Frontiers in Pharmacology | Cardiovascular and Smooth Muscle Pharmacology

Original Research

Published on 17 Oct 2025

Empagliflozin’s cardioenergetic protective effects through PPARα pathway modulation in heart failure

in Cardiovascular and Smooth Muscle Pharmacology

Hua Wei
Menghua Yin
Junshun Chang
Bo Feng
Qin Zhou
Xirong Li
Ping Wu
Xiaoshan Guo
Siyuan Chen
Bao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636810

1,782 views

Original Research

Published on 14 Oct 2025

Identification of an anti-inflammatory action of exosome release in P2Y4 loss-mediated cardioprotection

in Cardiovascular and Smooth Muscle Pharmacology

Esteban Diaz Villamil
Paul Rouvier
Michael Horckmans
Lucas De Roeck
Erika Hendrickx
Louise Conrard
Didier Communi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664015

1,505 views

Review

Published on 13 Oct 2025

Diabetic cardiomyopathy and COVID-19: intersecting pathways and amplified cardiovascular risk

in Cardiovascular and Smooth Muscle Pharmacology

Swati Prakash
Priyanka Choudhury
Shradha Bisht

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683159

2,392 views
1 citation

Case Report

Accepted on 10 Oct 2025

Clopidogrel-induced Drug-Induced Hypersensitivity Syndrome Following Percutaneous Coronary Intervention: A Case Report of Therapeutic Dilemma and Management Strategy

in Cardiovascular and Smooth Muscle Pharmacology

Sikun Wang
Jiang Zhou
Yuanhua Sun

Frontiers in Pharmacology

319 views

Original Research

Published on 09 Oct 2025

Forced intensity-controlled endurance training on a small-animal treadmill machine inducing murine cardiac hypertrophy: insights and comparison to voluntary running models

in Cardiovascular and Smooth Muscle Pharmacology

Maximillian Fischer
Agus Simahendra
Tobias Straub
Stefan Brunner
Bartolo Ferraro
Ludwig T. Weckbach

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682751

1,841 views

Review

Published on 09 Oct 2025

The crosstalk between mitochondrial dysfunction and fatty acid metabolism in heart failure: mechanisms and therapeutic strategies

in Cardiovascular and Smooth Muscle Pharmacology

Min Wang
Zheqin Zhu
Xuan He
Sisi Dai
Rongzhen Liu
Jianhe Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679085

3,386 views

Mini Review

Published on 09 Oct 2025

Tanshinone I, tanshinone IIA, and cryptotanshinone: key bioactive components modulating vascular smooth muscle cell function

in Cardiovascular and Smooth Muscle Pharmacology

Jixin Li
Wenru Wang
Hongbo Huang
Ruiling Zhou
Zhenyu Yang
Zhijie Cui
Zelong Niu
Shengnan Shi
Peili Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688338

1,717 views
2 citations

Original Research

Published on 08 Oct 2025

Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway

in Cardiovascular and Smooth Muscle Pharmacology

Maha Abdulrahman Aldubayan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694060

1,718 views

Original Research

Published on 08 Oct 2025

Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis

in Cardiovascular and Smooth Muscle Pharmacology

Ayman M. Mahmoud
Sulaiman M. Alnasser
Omnia A. M. Abd El-Ghafar
Reem S. Alruhaimi
Hanan S. Althagafy
Ahmed M. Atwa
Emad H. M. Hassanein

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678921

2,241 views

Review

Accepted on 06 Oct 2025

SIRT1: The First key to unlocking the mystery of cardiovascular diseases

in Cardiovascular and Smooth Muscle Pharmacology

Dinislam Khuzin
Muneer Ahmed Khoso
Valeriy Kataev
Svetlana Meshcheryakova
Heng Liu
Ling Liu
Madi Guo
Song Wang
Han Lou
Yong Zhang

Frontiers in Pharmacology

252 views

Original Research

Published on 01 Oct 2025

Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells

in Cardiovascular and Smooth Muscle Pharmacology

Hao Ling
Yu Zhang
Chunli Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658090

2,690 views

Correction

Published on 30 Sep 2025

Correction: An update of the molecular mechanisms underlying anthracycline induced cardiotoxicity

in Cardiovascular and Smooth Muscle Pharmacology

Sicong Xie
Yuwei Sun
Xuan Zhao
Yiqun Xiao
Fei Zhou
Liang Lin
Wei Wang
Bin Lin
Zun Wang
Zixuan Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708198

1,457 views

Original Research

Published on 30 Sep 2025

Thymidine exerts anti-doxorubicin-induced cardiomyopathy effect through the regulation of the PPAR signaling pathways and ferroptosis pathways

in Cardiovascular and Smooth Muscle Pharmacology

Bin Li
Qifei Wang
Jiashuo Zhou
Peihai Li
Chen Sun
Qing Xia
Yun Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524167

2,694 views

Review

Published on 29 Sep 2025

Mitochondrial dysfunction as a therapeutic nexus in HFpEF: therapeutic target and pharmacological advances

in Cardiovascular and Smooth Muscle Pharmacology

Tian Yue
Dezhi Zheng
Jian He
Shiqiang Xiong
Junbo Xu
Jun Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676988

3,242 views

Review

Published on 26 Sep 2025

Copper homeostasis and cuproptosis in myocardial infarction: molecular mechanisms, treatment strategies and potential therapeutic targets

in Cardiovascular and Smooth Muscle Pharmacology

Zhen Shen
Zhichao Liu
Siqi Cai
Huanjie Fu
Yongkang Gan
Xiaofeng Li
Xizhen Wang
Chang Liu
Wenjia Ma
Jinhong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525585

2,970 views
2 citations

Review

Published on 25 Sep 2025

Rivaroxaban versus low-molecular-weight heparin for venous thromboembolism prophylaxis: a systematic review of efficacy, safety, and cost-effectiveness

in Cardiovascular and Smooth Muscle Pharmacology

Bin Li
Ling Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652779

2,826 views
1 citation

Original Research

Published on 22 Sep 2025

Evaluation of left ventricular systolic function in different subtypes of pediatric acute lymphoblastic leukemia: a case-control study based on two-dimensional speckle tracking

in Cardiovascular and Smooth Muscle Pharmacology

Yanfeng Yang
Chunyan Fu
Kun Shi
Yonghong Guo
Peng Shi
Hanmin Liu
Ling Gu
Ying Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669049

1,741 views

Original Research

Published on 16 Sep 2025

Luteolin improves the systolic and diastolic functions of the thoracic aortic vessels in type 2 diabetic rats through the Kv7.1 channel

in Cardiovascular and Smooth Muscle Pharmacology

Weiping Li
Zerong Yang
Xingru Wang
Pengmei Guo
Li Wu
Yanru Wang
Yue Lyu
Xiaojia Xu
Haijie Ji

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651847

1,831 views

Review

Published on 10 Sep 2025

Therapeutic potential of human umbilical cord mesenchymal stem cell-derived exosomes in myocardial infarction: from molecular mechanisms to clinical translation-an update

in Cardiovascular and Smooth Muscle Pharmacology

Nianhui Ding
Zaiyong Zheng
Chunxiang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667140

3,050 views

Original Research

Published on 04 Sep 2025

Abnormal Ca2+ handling and reduced Ito contribute to citalopram-induced QT prolongation and cardiac arrhythmias

in Cardiovascular and Smooth Muscle Pharmacology

Yangpeng Li
Jiamin Xie
Yuqing Zheng
Jianhong Li
Min Zhao
Li Liu
Hongping Shen
Ming Lei
Xiaoqiu Tan
Juan Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613438

1,902 views

Original Research

Published on 04 Sep 2025

Hyperoside alleviates myocardial ischemia-reperfusion injury in heart transplantation by promoting mitochondrial fusion via activating the Stat3-Tom70-Opa1 pathway

in Cardiovascular and Smooth Muscle Pharmacology

Jincheng Hou
Hongwen Lan
Chenghao Li
Zihao Wang
Qiang Zheng
Kan Wang
Tixiusi Xiong
Yixuan Wang
Jiawei Shi
Nianguo Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566674

2,050 views
1 citation

Review

Published on 03 Sep 2025

Natural active herbal monomers for the treatment of thromboembolic diseases: a review

in Cardiovascular and Smooth Muscle Pharmacology

Zhou-Yu Nie
Jia-Qi Zhang
Yuan-Jia-Yi Shen
Jia-Qi Xi
Yong-Bing Cao
Li-Chao Zhang
Ling Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607415

2,138 views
2 citations

Review

Published on 03 Sep 2025

Which is the optimal choice in lipid-lowering therapy for reducing major cardiovascular events? a network meta-analysis

in Cardiovascular and Smooth Muscle Pharmacology

Qiang Niu
Qilei Wang
Feng Chen
Bo Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626681

3,145 views

Original Research

Published on 02 Sep 2025

Inflammatory-nutritional duality of NPAR: a novel biomarker for early prediction of acute liver injury in acute myocardial infarction complicated by type 2 diabetes mellitus

in Cardiovascular and Smooth Muscle Pharmacology

Xiaorui Huang
Zizhu Lian
Shanshan Qi
Hang Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643871

1,619 views

1,408 articles

articles

Empagliflozin’s cardioenergetic protective effects through PPARα pathway modulation in heart failure

Identification of an anti-inflammatory action of exosome release in P2Y4 loss-mediated cardioprotection

Diabetic cardiomyopathy and COVID-19: intersecting pathways and amplified cardiovascular risk

Clopidogrel-induced Drug-Induced Hypersensitivity Syndrome Following Percutaneous Coronary Intervention: A Case Report of Therapeutic Dilemma and Management Strategy

Forced intensity-controlled endurance training on a small-animal treadmill machine inducing murine cardiac hypertrophy: insights and comparison to voluntary running models

The crosstalk between mitochondrial dysfunction and fatty acid metabolism in heart failure: mechanisms and therapeutic strategies

Tanshinone I, tanshinone IIA, and cryptotanshinone: key bioactive components modulating vascular smooth muscle cell function

Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway

Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis

SIRT1: The First key to unlocking the mystery of cardiovascular diseases

Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells

Correction: An update of the molecular mechanisms underlying anthracycline induced cardiotoxicity

Thymidine exerts anti-doxorubicin-induced cardiomyopathy effect through the regulation of the PPAR signaling pathways and ferroptosis pathways

Mitochondrial dysfunction as a therapeutic nexus in HFpEF: therapeutic target and pharmacological advances

Copper homeostasis and cuproptosis in myocardial infarction: molecular mechanisms, treatment strategies and potential therapeutic targets

Rivaroxaban versus low-molecular-weight heparin for venous thromboembolism prophylaxis: a systematic review of efficacy, safety, and cost-effectiveness

Evaluation of left ventricular systolic function in different subtypes of pediatric acute lymphoblastic leukemia: a case-control study based on two-dimensional speckle tracking

Luteolin improves the systolic and diastolic functions of the thoracic aortic vessels in type 2 diabetic rats through the Kv7.1 channel

Therapeutic potential of human umbilical cord mesenchymal stem cell-derived exosomes in myocardial infarction: from molecular mechanisms to clinical translation-an update

Abnormal Ca2+ handling and reduced Ito contribute to citalopram-induced QT prolongation and cardiac arrhythmias

Hyperoside alleviates myocardial ischemia-reperfusion injury in heart transplantation by promoting mitochondrial fusion via activating the Stat3-Tom70-Opa1 pathway

Natural active herbal monomers for the treatment of thromboembolic diseases: a review

Which is the optimal choice in lipid-lowering therapy for reducing major cardiovascular events? a network meta-analysis

Inflammatory-nutritional duality of NPAR: a novel biomarker for early prediction of acute liver injury in acute myocardial infarction complicated by type 2 diabetes mellitus