Frontiers in Pharmacology

Original Research

Published on 21 Oct 2025

Drug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database

in Pharmacoepidemiology

Xiaozhi Li
Xiaofen Wen
Hongbo Fu
Xiaobing Hong
Danxia Lin
Xiaoyan Li
Zhikun Liang
Mengna Wang
Xihui Yu
Yanqiong Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700469

1,910 views

Clinical Trial

Published on 21 Oct 2025

Qifu Huazhuo formula for gout recurrence prevention: an interim analysis combining clinical outcomes with proteomic and metabolomic profiling

in Ethnopharmacology

Zhengdong Shen
Fangjie Zhu
Yongliang Chu
Haiyu Wang
Maojie Wang
Xiumin Chen
Yunting Xiao
Yongqiang Yang
Runyue Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642121

2,310 views

Original Research

Published on 21 Oct 2025

The interaction of AB-680, a CD73 inhibitor, with NBTI, a nucleoside transporter inhibitor, on the adenosinergic control of atrial contractility

in Cardiovascular and Smooth Muscle Pharmacology

Ignac Ovari
Agnes Boglarka Brezniczky
Attila Laczovics
Ervin Berényi
Tamas Erdei
Oluwatofunmi Ojo
Bence Hornok
Bela Juhasz
Zoltan Szilvassy
Judit Zsuga

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683950

1,156 views

Original Research

Published on 20 Oct 2025

Therapeutic effects of three-strain probiotic combination on slow transit constipation: mechanistic insights into MAPK signaling pathway and gut microbiota restoration

in Gastrointestinal and Hepatic Pharmacology

Liya Liu
Peiyao Li
Youqin Chen
Guangqing Yang
Ying Cheng
Sijia Liu
Xinran Zhang
Yulun Wu
Qihong Liu
Peilin Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684442

2,527 views

Original Research

Published on 20 Oct 2025

Comparative cardiovascular risks of canagliflozin and selective SGLT2 inhibitors in type 2 diabetes

in Cardiovascular and Smooth Muscle Pharmacology

Edy Kornelius
Shih-Chang Lo
Yi-Sun Yang
Yu-Hsun Wang
Chien-Ning Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686851

1,885 views

Review

Published on 20 Oct 2025

Epigenetic mechanisms of drug resistance in acute myeloid leukemia: advances in small-molecule targeted therapy

in Pharmacology of Anti-Cancer Drugs

Jialing Tang
Xibo Ye
Zhangyang Xu
Tianjiao Min
Zherun Tian
Li Ma
Ying He
Beier Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672524

3,188 views
1 citation

Review

Published on 20 Oct 2025

An overview of insights and updates on TTN mutations in cardiomyopathies

in Cardiovascular and Smooth Muscle Pharmacology

Sarmistha Saha
Gazmend Temaj
Pelin Telkoparan-Akillilar
Silvia Chichiarelli
Luciano Saso

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1668544

3,218 views
2 citations

Original Research

Published on 20 Oct 2025

Cost-effectiveness of iruplinalkib versus crizotinib in first-line anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer patients in China

in Drugs Outcomes Research and Policies

Wanjie Zhang
Yuqiong Lu
Zhanjing Dai
Linning Wang
Yang Zhou
Yun Lu
Feng Chang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651463

1,344 views

Correction

Published on 20 Oct 2025

Correction: Drug interactions between cephalosporins and 5-FU-based chemotherapy in the treatment of patients with gastrointestinal cancer - an exploratory cohort analysis

in Translational Pharmacology

Robert Siegel
Sophie Schlosser-Hupf
Martina Müller-Schilling
Samer A. Kharroubi
André Gessner
Nahed El-Najjar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721652

1,024 views

Review

Published on 20 Oct 2025

The dual role of glycogen synthase kinase-3 beta (GSK3β) in neurodegenerative pathologies: interplay between autophagy and disease progression

in Neuropharmacology

Hassan H. Alhassan
Komal Janiyani
Malvi Surti
Mohd Adnan
Mitesh Patel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693805

8,447 views
3 citations

Review

Published on 20 Oct 2025

Shaoyao Gancao Decoction: a comprehensive review of modern clinical applications and underlying pharmacological mechanisms

in Ethnopharmacology

Du Hong
Ying Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656217

3,043 views

Original Research

Published on 20 Oct 2025

The use of magnesium sulfate can reduce the mortality risk of cirrhosis patients: a retrospective cohort study

in Gastrointestinal and Hepatic Pharmacology

Boxian Chen
Yuping Yang
Mouji Liang
Yanqi Kou
Ruyin Ye
Liping Zhan
Yujie Huang
Qing Zhang
Haoyuan Huang
Jieming Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551495

2,651 views

Mini Review

Published on 20 Oct 2025

Pain and anesthesia — on fetal nervous system and brain development

in Obstetric and Pediatric Pharmacology

Mengjie Gao
Ganzhu Bao
Shuancheng Bai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710759

1,575 views

Original Research

Published on 20 Oct 2025

Hemodialysis-induced renal perfusion decline: unraveling the pathophysiological mechanisms linking intradialytic circulatory stress to residual renal function loss

in Renal Pharmacology

Dayang Xie
Jiaming Tan
Qingtao Zhang
Qian Yu
Yiqin Wang
Yujin Wang
Li Gao
Liyuan Yan
Jianhui Zhou
Nan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648608

1,560 views
1 citation

Original Research

Published on 20 Oct 2025

Remimazolam used for sedation during spinal anesthesia puncture provides faster sedation effect and increase recovery rate compared to midazolam: a randomized controlled trial

in Drugs Outcomes Research and Policies

Peipei Sun
Zhimin Tan
Lianxiong Liang
Jianbo Zhang
Xiaoqiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685312

1,667 views

Editorial

Published on 20 Oct 2025

Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development

in Predictive Toxicology

Fengxian Zhang
Feiyu Li
Jiaqi Tan
Nan Zhang
Yonglong Han
Jiayu Liao
Huaqiang Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721364

1,161 views

Review

Published on 20 Oct 2025

Structure and gating of kainate receptors

in Pharmacology of Ion Channels and Channelopathies

Shanti P. Gangwar
Maria V. Yelshanskaya
Laura Y. Yen
Thomas P. Newton
Alexander I. Sobolevsky

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662316

2,819 views
2 citations

Original Research

Published on 20 Oct 2025

Zhuriheng pills improve adipose tissue dysfunction and inflammation by modulating PPARγ to stabilize atherosclerotic plaques

in Ethnopharmacology

Qiong Zhai
Fangyuan Liang
Guanlin Yang
Zhimin Liu
Xin Dong
Ren Bu
Peifeng Xue
Shengsang Na
Xuan Zhang
Pengwei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576521

2,801 views

Original Research

Published on 20 Oct 2025

Real-world feasibility of co-administration of RSV, COVID-19, and influenza vaccines in older adults: a VAERS-based analysis

in Pharmacoepidemiology

Zhen Wei
Shilun Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682119

3,026 views

Mini Review

Published on 17 Oct 2025

Leveraging artificial intelligence to validate traditional biomarkers and drug targets in liver cancer recovery: a mini review

in Experimental Pharmacology and Drug Discovery

Shengjian Wu
Xiaoqiao Chen
Yuxiu Ji
Chi Zhang
Yujie Xie
Bin Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697608

2,407 views

Original Research

Published on 17 Oct 2025

Alkaloid-driven multi-target synergy of Tripterygium wilfordii polyglycosides overcomes cisplatin resistance in ovarian cancer by coordinated inhibition of PTPN11/EGFR/JAK signaling

in Pharmacology of Anti-Cancer Drugs

Bing Lin
Minxin Zhang
Ying Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686526

1,832 views

Original Research

Published on 17 Oct 2025

Empagliflozin’s cardioenergetic protective effects through PPARα pathway modulation in heart failure

in Cardiovascular and Smooth Muscle Pharmacology

Hua Wei
Menghua Yin
Junshun Chang
Bo Feng
Qin Zhou
Xirong Li
Ping Wu
Xiaoshan Guo
Siyuan Chen
Bao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636810

2,139 views

Original Research

Published on 17 Oct 2025

Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways

in Experimental Pharmacology and Drug Discovery

Ruohong Lin
Zhiwei Zhou
Yizhou Jiang
Song Liu
Jinfeng Xie
Haitao Wang
Henning Ulrich
Wenhua Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642167

2,511 views
1 citation

Original Research

Published on 17 Oct 2025

Low-dose mivacurium facilitates laryngeal mask airway insertion in patients undergoing hysteroscopic surgery: a prospective, single-center, double-blind randomized controlled trial

in Drugs Outcomes Research and Policies

Yingchao Guan
Lizhen Wu
Haochen Wang
Conghui Wang
Yusong Lin
Minghong Ju
Xiaojing Cong
Wen He
Xiaodong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700175

1,179 views

29,570 articles

articles

Drug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database

Qifu Huazhuo formula for gout recurrence prevention: an interim analysis combining clinical outcomes with proteomic and metabolomic profiling

The interaction of AB-680, a CD73 inhibitor, with NBTI, a nucleoside transporter inhibitor, on the adenosinergic control of atrial contractility

Therapeutic effects of three-strain probiotic combination on slow transit constipation: mechanistic insights into MAPK signaling pathway and gut microbiota restoration

Comparative cardiovascular risks of canagliflozin and selective SGLT2 inhibitors in type 2 diabetes

Epigenetic mechanisms of drug resistance in acute myeloid leukemia: advances in small-molecule targeted therapy

An overview of insights and updates on TTN mutations in cardiomyopathies

Cost-effectiveness of iruplinalkib versus crizotinib in first-line anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer patients in China

Correction: Drug interactions between cephalosporins and 5-FU-based chemotherapy in the treatment of patients with gastrointestinal cancer - an exploratory cohort analysis

The dual role of glycogen synthase kinase-3 beta (GSK3β) in neurodegenerative pathologies: interplay between autophagy and disease progression

Shaoyao Gancao Decoction: a comprehensive review of modern clinical applications and underlying pharmacological mechanisms

The use of magnesium sulfate can reduce the mortality risk of cirrhosis patients: a retrospective cohort study

Pain and anesthesia — on fetal nervous system and brain development

Hemodialysis-induced renal perfusion decline: unraveling the pathophysiological mechanisms linking intradialytic circulatory stress to residual renal function loss

Remimazolam used for sedation during spinal anesthesia puncture provides faster sedation effect and increase recovery rate compared to midazolam: a randomized controlled trial

Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development

Structure and gating of kainate receptors

Zhuriheng pills improve adipose tissue dysfunction and inflammation by modulating PPARγ to stabilize atherosclerotic plaques

Real-world feasibility of co-administration of RSV, COVID-19, and influenza vaccines in older adults: a VAERS-based analysis

Leveraging artificial intelligence to validate traditional biomarkers and drug targets in liver cancer recovery: a mini review

Alkaloid-driven multi-target synergy of Tripterygium wilfordii polyglycosides overcomes cisplatin resistance in ovarian cancer by coordinated inhibition of PTPN11/EGFR/JAK signaling

Empagliflozin’s cardioenergetic protective effects through PPARα pathway modulation in heart failure

Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways

Low-dose mivacurium facilitates laryngeal mask airway insertion in patients undergoing hysteroscopic surgery: a prospective, single-center, double-blind randomized controlled trial