Frontiers in Pharmacology

General Commentary

Published on 17 Oct 2025

Commentary: Efficacy and safety of HSK21542 for pruritus management in hemodialysis patients: a multicenter, randomized, double-blind, placebo-controlled trial

in Renal Pharmacology

Steven Fishbane

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689698

1,359 views

Systematic Review

Published on 17 Oct 2025

Systematic review and network meta-analysis of the effects of bioactive compounds on pain intensity and quality of life in neuropathic pain patients

in Neuropharmacology

Rong Tang
Chao-Yang Gong
Yu-Qian Liu
Yingbin Wang
Hai-Yu Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656400

6,489 views

Original Research

Published on 17 Oct 2025

Alpha-ketoglutarate rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice

in Experimental Pharmacology and Drug Discovery

Jing-Hui Qiu
Xiao-Bao Ruan
Yu Jiang
Wen-Ting Shi
Xia Tao
Alex F. Chen
Cheng Peng
He-Hui Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656473

2,011 views

Systematic Review

Published on 17 Oct 2025

Cannabis and cannabinoids in dermatology: a systematic review and meta-analysis of quantitative outcomes

in Experimental Pharmacology and Drug Discovery

Pim Sermsaksasithorn
Tanawin Nopsopon
Chatpol Samuthpongtorn
Korn Chotirosniramit
Krit Pongpirul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609667

4,373 views

Systematic Review

Published on 17 Oct 2025

The clinical efficacy of herbal medicines containing leeches in the treatment of coronary heart disease: a systematic review and meta-analysis

in Ethnopharmacology

Zhao Ziyuan
Ye Di
Liang Mei
Jin Yujing
Zheng Jinghui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643611

2,661 views

Case Report

Published on 17 Oct 2025

Cardiotoxicity related to intrapericardial infusion of bevacizumab in the treatment of lung cancer-mediated malignant pericardial effusion: a case report

in Pharmacology of Anti-Cancer Drugs

Shilong Wu
Yanjun Lu
Chenyang Xu
Huafeng Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573297

1,262 views
1 citation

Original Research

Published on 17 Oct 2025

GEODE: an in silico tool that translates in vitro to in vivo predictions of tuberculosis antibiotic combination efficacy

in Pharmacology of Infectious Diseases

Maral Budak
Mariana Pereira Moraes
Talia Greenstein
Pauline Maiello
H. Jacob Borish
Harris B. Chishti
Kara Kracinovsky
Mark Rodgers
Jaime Tomko
Philana Ling Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639673

2,637 views
1 citation

Review

Published on 17 Oct 2025

Application and research progress on artificial intelligence in the quality of Traditional Chinese Medicine

in Ethnopharmacology

Mei-Yu Li
Jun-Qing Zhu
Xiao-Nan Liu
Meng-Yue Wu
Kun Dong
Xiao-Yan Li
Peng Gao
Zhi-Hui Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687681

4,383 views
1 citation

Original Research

Published on 17 Oct 2025

A double layer oral film loaded with doxepin hydrochloride for the treatment of chemotherapy-induced oral mucositis

in Inflammation Pharmacology

Peiyan Wang
Tianlu Wang
Hui Zhang
Pei Sun
Changqing Yuan
Yiqing Guo
Zhaochen Liu
Mengyu Jiao
Jingwen Chi
Kexin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673190

1,448 views

Original Research

Published on 17 Oct 2025

Huoxue-Jiangtang decoction ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced rats

in Ethnopharmacology

Maosheng Lee
Yanyan Tan
Huilin Li
Deliang Liu
Hengxia Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675295

1,669 views

Review

Published on 17 Oct 2025

Modulating M1/M2 macrophage polarization with plant metabolites: a therapeutic strategy for rheumatoid arthritis

in Ethnopharmacology

Yuanyuan Yang
Xiaoyu Wang
Youqian Kong
Yang Pan
Xiadong Yang
Ziyi Zhang
Zeguang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651763

2,554 views

Review

Published on 17 Oct 2025

Clinically approved immunotoxins targeting hematological cancers: “the best of both worlds”

in Pharmacology of Anti-Cancer Drugs

Yasmine Rashad
Eckhard U. Alt
Reza Izadpanah
Xuebin Qin
Stephen E. Braun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569502

2,653 views
2 citations

Original Research

Published on 17 Oct 2025

QSAR-based physiologically based pharmacokinetic (PBPK) modeling for 34 fentanyl analogs: model validation, human pharmacokinetic prediction and abuse risk insights

in Drug Metabolism and Transport

Simeng Zhang
Yawen Xu
Xianbin Zeng
Jingzhi Ran
Yuanyuan Chen
Lixin Kuai
Kaixi Li
Peng Xu
Fang Yan
Dan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692293

2,580 views

Original Research

Published on 16 Oct 2025

BYS10, a novel selective RET inhibitor, exhibits potent antitumor activity in preclinical models

in Pharmacology of Anti-Cancer Drugs

Fei Qin
Yiman Chen
Jinhai Deng
Ruizhi Guo
Zhoufan Xie
Zhibo Luo
Lin Wang
Tianbai Huang
Jiaji Zhao
Jiansong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670140

1,748 views
1 citation

Mini Review

Published on 16 Oct 2025

Therapeutic potential of Licochalcone A in dermatological diseases: from basic to clinical research

in Ethnopharmacology

Deming Liu
Xue Jiang
Fujin Yang
Jingjing Zhou
Yanxi Li
Hua Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632006

2,518 views
1 citation

Review

Published on 16 Oct 2025

Novel strategies for nanovaccine application in breast cancer treatment

in Pharmacology of Anti-Cancer Drugs

Huan Liu
Ning Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691991

1,961 views

Review

Published on 16 Oct 2025

Gypenosides, a promising phytochemical triterpenoid: research progress on its pharmacological activity and mechanism

in Ethnopharmacology

Xue Li
Yiwei Chen
Ruyu Wang
Baorui Cao
Tingting Deng
Jinxiang Han
Meina Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705946

1,995 views
2 citations

Original Research

Published on 16 Oct 2025

Personalizing voriconazole dosing in Chinese hematological patients: CYP2C19 phenotype and albumin-bilirubin grade as key predictors of trough concentrations

in Pharmacoepidemiology

Lin Hu
Xi Tang
Yanfei Li
Juanjuan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667461

1,102 views

Original Research

Published on 16 Oct 2025

Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala

in Neuropharmacology

Laura Broccoli
Rick E. Bernardi
Francesco Giannone
Anika Hoppe
Kay Jungling
Dasiel O. Borroto-Escuela
Roberto Rimondini-Giorgini
Miguel Pérez de la Mora
Oliver von Bohlen und Halbach
Kjell Fuxe

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677510

7,467 views
1 citation

Clinical Trial

Published on 16 Oct 2025

Comparative study of the pharmacokinetics, efficacy and safety of ET-26 in elderly and non-elderly subjects: the results of a phase I clinical trial

in Drug Metabolism and Transport

Fan Yang
Jing Sun
Pan-Pan Ye
Wen-Shuo Lv
Li-Ze Li
Bao-Zhong Zhao
John Van Den Anker
Yi Zheng
Bo-Wen Ke
Xiao-Ran Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665322

1,279 views

Original Research

Published on 16 Oct 2025

Prediction of long-term adherence to direct oral anti-coagulants in patients with atrial fibrillation using first-order Markov models

in Pharmacoepidemiology

Elias Edward Tannous
Shlomo Selitzky
Shlomo Vinker
Nicola Toukan
David Stepensky
Eyal Schwarzberg

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673919

1,140 views

Review

Published on 16 Oct 2025

Flavonoids as modulators of gut-liver axis: emerging therapeutic strategies for MAFLD

in Ethnopharmacology

Mengxuan Hao
Zihui Wang
Liren Wang
Aidiya Yimamu
Xiaoling Su
Minmin Zhang
Xincan Li
Quanlong Zhang
Zeyu Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657751

3,151 views
2 citations

Original Research

Published on 16 Oct 2025

Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury

in Ethnopharmacology

Shiying Xie
Min Liu
Lei Chen
Yincai Xie
Li Liu
Weina Chen
Huanwen Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690067

1,918 views

Original Research

Published on 15 Oct 2025

Epigallocatechin-3-gallate conjugated with selenium nanoparticles prevents neurological complications in rats exhibiting schizophrenia-like behaviors

in Neuropharmacology

Hadeer M. Gamal El-Deen
Amina E. Essawy
Nema A. Mohammed
Mohamed S. Abdelfattah
Ayah S. Fathalla
Manal F. El-khadragy
Ahmed E. Abdel Moniem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1680380

4,830 views