Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 30 Sep 2025

Study on cerebrospinal fluid meropenem, vancomycin and tigecycline monitoring in patients with central nervous system infection following neurosurgery under different drug regimens

in Drug Metabolism and Transport

Xiaoman Zhao
Yanan Qiao
Qing Xie
Zheng Zhang
Yan Song
Jianbang Kang
Jinchuan Li
Jinju Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666168

1,346 views

Original Research

Published on 30 Sep 2025

Characterization of trazodone metabolic pathways and species-specific profiles

in Drug Metabolism and Transport

Vanessa Petrucci
Patrizia Dragone
Marcello C. Laurenti
Laura Oggianu
Volha Zabela
Agnese Cattaneo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636919

765 views

Original Research

Accepted on 29 Sep 2025

1H-NMR-based metabolomics study of Rifafour in a healthy Kramnik (C3HeB/FeJ) tuberculosis mouse model

in Drug Metabolism and Transport

Oluwadara Pelumi Omotayo
Siyethemba Bhengu
Yolandy Lemmer
Kobus Venter
Shayne Mason

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661938

334 views

Clinical Trial

Published on 26 Sep 2025

Pharmacokinetics, safety and tolerability of ipatasertib in combination with palbociclib and fulvestrant in patients with advanced breast cancer in a phase Ib study

in Drug Metabolism and Transport

Kit Wun Kathy Cheung
Ksenia Arzumanova
Victor Poon
Adam Harris
Ryan Johnson
Frauke Schimmoller
Rucha Sane

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670582

1,258 views

Original Research

Published on 26 Sep 2025

Pharmacokinetic-pharmacodynamic target attainment analyses as support for meropenem dosing regimens in critically ill adult and elderly patients with Pseudomonas aeruginosa infections

in Drug Metabolism and Transport

Ruyu Tao
Sumyeut Chan
Jinxingyi Wang
Xianhe Wang
Lei Shi
Xue Lan
Ling Chen
Xiaohui Mu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643553

1,657 views

Original Research

Published on 23 Sep 2025

Evaluation the inhibitory effect of nicardipine on the metabolism of quetiapine

in Drug Metabolism and Transport

Jinzhao Yang
Hailun Xia
Qingqing Li
Ruibin Li
Lu Cao
Congrong Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567044

2,535 views

Clinical Trial

Accepted on 22 Sep 2025

A Phase I Study of HEC73543, an oral FLT3 inhibitor: the Effect of Food on Pharmacokinetics after Oral Dosing in Healthy Chinese Volunteers

in Drug Metabolism and Transport

Di Wang
Min Wu
Xiaojiao Li
Yingzhi Jiang
Bing Liu
Yingjun Zhang
Li Deng
Yanhua Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636504

1,061 views

Original Research

Accepted on 22 Sep 2025

QSAR-based Physiologically Based Pharmacokinetic (PBPK) Modeling for 34 Fentanyl Analogs: Model Validation, Human Pharmacokinetic Prediction and Abuse Risk Insights

in Drug Metabolism and Transport

Simeng Zhang
Yawen Xu
Xianbin Zeng
Jingzhi Ran
Yuanyuan Chen
Lixin Kuai
Kaixi Li
Peng Xu
Fang Yan
Dan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692293

632 views

Review

Accepted on 22 Sep 2025

The Impact of the Exposome on Cytochrome P450-Mediated Drug Metabolism

in Drug Metabolism and Transport

Hwaida Ali
Mireille Hanna
Noha Alziny
Shuaib Mahmoud
Abdallah Borham
Aya Mustafa
A. Abdelnaser

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639646

593 views

Original Research

Published on 19 Sep 2025

Stability study of common vasoactive drugs diluted in five types of solutions

in Drug Metabolism and Transport

Han Yang
Bingbing Xiang
Deiying Gong
Guoyan Zhao
Wensheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670183

1,433 views

Editorial

Accepted on 18 Sep 2025

Editorial: Diverse Functions of Drug Transporters

in Drug Metabolism and Transport

Jeffry Carlos Granados
Kit Wun Kathy Cheung
Bhagwat Prasad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697775

Original Research

Published on 17 Sep 2025

Risk factor identification for delayed excretion in pediatric high-dose methotrexate therapy: a machine learning analysis of real-world data

in Drug Metabolism and Transport

Chengyu Zhou
Yali Qian
Yao Xue
Liucheng Rong
Yu Wan
Kaiqiang Leng
Hongjun Miao
Feng Chen
Yongjun Fang
Xuhua Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662718

1,253 views

Original Research

Published on 11 Sep 2025

Impact of metabolic enzyme activity variability on dabrafenib disposition

in Drug Metabolism and Transport

Shi-yu Wang
Qing Chen
Zhong-xi Chen
Jing Chen
Jing Yuan
Li-shang Dai
Lian-guo Chen
Xiao-dan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643618

1,203 views

Original Research

Published on 10 Sep 2025

Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS

in Drug Metabolism and Transport

Chun-nan Zhang
Zhi-bin Wang
Rui-tong Du
Shu-lu Zhang
Chu-qiao Wang
Meng Wang
Li-hong Wu
De-qiang Yang
Chen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1647015

1,979 views

Original Research

Published on 03 Sep 2025

Safety, tolerability, and pharmacokinetics of faldaprevir after single increasing doses in healthy subjects

in Drug Metabolism and Transport

Chan-Loi Yong
Regina Sennewald
Gerhard Nehmiz
Anne-Marie Quinson
Fenglei Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622249

1,413 views

Original Research

Published on 29 Aug 2025

Semi-mechanistic population pharmacokinetic model incorporating glutathione S-transferase activity for personalized busulfan dosing in pediatric allogeneic hematopoietic cell transplantation

in Drug Metabolism and Transport

Di Cao
Xiaowen Qian
Ping Wang
Xinyi Zheng
Shan Huang
Zhonglin Wei
Wenjin Jiang
Ling Yu
Xin Jiang
Ying Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632588

951 views