Frontiers in Pharmacology | Drug Metabolism and Transport

Clinical Trial

Published on 30 May 2025

The food effect on the pharmacokinetics of TQB3616 capsule in Chinse healthy subjects: a randomized, open-label, single-center, two-period, two-sequence crossover phase I clinical trial

in Drug Metabolism and Transport

Jun Dai
Yanan Zhou
Lei Zhang
Qing Ren
Zhengzhi Liu
Yanli Wang
Yang Cheng
Qiaohuan Deng
Haimiao Yang
Hong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586368

397 views

Review

Accepted on 27 May 2025

Ferroptosis as a potential therapeutic target for obesity-related metabolic diseases

in Drug Metabolism and Transport

Chaodong Huang
Tao Luo
HUA ZHANG
Linhui Cheng
Shuhong Peng
Xiaowei Zhou
Lan Cao
Fangyou Chen
Junwei He
Chen Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581632

334 views

Original Research

Accepted on 27 May 2025

Impact of administration route and gene polymorphisms on the serum concentration of voriconazole among Chinese patients with hematologic malignancies

in Drug Metabolism and Transport

Zhiyao Chen
Menghua Zhang
Lin Wang
Yuzhu Cheng
Liyan Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1445583

255 views

Original Research

Published on 26 May 2025

Bioanalytical assay for the quantification of rucaparib in rat plasma using UPLC-MS/MS: development, and validation for interaction with myricetin

in Drug Metabolism and Transport

Jingjing Nie
Hailun Xia
Jie Chen
Jun Wu
Jinming Yang
Xuegu Xu
Congrong Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576131

675 views

Original Research

Published on 23 May 2025

Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples

in Drug Metabolism and Transport

Dong Hwan Lee
Jae Ha Lee
Ji Hoon Jang
Yong Kyun Kim
Gaeun Kang
So Young Jung
Minyoung Her
Hang Jea Jang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541131

896 views

Original Research

Published on 21 May 2025

Serum retinol binding protein as a novel marker for clearance and dosage optimization: pharmacokinetics study of voriconazole in a cirrhosis population

in Drug Metabolism and Transport

Juping Yun
Haihong Bai
Zihe Wang
Yingmin Ma
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543323

601 views

Original Research

Published on 19 May 2025

Population pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma

in Drug Metabolism and Transport

Shifeng Wei
Sitian Zhang
Dan Wang
Dongjie Zhang
Qian Lu
Jiayi Mo
Zhilin Yang
Leyi Guan
Yingjun He
Zhigang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578033

980 views

Original Research

Published on 19 May 2025

Liquid chromatography–tandem mass spectrometry assay for the simultaneous determination of apalutamide and its active metabolite N-desmethyl apalutamide, and its application in real-world patients with castration-resistant prostate cancer

in Drug Metabolism and Transport

Yuxuan Zhu
Lu Chen
Wenqiang Cheng
Dingyuan Yang
Lijuan Zhang
Jun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510583

1,009 views

Brief Research Report

Published on 19 May 2025

Study of genetic polymorphisms and steady-state trough concentrations of imatinib and its active metabolite in predicting efficacy in gastrointestinal stromal tumors

in Drug Metabolism and Transport

Menghua Zhang
Zhiyao Chen
Xiaoxue Liu
Xiaojun Zhou
Liyan Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604619

708 views

Review

Published on 14 May 2025

Nanocarrier-based targeted drug delivery for Alzheimer’s disease: addressing neuroinflammation and enhancing clinical translation

in Drug Metabolism and Transport

Kang Wang
Rongying Yang
Jing Li
Haitao Wang
Li Wan
Jiale He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591438

1,787 views

Review

Published on 12 May 2025

Global research on the utilization of population pharmacokinetic model: a bibliometric analysis from 2000 to 2024

in Drug Metabolism and Transport

Yucheng Yao
Liyuan Zhang
Dan Chen
Shiran Qin
Mingyu Meng
Qiuyan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548023

1,146 views

Original Research

Published on 12 May 2025

Development and application of a UHPLC-MS/MS method for the simultaneous determination of firmonertinib and its main metabolite AST-5902 in rat plasma: a study on the in vivo drug interaction between firmonertinib and paxlovid

in Drug Metabolism and Transport

Peng-Fei Tang
Su-Su Bao
Wei-Fei Xie
Zhong-Xiang Xiao
Xue-Meng Wu
Hong-Lei Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570206

653 views

Clinical Trial

Published on 12 May 2025

Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers

in Drug Metabolism and Transport

Yike Wang
Dai Li
Tong Zhang
Sumei Xu
Yanxin Zhang
Kaijing Zhao
Shaorong Li
Kai Shen
Xiaomin Li
Pingsheng Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563556

940 views

Brief Research Report

Published on 12 May 2025

Osmotic laxatives do not alter dabigatran plasma concentration in healthy volunteers – a randomized, controlled, cross-over trial

in Drug Metabolism and Transport

Matthias Weiss-Tessbach
Al Medina Dizdarevic
Alexander Kupis
Thorsten Bischof
Christa Firbas
Peter Quehenberger
Ulla Derhaschnig
Max Frimmel
Bernd Jilma
Christian Schoergenhofer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579014

678 views

Original Research

Published on 02 May 2025

Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

in Drug Metabolism and Transport

Peile Wang
Jingli Lu
Jing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578643

1,566 views

Original Research

Published on 30 Apr 2025

Molecular pharmacokinetic mechanism of JBP485 against aristolochic acid I (AAI) -induced nephrotoxicity

in Drug Metabolism and Transport

Chong Wang
Huan Jin
Changyuan Wang
Jingjing Wu
Qiang Meng
Ming Zhong
Huijun Sun
Yuheng Wei
Ge Gao
Taiichi Kaku

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577942

1,224 views