Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 08 Nov 2024

Combined carbapenem resulted in a 4.48-fold increase in valproic acid clearance: a population pharmacokinetic model in Chinese children and adults with epilepsy or after neurosurgery

in Drug Metabolism and Transport

Luofei Zhang
Ruoyun Wu
Xingmeng Li
Weixing Feng
Zhigang Zhao
Shenghui Mei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423411

1,200 views

Original Research

Published on 07 Nov 2024

In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor

in Drug Metabolism and Transport

Xiuqing Zhu
Yuexin Li
Huan Luo
Yunxia Zhang
Zhenqing Zhang
Jinglai Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486856

1,749 views

Original Research

Published on 06 Nov 2024

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

in Drug Metabolism and Transport

Milda Girdenytė
Yang Hu
Aghavni Ginosyan
Margareta Hammarlund-Udenaes
Irena Loryan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486686

1,857 views
1 citation

Mini Review

Published on 05 Nov 2024

Evaluating in vivo data for drug metabolism and transport: lessons from Kirchhoff’s Laws

in Drug Metabolism and Transport

Leslie Z. Benet
Jasleen K. Sodhi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1456677

1,085 views
2 citations

Original Research

Published on 24 Oct 2024

Pharmacokinetics study of atracurium, dexmedetomidine, midazolam and 1-hydroxymidazolam in patients undergoing acute aortic dissection surgery

in Drug Metabolism and Transport

Huiling Si
Xuanxuan Xu
Yuhao Liang
Shuaibo Shi
Fan Xie
Jie Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427553

968 views

Review

Published on 23 Oct 2024

Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology

in Drug Metabolism and Transport

Yutao Zou
Jiayi Chen
Xuanxuan Luo
Yijie Qu
Mengjiao Zhou
Rui Xia
Weiqi Wang
Xiaohua Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481168

2,159 views
7 citations

Original Research

Published on 09 Oct 2024

Study on biotransformation and absorption of genistin based on fecal microbiota and Caco-2 cell

in Drug Metabolism and Transport

Zhe Li
Yuqing Wang
Zicheng Wang
Dongxue Wu
Yuhao Zhao
Xun Gong
Quan Jiang
Congmin Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437020

1,745 views
2 citations

Correction

Published on 27 Sep 2024

Corrigendum: Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism

in Drug Metabolism and Transport

Hailun Xia
Xinhao Xu
Jie Chen
Hualu Wu
Yuxin Shen
Xiaohai Chen
Ren-ai Xu
Wenzhi Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495855

765 views

Original Research

Published on 23 Sep 2024

Study of transport, tissue distribution, depletion, and hepatotoxicity of Cyadox, a quinoxaline-1,4-dioxide derivative

in Drug Metabolism and Transport

Zhu Tao
Changchun Li
Aiqun Zhang
Zhilin Zhang
Jing Huang
Sechenchogt Harnud

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1401275

871 views

Original Research

Published on 20 Sep 2024

Metabolomics and network pharmacology reveal partial insights into the hypolipidemic mechanisms of ferulic acid in a dyslipidemia mouse model

in Drug Metabolism and Transport

Zhihao Zeng
Guanlin Xiao
Yanchang Liu
Minshan Wu
Xingqin Wei
Canhui Xie
Guangying Wu
Dezheng Jia
Yangxue Li
Sumei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466114

2,070 views

Methods

Published on 20 Sep 2024

A validated UPLC-MS/MS method for quantification of pyrotinib and population pharmacokinetic study of pyrotinib in HER2-positive breast cancer patients

in Drug Metabolism and Transport

Yunfang Zhu
Yuxiang Xu
Haopeng Zhao
Hongxin Qie
Xiaonan Gao
Jinglin Gao
Zhangying Feng
Jing Bai
Rui Feng
Mingxia Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432944

1,407 views

Review

Published on 19 Sep 2024

Isoniazid-historical development, metabolism associated toxicity and a perspective on its pharmacological improvement

in Drug Metabolism and Transport

Jishnu Sankar
Anjali Chauhan
Ramandeep Singh
Dinesh Mahajan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1441147

5,345 views
5 citations

Original Research

Published on 18 Sep 2024

Analysis of riociguat and desmethyl riociguat by UPLC-MS/MS and its interaction with quercetin

in Drug Metabolism and Transport

Qingqing Li
Xiaohai Chen
Siping Zhang
Wanshu Li
Hangjuan Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1470377

1,271 views

Original Research

Published on 13 Sep 2024

Quantitative pulmonary pharmacokinetics of tetrandrine for SARS-CoV-2 repurposing: a physiologically based pharmacokinetic modeling approach

in Drug Metabolism and Transport

Furun Wang
Liuhan Dong
Juanwen Hu
Shijie Yang
Lingchao Wang
Zhiwei Zhang
Wenpeng Zhang
Xiaomei Zhuang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1457983

1,466 views

Original Research

Published on 12 Sep 2024

Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism

in Drug Metabolism and Transport

Hailun Xia
Xinhao Xu
Jie Chen
Hualu Wu
Yuxin Shen
Xiaohai Chen
Ren-ai Xu
Wenzhi Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1403649

1,739 views

Original Research

Published on 06 Sep 2024

Exploring pharmacokinetic variability of palbociclib in HR+/HER2- metastatic breast cancer: a focus on age, renal function, and drug–gene interactions

in Drug Metabolism and Transport

Elena Peruzzi
Bianca Posocco
Lorenzo Gerratana
Margherita Nuti
Marco Orleni
Sara Gagno
Elena De Mattia
Fabio Puglisi
Erika Cecchin
Giuseppe Toffoli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1420174

1,796 views
3 citations