Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Accepted on 26 Feb 2025

Influence of the ABCB1-rs1045642 gene polymorphism on blood drug concentration in voriconazole-treated patients with a severe invasive fungal infection

in Drug Metabolism and Transport

Qian Zhang
Xing Gao
Dongmei Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510890

Original Research

Published on 26 Feb 2025

MONSTROUS: a web-based chemical-transporter interaction profiler

in Drug Metabolism and Transport

Mohamed Diwan M. AbdulHameed
Souvik Dey
Zhen Xu
Ben Clancy
Valmik Desai
Anders Wallqvist

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498945

Original Research

Published on 25 Feb 2025

Pharmacokinetics and pharmacodynamics of insulin lispro 25 versus the original preparation (Humalog®25) in Chinese healthy male volunteers

in Drug Metabolism and Transport

Mingxue Zhu
Yuan Chen
Lei Wan
Zhongping Li
Junliang Pu
Chengyong Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533548

107 views

Original Research

Accepted on 20 Feb 2025

High-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring

in Drug Metabolism and Transport

Jinglong Wang
Chenxiao Zhang
Junjie Wang
Guofei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531496

Review

Published on 20 Feb 2025

Effect of hypoalbuminemia on drug pharmacokinetics

in Drug Metabolism and Transport

Ilona Idasiak-Piechocka
Dominik Lewandowski
Wojciech Świgut
Jan Kalinowski
Klaudia Mikosza
Piotr Suchowiejski
Edyta Szałek
Agnieszka Karbownik
Miłosz Miedziaszczyk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546465

411 views

Original Research

Published on 19 Feb 2025

Pharmacokinetics and bioequivalence of two formulations of the S-1 (tegafur/gimeracil/oxonate) capsule in Chinese cancer patients under fasting and fed conditions: a multicenter, randomized, open-label, single-dose, double-cycle crossover study

in Drug Metabolism and Transport

Junli Lu
Yuyan Lei
Yuanyuan Mo
Xiangping Wang
Wanying Liu
Yu Yan
Hongying Yang
Canxia Li
Lifeng Huang
Qiuxia Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1494902

122 views

Original Research

Accepted on 17 Feb 2025

Bioequivalence of China- and Germany-Manufactured Bisoprolol (Concor®) Tablets in Fasted and Fed Healthy Chinese Participants: A Randomized, Open-Label, Two-Way Crossover Study

in Drug Metabolism and Transport

Hang Yin
Zhili Jin
Ran Li
Dandan Li
Lusha Wang
Ruihua Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527623

Review

Published on 17 Feb 2025

Contribution and expression of renal drug transporters in renal cell carcinoma

in Drug Metabolism and Transport

Yawen Zuo
Tong Li
Shilei Yang
Xuyang Chen
Xufeng Tao
Deshi Dong
Fang Liu
Yanna Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466877

314 views

Original Research

Accepted on 14 Feb 2025

Molecular determinants of neuroprotection in blood-brain interfaces of the cynomolgus monkey

in Drug Metabolism and Transport

Nathalie Strazielle
Sandrine Blondel
Joachim Confais
Rita El Khoury
Hugues Contamin
Jean-François Ghersi-Egea

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523819

Original Research

Published on 13 Feb 2025

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

in Drug Metabolism and Transport

Fengyichi Zhang
Fanxi Guo
Xinyu Zhao
Chongyang Li
Junli Wang
Mengyun Wang
Ruixia Ma
Baochang Chen
Qiangqiang Miao
Yimeng Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544215

157 views

Original Research

Accepted on 12 Feb 2025

Inhibitory effect of luteolin on the metabolism of vandetanib in vivo and in vitro

in Drug Metabolism and Transport

Yuxin Shen
Fengsheng Hong
Hualu Wu
Xiaohai Chen
Hailun Xia
Ren-ai Xu
Guanyang Lin
Lu Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526159

Original Research

Published on 12 Feb 2025

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

in Drug Metabolism and Transport

Sadegh Faramarzi
Arianna Bassan
Kevin P. Cross
Xinning Yang
Glenn J. Myatt
Donna A. Volpe
Lidiya Stavitskaya

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451164

279 views

Review

Accepted on 11 Feb 2025

Microalgae in Health Care and Functional Foods: β-Glucan Applications, Innovations in Drug Delivery and Synthetic Biology

in Drug Metabolism and Transport

Chao Li
Ming Du
Yujie Han
Wentao Sun
Zixi Chen
Qiong Liu
Hui Zhu
Liqing Zhao
Shangfei Li
Jiangxin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557298

100 views

Original Research

Published on 11 Feb 2025

Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies

in Drug Metabolism and Transport

Jifeng Gu
Huishan Zhang
Mei Wang
Yuyang Zhou
Zhipeng Deng
Rong Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1522857

187 views

Original Research

Accepted on 10 Feb 2025

Model-informed drug development of novel ROCK2 inhibitor TDI01: population pharmacokinetic study and simulation

in Drug Metabolism and Transport

Xiwei Ji
Yimin Cui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1477607

Opinion

Accepted on 03 Feb 2025

Two-faced Janus SkQ1/SkQR1: patterns and molecular volume threshold for substrate recognition by the AcrAB-TolC pump

in Drug Metabolism and Transport

Marina V. Karakozova
Alexandra I Sorochkina
Pavel A. Nazarov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1480955

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Articles

Influence of the ABCB1-rs1045642 gene polymorphism on blood drug concentration in voriconazole-treated patients with a severe invasive fungal infection

MONSTROUS: a web-based chemical-transporter interaction profiler

Pharmacokinetics and pharmacodynamics of insulin lispro 25 versus the original preparation (Humalog®25) in Chinese healthy male volunteers

High-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring

Effect of hypoalbuminemia on drug pharmacokinetics

Pharmacokinetics and bioequivalence of two formulations of the S-1 (tegafur/gimeracil/oxonate) capsule in Chinese cancer patients under fasting and fed conditions: a multicenter, randomized, open-label, single-dose, double-cycle crossover study

Bioequivalence of China- and Germany-Manufactured Bisoprolol (Concor®) Tablets in Fasted and Fed Healthy Chinese Participants: A Randomized, Open-Label, Two-Way Crossover Study

Contribution and expression of renal drug transporters in renal cell carcinoma

Molecular determinants of neuroprotection in blood-brain interfaces of the cynomolgus monkey

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

Inhibitory effect of luteolin on the metabolism of vandetanib in vivo and in vitro

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

Microalgae in Health Care and Functional Foods: β-Glucan Applications, Innovations in Drug Delivery and Synthetic Biology

Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies

Model-informed drug development of novel ROCK2 inhibitor TDI01: population pharmacokinetic study and simulation

Two-faced Janus SkQ1/SkQR1: patterns and molecular volume threshold for substrate recognition by the AcrAB-TolC pump