9,022 views

Review

Published on 29 Oct 2025

Eleutherococcus root: a comprehensive review of its phytochemistry and pharmacological potential in the context of its adaptogenic effect

in Ethnopharmacology

Andrzej Patyra
Małgorzata Kołtun-Jasion
Katarzyna Kupniewska
Andrzej Parzonko
Anna Karolina Kiss

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683795

3,007 views

Review

Published on 29 Oct 2025

Mechanistic insights into the antitumor effects of astragaloside IV and astragalus polysaccharide in digestive system cancers

in Pharmacology of Anti-Cancer Drugs

Zhenhua Cui
Qingxin Shang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691011

2,285 views
3 citations

Original Research

Published on 29 Oct 2025

CEST MRI detects antiretroviral drug toxicities in the developing mouse brain

in Predictive Toxicology

Micah Summerlin
Mariano G. Uberti
Dhananjay Shinde
Emma G. Foster
Brady Sillman
Manjeet Kumar
Baojin Yao
Dongming Peng
Benson J. Edagwa
Howard E. Gendelman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681094

1,421 views

29,545 articles

articles

Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarction

Therapeutic efficacy of deslanoside in oleic acid-induced acute lung injury in rabbits: Implications for clinical drug use and pharmacological strategies

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

The herbal pharmacopoeia of Ecuador: a national model for integrating traditional knowledge and biodiscovery

Effect of adjuvant treatment with Xiyanping injection on the prognosis of viral encephalitis in children: a multicenter retrospective study

Assessment of the efficacy of Chinese herbal medicine combined with western medicine for treating severe acute pancreatitis-related acute lung injury/acute respiratory distress syndrome: a systematic review and meta-analysis based on randomized controlled trials

Impact on health outcomes and productive work of adding anti-PD-1 agents to treat early-stage cancers in the United Kingdom: a modelling study

Editorial: Emerging trends in the quality check of herbal medicines, supplements, and “botanicals”

1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing

Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulation

Pharmacological insights into Arthrospira platensis (Oscillatoriaceae): Ethnopharmacology, mechanisms, and therapeutic potential in smooth muscle disorders

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Comparative safety and tolerability of ketamine and esketamine for major depressive disorder: a systematic review and meta-analysis

Atorvastatin as an immunomodulatory adjunct in ulcerative colitis, beyond lipid lowering to inflammation control: a randomized controlled pilot study

Febuxostat may decrease the incidence of COVID-19 infection among patients with gout: a retrospective cohort study

A galactoarabinan-containing glycoprotein isolated from the fruits of Lycium barbarum reverses the tumor-associated macrophage phenotype

The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation

Medicinal plants and compounds for chronic bronchitis treatment: efficacy and action mechanisms

Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR

Factors affecting the effectiveness and safety of colistin in treating drug-resistant gram-negative bacterial infections: a meta-analysis

Exposure to β-hydroxybutyrate reduces the operating set point and increases excitability in hippocampal circuitry of healthy mice

Eleutherococcus root: a comprehensive review of its phytochemistry and pharmacological potential in the context of its adaptogenic effect

Mechanistic insights into the antitumor effects of astragaloside IV and astragalus polysaccharide in digestive system cancers

CEST MRI detects antiretroviral drug toxicities in the developing mouse brain