Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 02 Nov 2022

Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1

in Drug Metabolism and Transport

David Siegel
Peter S. Harris
Cole R. Michel
Rafael de Cabo
Kristofer S. Fritz
David Ross

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1015642

1,764 views
4 citations

Original Research

Published on 01 Nov 2022

The intervention effect of Amygdalus mongolica oil on the metabolomics and intestinal flora in pulmonary fibrosis

in Drug Metabolism and Transport

Qian Li
Hong-Bing Zhou
Jia-Qi Liu
Wan-Fu Bai
Jia Wang
Zhan-Jun Yang
Min Qiu
Hong Chang
Song-Li Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1037563

3,159 views
8 citations

Original Research

Published on 31 Oct 2022

Plasma metabolomic profiling reveals factors associated with dose-adjusted trough concentration of tacrolimus in liver transplant recipients

in Drug Metabolism and Transport

Huaijun Zhu
Min Wang
Xiaofu Xiong
Yao Du
Danying Li
Zhou Wang
Weihong Ge
Yizhun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1045843

2,913 views
6 citations

Original Research

Published on 28 Oct 2022

Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

in Drug Metabolism and Transport

Dongyan Feng
Guorui Zhong
Qingxia Zuo
Yanbin Wan
Wanqing Xu
Changsheng He
Cailing Lin
Dongchao Huang
Feng Chen
Lizhen Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1015940

3,345 views
5 citations

Original Research

Published on 25 Oct 2022

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

in Drug Metabolism and Transport

Ziqiang Li
Xi Du
Shuang Tian
Shanshan Fan
Xurui Zuo
Yanfen Li
Ruihua Wang
Baohe Wang
Yuhong Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1033667

2,543 views
1 citation

Original Research

Published on 24 Oct 2022

Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison

in Drug Metabolism and Transport

Junjun Mao
Yuhao Chen
Luyang Xu
Weihuang Chen
Biwen Chen
Zhuo Fang
Weiwei Qin
Mingkang Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1016399

4,007 views
10 citations

Original Research

Published on 24 Oct 2022

Plasma metabolomic and lipidomic alterations associated with anti-tuberculosis drug-induced liver injury

in Drug Metabolism and Transport

Ming-Gui Wang
Shou-Quan Wu
Meng-Meng Zhang
Jian-Qing He

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1044808

3,989 views
12 citations

Original Research

Published on 21 Oct 2022

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

in Drug Metabolism and Transport

Yueqiu Liu
Xinyi Hu
Wen Zheng
Lu Zhang
Luolan Gui
Ge Liang
Yong Zhang
Liqiang Hu
Xin Li
Yi Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1011608

3,454 views
8 citations

Original Research

Published on 19 Oct 2022

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

in Drug Metabolism and Transport

Tingting Ma
Yanli Dong
Lei Huang
Yuanxun Yang
Yan Geng
Fei Fei
Pinhao Xie
Yu Zhao
Hui Lin
Zeyu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1027627

3,379 views
8 citations

Correction

Published on 14 Oct 2022

Corrigendum: Impact of sampling time variability on tacrolimus dosage regimen in pediatric primary nephrotic syndrome: Single-center, prospective, observational study

in Drug Metabolism and Transport

Lingfei Huang
Junyan Wang
Jufei Yang
Huifen Zhang
Yan Hu
Jing Miao
Jianhua Mao
Luo Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1051794

776 views

Original Research

Published on 13 Oct 2022

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

in Drug Metabolism and Transport

Jianbo Huang
Hong Wang
Lei Huang
Yuqing Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2022.968835

1,437 views
1 citation

Methods

Published on 11 Oct 2022

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry

in Drug Metabolism and Transport

Kai On Chu
Gene Chi Wai Man
Sze Wan Hung
Tak Hang Chan
Wai Yip Thomas Lee
Kwok Ping Chan
Chi Pui Pang
Chi Chiu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1025053

1,910 views

Review

Published on 11 Oct 2022

The status of industrialization and development of exosomes as a drug delivery system: A review

in Drug Metabolism and Transport

Yi Yin
Xing Han
Cheng Li
Tonghui Sun
Kailin Li
Xionghao Liu
Mujun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.961127

3,730 views
9 citations

Review

Published on 10 Oct 2022

Application of traditional Chinese medicine in film drug delivery system

in Drug Metabolism and Transport

Qianhang Li
Feng Luo
Pingnan Jiang
Chenxi Feng
Feifei He
Lina Dong
Delin Xu
Junhua Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2022.956264

10,764 views
3 citations

Original Research

Published on 10 Oct 2022

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

in Drug Metabolism and Transport

Lu Chen
Chao Li
Hao Bai
Lixian Li
Wanyi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2022.960186

2,678 views
5 citations

Original Research

Published on 07 Oct 2022

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

in Drug Metabolism and Transport

Muhammad Talha Saleem
Muhammad Harris Shoaib
Rabia Ismail Yousuf
Farrukh Rafiq Ahmed
Kamran Ahmed
Fahad Siddiqui
Zafar Alam Mahmood
Muhammad Sikandar
Muhammad Suleman Imtiaz

Frontiers in Pharmacology

doi 10.3389/fphar.2022.974715

5,451 views
3 citations

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Articles

Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1

The intervention effect of Amygdalus mongolica oil on the metabolomics and intestinal flora in pulmonary fibrosis

Plasma metabolomic profiling reveals factors associated with dose-adjusted trough concentration of tacrolimus in liver transplant recipients

Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison

Plasma metabolomic and lipidomic alterations associated with anti-tuberculosis drug-induced liver injury

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

Corrigendum: Impact of sampling time variability on tacrolimus dosage regimen in pediatric primary nephrotic syndrome: Single-center, prospective, observational study

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry

The status of industrialization and development of exosomes as a drug delivery system: A review

Application of traditional Chinese medicine in film drug delivery system

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™