Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 22 Jan 2025

Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method

in Drug Metabolism and Transport

Cassandra Yun
Kazuki Fukami
Raku Shinkyo
Rongrong (Rosa) Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481937

516 views

Original Research

Published on 17 Jan 2025

Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans

in Drug Metabolism and Transport

Ying Qi
Pengfei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463575

500 views

Original Research

Published on 15 Jan 2025

Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury

in Drug Metabolism and Transport

Sin Yin Lim
Cameron O. Scarlett
Sefer Yapici
Peter Ferrazzano
Pelin Cengiz

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1508696

470 views

Original Research

Published on 13 Jan 2025

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment

in Drug Metabolism and Transport

Yuyi Feng
Danxia Qiu
Yangcheng He
Hai Jin
Liping Chen
Fen Xi
Zhiwen Hu
Yanlin Xie
Yucai Li
Minhua Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1502349

449 views

Original Research

Published on 13 Jan 2025

Effects of acteoside from Cistanche tubulosa on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells

in Drug Metabolism and Transport

Shilei Zhang
Fukai Gong
Jiali Liu
Shuping You
Tao Liu
Jianhua Yang
Junping Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1370264

627 views

Original Research

Published on 10 Jan 2025

Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling

in Drug Metabolism and Transport

Valdeene Vieira Santos
Laiz Campos Pereira
Jackeline Marley Santos de Araújo
Matheus Antônio da Hora Borges
Carolina Magalhães Brandão
Luisa Oliveira Santos
Cristiane Flora Villarreal
Francine Johansson Azeredo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1515462

400 views

Original Research

Published on 09 Jan 2025

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans

in Drug Metabolism and Transport

Jin-Woo Park
Jong-Min Kim
Young Yoon Bang
Kyoung-Ah Kim
Sungwook Yu
Ji-Young Park

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1507915

336 views

Original Research

Published on 08 Jan 2025

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

in Drug Metabolism and Transport

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
Zhilin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1510903

467 views

Original Research

Published on 08 Jan 2025

stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments

in Drug Metabolism and Transport

Roberto Visintainer
Anna Fochesato
Daniele Boaretti
Stefano Giampiccolo
Shayne Watson
Micha Levi
Federico Reali
Luca Marchetti

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1462193

402 views

Original Research

Published on 07 Jan 2025

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

in Drug Metabolism and Transport

Mihaela Butiulca
Lenard Farczadi
Silvia Imre
Camil Eugen Vari
Laurian Vlase
Bogdan Cordos
Leonard Azamfirei
Alexandra Elena Lazar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1494646

402 views

Original Research

Published on 07 Jan 2025

The effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients

in Drug Metabolism and Transport

Anna Mach
Anna Wnorowska
Marcin Siwek
Marcin Wojnar
Maria Radziwoń-Zaleska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518739

436 views

Methods

Published on 06 Jan 2025

Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma

in Drug Metabolism and Transport

Jiahui Lin
Aiting Jiang
Juntao Zheng
Jingjing Wu
Hao Li
Shirong Cai
Yulong He
Xiao Chen
Guoping Zhong
Ke-Jing Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506931

372 views

Original Research

Published on 03 Jan 2025

Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway

in Drug Metabolism and Transport

Xiaokang Wang
Chunxiao Ye
Xixiao Yang
Maoxun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1522271

386 views

Clinical Trial

Published on 03 Jan 2025

Evaluating the pharmacokinetics and safety of blonanserin tablets and Lonasen®: a randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial

in Drug Metabolism and Transport

Bo Qiu
Haojing Song
Xue Sun
Congyang Ding
Runxuan Du
Wanjun Bai
Zhanjun Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1511214

279 views

Original Research

Published on 03 Jan 2025

Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects

in Drug Metabolism and Transport

Feng Cheng
Tao Shen
Fucheng Zhang
Chenghao Lei
Ye Zhu
GuoJun Luo
Dawei Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1452596

520 views

Original Research

Accepted on 19 Dec 2024

Evaluation of Drug-Drug Interaction between Suraxavir Marboxil (GP681) and Itraconazole, and Assessment of the Impact of Gene Polymorphism

in Drug Metabolism and Transport

Mai Han
Gang Cui
Yan Zhao
Xianbo Zuo
Xiaoxue Wang
Xin Zhang
Na Mi
Jiangli Jin
Chunyan Xiao
Jing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505557

282 views

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Articles

Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method

Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans

Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment

Effects of acteoside from Cistanche tubulosa on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells

Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

The effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients

Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma

Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway

Evaluating the pharmacokinetics and safety of blonanserin tablets and Lonasen®: a randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial

Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects

Evaluation of Drug-Drug Interaction between Suraxavir Marboxil (GP681) and Itraconazole, and Assessment of the Impact of Gene Polymorphism