Frontiers in Pharmacology

Original Research

Published on 18 Dec 2025

Nanozyme-armored natural enzymes for acute kidney injury management via inflammation regulation and oxidative damage mitigation

in Renal Pharmacology

Juntao Wang
Ruifeng Li
Xiaofei Fu
Shuai Huo
Lijiao Wang
Fengmin Shao
Yue Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686323

317 views

Original Research

Published on 18 Dec 2025

Effect of itraconazole on pharmacokinetics of ZX-7101A tablets in healthy Chinese subjects

in Drug Metabolism and Transport

Junzhen Wu
Yin Wang
Wei Liu
Jinjie He
Jufang Wu
Jicheng Yu
Xiaojie Wu
Jianguang Su
Mei Liu
Yilin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722747

282 views

Policy and Practice Reviews

Published on 18 Dec 2025

Regulatory considerations for developing phage therapy medicinal products for the treatment of antimicrobial resistant bacterial infections

in Pharmacology of Infectious Diseases

Ai Fukaya-Shiba
Akiko Ogata
Ryosuke Kuribayashi
Akira Sakurai
Kanako Suzuki
Shunsuke Takadama
Jihei Nishimura
Jumpei Uchiyama
Hiroki Ohge
Takamasa Takeuchi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713471

1,177 views

Original Research

Published on 18 Dec 2025

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

in Renal Pharmacology

Stefano Turolo
Alberto Edefonti
Marie-Louise Syren
Anita S. Bellotti
William Morello
Federica Collino
Carlo Agostoni
Giovanni Montini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672304

306 views

Original Research

Published on 18 Dec 2025

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue

in Inflammation Pharmacology

Amal Kouadri
Camille Lyko
Carine El Hajjar
Johanna Cormenier
Kevin Kevin Gemy
Nadia Alfaidy
Mohamed Benharouga

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657688

400 views

Original Research

Published on 18 Dec 2025

Nonclinical evaluation of HS630, a proposed biosimilar of trastuzumab emtansine: affinity, pharmacokinetics, and immunogenicity

in Drug Metabolism and Transport

Hui Jiang
Jinjing Che

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698727

494 views

Original Research

Published on 18 Dec 2025

Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation

in Pharmacology of Anti-Cancer Drugs

Yanjie Zhong
Ruiqi Zou
Ximei Luo
Siqi Yang
Zhiqiang He
Haijie Hu
Fuyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658462

288 views

Mini Review

Published on 18 Dec 2025

Intranasal delivery of iron chelators and management of central nervous system disease

in Experimental Pharmacology and Drug Discovery

Ruiying Cheng
Jonghan Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709259

523 views

Clinical Trial

Published on 18 Dec 2025

Pharmacokinetics and safety of the antitumor drug everolimus in healthy Chinese subjects: a single-dose, open-label, randomized, two-sequence, two-period crossover, phase I bioequivalence study

in Pharmacology of Anti-Cancer Drugs

Xiaodan Chen
Xiaoyi Yi
Yuting Liu
Xiaosong Wang
Yahui Peng
Qiong Wang
Ying Shuai
Hong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718032

392 views

Opinion

Published on 18 Dec 2025

Voriconazole injection use in patients receiving continuous renal replacement therapy

in Drug Metabolism and Transport

Ling Zhou
Zhenwei Yu
Xia Wang
Huaiyu Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736767

422 views

Original Research

Published on 18 Dec 2025

Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration in vitro and in vivo of clear cell renal cell carcinoma

in Pharmacology of Anti-Cancer Drugs

Zhongjun Jiang
Lanlan Wang
Zhongrun He
Lian Guo
Wen Luo
Ying Fu
Qiyu Xiao
Guanglan Chen
Yinzi Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736086

305 views

Original Research

Published on 18 Dec 2025

Differential effects of PCSK9 inhibitors and statins on plasma ceramides in coronary artery disease

in Cardiovascular and Smooth Muscle Pharmacology

Liang Zhang
Yaodong Ding
Yong Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726925

451 views

Original Research

Published on 18 Dec 2025

Anti-inflammatory effect of a pimarane diterpenoid isolated from Nepeta adenophyta Hedge based on a network analysis approach and experimental assessment

in Ethnopharmacology

Wei Zhao
Meng Li
Chuanqing Jia
Iftikhar Ali
Long Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652902

499 views

Review

Published on 18 Dec 2025

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

in Renal Pharmacology

Jiahuan Gong
Xingxing Fang
Xinlei Yao
Fei Xue
Guangdong Qi
Bingqian Chen
Hualin Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729941

411 views

Original Research

Published on 18 Dec 2025

Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment

in Ethnopharmacology

Hayder A. Hammoodi
Rofida Albash
Mohammed I. A. Hamed
Khaled M. Darwish
Amira B. Kassem
Asmaa Saleh
Jawaher Abdullah Alamoudi
Noha M. Badawi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685423

413 views

Hypothesis and Theory

Accepted on 17 Dec 2025

X-inactive specific transcript (XIST) can determine sex differences in cardiovascular drug responses: focus on RNA therapeutics

in Cardiovascular and Smooth Muscle Pharmacology

Timur O Yarovinsky
Vinod S Ramgolam
Iva Knezevic
Nina S Stachenfeld
Jeffrey R Bender

Frontiers in Pharmacology

213 views

Review

Accepted on 17 Dec 2025

Roxadustat for renal anemia: current clinical experience

in Renal Pharmacology

Jialing Ji
Zhongtang Li
Shuping Fang
Zuo-Lin Li

Frontiers in Pharmacology

273 views

Systematic Review

Accepted on 17 Dec 2025

Knowledge Domain and Evolutionary Trends of P2Y Receptors in Cardiovascular Diseases: A Bibliometric and Altmetric Analysis

in Inflammation Pharmacology

Mengyu Yang
Xuanrui Chen
Shiyin Lie
Jingjing Li
Xuezhang Chen
Ju Chen
Zhiqiang Zhang
Liming Lu
Jingchun Zeng

Frontiers in Pharmacology

102 views

Original Research

Accepted on 17 Dec 2025

Benefit-risk Assessment of the use of toxic botanical drugs in superiority field: A case study on Aconitum carmichaeli Debx

in Ethnopharmacology

Xiaomeng Zhang
Bing Zhang
Jintao Lyv
Zhijian Lin
Xinlong Liu

Frontiers in Pharmacology

Review

Accepted on 17 Dec 2025

Fibroblast Growth Factor Receptor Inhibitors in Glioma: A Narrative Review of Recent Advances

in Pharmacology of Anti-Cancer Drugs

Mingyu Han
Kai Zhao Zhou
Bi Qian
Qi Yuan Zhang
Cheng Peng
Fu Peng

Frontiers in Pharmacology

Mini Review

Accepted on 17 Dec 2025

AI-Driven Immunotherapy: Synergizing with Radiotherapy to Reconfigure the Tumor Microenvironment and Treatment Landscape

in Pharmacology of Anti-Cancer Drugs

Dongling Gu
Yi Feng
Hongyan Li

Frontiers in Pharmacology

Original Research

Accepted on 17 Dec 2025

Cost-effectiveness analysis of inavolisib combined with palbociclib plus fulvestrant in PIK3CA-mutated HR+/Her2-advanced breast cancer in China

in Pharmacology of Anti-Cancer Drugs

Weiwei Huang
Cijuan Li
Yuanqing Huang
Chang Wang
Yingxin Zhang
Yingtao Lin

Frontiers in Pharmacology

113 views

Review

Accepted on 17 Dec 2025

How do nanoparticle properties shape pharmacokinetics and pharmacodynamics? A mechanistic review

in Drug Metabolism and Transport

Esperanza Peralta-Cuevas
Nahomi Y. Degollado-Hernández
Iliana C. Martínez-Ortiz
Ashley J. Gutierrez-Onofre
Igor Garcia-Atutxa
Francisca Villanueva-Flores

Frontiers in Pharmacology

146 views

Original Research

Accepted on 17 Dec 2025

Identification of Novel Germline and Somatic Mutations Associated with Hepatocellular Carcinoma by Next-Generation Sequencing

in Pharmacology of Anti-Cancer Drugs

Ahmed Baligh Laaribi
Wafa BABAY
Abdelmalek Lekired
Bochra Bouchabou
Asma Mehri
Dhouha Bacha
Riadh Sassi
Sana Ben Slama
Rached Bayar
Sahir Omrani

Frontiers in Pharmacology

172 views

29,101 articles

articles

Nanozyme-armored natural enzymes for acute kidney injury management via inflammation regulation and oxidative damage mitigation

Effect of itraconazole on pharmacokinetics of ZX-7101A tablets in healthy Chinese subjects

Regulatory considerations for developing phage therapy medicinal products for the treatment of antimicrobial resistant bacterial infections

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue

Nonclinical evaluation of HS630, a proposed biosimilar of trastuzumab emtansine: affinity, pharmacokinetics, and immunogenicity

Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation

Intranasal delivery of iron chelators and management of central nervous system disease

Pharmacokinetics and safety of the antitumor drug everolimus in healthy Chinese subjects: a single-dose, open-label, randomized, two-sequence, two-period crossover, phase I bioequivalence study

Voriconazole injection use in patients receiving continuous renal replacement therapy

Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration in vitro and in vivo of clear cell renal cell carcinoma

Differential effects of PCSK9 inhibitors and statins on plasma ceramides in coronary artery disease

Anti-inflammatory effect of a pimarane diterpenoid isolated from Nepeta adenophyta Hedge based on a network analysis approach and experimental assessment

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment

X-inactive specific transcript (XIST) can determine sex differences in cardiovascular drug responses: focus on RNA therapeutics

Roxadustat for renal anemia: current clinical experience

Knowledge Domain and Evolutionary Trends of P2Y Receptors in Cardiovascular Diseases: A Bibliometric and Altmetric Analysis

Benefit-risk Assessment of the use of toxic botanical drugs in superiority field: A case study on Aconitum carmichaeli Debx

Fibroblast Growth Factor Receptor Inhibitors in Glioma: A Narrative Review of Recent Advances

AI-Driven Immunotherapy: Synergizing with Radiotherapy to Reconfigure the Tumor Microenvironment and Treatment Landscape

Cost-effectiveness analysis of inavolisib combined with palbociclib plus fulvestrant in PIK3CA-mutated HR+/Her2-advanced breast cancer in China

How do nanoparticle properties shape pharmacokinetics and pharmacodynamics? A mechanistic review

Identification of Novel Germline and Somatic Mutations Associated with Hepatocellular Carcinoma by Next-Generation Sequencing