Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 10 May 2024

The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis

in Drug Metabolism and Transport

Zikai Song
Haidi Wu
Xiaoqi Fang
Xuemin Feng
Liting Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1336369

4,972 views
16 citations

Original Research

Published on 09 May 2024

Improving prediction of tacrolimus concentration using a combination of population pharmacokinetic modeling and machine learning in chinese renal transplant recipients

in Drug Metabolism and Transport

Yu-Ping Wang
Xiao-Ling Lu
Kun Shao
Hao-Qiang Shi
Pei-Jun Zhou
Bing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389271

2,779 views
4 citations

Review

Published on 07 May 2024

Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review

in Drug Metabolism and Transport

Yuhan Ma
Yongxia Zhao
Mingxia Luo
Qin Jiang
Sha Liu
Qi Jia
Zhixun Bai
Faming Wu
Jian Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1393409

5,079 views
15 citations

Original Research

Published on 02 May 2024

Population pharmacokinetics of intravenous daptomycin in critically ill patients: implications for selection of dosage regimens

in Drug Metabolism and Transport

Jianhua Wu
Xiangyi Zheng
Liu Zhang
Jiajun Wang
Yifei Lv
Yujie Xi
Dongfang Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378872

2,087 views

Original Research

Published on 02 May 2024

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

in Drug Metabolism and Transport

Yujie Yang
Xiqian Zhang
Yirong Wang
Heng Xi
Min Xu
Liang Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342515

3,283 views

Original Research

Published on 29 Apr 2024

The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses

in Drug Metabolism and Transport

Yuanxun Yang
Lei Yu
Zejuan Sheng
Hui Lin
Zuyi Weng
Wei Song
Bei Cao
Yu Zhao
Yingsheng Gao
Shumao Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1327008

2,141 views
2 citations

Original Research

Published on 29 Apr 2024

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

in Drug Metabolism and Transport

Jan Thomann
Karolina E. Kolaczynska
Oliver V. Stoeckmann
Deborah Rudin
Patrick Vizeli
Marius C. Hoener
Christopher R. Pryce
Franz X. Vollenweider
Matthias E. Liechti
Urs Duthaler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1391689

16,279 views
20 citations

Original Research

Published on 29 Apr 2024

The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism

in Drug Metabolism and Transport

Xiaodan Zhang
Qingqing Li
Xinwu Ye
Qing Chen
Chen Chen
Guoxin Hu
Likang Zhang
Lianguo Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1373048

1,582 views
1 citation

Original Research

Published on 19 Apr 2024

Investigation of the hypoglycemic mechanism of the ShenQi compound formula through metabonomics and 16S rRNA sequencing

in Drug Metabolism and Transport

Juan Gao
Xiujuan Zhou
Hong Gao
Guiping Xu
Chunguang Xie
Hongyan Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1349244

2,233 views
2 citations

Original Research

Published on 09 Apr 2024

Iodine-induced synthetic method and pharmacokinetic study of cis- and trans-crocetin

in Drug Metabolism and Transport

Boshen Li
Yuxuan Zhang
Zhiqiang Yang
Xiaolin Li
Jun Yang
Kai Luo
Renjie Wang
Chengrong Xiao
Maoxing Li
Yue Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1364286

1,535 views
1 citation

Original Research

Published on 08 Apr 2024

Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism

in Drug Metabolism and Transport

Yu Wang
Quan Zhou
Huihui Wang
Wei Song
Jianfeng Wang
Abdullah Al Mamun
Peiwu Geng
Yunfang Zhou
Shuanghu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1351882

1,673 views
2 citations

Clinical Trial

Published on 04 Apr 2024

Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant–randomized controlled trial

in Drug Metabolism and Transport

Miłosz Miedziaszczyk
Marek Karczewski
Tomasz Grabowski
Anna Wolc
Ilona Idasiak-Piechocka

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352323

3,386 views
5 citations

Original Research

Published on 02 Apr 2024

Pharmacokinetics of desflurane uptake and disposition in piglets

in Drug Metabolism and Transport

Chih-Cherng Lu
Shung-Tai Ho
Oliver Yao-Pu Hu
Cheng-Huei Hsiong
Yuan-Chen Cheng
Che-Hao Hsu
Tso-Chou Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1339690

3,810 views

Original Research

Published on 27 Mar 2024

Clinical and pharmacological factors influencing serum clozapine and norclozapine levels

in Drug Metabolism and Transport

Anna Mach
Anna Wnorowska
Marcin Siwek
Marcin Wojnar
Maria Radziwoń-Zaleska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356813

2,654 views
2 citations

Original Research

Published on 25 Mar 2024

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

in Drug Metabolism and Transport

Heechun Kwak
Min-Soo Kim
Suyong Kim
Jiyoung Kim
Yasunori Aoki
Suk-Jae Chung
Hyun-Ja Nam
Wooin Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352842

2,315 views
1 citation

Original Research

Published on 18 Mar 2024

Application of machine learning combined with population pharmacokinetics to improve individual prediction of vancomycin clearance in simulated adult patients

in Drug Metabolism and Transport

Guodong Li
Yubo Sun
Liping Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352113

2,212 views
3 citations