Frontiers in Pharmacology

Systematic Review

Published on 29 Oct 2025

Evaluating dexmedetomidine in mitigating emergence agitation and perioperative complications in pediatric tonsillectomy and/or adenoidectomy: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jihong He
Xianghong Lian
Ting Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681936

1,289 views

Original Research

Published on 29 Oct 2025

CEST MRI detects antiretroviral drug toxicities in the developing mouse brain

in Predictive Toxicology

Micah Summerlin
Mariano G. Uberti
Dhananjay Shinde
Emma G. Foster
Brady Sillman
Manjeet Kumar
Baojin Yao
Dongming Peng
Benson J. Edagwa
Howard E. Gendelman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681094

1,421 views

Original Research

Published on 28 Oct 2025

Parishin E from ginger-processed Gastrodia elata Bl. alleviates rheumatoid arthritis by regulating histone 3 lactylation at H3K18la and H3K27la sites

in Ethnopharmacology

Xinyue Liu
Yijing Pan
Chenxi Deng
Meiliang Zhu
Dongmei Guo
Jiaqin Wu
Fan Feng
Lianhong Pan
Chunli Wang
Kang Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682504

2,688 views
1 citation

Review

Published on 28 Oct 2025

Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer’s disease therapy

in Pharmacology of Ion Channels and Channelopathies

Christophe Porcher
Claudio Rivera
Igor Medina
Lejla Koric

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675799

1,868 views
1 citation

Perspective

Published on 28 Oct 2025

Advances in clinical application on nursing intervention for ribavirin-associated adverse events

in Drugs Outcomes Research and Policies

Li-Li Jiang
Qing Wang
Jia-Xin Zhang
Jing-Hui Fan
Jing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596007

1,232 views

Original Research

Published on 28 Oct 2025

The involvement of GABA-rho receptors in regulating ethanol-induced elevation of dopamine, glycine and taurine within the nucleus accumbens of Wistar rats

in Neuropharmacology

Davide Cadeddu
Anna Loftén
Karin Ademar
Bo Söderpalm
Louise Adermark
Mia Ericson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1668669

8,341 views

Original Research

Published on 28 Oct 2025

Regulation of inflammatory pathways by cannabigerol in the collagen induced arthritis model in rats

in Inflammation Pharmacology

Monika Šteigerová
Michaela Sklenárová
Mykhaylo Bazyuk
Luděk Záveský
Petr Jelínek
Mahak Arora
Daniel Stránský
Tomáš Kučera
Bruno Sepodes
Miroslav Šoóš

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705962

1,992 views

Mini Review

Published on 28 Oct 2025

PLGA-based nanoparticles in colorectal cancer immunotherapy: current concepts and future perspectives

in Pharmacology of Anti-Cancer Drugs

Yuhan Wang
Peng Huang
Chun Li
Shengjin Tu
Hua Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714460

2,155 views

Original Research

Published on 28 Oct 2025

Serum amyloid A-mediated neuro-inflammation induces hippocampal neuron apoptosis and postoperative cognitive dysfunction in mice

in Neuropharmacology

Xiaochen Fu
Zhenbin Cai
Yuxuan Wu
Yiwen Xu
Ze Gao
Minghui Tan
Jing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661881

7,348 views

Systematic Review

Published on 28 Oct 2025

The impact of proton pump inhibitor exposure on pneumonia: an updated meta-analysis based on randomized controlled trials

in Gastrointestinal and Hepatic Pharmacology

Zhujun Wu
Yixuan Wu
Zhiyi Xiang
Yi Qiu
Wangyi Xuan
Shengying Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713256

1,762 views

Systematic Review

Published on 28 Oct 2025

Oral commercial Chinese polyherbal preparations combined with conventional biomedicine for pulmonary tuberculosis: network meta-analysis

in Ethnopharmacology

Jiankang Jiang
Siqi Zhang
Hui Wang
Lu Zhang
Zegeng Li
Jiabing Tong
Fan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588586

1,678 views

Review

Published on 28 Oct 2025

Traditional Chinese medicines alleviate experimental chronic cerebral hypoperfusion injury through multi-components and multi-target mechanisms

in Ethnopharmacology

Xiao-Ting Ma
Bing-Yu Lou
Jie Liu
Bo Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698436

2,407 views

Review

Published on 28 Oct 2025

The efficacy and safety of tislelizumab in the treatment of locally advanced or metastatic lung cancer: a systematic review and meta-analysis

in Pharmacology of Anti-Cancer Drugs

Yue Zhou
Sanmao Liu
Shaochu Zheng
Jiahui Han
Haizhu Huang
Jinliang Kong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671018

1,530 views

Clinical Trial

Published on 27 Oct 2025

Determination of the effective dose of oliceridine combined with propofol using the modified Dixon’s up-and-down method in painless gastroscopy

in Gastrointestinal and Hepatic Pharmacology

Jinfeng Cao
Xiaoyu Gu
Xinyang Zhang
Yao Cheng
Liuqin Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620158

1,426 views

Mini Review

Published on 27 Oct 2025

Protective effects of medicinal plant-derived metabolites in cardiovascular disease targeting exosomal pathways

in Ethnopharmacology

Liwen Fu
Jiaxiu Han
Rong Lu
Aifeng Song
Ao Shen
Changjiang Xiong
Yanzhu Liu
Zu Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681625

1,576 views

Original Research

Published on 27 Oct 2025

Effects of different opioids on the contractile tension of isolated rat intestinal smooth muscle

in Gastrointestinal and Hepatic Pharmacology

Chen Yang
Jianying Hu
Yan Cheng
Shen Sun
Shaoqiang Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617936

963 views

Review

Published on 27 Oct 2025

Potential signaling pathways, biomarkers, natural drugs, and chronic myeloid leukemia therapeutics

in Pharmacology of Anti-Cancer Drugs

Sultan Alqahtani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615770

1,831 views

Systematic Review

Published on 27 Oct 2025

Stereotactic body radiotherapy (SBRT) in oligometastatic ovarian cancer (OMOC): a systematic review and meta-analysis of clinical outcomes and toxicity profiles

in Pharmacology of Anti-Cancer Drugs

Mauro Francesco Pio Maiorano
Brigida Anna Maiorano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620922

1,406 views

Original Research

Published on 27 Oct 2025

Treatment of diabetic ulcers with Chuang Ling Ye: systems pharmacology and functional validation reveal the mechanism of angiogenesis and inflammation abatement driven by the PI3K-AKT signaling pathway

in Ethnopharmacology

Xiao Feng
Nan Yi
Ya Zhao
Cunyu Zhang
Yue Chen
Qian Wang
Xindong Yin
Yuanzi Zhou
Ying Liu
Chao Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644541

1,189 views

Review

Published on 27 Oct 2025

Molecular docking and dynamics in protein serine/threonine kinase drug discovery: advances, challenges, and future perspectives

in Experimental Pharmacology and Drug Discovery

Gulam Mustafa Hasan
Taj Mohammad
Sobia Zaidi
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1696204

2,758 views
1 citation

Original Research

Published on 27 Oct 2025

Association between immune check point inhibitors and digestive system inflammatory adverse reactions: evidence from pharmacovigilance analysis and systematic review

in Drugs Outcomes Research and Policies

Ya Zou
Qinchuan Li
Lu Zhou
Yun Lu
Hua Wei
Yan Zhou
Shibo Lin
Xirui Guo
Shihao Yan
Hongju Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684475

1,888 views

Original Research

Published on 27 Oct 2025

Proanthocyanidins from Ginkgo biloba extract EGb 761® exert antioxidative activity in vitro and antiamnesic activity in vivo

in Ethnopharmacology

Carla Sens-Albert
Markus Schmitt
Gabriele Luderer
Beatrix C. König
Silas F. Melcher
Heike Schneider
Simone Kaiser
Sabine Tremmel
Sabrina Weisenburger
Žarko Kulić

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673248

2,393 views

Original Research

Published on 27 Oct 2025

Study on Chaiyuwendan decoction’s inhibition of hippocampal neuron apoptosis to alleviating depression by activating the AKT/CREB pathway

in Neuropharmacology

Shaoliang Zhang
Sijie Cheng
Huiqing Liang
Yan Qiu
Jie Ren
Yv Huang
Bangyan Zhou
Chunrong Li
Jingmin Zhang
Tianxiang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610899

7,253 views

Systematic Review

Published on 27 Oct 2025

Comparison of multiple doses of corticosteroids in Kawasaki disease: a Bayesian network analysis

in Inflammation Pharmacology

Xuan Li
Xuan Tang
Daoping Yang
Miao Hou
Qiuqin Xu
Yunjia Tang
Bo Wang
Hongbiao Huang
Ye Chen
Zhiheng Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661380

2,397 views