Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 09 Jul 2025

Prediction of drug concentrations in humans for long-acting injectable suspensions by a semi-mechanical muscle compartment model: a case study of paliperidone palmitate

in Drug Metabolism and Transport

Panpan Yu
Mengjun Zhang
Xiong Jin
Keheng Wu
Sihui Long
Shishi Cheng
Long Fu
Xiao Xu
Jie Liu
Dan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507828

215 views

Original Research

Published on 09 Jul 2025

Population pharmacokinetic analysis of remimazolam after continuous infusion for sedation in critically ill patients

in Drug Metabolism and Transport

Jingchun Chen
Xipei Wang
Dong Chen
Xiaolong Liu
Kaiyi Peng
Ruizheng Tang
Linhui Hu
Yirong Wang
Yunpeng Bai
Lin Chang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526266

176 views

Clinical Trial

Published on 07 Jul 2025

A phase I study to evaluate the effect of high-dose carbidopa on levodopa pharmacokinetics

in Drug Metabolism and Transport

Akane Hayashi
Atsushi Hosomi
Shinsaku Kihara
Masato Nishi
Saori Torisawa
Yoshiumi Ouchi
Hidenori Takada
Junichi Enokizono

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596139

360 views

Review

Published on 04 Jul 2025

Ferroptosis as a potential therapeutic target for obesity-related metabolic diseases

in Drug Metabolism and Transport

Chao-Dong Huang
Tao Luo
Hua Zhang
Lin-Hui Cheng
Shu-Hong Peng
Xiao-Wei Zhou
Lan Cao
Fang-You Chen
Jun-Wei He
Chen Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581632

595 views

Original Research

Published on 01 Jul 2025

Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy

in Drug Metabolism and Transport

Qian Sun
Jiang Jian
Xueqiang Zhou
Zhu Hong
Suwen Yang
Yanping Zheng
Siyi Wang
Maojun Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621959

383 views

Review

Accepted on 30 Jun 2025

Application of cell-derived vesicle-based biomimetic drug delivery system in tumor therapy

in Drug Metabolism and Transport

Yan Mei
Maochang Liu
Meng Mei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632361

129 views

Original Research

Accepted on 27 Jun 2025

Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: A new avenue for liver cancer management

in Drug Metabolism and Transport

Hebatollah Eitah
Rabab Sayed
yousreya maklad
amina Gamal el Din
khaled mahmoud
Ayman Elsahar
Amani Alhejely
Amal Abdulbaqi
Hanan Naeim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559303

194 views

Original Research

Published on 26 Jun 2025

Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response

in Drug Metabolism and Transport

Maja Đanić
Nebojša Pavlović
Natalija Dedić
Dragana Zaklan
Slavica Lazarević
Bojan Stanimirov
Momir Mikov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1608110

365 views

Review

Published on 26 Jun 2025

Advances in clinical applications of microneedle

in Drug Metabolism and Transport

Kequan Chen
Xinyu Sun
Yangkaiyuan Liu
Shiyu Li
Dianhuai Meng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607210

677 views

Review

Published on 17 Jun 2025

A comprehensive overview of triptolide utilizing nanotechnology and its potential applications in prostate diseases

in Drug Metabolism and Transport

Tongyin Yan
Yiao Wang
Zhiyan Hou
Pan Song
Puze Wang
Jinze Li
Jing Zheng
Dong Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592066

490 views

Original Research

Published on 17 Jun 2025

Pulmonary delivery of excipient-free tobramycin DPIs for the treatment of Pseudomonas aeruginosa lung infection with CF

in Drug Metabolism and Transport

Song Cheng
Haozhou Huang
Zhihao Zhang
Mateng Chen
Yulong Zhang
Mengxing Lin
Gang Yang
Lynda Thubelihle Kanye
Qingzhen Zhang
Ning Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528905

883 views

Original Research

Published on 12 Jun 2025

Machine learning approach for personalized vancomycin steady-state trough concentration prediction: a superior approach over Bayesian population pharmacokinetic model

in Drug Metabolism and Transport

Ting Hu
Xian Ding
Feifei Han
Zhuoling An

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549500

611 views

Original Research

Published on 12 Jun 2025

Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice

in Drug Metabolism and Transport

Linxi Wang
Zhouyangyang Zhang
Menghua Lin
Liqin Qi
Libin Liu
Zhuo Chen
Shuzhi Tang
Lijing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596655

743 views

Review

Published on 05 Jun 2025

Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review

in Drug Metabolism and Transport

Carlos D.F. Fonseca
Ondřej Zendulka
Jan Juřica

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599012

1,412 views

Clinical Trial

Published on 02 Jun 2025

Safety, tolerability, pharmacokinetics, and pharmacodynamics of etrasimod in healthy Chinese adults: a randomized, double-blind, placebo-controlled dose-escalation phase 1 study

in Drug Metabolism and Transport

Fangfang Wang
Xiaoye Niu
Na Liu
Zhengying Zhu
Yun Lin
Lisa Ying
Haiyan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523339

866 views

Original Research

Published on 30 May 2025

Integrated UPLC–MS/MS and UPLC–Q–TOF–MS/MS analysis to reveal pharmacokinetics, tissue distribution, metabolism, and excretion of sipeimine in rats

in Drug Metabolism and Transport

Hui Zong
Chongyang Wang
Dongdong He
Liting Liu
Juanjuan Wan
Guodong Wang
Dingtao Li
Jun Ran
Meiling Zhang
Hui Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595731

842 views