Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 25 Feb 2025

Pharmacokinetics and pharmacodynamics of insulin lispro 25 versus the original preparation (Humalog®25) in Chinese healthy male volunteers

in Drug Metabolism and Transport

Mingxue Zhu
Yuan Chen
Lei Wan
Zhongping Li
Junliang Pu
Chengyong Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533548

1,063 views

Review

Published on 20 Feb 2025

Effect of hypoalbuminemia on drug pharmacokinetics

in Drug Metabolism and Transport

Ilona Idasiak-Piechocka
Dominik Lewandowski
Wojciech Świgut
Jan Kalinowski
Klaudia Mikosza
Piotr Suchowiejski
Edyta Szałek
Agnieszka Karbownik
Miłosz Miedziaszczyk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546465

6,047 views

Original Research

Published on 19 Feb 2025

Pharmacokinetics and bioequivalence of two formulations of the S-1 (tegafur/gimeracil/oxonate) capsule in Chinese cancer patients under fasting and fed conditions: a multicenter, randomized, open-label, single-dose, double-cycle crossover study

in Drug Metabolism and Transport

Junli Lu
Yuyan Lei
Yuanyuan Mo
Xiangping Wang
Wanying Liu
Yu Yan
Hongying Yang
Canxia Li
Lifeng Huang
Qiuxia Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1494902

1,037 views

Review

Published on 17 Feb 2025

Contribution and expression of renal drug transporters in renal cell carcinoma

in Drug Metabolism and Transport

Yawen Zuo
Tong Li
Shilei Yang
Xuyang Chen
Xufeng Tao
Deshi Dong
Fang Liu
Yanna Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466877

1,476 views

Original Research

Published on 13 Feb 2025

UPLC-MS/MS method for simultaneous determination of pyrantel, praziquantel, febantel, fenbendazole and oxfendazole in dog plasma and its application to a bioequivalence study

in Drug Metabolism and Transport

Fengyichi Zhang
Fanxi Guo
Xinyu Zhao
Chongyang Li
Junli Wang
Mengyun Wang
Ruixia Ma
Baochang Chen
Qiangqiang Miao
Yimeng Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544215

989 views

Original Research

Published on 12 Feb 2025

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

in Drug Metabolism and Transport

Sadegh Faramarzi
Arianna Bassan
Kevin P. Cross
Xinning Yang
Glenn J. Myatt
Donna A. Volpe
Lidiya Stavitskaya

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451164

1,837 views
1 citation

Original Research

Published on 11 Feb 2025

Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies

in Drug Metabolism and Transport

Jifeng Gu
Huishan Zhang
Mei Wang
Yuyang Zhou
Zhipeng Deng
Rong Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1522857

937 views

Review

Published on 24 Jan 2025

Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects

in Drug Metabolism and Transport

Dwi Pratiwi Kasmara
Erlina Abdullah
Zaliha Harun
Fatmi Nirmala Sari
Norhashima Abd Rashid
Seong Lin Teoh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1522814

1,913 views

Original Research

Published on 22 Jan 2025

Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method

in Drug Metabolism and Transport

Cassandra Yun
Kazuki Fukami
Raku Shinkyo
Rongrong (Rosa) Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481937

1,897 views
1 citation

Original Research

Published on 17 Jan 2025

Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans

in Drug Metabolism and Transport

Ying Qi
Pengfei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463575

1,627 views

Original Research

Published on 15 Jan 2025

Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury

in Drug Metabolism and Transport

Sin Yin Lim
Cameron O. Scarlett
Sefer Yapici
Peter Ferrazzano
Pelin Cengiz

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1508696

1,407 views

Original Research

Published on 13 Jan 2025

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment

in Drug Metabolism and Transport

Yuyi Feng
Danxia Qiu
Yangcheng He
Hai Jin
Liping Chen
Fen Xi
Zhiwen Hu
Yanlin Xie
Yucai Li
Minhua Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1502349

1,006 views

Original Research

Published on 13 Jan 2025

Effects of acteoside from Cistanche tubulosa on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells

in Drug Metabolism and Transport

Shilei Zhang
Fukai Gong
Jiali Liu
Shuping You
Tao Liu
Jianhua Yang
Junping Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1370264

2,015 views
1 citation

Original Research

Published on 10 Jan 2025

Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling

in Drug Metabolism and Transport

Valdeene Vieira Santos
Laiz Campos Pereira
Jackeline Marley Santos de Araújo
Matheus Antônio da Hora Borges
Carolina Magalhães Brandão
Luisa Oliveira Santos
Cristiane Flora Villarreal
Francine Johansson Azeredo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1515462

1,019 views

Original Research

Published on 09 Jan 2025

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans

in Drug Metabolism and Transport

Jin-Woo Park
Jong-Min Kim
Young Yoon Bang
Kyoung-Ah Kim
Sungwook Yu
Ji-Young Park

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1507915

944 views

Original Research

Published on 08 Jan 2025

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

in Drug Metabolism and Transport

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
Zhilin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1510903

1,118 views