Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 26 Aug 2024

Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

in Drug Metabolism and Transport

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
Zhilin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423175

1,765 views
1 citation

Original Research

Published on 26 Aug 2024

In vitro mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others

in Drug Metabolism and Transport

Junjun Mao
Feifei Yu
Weiwei Qin
Guixian She
Yi Rong
Zhuohan Hu
Mingkang Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1443794

2,037 views
1 citation

Original Research

Published on 23 Aug 2024

Population pharmacokinetics study of tacrolimus in liver transplant recipients: a comparison between patients with or without liver cancer before surgery

in Drug Metabolism and Transport

Haihong Bai
Juping Yun
Zihe Wang
Yingmin Ma
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449535

1,552 views

Original Research

Published on 23 Aug 2024

Enhanced anti-inflammatory activity of chlorogenic acid via folic acid-TPGS-modified liposomes encapsulation: characterization and In vivo evaluation on colitis mice

in Drug Metabolism and Transport

Qing-qing Li
Jia-hui Yan
Zhi-e Zhou
Xiang Geng
Jian-hua Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437773

1,785 views
3 citations

Original Research

Published on 21 Aug 2024

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

in Drug Metabolism and Transport

Godefridus J. Peters
Ietje Kathmann
Elisa Giovannetti
Kees Smid
Yehuda G. Assaraf
Gerrit Jansen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1450418

2,716 views
1 citation

Original Research

Published on 20 Aug 2024

Effects of three flavonoids on the metabolism of lenvatinib

in Drug Metabolism and Transport

Jinzhao Yang
Jie Chen
Qingqing Li
Ren-ai Xu
Xiaohai Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1438259

1,527 views
1 citation

Original Research

Published on 20 Aug 2024

Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis

in Drug Metabolism and Transport

Jing Ling
Xuping Yang
Lulu Dong
Yan Jiang
Sulan Zou
Nan Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455721

1,724 views
1 citation

Original Research

Published on 16 Aug 2024

A simple HPLC–MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria

in Drug Metabolism and Transport

Sheng Hu
Nan Guo
Juan Zeng
Yue Li
Yahui Zhang
Jinjiao Jiang
Bing Leng
Chengwu Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1396307

2,831 views

Review

Published on 12 Aug 2024

Potential role of endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity-an update

in Drug Metabolism and Transport

Mingli Sun
Xin Zhang
Boxuan Tan
Qingya Zhang
Xiaopeng Zhao
Dan Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415108

2,972 views
8 citations

Original Research

Published on 07 Aug 2024

The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

in Drug Metabolism and Transport

Jhohann Richard de Lima Benzi
Yik Pui Tsang
Jashvant D. Unadkat

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440010

2,817 views
3 citations

Original Research

Published on 07 Aug 2024

Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients

in Drug Metabolism and Transport

Salman Khan
Nisar Ahmad
Hina Fazal
Ibrahim A. Saleh
Mostafa A. Abdel-Maksoud
Abdul Malik
Gehad AbdElgayed
Arshad Jalal
Kamran Rauf
Liaqat Ali

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1377916

2,743 views
3 citations

Editorial

Published on 05 Aug 2024

Editorial: Pharmacokinetic-pharmacodynamic model of drugs and their pharmacokinetic differences between normal and disease states

in Drug Metabolism and Transport

Zipeng Gong
Ruixing Chen
Ling Ye
Guo Ma
Yanfang Xian
Kaustubh Kulkarni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451176

1,215 views

Correction

Published on 01 Aug 2024

Corrigendum: Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury

in Drug Metabolism and Transport

Xinzhu Zhang
Wu Xiong
Guang Kong
Yushan Zhen
Qiang Zeng
Siming Wang
Sheng Chen
Jun Gu
Cong Li
Kaijin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451951

924 views

Review

Published on 24 Jul 2024

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs

in Drug Metabolism and Transport

Yimei Wang
Mei-Juan Tu
Ai-Ming Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423416

3,792 views
4 citations

Original Research

Published on 22 Jul 2024

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

in Drug Metabolism and Transport

Jiacheng Meng
Chenxu Qiu
Chenyue Lu
Xin He
Xinghua Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1385637

2,023 views
1 citation

Original Research

Published on 18 Jul 2024

Metabolic characterization of the new benzimidazole synthetic opioids - nitazenes

in Drug Metabolism and Transport

Gajanan R. Jadhav
Pius S. Fasinu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1434573

6,077 views
8 citations