Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 19 Nov 2025

Pharmacokinetics of mycophenolic acid in plasma and peripheral blood mononuclear cells and its relationship with activity of inosine monophosphate dehydrogenase in Chinese adult kidney allograft recipients

in Drug Metabolism and Transport

Yun-Zhu Lu
Xiao-Ling Lu
Jia-Qian Lu
Kun Shao
Hui-Min An
Pei-Jun Zhou
Hao-Qiang Shi
Bing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712932

155 views

Original Research

Accepted on 17 Nov 2025

Estrogen Associations with Human Pregnancy Related Increases in Cytochrome P450 3A Activity

in Drug Metabolism and Transport

Muluneh M. Fashe
Jonghwa Lee
Joseph T. Grieco
John K Fallon
Ian R. Mulrenin
Megan N. Gower
Klarissa D. Jackson
Kim A. Boggess
Craig R. Lee

Frontiers in Pharmacology

Original Research

Published on 17 Nov 2025

1H-NMR-based metabolomics study of Rifafour in a healthy Kramnik (C3HeB/FeJ) tuberculosis mouse model

in Drug Metabolism and Transport

Oluwadara Pelumi Omotayo
Siyethemba Bhengu
Yolandy Lemmer
Kobus Venter
Shayne Mason

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661938

618 views

Original Research

Accepted on 14 Nov 2025

Serum Metabolomics Identifies Novel Prognostic Biomarkers in Amanita Poisoning

in Drug Metabolism and Transport

Dan Zhu
Zou Linahong

Frontiers in Pharmacology

Methods

Published on 14 Nov 2025

Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency

in Drug Metabolism and Transport

Vincent Rönnpagel
Felix Morof
Giuliano Ciarimboli
Markus Grube
Marleen J. Meyer-Tönnies
Mladen V. Tzvetkov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629421

415 views

Original Research

Published on 13 Nov 2025

Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia

in Drug Metabolism and Transport

Péter Szatmári
Adrienn Seres-Bokor
Anita Sztojkov-Ivanov
Gabriella Kékesi
Gyöngyi Horváth
Eszter Ducza

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673124

428 views

Editorial

Published on 12 Nov 2025

Editorial: Non-invasive methods in drug metabolism and transport: insights from biological samples to oral administration

in Drug Metabolism and Transport

Karol Wróblewski
Yi Zheng
Xuyi Yue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1735743

296 views

Mini Review

Published on 12 Nov 2025

Concerns from bench and insights from bedside: the puzzle of Roxadustat in cancer patients with chemotherapy-induced anemia

in Drug Metabolism and Transport

Lin Chen
Shigen Liao
Dan Jing
Linxiu Mao
Jing Tan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703424

359 views

Mini Review

Accepted on 11 Nov 2025

Overcoming the Blood-Brain Barrier: Targeted Delivery Strategies for Gliomas

in Drug Metabolism and Transport

Xue Du
Chunbao Chen
Yijun Zeng
Zhimei Lin

Frontiers in Pharmacology

Original Research

Accepted on 10 Nov 2025

Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes

in Drug Metabolism and Transport

Pius S Fasinu
Gajanan Jadhav

Frontiers in Pharmacology

Clinical Trial

Published on 10 Nov 2025

Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [14C]JP-1366

in Drug Metabolism and Transport

Xuemei Liu
Decheng Deng
Jian Meng
Haitang Hu
Quankun Zhuang
Xue Zhou
Long Fu
Binke Fan
Xueting Xu
Qin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701581

434 views

Original Research

Accepted on 07 Nov 2025

Nonclinical evaluation of HS630, a proposed biosimilar of Trastuzumab Emtansine: Affinity, pharmacokinetics, and immunogenicity

in Drug Metabolism and Transport

Hui Jiang
Jinjing Che

Frontiers in Pharmacology

118 views

Clinical Trial

Published on 07 Nov 2025

Evaluation of the pharmacokinetics, pharmacodynamics, and liver ultrasound imaging characteristics of a novel perfluoropropane microbubble in Chinese volunteers

in Drug Metabolism and Transport

Pengfei Li
Ping Du
Zhixia Zhao
Fei Jia
Weiyue Yu
Peng Qu
Jiangfan Li
Xuhong Wang
Lihong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704972

413 views

Mini Review

Accepted on 06 Nov 2025

Small RNA or oligonucleotide drugs and challenges in evaluating drug-drug interactions

in Drug Metabolism and Transport

Joseph M. Cronin
Aiming Yu

Frontiers in Pharmacology

167 views

Original Research

Accepted on 06 Nov 2025

Endogenous Tetrahydrobiopterin in Humans: Circadian Rhythm, Sex, Race, Age, and Disease Status

in Drug Metabolism and Transport

Lan Gao
Neil Smith
Ronald Kong

Frontiers in Pharmacology

Original Research

Published on 06 Nov 2025

Low-dose methotrexate adverse reaction risk in renal impairment: pharmacovigilance and physiological pharmacokinetic model assessment

in Drug Metabolism and Transport

Lichang Zhang
Jianling Li
Xin Wang
Yaolei Zhang
Sen Gao
Deshi Dong
Yanna Zhu
Shilei Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703557

726 views