Frontiers in Pharmacology

Review

Published on 27 Oct 2025

The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research

in Respiratory Pharmacology

Mingjun Wu
Qian Yang
Youcheng Xie
Yan Hou
Qingliang Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649570

1,985 views

Original Research

Published on 27 Oct 2025

Risk of post-polypectomy bleeding and thromboembolic events during colonoscopy in patients on continued or interrupted antiplatelet therapy: a pooled analysis

in Cardiovascular and Smooth Muscle Pharmacology

Nan-Nan Shen
Jun-Hong Ma
Hua Qian
Yong-Ping Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660871

1,160 views

Original Research

Published on 27 Oct 2025

Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation

in Neuropharmacology

Dongmei Zhang
Ling Han
Wenmo Zhang
Di Wang
Di Huo
Xingli Tan
Xiaoli Su
Ming Wang
Jing Xu
Jiling Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681929

5,874 views
1 citation

Original Research

Published on 27 Oct 2025

Comparative in vitro susceptibility of clinical Leishmania isolates to miltefosine and oleylphosphocholine

in Pharmacology of Infectious Diseases

Ali Khamesipour
Minoo Tasbihi
Akram Mir Amin Mohammadi
Jodie Dixon
David J. Clark
Henry M. Staines
Sanjeev Krishna
Vanessa Yardley
Simon L. Croft
Neal Alexander

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688856

1,664 views

Opinion

Published on 27 Oct 2025

Drug repurposing of natural depsipeptide from Eleftheria terrae isolated via iChip for anti-breast cancer therapy

in Experimental Pharmacology and Drug Discovery

Nuriyatul Fhatonah
Tedi Rustandi
Usama Ramadan Abdelmohsen
La Ode Akbar Rasydy
Ma’sum
Yomna Elghanam
Imran Pashar
Nordin
Ahmed Mahal
Akhmad Riski

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694322

1,537 views

Review

Published on 27 Oct 2025

Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction

in Drug Metabolism and Transport

Zhimin Li
Yue Wu
Siyu Zeng
Fei Wang
Jiao Zhang
Shiran Li
Yong Yang
Yujie Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694886

2,074 views
1 citation

Correction

Published on 27 Oct 2025

Correction: Astragaloside IV alleviates tacrolimus-induced chronic nephrotoxicity via p62-Keap1-Nrf2 pathway

in Renal Pharmacology

Ping Gao
Xiaoyi Du
Lili Liu
Hua Xu
Maochang Liu
Xinlei Guan
Chengliang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710116

821 views

Original Research

Published on 27 Oct 2025

Synthetic bakuchiol derivatives: ester and ether analogs with activity against clinically important bacteria

in Pharmacology of Infectious Diseases

Francisca Valdés
Evelyn Muñoz
Manuel Martinez
Catalina Ferreira
Valentina Silva
Alejandro Madrid
Katy Díaz
Constanza Villarroel
Iván Montenegro

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1619997

1,366 views

Original Research

Published on 27 Oct 2025

Comparative study between calcium gluconate with diosmin, cabergoline, and cabergoline with diosmin in prevention of ovarian hyperstimulation syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) procedures

in Obstetric and Pediatric Pharmacology

Aya M. Abdallah
Amal K. Hussien
Sumaiah J. Alarfaj
Thanaa A. Elmasry
Marwa Kamal
Hatem Sarhan
Mohammed H. Mosbeh
Eman Mohamed Sadek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655866

1,104 views

Original Research

Published on 24 Oct 2025

Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice

in Ethnopharmacology

Akiko Maruko
Naoki Ito
Kenshiro Oshima
Akinori Nishi
Yoshinori Kobayashi
Norihiro Okada

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600176

1,986 views

Original Research

Published on 24 Oct 2025

Overcoming barriers to off-patent drug repurposing: a lifecycle-based policy solutions

in Drugs Outcomes Research and Policies

Mario Garcia-Diaz
David Epstein
Jaime Espin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670845

1,959 views

Opinion

Published on 24 Oct 2025

Green-synthesized silver nanoparticle hydrogels for biofilm-infected wounds: Bridging sustainability and clinical translation

in Pharmacology of Infectious Diseases

M. Rifqi Fadillah Muslim
Lutfi Chabib
Betty Ekawati Suryaningsih
Farida Hayati
Viviane Annisa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694144

1,657 views
3 citations

Original Research

Published on 24 Oct 2025

Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis

in Neuropharmacology

San-Qiao Yang
Yu-Hui Tang
Si-Min Chen
Fen Liu
Ping Zhang
Wei Zou
Bo Wang
Xiao-Qing Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691204

5,439 views

Original Research

Published on 24 Oct 2025

Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting

in Cardiovascular and Smooth Muscle Pharmacology

Maxx Holmes
Hector Martinez-Navarro
Marcel Mohr
Jean-Marie Chambard
Veronique Ballet
Eva Vermersch
Ambroise Garry
Friedemann Schmidt
Blanca Rodriguez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671199

1,732 views

Editorial

Published on 24 Oct 2025

Editorial: Advancing drug discovery with AI: drug–target interactions, mechanisms of action, and screening

in Experimental Pharmacology and Drug Discovery

Xutong Li
Jing Xing
Sulin Zhang
Jiayu Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721323

2,292 views

Review

Published on 24 Oct 2025

Targeting type H vessels with bioactive metabolites from traditional Chinese botanical drugs: a therapeutic strategy for skeletal disorders

in Ethnopharmacology

Shengping Tang
Jinkao Li
Zhuqing Dong
Yangjie Cai
Jianwei Hu
Xiaofei Ding
Shijie Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693131

2,250 views

Original Research

Published on 24 Oct 2025

Rituximab in PR3-ANCA positive patients with moderately to severely active ulcerative colitis: a multicenter real-world pilot study

in Gastrointestinal and Hepatic Pharmacology

Qi Yu
Yiyu Cheng
Huan Wang
Yidong Chen
Fang Liu
Xiaopeng Zhang
Xiaoyu Fu
Jiamin Li
Junrong Li
Ying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621795

1,556 views

Original Research

Published on 24 Oct 2025

Targeted degradation of EGFR 19Del by PROTACs suppresses tumor growth in non-small-cell lung cancer

in Pharmacology of Anti-Cancer Drugs

Lianhua Piao
Ying Gao
Yangyang Su
Qihui Li
Xiaofeng Yuan
Wangqiu He
Wanzhou Zhao
Janne Kulpakko
Pei-Chieng Cha
Shan Chang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604661

3,239 views
1 citation

Original Research

Published on 24 Oct 2025

Montelukast: risk of mental disorders vs. efficacy–a meta-analysis

in Respiratory Pharmacology

Marharyta Sobczak
Rafał Pawliczak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659852

5,799 views
1 citation

Original Research

Published on 24 Oct 2025

Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression

in Ethnopharmacology

Jinghuai Ni
Lingling Yu
Bingjie Wang
Shuai Chen
Wenbin Shang
Penghua Fang
Bin Du
Wen Min

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604096

1,897 views

Original Research

Published on 24 Oct 2025

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway

in Ethnopharmacology

Huan Yu
Tianzhao Xu
Qiaozong Feng
Yilin Wang
Jun Zou
Xiaoyun Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660294

1,344 views

Original Research

Published on 24 Oct 2025

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis

in Translational Pharmacology

Jiaxi Chen
Yuan He
Min Zhao
Zihan Liu
Zixin Su
Chuanzhou Li
Chen Yang
Jieping Zhang
Shuichun Mao
Hua Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667156

1,495 views

Review

Published on 23 Oct 2025

Diabetes mellitus-driven pulmonary injury: multidimensional mechanisms linking metabolic dysregulation to gut-lung axis and promising therapies

in Respiratory Pharmacology

Jiacheng Sun
Junyang Chen
Yuntian Shen
Xinlei Yao
Hualin Sun
Bingqian Chen
Jian Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689522

2,304 views

Original Research

Published on 23 Oct 2025

Enhanced pharmacokinetic and therapeutic of GSH-responsive mPEG-b-P(HPMA)-SGI1776 conjugate for osteosarcoma

in Translational Pharmacology

Xingchen Shi
Rourou Wang
Zhenghua Zhang
Zixuan Wang
Weibing Xu
Xinhe Shi
Zhe Geng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676770

1,227 views

29,545 articles

articles

The role of TGF-β1 in chronic multilobar segmental bronchial stenosis and advances in targeted drug research

Risk of post-polypectomy bleeding and thromboembolic events during colonoscopy in patients on continued or interrupted antiplatelet therapy: a pooled analysis

Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation

Comparative in vitro susceptibility of clinical Leishmania isolates to miltefosine and oleylphosphocholine

Drug repurposing of natural depsipeptide from Eleftheria terrae isolated via iChip for anti-breast cancer therapy

Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction

Correction: Astragaloside IV alleviates tacrolimus-induced chronic nephrotoxicity via p62-Keap1-Nrf2 pathway

Synthetic bakuchiol derivatives: ester and ether analogs with activity against clinically important bacteria

Comparative study between calcium gluconate with diosmin, cabergoline, and cabergoline with diosmin in prevention of ovarian hyperstimulation syndrome in high-risk women undergoing intracytoplasmic sperm injection (ICSI) procedures

Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice

Overcoming barriers to off-patent drug repurposing: a lifecycle-based policy solutions

Green-synthesized silver nanoparticle hydrogels for biofilm-infected wounds: Bridging sustainability and clinical translation

Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis

Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting

Editorial: Advancing drug discovery with AI: drug–target interactions, mechanisms of action, and screening

Targeting type H vessels with bioactive metabolites from traditional Chinese botanical drugs: a therapeutic strategy for skeletal disorders

Rituximab in PR3-ANCA positive patients with moderately to severely active ulcerative colitis: a multicenter real-world pilot study

Targeted degradation of EGFR 19Del by PROTACs suppresses tumor growth in non-small-cell lung cancer

Montelukast: risk of mental disorders vs. efficacy–a meta-analysis

Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis

Diabetes mellitus-driven pulmonary injury: multidimensional mechanisms linking metabolic dysregulation to gut-lung axis and promising therapies

Enhanced pharmacokinetic and therapeutic of GSH-responsive mPEG-b-P(HPMA)-SGI1776 conjugate for osteosarcoma