Frontiers in Pharmacology

Original Research

Published on 19 Dec 2025

Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia

in Integrative and Regenerative Pharmacology

Patrícia Terra Alves
Sayone Andrade de Moura
Helen Taylor
Antonella Fidanza
Cristiane Damas Gil
Leonardo Martin
Aléx Martins Nasare
André van Helvoort Lengert
Bianca Bonetto Moreno Garcia
Gabriel Cicolin Guarache

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698623

625 views

Mini Review

Published on 19 Dec 2025

Abhraka Bhasma (mica based nanomedicine): an ayurvedic herbomineral perspective in breast cancer management

in Ethnopharmacology

Dhanya Soman Pillai
Amarnath Karavettekudy Ranjit

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656846

689 views

Case Report

Published on 19 Dec 2025

Case Report: Tislelizumab–induced panuveitis: a report of two cases

in Pharmacology of Anti-Cancer Drugs

Huan Ding
Shuyuan Zhang
Lin Lin
Kaiyan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678663

720 views

Systematic Review

Published on 19 Dec 2025

Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

in Drugs Outcomes Research and Policies

Marta Mazur
Artnora Ndokaj
Claudia Salerno
Jessica Vallone
Roman Ardan
Sabina Bietolini
Florence Carrouel
Aleksandra Wilk
Rachel Sarig
Livia Ottolenghi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602976

2,245 views

Mini Review

Published on 19 Dec 2025

Transcriptional rewiring in cancer driven by POLR2A/RPB1: mechanistic insights, non-coding RNA crosstalk, and therapeutic opportunities

in Pharmacogenetics and Pharmacogenomics

Adrian Szczepaniak
Kinga Jaskuła
Marta Zielińska
Jakub Godlewski

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1745087

609 views

Systematic Review

Published on 19 Dec 2025

Efficacy and safety of later-line targeted therapies in advanced non-small cell lung cancer with EGFR exon 20 insertion mutations: a systematic review

in Pharmacology of Anti-Cancer Drugs

Qiang Wen
Yue Zhuang
Silv Fu
Chunguo Pan
Zhihua Liu
Lei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707050

1,222 views

Original Research

Accepted on 18 Dec 2025

Integrative Multi-Omics and Experimental Analyses Implicate PTK2 as a Lorazepam-Associated Biomarker and Potential Therapeutic Target in Ovarian Cancer

in Experimental Pharmacology and Drug Discovery

Xia Hong
Xingjun He
Suli He

Frontiers in Pharmacology

253 views

Original Research

Accepted on 18 Dec 2025

Piperine Encapsulated in Solid Lipid Nanoparticles: A Promising Nano-Phytomedicine Approach for Non-Alcoholic Fatty Liver Disease Treatment

in Experimental Pharmacology and Drug Discovery

Afrasim Moin
Shwetha Ram
Sateesha SB
Talib Hussain
Amr Selim Abu Lila
Rajamma AJ
Syed Mohd Danish Rizvi
Sirajudheen Anwar
Chandan K

Frontiers in Pharmacology

259 views

Original Research

Accepted on 18 Dec 2025

Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic LTP in a mouse model of Fragile X Syndrome

in Neuropharmacology

Max A Wilson
Anna Sumera
Emre Berk
Sam A Booker

Frontiers in Pharmacology

110 views

Original Research

Accepted on 18 Dec 2025

Pharmacological Activation of SIRT1-AMPK by Ginsenoside Rb1: A Novel Therapeutic Strategy for Pressure Injury via Dual Suppression of Ferroptosis and Inflammation

in Integrative and Regenerative Pharmacology

Hongbo Zhu
Hang Li
Yinong Shi
Hua Zhi
Xuelu Zhao
Zhiwen Wang
Jinhui Liu

Frontiers in Pharmacology

157 views

Review

Accepted on 18 Dec 2025

Plant Polysaccharides in Neuroprotection: Mechanistic Insights Across Central Nervous System Disorders.

in Ethnopharmacology

Qiyue Yu
Hui Chen
Zhuofeng Qu
Jialin Qu
Yan Wang
Lina Liang
Shouyu Hu

Frontiers in Pharmacology

Original Research

Accepted on 18 Dec 2025

PTX-Loaded, Polysorbate 80-Functionalized Brain-Targeting Pullulan Nanoparticles for Drug Delivery

in Translational Pharmacology

Huabing Yuan
Lu Han
Hao Deng
Yue Tan
Yi Yang
Yi Liu
Jiaxin Ying
Mengqi Fang
Hui Wei
Zhihe Tao

Frontiers in Pharmacology

163 views

Review

Accepted on 18 Dec 2025

The Role of Probiotics in Modulation of the Gut-Brain Axis: A Prospective Therapy for Depression and Mood Disorders

in Neuropharmacology

Hui Wang
Yining Chen
Allen Zhao
Zhongxia Shen
Yu Zhang

Frontiers in Pharmacology

215 views

Original Research

Accepted on 18 Dec 2025

Hypericin Alleviates Cerebral Ischemia/Reperfusion Injury by Modulating Endoplasmic Reticulum Stress

in Experimental Pharmacology and Drug Discovery

Tingting Li
Chao Wang

Frontiers in Pharmacology

122 views

Original Research

Accepted on 18 Dec 2025

Anwuligan promote the Transition of Hair Follicle Cycle via Wnt/β-catenin signaling pathway

in Experimental Pharmacology and Drug Discovery

Fang Li
Leyao Zhang
Yan Li
Xiang Zheng

Frontiers in Pharmacology

114 views

Original Research

Published on 18 Dec 2025

Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology

in Pharmacology of Infectious Diseases

Hanem F. El-Gendy
Shimaa R. Masoud
Nagwa I. Sheraiba
Shimaa S. Elnahriry
Doaa A. Madkour
Reda M. S. Korany
Hazim O. Khalifa
Hanaa Y. Elnagar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679854

554 views

Original Research

Published on 18 Dec 2025

Impact of postoperative flurbiprofen axetil on renal function in spontaneously hypertensive rats

in Renal Pharmacology

Liang Sun
Xiaoran Ma
Yuhui Jiang
Wanda Zhang
Yi Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686334

514 views

Original Research

Published on 18 Dec 2025

Exploring medication adherence in racial/ethnic minorities

in Drugs Outcomes Research and Policies

Joronia Chery
Lisa Gualtieri
Ian Lee
Grace Sheng
Meera Singhal
Sebastian Z. Ramos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670633

433 views

Original Research

Published on 18 Dec 2025

Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations

in Pharmacology of Anti-Cancer Drugs

Jia Xu
Liang Qin
Xiao Liang
Lulu Chen
Juexin Wang
Hua Guo
Fengmei Wang
Ran Wu
Xiaojing An
Wenjuan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627864

388 views

Editorial

Published on 18 Dec 2025

Editorial: Non-coding RNAs as potential therapeutics and biomarkers for human diseases

in Experimental Pharmacology and Drug Discovery

Margarida Gama-Carvalho
Alice Conigliaro
Chiara De Santi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1753536

534 views

Review

Published on 18 Dec 2025

Systemic metabolic reprogramming and microbial dysbiosis in Fabry disease: Multi-omics mechanisms and implications for drug development

in Experimental Pharmacology and Drug Discovery

Nuria Gómez-Cebrián
María Chovi Trull
Elena Gras-Colomer
María Dolores Edo Solsona
José Luis Poveda Andrés
Leonor Puchades-Carrasco

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702682

728 views

Original Research

Published on 18 Dec 2025

The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids

in Predictive Toxicology

Rocío Rivera Rodríguez
Siri Sæterstad
Ann-Therese Chattergoon Ali
Linn-Karina M. Selvik
Ingunn Bakke
Torunn Bruland
Jeremy J. Johnson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1696576

451 views

Systematic Review

Published on 18 Dec 2025

Synergistic antitumor effects of astragalus polysaccharide: a preclinical systematic review and meta-analysis

in Ethnopharmacology

Ruo Zhang
Qian Yang
Zhi Chen
Jianming Huang
Guonan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672450

685 views

Original Research

Published on 18 Dec 2025

A warming-yang herbal decoction protects against high-altitude hypoxia–induced osteoblast injury through modulation of HIF-1 signaling

in Ethnopharmacology

Xuehai Liu
Yaqian Qi
Rui Zhao
Binkui Jia
Xilin Lei
Hongfan Li
Di Wang
Haoling Zhang
Wei Wang
Zhijing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673146

417 views