Frontiers in Pharmacology

Original Research

Accepted on 30 Jun 2025

CDFA: calibrated deep feature aggregation for screening synergistic drug combinations

in Pharmacology of Anti-Cancer Drugs

Xiaorui Kang
XIAOYAN LIU
Quan Zou
Tiantian Li
Ximei Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1608832

109 views

Systematic Review

Accepted on 30 Jun 2025

Long-term Efficacy of CDK4/6 Inhibitors in Early HR+, HER2-High-Risk Breast Cancer: An Updated Systematic Review and Meta-Analysis

in Pharmacology of Anti-Cancer Drugs

Ying Liu
Jun Su
Ping Wu
Wenjie Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564437

Review

Accepted on 30 Jun 2025

Mapping the Oxidative Landscape in Cystic Fibrosis: Methodological Frontiers and Application

in Respiratory Pharmacology

Giorgio Cozza
Michela Rubin
Ilaria Artusi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632924

Original Research

Accepted on 30 Jun 2025

Integrative Genomic Analysis Identifies DPP4 Inhibition as a Modulator of FGF17 and PDGFRA Downregulation and PI3K/Akt Pathway Suppression Leading to Apoptosis

in Pharmacology of Anti-Cancer Drugs

Kiran Kumar Chitluri
Arnold Emerson Isaac

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606914

Original Research

Accepted on 30 Jun 2025

STAT3 mediates CAF-induced osimertinib resistance via regulating protein secretion in non-small cell lung cancer

in Pharmacology of Anti-Cancer Drugs

Xuchen Fan
Sheng Wu
Honglong Wu
Yingying Huang
Xuhui Tong
Meiling Yu
Zhe Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546491

Systematic Review

Accepted on 30 Jun 2025

Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials

in Experimental Pharmacology and Drug Discovery

Dangzhen Liu
Haiyan Zhao
Yiwen Zhang
Jingqing Hu
Hong Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572197

207 views

Review

Accepted on 30 Jun 2025

Unlocking the Potential of Antibody-drug Conjugates in Cervical Cancer: Emerging Targets and Clinical Trials

in Pharmacology of Anti-Cancer Drugs

Yue Zhang
Yao Ding
Yiran Liao
Jin Shu
Yi Gong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636120

168 views

Review

Accepted on 30 Jun 2025

Copper homeostasis and cuproptosis in myocardial infarction: molecular mechanisms, treatment strategies and potential therapeutic targets

in Cardiovascular and Smooth Muscle Pharmacology

Zhichao Liu
Siqi Cai
Huanjie Fu
Yongkang Gan
Shen Zhen
Xiaofeng Li
Xizhen Wang
Chang Liu
Wenjia Ma
Jinhong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525585

594 views

Original Research

Accepted on 30 Jun 2025

Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation

in Neuropharmacology

Junbin Liu
Zhang Xiaoting
Jingpei Guo
Yun Zhang
Junfeng Liu
Jin-Ming Fan
Jiawen Chen
Jiawei Jiang
Benshuai Yu
Ke Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622131

Original Research

Accepted on 30 Jun 2025

DMH1-Loaded Peptide Nanomicelles Restore Myelin and Attenuate Neuroinflammation in Trigeminal Neuralgia via CCL5 Suppression

in Neuropharmacology

Shuangyin Xia
Xiunan Qin
Yaping Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590624

1,335 views

Original Research

Accepted on 30 Jun 2025

The unexploited potential of data systems tracking medicines utilization: An opportunity to improve access to oncology combination therapies

in Drugs Outcomes Research and Policies

Steven Simoens
David Dodwell
Michael Hartevelt
Peter Lindgren
Michele Pistollato
Lisa§ G Pont
Caridad Pontes
Alexander Roediger
Antun Sablek
Eric Van Ganse

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532022

130 views

Original Research

Accepted on 30 Jun 2025

Unique compound with anti-allergic action: inhibition of kinase activity of Lyn by KIRA6

in Inflammation Pharmacology

Goshi Matsushima
Yuri Matsui
Hanano Okamoto
Nagisa Umeda
Mai Kakimoto
Megumi Mino
Tadashi Nakagawa
Kaori Ishii
Yoshimi Matsuo
Daiki Matsubara

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625798

Original Research

Accepted on 30 Jun 2025

Exploring the biological basis for the identification of different syndromes in ischemic heart failure based on joint multi-omics analysis

in Cardiovascular and Smooth Muscle Pharmacology

Yilin Zhang
Jingjing Wei
Lijie Qiao
Rui Yu
Hongjie Ren
Anshe Zhao
Yang Sun
Aolong Wang
Bin Li
Xinlu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641422

Original Research

Accepted on 30 Jun 2025

Huangkui capsule combined with finerenone attenuate diabetic n ephropathy by regulating JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking and experimental verification

in Renal Pharmacology

Xunake Liua
Chunjiang Zhanga
Yanjie Fua
JingJing Daia
Jiaying Lua
Gang Lua
Xiaoping Yanga

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625286

103 views

Original Research

Accepted on 30 Jun 2025

Impact of Complex Interventions on Antibacterial Therapy and Etiological Diagnostics in Community-Acquired Pneumonia: A 12-Month Pre-and Post-Intervention Study

in Pharmacology of Infectious Diseases

Nurgul Ablakimova
Svetlana Rachina
Gaziza Smagulova
Anna Vlasenko
Aigul Mussina
Aliya Zhylkybekova
Ardak Yessenzhulova
Gulbakit Koshmaganbetova
Yerbolat Iztleuov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627858

105 views

Study Protocol

Accepted on 30 Jun 2025

Xiao'er Fengreqing Oral Liquid versus Xiao'er Yanbian Granules for pediatric acute pharyngitis/tonsillitis (external wind heat syndrome): Protocol and statistical analysis plan for a multi-center, randomized, double-blind, active drug-controlled trial

in Obstetric and Pediatric Pharmacology

Kai Liu
Lei Shi
Yike Song
Yu Du
Yi Yuan
Zeyang Shi
Jian-Ping Liu
Hui-Lan Liu
Zhaolan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625547

131 views