Frontiers in Pharmacology | Cardiovascular and Smooth Muscle Pharmacology

Review

Published on 10 Jul 2025

Beyond the heart: a review exploring non-cardiovascular effects of vasoactive agents

in Cardiovascular and Smooth Muscle Pharmacology

Peng Lan
Lina Chen
Chen Zhang
Jun Ni
Peihao Yu
Jiancang Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533437

14,207 views

Original Research

Published on 07 Jul 2025

Bitter taste receptor agonists induce vasorelaxation in porcine coronary arteries

in Cardiovascular and Smooth Muscle Pharmacology

Ching-Chung Tsai
Yi-Chen Li
Li-Ching Chang
Shih-Che Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578913

2,138 views

Review

Published on 04 Jul 2025

Harnessing the therapeutic value of Tanshinone IIA: a breakthrough therapy in cardiovascular diseases

in Cardiovascular and Smooth Muscle Pharmacology

Lanxiang Du
Chengyan Guan
Hao Zhang
Haoyue Jia
Qiang Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620152

2,512 views

Review

Published on 03 Jul 2025

Adenosine and adenosine receptors: a “double-edged sword” in cardiovascular system

in Cardiovascular and Smooth Muscle Pharmacology

Yongqi Qian
Yixuan Zheng
Liang Leng
Qingqing Liu
Xiaojuan Tian
Shilin Chen
Sanyin Zhang
Jiang Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538680

3,024 views
2 citations

Review

Published on 03 Jul 2025

Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives

in Cardiovascular and Smooth Muscle Pharmacology

Zilv Ye
Sutong Wang
Zhengdong Wan
Birun Huang
Jiawei Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610429

3,739 views
3 citations

Original Research

Published on 26 Jun 2025

Pedunculoside targets P2X7R to protect against myocarditis by regulating the NLRP3/PIP2/MAPK signaling pathway

in Cardiovascular and Smooth Muscle Pharmacology

Youqiong Zhuo
Jia He
Qin-Qin Wang
Yuntian Xiao
Xiaoyun Xie
Lina Liu
Shilin Yang
Jingjing Li
Renyikun Yuan
Hongwei Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589298

1,944 views
1 citation

Review

Published on 25 Jun 2025

Efficacy of different dosages of common uric acid-lowering medications in gout patients: a network meta-analysis of randomized control trials

in Cardiovascular and Smooth Muscle Pharmacology

Xiaojia Zheng
Cunxiang Xie
Jinying Fang
Zhenghui Huang
Jian Huang
Luming Zhao
Guancheng Ye
Hailong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565530

4,679 views
1 citation

Original Research

Published on 24 Jun 2025

A naphthalimide derivative exerts potent antiplatelet and antithrombotic activities without a bleeding tendency

in Cardiovascular and Smooth Muscle Pharmacology

Wan-Jung Lu
Jiun-Yi Li
Tzenge-Lien Shih
Ray-Jade Chen
Ting-Yu Chen
Wei-Ting Kao
Jen-Wei Liu
Hsueh-Hsiao Wang
Hsien-Yu Peng
Kuan-Hung Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541255

1,536 views

Original Research

Published on 18 Jun 2025

Protective effect of Salvianolic acid B against atherosclerosis: a preclinical systematic review and meta-analysis

in Cardiovascular and Smooth Muscle Pharmacology

Xing Ji
Kailin Huang
Aimei Lu
Xiaomeng Hu
Huanlin Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548811

1,877 views
1 citation

Original Research

Published on 18 Jun 2025

Qishen Yiqi alleviates periostin-mediated cardiac fibrosis and hypertrophy in Dahl hypertensive rat hearts and angiotensin II-induced cardiac organoids

in Cardiovascular and Smooth Muscle Pharmacology

Siwen Fan
Hongxia Du
Siyu Li
Guangxu Xiao
Yuhan Zhao
Shuang He
Guanwei Fan
Yan Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1491582

2,540 views

Original Research

Published on 11 Jun 2025

Multicenter retrospective comparison of safety and efficacy among three antithrombotic regimens following TAVI

in Cardiovascular and Smooth Muscle Pharmacology

Yu Ren
Jing Chen
Suchun Wang
Zhengli Jiang
Hua Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531361

1,678 views

Original Research

Published on 10 Jun 2025

Gastrodin mitigates aortic valve calcification by inhibiting glycolysis and histone lactylation through interfering with valve interstitial cells

in Cardiovascular and Smooth Muscle Pharmacology

Yu Zhang
Shunshun Wang
Jiaqin Wu
Qianqian Du
Huiming Yu
Li Yang
Xianqiong Liu
Kang Xu
Chunli Wang
Fan Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547716

3,881 views
2 citations

Original Research

Published on 09 Jun 2025

Revealing the mechanisms of warfarin-induced vascular calcification through metabolomics and network toxicology

in Cardiovascular and Smooth Muscle Pharmacology

Zhijiao Zhang
Pengyan Jia
Chunqi Feng
Juan Xu
Jingmin Zhang
Niuniu Bai
Weihong Chen
Weiqi Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554987

2,802 views
1 citation

Correction

Published on 09 Jun 2025

Correction: Cardioprotective effects of the electrolyte solution sterofundin and the possible underlying mechanisms

in Cardiovascular and Smooth Muscle Pharmacology

Min Chen
Yingying Xiao
Jijian Zheng
Peibin Zhao
Lin Cheng
Chuan Jiang
Sixie Zheng
Zheng Wang
Sijuan Sun
Lincai Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633008

1,099 views

Review

Published on 06 Jun 2025

Mechanism of action and potential therapeutic targets of TGF-β-related signaling pathway and its downstream miRNA expression in pulmonary arterial hypertension

in Cardiovascular and Smooth Muscle Pharmacology

Yimo Huang
Wende Ma
Cen Guo
Xiaoling Su

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596767

3,935 views

Original Research

Published on 03 Jun 2025

Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis

in Cardiovascular and Smooth Muscle Pharmacology

Zihao Wang
Yingzi Sun
Juanjuan Wang
Qiuyue Xu
Liuxing Wang
Qi Zhang
Juan Song
Yuchun Wang
Zhanpeng Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566622

2,368 views

Original Research

Published on 30 May 2025

Trifolin inhibits the calcium-driven contraction pathway in vascular smooth muscle

in Cardiovascular and Smooth Muscle Pharmacology

Renfeng Li
Jinkong Wu
Meizhu Wu
Farman Ali
Yanyan Yang
Hong Chen
Zhi Guo
Dawei Lian
Aling Shen
Jun Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573483

2,543 views

Original Research

Published on 29 May 2025

Population pharmacokinetic analysis of rivaroxaban in healthy volunteers and patients with radiofrequency ablation of non-valvular atrial fibrillation in China

in Cardiovascular and Smooth Muscle Pharmacology

Fangfang Gu
Kaixian Tang
Cong Zhang
Mingsheng Hu
Junlong Sun
Xiang Yu
Mengli Tian
Chen Zhang
Yingrong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562259

2,508 views

Review

Published on 26 May 2025

The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases

in Cardiovascular and Smooth Muscle Pharmacology

Lu Gan
Xiaofei Guo
Shichao Dong
Chuan Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529375

1,752 views
5 citations

Review

Published on 26 May 2025

Metalloproteinases (MMPs) in hypertensive disorders: role, function, pharmacology, and potential strategies to mitigate pathophysiological changes

in Cardiovascular and Smooth Muscle Pharmacology

Soroush Taherkhani
Mohammad Sheibani
Ali Mohammadkhanizadeh
Jitka A. I. Virag
Lisandra de Castro Braz
Yaser Azizi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559288

3,598 views
3 citations

Review

Published on 23 May 2025

Advances in the treatment of lower-extremity ischemia-reperfusion injury

in Cardiovascular and Smooth Muscle Pharmacology

Jin Peng
Tang Deng
Xunkai Wang
Jinxi Liang
Jiangpeng Wu
Binglong Li
Jun Lv
Shenmei Wu
Shijie Zhong
Chen Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576091

4,362 views
1 citation

Original Research

Published on 21 May 2025

Adenosine deaminase mediates endothelial inflammation via an ADA1-CD26 interaction in post-COVID

in Cardiovascular and Smooth Muscle Pharmacology

Ada Kawecka
Klaudia Stawarska
Marzena Romanowska-Kocejko
Marta Żarczyńska-Buchowiecka
Agata Jędrzejewska
Alicja Braczko
Milena Deptuła
Małgorzata Zawrzykraj
Oliwia Król
Marika Frańczak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578973

1,744 views

Review

Published on 21 May 2025

Multifunctional applications and research advances of low-molecular-weight heparin

in Cardiovascular and Smooth Muscle Pharmacology

Yanru Zhang
Shuixian Guo
Jingchao Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585762

3,999 views
3 citations

Original Research

Published on 20 May 2025

Cardiovascular effects of 6-nitrodopamine, adrenaline, noradrenaline, and dopamine in normotensive and hypertensive rats

in Cardiovascular and Smooth Muscle Pharmacology

Vivian Fuguhara
Mariana Gonçalves De Oliveira
Carlos Alberto Aguiar da Silva
Pedro Renato Guazzelli
Larryn W. Peterson
Gilberto De Nucci

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557997

2,426 views
3 citations

1,408 articles

articles

Beyond the heart: a review exploring non-cardiovascular effects of vasoactive agents

Bitter taste receptor agonists induce vasorelaxation in porcine coronary arteries

Harnessing the therapeutic value of Tanshinone IIA: a breakthrough therapy in cardiovascular diseases

Adenosine and adenosine receptors: a “double-edged sword” in cardiovascular system

Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives

Pedunculoside targets P2X7R to protect against myocarditis by regulating the NLRP3/PIP2/MAPK signaling pathway

Efficacy of different dosages of common uric acid-lowering medications in gout patients: a network meta-analysis of randomized control trials

A naphthalimide derivative exerts potent antiplatelet and antithrombotic activities without a bleeding tendency

Protective effect of Salvianolic acid B against atherosclerosis: a preclinical systematic review and meta-analysis

Qishen Yiqi alleviates periostin-mediated cardiac fibrosis and hypertrophy in Dahl hypertensive rat hearts and angiotensin II-induced cardiac organoids

Multicenter retrospective comparison of safety and efficacy among three antithrombotic regimens following TAVI

Gastrodin mitigates aortic valve calcification by inhibiting glycolysis and histone lactylation through interfering with valve interstitial cells

Revealing the mechanisms of warfarin-induced vascular calcification through metabolomics and network toxicology

Correction: Cardioprotective effects of the electrolyte solution sterofundin and the possible underlying mechanisms

Mechanism of action and potential therapeutic targets of TGF-β-related signaling pathway and its downstream miRNA expression in pulmonary arterial hypertension

Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis

Trifolin inhibits the calcium-driven contraction pathway in vascular smooth muscle

Population pharmacokinetic analysis of rivaroxaban in healthy volunteers and patients with radiofrequency ablation of non-valvular atrial fibrillation in China

The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases

Metalloproteinases (MMPs) in hypertensive disorders: role, function, pharmacology, and potential strategies to mitigate pathophysiological changes

Advances in the treatment of lower-extremity ischemia-reperfusion injury

Adenosine deaminase mediates endothelial inflammation via an ADA1-CD26 interaction in post-COVID

Multifunctional applications and research advances of low-molecular-weight heparin

Cardiovascular effects of 6-nitrodopamine, adrenaline, noradrenaline, and dopamine in normotensive and hypertensive rats