Frontiers in Pharmacology

Opinion

Published on 24 Oct 2025

Green-synthesized silver nanoparticle hydrogels for biofilm-infected wounds: Bridging sustainability and clinical translation

in Pharmacology of Infectious Diseases

M. Rifqi Fadillah Muslim
Lutfi Chabib
Betty Ekawati Suryaningsih
Farida Hayati
Viviane Annisa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694144

1,657 views
3 citations

Original Research

Published on 24 Oct 2025

Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis

in Neuropharmacology

San-Qiao Yang
Yu-Hui Tang
Si-Min Chen
Fen Liu
Ping Zhang
Wei Zou
Bo Wang
Xiao-Qing Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691204

5,439 views

Original Research

Published on 24 Oct 2025

Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting

in Cardiovascular and Smooth Muscle Pharmacology

Maxx Holmes
Hector Martinez-Navarro
Marcel Mohr
Jean-Marie Chambard
Veronique Ballet
Eva Vermersch
Ambroise Garry
Friedemann Schmidt
Blanca Rodriguez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671199

1,732 views

Original Research

Published on 24 Oct 2025

Rituximab in PR3-ANCA positive patients with moderately to severely active ulcerative colitis: a multicenter real-world pilot study

in Gastrointestinal and Hepatic Pharmacology

Qi Yu
Yiyu Cheng
Huan Wang
Yidong Chen
Fang Liu
Xiaopeng Zhang
Xiaoyu Fu
Jiamin Li
Junrong Li
Ying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621795

1,556 views

Editorial

Published on 24 Oct 2025

Editorial: Advancing drug discovery with AI: drug–target interactions, mechanisms of action, and screening

in Experimental Pharmacology and Drug Discovery

Xutong Li
Jing Xing
Sulin Zhang
Jiayu Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721323

2,292 views

Review

Published on 24 Oct 2025

Targeting type H vessels with bioactive metabolites from traditional Chinese botanical drugs: a therapeutic strategy for skeletal disorders

in Ethnopharmacology

Shengping Tang
Jinkao Li
Zhuqing Dong
Yangjie Cai
Jianwei Hu
Xiaofei Ding
Shijie Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693131

2,250 views

Original Research

Published on 24 Oct 2025

Targeted degradation of EGFR 19Del by PROTACs suppresses tumor growth in non-small-cell lung cancer

in Pharmacology of Anti-Cancer Drugs

Lianhua Piao
Ying Gao
Yangyang Su
Qihui Li
Xiaofeng Yuan
Wangqiu He
Wanzhou Zhao
Janne Kulpakko
Pei-Chieng Cha
Shan Chang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604661

3,239 views
1 citation

Original Research

Published on 24 Oct 2025

Montelukast: risk of mental disorders vs. efficacy–a meta-analysis

in Respiratory Pharmacology

Marharyta Sobczak
Rafał Pawliczak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659852

5,799 views
1 citation

Original Research

Published on 24 Oct 2025

Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression

in Ethnopharmacology

Jinghuai Ni
Lingling Yu
Bingjie Wang
Shuai Chen
Wenbin Shang
Penghua Fang
Bin Du
Wen Min

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604096

1,897 views

Original Research

Published on 24 Oct 2025

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway

in Ethnopharmacology

Huan Yu
Tianzhao Xu
Qiaozong Feng
Yilin Wang
Jun Zou
Xiaoyun Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660294

1,344 views

Original Research

Published on 24 Oct 2025

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis

in Translational Pharmacology

Jiaxi Chen
Yuan He
Min Zhao
Zihan Liu
Zixin Su
Chuanzhou Li
Chen Yang
Jieping Zhang
Shuichun Mao
Hua Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667156

1,495 views

Review

Published on 23 Oct 2025

Diabetes mellitus-driven pulmonary injury: multidimensional mechanisms linking metabolic dysregulation to gut-lung axis and promising therapies

in Respiratory Pharmacology

Jiacheng Sun
Junyang Chen
Yuntian Shen
Xinlei Yao
Hualin Sun
Bingqian Chen
Jian Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689522

2,304 views

Original Research

Published on 23 Oct 2025

Enhanced pharmacokinetic and therapeutic of GSH-responsive mPEG-b-P(HPMA)-SGI1776 conjugate for osteosarcoma

in Translational Pharmacology

Xingchen Shi
Rourou Wang
Zhenghua Zhang
Zixuan Wang
Weibing Xu
Xinhe Shi
Zhe Geng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676770

1,227 views

Original Research

Published on 23 Oct 2025

Anti-convulsant efficacy of long-acting injectable cannabidiol formulation (IVL5005) in the pentylenetetrazol-induced convulsions, with pharmacokinetic characterization

in Experimental Pharmacology and Drug Discovery

Soyoung Youm
Joo Young Cha
Slgirim Lee
Young Dai Seo
Kun Hee Park
Aeri Song
Hyun-Je Park
Woo Chan Son
Juhee Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692123

1,989 views

Original Research

Published on 23 Oct 2025

Modulatory efficacy of bone metabolism and safety of denosumab versus zoledronic acid in the treatment of bone and joint osteoporosis in elderly men

in Experimental Pharmacology and Drug Discovery

Jing He
Yuhui Mao
Wanran Gong
Haitao Zhu
Peng Xiang
Shui Wang
Xiaofeng Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666421

2,001 views

Mini Review

Published on 23 Oct 2025

Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?

in Predictive Toxicology

Li You
Eugenie Nepovimova
Klara Sklenarikova
Qinghua Wu
Kamil Kuca

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700863

1,489 views

Original Research

Published on 23 Oct 2025

Implementation and impact analysis of a clinical pharmacy ambulatory: a two-year experience

in Pharmacoepidemiology

Daniele Mengato
Laura Camuffo
Federica Todino
Luisella Cordiano
Domenica Condello
Catia Bucciol
Franca Benini
Francesco Paolo Russo
Alberto Cipriani
Stefano Sartori

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706056

1,640 views

Original Research

Published on 23 Oct 2025

Development and validation of a UHPLC-QqQ-MS/MS method for simultaneous determination of fifteen major components from Oroxyli seed extract in rat plasma and its application in the pharmacokinetic study

in Ethnopharmacology

Zhenguo Lv
Kaili Zhang
Zijing Zhang
Jinyue Ma
Wenwen Li
Lu Chen
Wenhan Lin
Yameng Zhu
Minglei Ge
Huizi Ouyang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691629

1,364 views

Original Research

Published on 23 Oct 2025

Integrated chemometric evaluation of morphological traits, chemical composition, and hepatotoxicity of Polygonum multiflorum

in Predictive Toxicology

Yanyi Li
Qi Wang
Yanrong Yang
Xiaobin Huang
Yujie Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666300

1,190 views

Original Research

Published on 23 Oct 2025

Adherence, satisfaction, and quality of life in Wilson disease patients after switching to trientine tetrahydrochloride: observational data from a dual cohort study

in Drugs Outcomes Research and Policies

Valentina Medici
Nora Cazzagon
Pier M. Battezzati
Andrea Crosignani
Alberto Civolani
Emanuela Bonaiuto
Renata D’Incà
Emanuela Vargiu
Fabio Tedone
Stefania Lopatriello

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1515686

1,564 views

Mini Review

Published on 22 Oct 2025

Effect of formononetin on progressive pulmonary pathologies: multitarget mechanisms and therapeutic prospects

in Ethnopharmacology

Dan Yan
Saibin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645964

1,967 views

Systematic Review

Published on 22 Oct 2025

Tongxinluo capsule for acute myocardial infarction: a systematic review and meta-analysis

in Ethnopharmacology

Yang Wu
Jingxue Guo
Jiasai Fan
Xian Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632809

2,110 views

Correction

Published on 22 Oct 2025

Correction: Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms

in Pharmacology of Anti-Cancer Drugs

Zhichun Li
Ruohan Feng
Jinze Li
Jinglu Bai
Nuo Li
Zhenhua Cui
Xiaobin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705251

698 views

Correction

Published on 22 Oct 2025

Correction: Therapeutic effects of Eucommia ulmoides extract on osteoporosis rat models: a systematic review and meta-analysis

in Ethnopharmacology

Zhen Chen
Chuan Leng
Tang Rui
Chaoqun Feng
Tong Li
Yang Yu
Lei Zhong
Xiaohong Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1711404

875 views

29,558 articles

articles

Green-synthesized silver nanoparticle hydrogels for biofilm-infected wounds: Bridging sustainability and clinical translation

Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis

Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting

Rituximab in PR3-ANCA positive patients with moderately to severely active ulcerative colitis: a multicenter real-world pilot study

Editorial: Advancing drug discovery with AI: drug–target interactions, mechanisms of action, and screening

Targeting type H vessels with bioactive metabolites from traditional Chinese botanical drugs: a therapeutic strategy for skeletal disorders

Targeted degradation of EGFR 19Del by PROTACs suppresses tumor growth in non-small-cell lung cancer

Montelukast: risk of mental disorders vs. efficacy–a meta-analysis

Scorpion-Centipede extracts mitigate ovariectomy-induced osteoporosis in mice through facilitating Cx3cr1 expression

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway

Cholestane-3β,5α,6β-triol induces cancer cell death by activating GSDME-mediated pyroptosis

Diabetes mellitus-driven pulmonary injury: multidimensional mechanisms linking metabolic dysregulation to gut-lung axis and promising therapies

Enhanced pharmacokinetic and therapeutic of GSH-responsive mPEG-b-P(HPMA)-SGI1776 conjugate for osteosarcoma

Anti-convulsant efficacy of long-acting injectable cannabidiol formulation (IVL5005) in the pentylenetetrazol-induced convulsions, with pharmacokinetic characterization

Modulatory efficacy of bone metabolism and safety of denosumab versus zoledronic acid in the treatment of bone and joint osteoporosis in elderly men

Circadian rhythm in mycotoxin-induced immunotoxicity: an emerging regulatory axis?

Implementation and impact analysis of a clinical pharmacy ambulatory: a two-year experience

Development and validation of a UHPLC-QqQ-MS/MS method for simultaneous determination of fifteen major components from Oroxyli seed extract in rat plasma and its application in the pharmacokinetic study

Integrated chemometric evaluation of morphological traits, chemical composition, and hepatotoxicity of Polygonum multiflorum

Adherence, satisfaction, and quality of life in Wilson disease patients after switching to trientine tetrahydrochloride: observational data from a dual cohort study

Effect of formononetin on progressive pulmonary pathologies: multitarget mechanisms and therapeutic prospects

Tongxinluo capsule for acute myocardial infarction: a systematic review and meta-analysis

Correction: Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms

Correction: Therapeutic effects of Eucommia ulmoides extract on osteoporosis rat models: a systematic review and meta-analysis